wyświetlamy 1000 najlepszych wyników Pomoc
Wyniki wyszukiwania dla: METABOLIC SYNDROME
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Electrochemical and in silico approaches for liver metabolic oxidation of antitumor-active triazoloacridinone C -1305
Publikacja5-Dimethylaminopropylamino-8-hydroxytriazoloacridinone (C-1305) is a promising antitumor compound developed in our laboratory. A better understanding of its metabolic transformations is still needed to explain the multidirectional mechanism of pharmacological action of triazoloacridinone derivatives at all. Thus, the aim of the current work was to predict oxidative pathways of C-1305 that would reflect its phase I metabolism. The...
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Pathogenesis of psoriasis in the “omic” era. Part III. Metabolic disorders, metabolomics, nutrigenomics in psoriasis
PublikacjaPsoriasis is a systemic disease that is strictly connected with metabolic disorders (insulin resistance, atherogenic dyslipidemia, arterial hypertension, and cardiovascular diseases). It occurs more often in patients with a more severe course of the disease. Obesity is specially an independent risk factor and it is associated with a worse treatment outcome because of the high inflammatory activity of visceral fatty tissue and...
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Ability of Yeast Metabolic Activity to Reduce Sugars and Stabilize Betalains in Red Beet Juice
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Cellular Turnover: A Potential Metabolic Rate–Driven Mechanism to Mitigate Accumulation of DNA Damage
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Metabolic transformations of antitumor imidazoacridinone, C-1311, with microsomal fractions of rat and human liver
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Metabolic transformations of antitumor imidazoacridinone, C-1311, with microsomal fractions of rat and human liver
PublikacjaWykazano, że enzymatyczna aktywacja jest konieczna dla aktywności biologicznej pochodnej C-1311 (Symadex R), która znajduje się w II fazie badań klinicznych. Zbadano przemiany enzymatyczne tego związku w obecności frakcji enzymatycznych mikrosomalnych komórek wątroby szczura i ludzkiej. Badania te wykazały, że związek C-1311 jest bardziej podatny na przemiany w obecności frakcji mikrosomalnej niż S9 i cytozolowej. Inkubacja związku...
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Metabolic Gene Expression in the Muscle and Blood Parameters of Broiler Chickens Stimulated In Ovo with Synbiotics
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Effect of GO-Fe3O4 and rotating magnetic field on cellular metabolic activity of mammalian cells
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The influence of different expression of CYP3A4 izoenzymes on metabolic pathway derivatives in human hepatoma cells
PublikacjaCelem przeprowadzonych badań było określenie różnic w metabolizmie pochodnych C-857 i C-1748 w komórkach ludzkiego nowotworu wątroby HepG2 oraz określenie wpływu na ich biotransformację w podwyższonej ekspresji izoenzymu CYP3A4 w tejże linii. Uzyskane wyniki wskazały, że związek C-857, jak również C-1748 metabolizuje w komórkach HepG2 oraz Hep3A4 do wielu reaktywnych, niestabilnych metabolitów. Różnice w biotransformacji były bardzo...
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Diminshed toxicity of C-1748, 4-methyl-9-hydroxyethylamino-1-nitroacridine, compared with its demethyl analog, C-857, corresponds to its resistance to metabolism in HepG2 cells
PublikacjaThe narrow "therapeutic window" of anti-tumour therapy may be the result of drug metabolism leading to the activation or detoxification of antitumour agents. The aim of this work is to examine (i) whether the diminished toxicity of a potent antitumour drug, C-1748, 9-(2'-hydroxyethylamino)-4-methyl-1-nitroacridine, compared with its 4-demethyl analogue, C-857, results from the differences between the metabolic pathways for the...
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The relationship between chronotype and personality among patients with alcohol dependence syndrome: Pilot study
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Optical coherence tomography and magnetic resonance imaging visual pathway evaluation in Wolfram syndrome
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Cutaneous manifestations of autoimmune polyglandular syndrome type 1 – case report and literature review
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Prevalence of polycystic ovary syndrome in European countries and USA: A systematic review and meta-analysis
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Clinical characteristics of children with MIS-C fulfilling classification criteria for macrophage activation syndrome
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Histological Features of Neovaginal Epithelium after Vaginoplasty in Mayer-Rokitansky-Küster-Hauser Syndrome
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Arterial structure and function in subjects with acute coronary syndrome after one-year of treatment
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Serum bisphenol A concentrations correlate with serum testosterone levels in women with polycystic ovary syndrome
PublikacjaThe aim of this study was to determine serum bisphenol A (BPA) concentrations using high performance liquid chromatography with tandem mass spectrometry (HPLC–MS/MS) in women with polycystic ovary syndrome (PCOS) (n=106, age range 18–40 yrs) and to evaluate its potential impact on their hormonal and metabolic profile. The control group consisted of age- and BMI-matched 80 eumenorrheic women with no clinical or biochemical hyperandrogenism....
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Adipokine and cytokine levels in patients with adrenocortical cancer, subclinical Cushing's syndrome and healthy controls
PublikacjaIntroduction In recent years researchers have focused at hormonal activity in Cushing’s syndrome (CS) in connection with metabolic disorders and the role of adipokines and cytokines secreted by the adipose tissue. The aim of the study was to investigate levels of adipokines and cytokines in patients with: subclinical CS (SCS) – in relation to hormonal parameters of hypercortisolemia, and, adrenocortical cancer (ACC). Materials...
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Conducting polymers for biodegradable metallic implants
PublikacjaNowadays permanent metallic cardiovascular stents are long-term implants. The long-time presence of such an implant in human body can cause overgrowth of tissue within the treated portion of the vessel, blockage of the circulatory system and many other clinical complications, such as thrombosis, prolonged physical irritations or chronic inflammation. Therefore, in recent years, there is an interest to create biodegradable metallic...
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Machining by abrasive-metallic lapping tools.
PublikacjaPrzedstawiono kontrukcję niekonwencjonalnych narzędzi ścierno-metalowych do docierania. Opracowane narzędzia wykorzystano do badań wydajności i jakości docierania elementów ceramicznych. Określono wpływ podstawowych warunków docierania na efekty obróbki powierzchni płaskich.
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Journal of Diabetes and Metabolic Disorders
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Nutrition, Obesity & Metabolic Surgery
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JOURNAL OF INHERITED METABOLIC DISEASE
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REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
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Clinical Lipidology and Metabolic Disorders
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Metabolic responses to a 48-h ultra-marathon run in middle-aged male amateur runners
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Positive Regulation of Macromolecule Metabolic Process Belongs to the Main Mechanisms Crucial for Porcine Oocytes Maturation
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Expression Changes in Fatty acid Metabolic Processrelated Genes in Porcine Oocytes During in Vitro Maturation
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New markers for regulation of transcription and macromolecule metabolic process in porcine oocytes during in vitro maturation
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Evaluation of early cerebral metabolic, perfusion and microstructural changes in HCV-positive patients: A pilot study
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The studies of imidazoacridinone antitumor agent, C-1311, in the field of metabolic transformations with cytochrome P450 isoenzymes
PublikacjaPraca zawiera wyniki badań metabolicznej transformacji przeciwnowotworowej pochodnej imidazoakrydonu C-1311 wobec rekombinantowych ludzkich izoenzymów P450. Związek nie ulegał transformacji w badanych warunkach, natomiast wykazano, że ma zdolność hamowania aktywności izoezymów CYP1A2 i CYP3A4.
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GC-MS-based untargeted metabolomics of plasma and urine to evaluate metabolic changes in prostate cancer
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Comparison of RP-HPLC columns used for determination of nucleoside metabolic patterns in urine of cancer patients
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Metabolic activation of adriamycin by NADPH-cytochrome P450 reductase; overview of its biological and biochemical effects
PublikacjaOmówione zostały efekty aktywacji metabolicznej adriamycyny przez NADPH-zależną reduktazę cytochromu P450. Wykazano, że ten rodzaj aktywacji zwiększa aktywność biologiczną tego związku, a przy tym powoduje jego wiązanie się kowalencyjne z ważnymi biologicznie makromolekułami komórkowymi.
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Synthesis, Molecular Structure, Metabolic Stability and QSAR Studies of a Novel Series of Anticancer N-Acylbenzenesulfonamides
PublikacjaA series of novel N-acyl-4-chloro-5-methyl-2-(R1-methylthio)benzenesulfonamides 18–47 have been synthesized by the reaction of N-[4-chloro-5-methyl-2-(R1-methylthio) benzenesulfonyl]cyanamide potassium salts with appropriate carboxylic acids. Some of them showed anticancer activity toward the human cancer cell lines MCF-7, HCT-116 and HeLa, with the growth percentages (GPs) in the range from 7% to 46%. Quantitative structure-activity relationship...
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Cell Metabolism
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Molecular Metabolism
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Endocrinology and Metabolism
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Cancer & Metabolism
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Heart and Metabolism
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Obesity and Metabolism
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Nutrition & Metabolism
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Nature Metabolism
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JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
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Peripheral neuropathy and health-related quality of life in patients with primary Sjögren’s syndrome: a preliminary report
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5-formylcytosine and 5-hydroxymethyluracil as surrogate markers of TET2 and SF3B1 mutations in myelodysplastic syndrome, respectively
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Single median maxillary central incisor syndrome and variant in SMO gene associated with SHH pathway
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SOCS3 and SOCS5 mRNA expressions may predict initial steroid response in nephrotic syndrome children
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POEMS Syndrome: Real World Experience in Diagnosis and Systemic Therapy - 108 Patients Multicenter Analysis
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