Wyniki wyszukiwania dla: drugs dosage

• Pharmaceutical and forensic drug applications of chiral supercritical fluid chromatography

  Publikacja

  • J. Płotka-Wasylka
  • M. Biziuk
  • C. Morrison
  • J. Namieśnik

  - TRAC-TRENDS IN ANALYTICAL CHEMISTRY - Rok 2014

  THE SUPERCRITICAL FLUID IS AN EXCELLENT CHOICE AS THE CHROMATOGRAPHIC MOBILE PHASE BECAUSE IT ALLOWS RAPID SEPARATION WITH HIGH EFFICIENCY AND APPLICATIONS INVOLVING ENANTIORESOLUTION ARE COMMON. SUPERCRITICAL FLUID CHROMATOGRAPHY (SFC) IS INCREASINGLY USED FOR ANALYTICAL, SEMI-PREPARATIVE AND PREPARATIVE PURIFICATION OF CHIRAL COMPOUNDS, INCLUDING PRODUCTION OF ENANTIOMERS THAT ARE MAINLY ENCOUNTERED DURING DRUG DEVELOPMENT. SFC...

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• Effective Drug Concentration and Selectivity Depends on Fraction of Primitive Cells

  Publikacja

  • J. Lica
  • M. Wieczór
  • G. J. Grabe
  • M. Heldt
  • M. Jancz
  • M. Misiak
  • K. Gucwa
  • W. Brankiewicz
  • N. Maciejewska
  • A. Stupak... i 4 innych

  - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES - Rok 2021

  Poor efficiency of chemotherapeutics in the eradication of Cancer Stem Cells (CSCs) has been driving the search for more active and specific compounds. In this work, we show how cell density-dependent stage culture profiles can be used in drug development workflows to achieve more robust drug activity (IC50 and EC50) results. Using flow cytometry and light microscopy, we characterized the cytological stage profiles of the HL-60-,...

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• SAGE Open

  Czasopisma

  ISSN: 2158-2440

• Is sequential batch reactor an efficient technology to protect recipient against non-steroidal anti-inflammatory drugs and paracetamol in treated wastewater?

  Publikacja

  • K. Kołecka
  • M. Gajewska
  • S. Cytawa
  • P. Stepnowski
  • M. Caban

  - BIORESOURCE TECHNOLOGY - Rok 2020

  The tested facility was a wastewater treatment plant (WWTP) in Swarzewo, where the wastewater treatment takes place in aeration chambers with activated sludge using sequential batch reactors (SBRs). The concentration of the following pharmaceuticals: ibuprofen, paracetamol, flurbiprofen, naproxen, diclofenac, and its metabolites 5OH-diclofenac and 4OH-diclofenac was tested in influents and effluents. Simultaneously, the conventional...

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• Iso-Partricin, an Aromatic Analogue of Amphotericin B: How Shining Light on Old Drugs Might Help Create New Ones

  Publikacja

  • P. Szczeblewski
  • J. Górska
  • W. Andrałojć
  • P. Janke
  • K. Wąsik
  • T. Laskowski

  - Antibiotics-Basel - Rok 2021

  Partricin is a heptaene macrolide antibiotic complex that exhibits exceptional antifungal activity, yet poor selective toxicity, in the pathogen/host system. It consists of two compounds, namely partricin A and B, and both of these molecules incorporate two cis-type bonds within their heptaenic chromophores: 28Z and 30Z. In this contribution, we have proven that partricins are susceptible to a chromophore-straightening photoisomerization...

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• Ti/TiO2 nanotubes sensitized PbS quantum dots as photoelectrodes applied for decomposition of anticancer drugs under simulated solar energy

  Publikacja

  • P. Mazierski
  • P. Wilczewska
  • W. Lisowski
  • T. Klimczuk
  • A. Białk-Bielińska
  • A. Zaleska-Medyska
  • E. Siedlecka
  • A. Pieczyńska

  - JOURNAL OF HAZARDOUS MATERIALS - Rok 2022

  One of the challenges in research into photoelectrocatalytic (PEC) degradation of pollutants is finding the appropriate photoanode material, which has a significant impact on the process efficiency. Among all others, photoelectrodes based on an ordered TiO2 nanotube arrays are a promising material due to well-developed surface area and efficient charge separation. To increase the PEC activity of this material, the SILAR method was...

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• Design, synthesis and biological evaluation of novel N-phosphorylated and O-phosphorylated tacrine derivatives as potential drugs against Alzheimer’s disease

  Publikacja

  • M. Przybyłowska
  • K. Dzierzbicka
  • K. Szymon
  • S. Demkowicz
  • M. Daśko
  • I. Inkielewicz-Stępniak

  - JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY - Rok 2022

  In this work, we designed, synthesised and biologically investigated a novel series of 14N- and O-phosphorylated tacrine derivatives as potential anti-Alzheimer’s disease agents. In the reaction of 9-chlorotacrine and corresponding diamines/aminoalkylalcohol we obtained diamino and aminoalkylhydroxy tacrine derivatives. Next, the compounds were acid to give final products 6–13 and 16–21 that were characterised by 1H, 13 C, 31P...

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• The use of HPLC-Q-TOF-MS for comprehensive screening of drugs and psychoactive substances in hair samples and several “legal highs” products

  Publikacja

  • J. Aszyk
  • A. Kot-Wasik

  - MONATSHEFTE FUR CHEMIE - Rok 2016

  Non-targeted screening of drugs present in herbal products, known as “legal high” drugs and in hair as a biological matrix commonly used in toxicological investigations was accomplished with the use of high pressure liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (HPLC-Q-TOF-MS). In total, 25 and 14 therapeutical drugs and psychoactive substances/metabolites were detected in investigated hair samples...

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• Development of different methods for drugs and psychoactive substances extraction from hair samples and their identification based on HPLC-ESI-QTOF analysis

  Publikacja

  • J. Aszyk
  • A. Kot-Wasik

  - Rok 2015

  Over the past decade, the use of non-controlled designer drugs and drug of abuse has rapidly increased. Hair, as a human matrix, enables detection of drugs incorporated into its structure. Studies of presence and identification of drug metabolites in human hair samples has been performed using liquid chromatography electrospray ionization quadrupole time of flight mass spectrometry (HPLC-ESI-QTOF-MS) with steady alternation of...

• Damage identification by wavelet analysis

  Publikacja

  • J. Grabowska
  • M. Palacz
  • M. Krawczuk

  - MECHANICAL SYSTEMS AND SIGNAL PROCESSING - Rok 2008

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• Damage identification by wavelet analysis

  Publikacja

  • J. Grabowska
  • M. Palacz
  • M. Krawczuk

  - MECHANICAL SYSTEMS AND SIGNAL PROCESSING - Rok 2008

  W pracy omówiono metodę identyfikacji rodzaju nieciagłości w 1 wymiarowych elementach konstrukcji wykorzystującą pomiar propagacji fali sprężystej i jej analizę metodą transformacji falkowej.

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• Subdivision and damage stability of ships.

  Publikacja

  • M. Pawłowski

  - Rok 2004

  Pierwszy kompleksowy podręcznik na świecie na poziomie akademickim dotyczący niezatapialności statku w ujęciu probabilistycznym, w którym za miarę bezpieczeństwa statku przyjmuje się prawdopodobieństwo przetrwania kolizji przez statek, zwane wskaźnikiem niezatapialności, względnie wskaźnikiem podziału grodziowego statku. Obejmuje zarówno zagadnienia teoretyczne jak i praktyczne, dając projektantom wykładnię stosowania obowiązujących...

• Revue Sage - Femme

  Czasopisma

  ISSN: 1637-4088

• SAGE Open Nursing

  Czasopisma

  ISSN: 2377-9608

• SAGE Open Medicine

  Czasopisma

  ISSN: 2050-3121

• Results of modeling of pharmaceuticals mixtures toxicity with deviation ratio and best-fit functions models using Aliivibrio fischeri bacterium as model organism

  Dane Badawcze

  open access

  • M. Wieczerzak
  • B. Kudłak

  The research was concerned with verifying the impact of mixtures of nine pharmaceuticals against a selected organism, i.e., the bacterium Aliivibrio fischeri. A. fisheri is used as a model organism in the monitoring of acute toxicity in environmental and reference samples in Microtox® systems.  Tested pharmaceuticals, namely: diclofenac (sodium salt),...

• To donate or not to donate? Future healthcare professionals’ opinions on biobanking of human biological material for research purposes

  Publikacja

  • J. Domaradzki
  • J. Czekajewska
  • D. Walkowiak

  - BMC Medical Ethics - Rok 2023

  Background Over the last few decades biobanks have been recognised as institutions that may revolutionisebiomedical research and the development of personalised medicine. Poland, however, still lacks clear regulationsregarding the running of biobanks and the conducting of biomedical research. While the awareness of the generalpublic regarding biobanks is low, healthcare professions and medical students also...

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• To donate or not to donate? Future healthcare professionals’ opinions on biobanking of human biological material for research purposes

  Publikacja

  • J. Domaradzki
  • J. Czekajewska
  • D. Walkowiak

  - BMC Medical Ethics - Rok 2023

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• BIOPHARMACEUTICS & DRUG DISPOSITION

  Czasopisma

  ISSN: 0142-2782 , eISSN: 1099-081X

• CLINICAL DRUG INVESTIGATION

  Czasopisma

  ISSN: 1173-2563 , eISSN: 1179-1918

• DRUG NEWS & PERSPECTIVES

  Czasopisma

  ISSN: 0214-0934

• DRUG INFORMATION JOURNAL

  Czasopisma

  ISSN: 0092-8615

• Drug Target Insights

  Czasopisma

  ISSN: 1177-3928

• Drug Discoveries and Therapeutics

  Czasopisma

  ISSN: 1881-7831 , eISSN: 1881-784X

• Drug Testing and Analysis

  Czasopisma

  ISSN: 1942-7603 , eISSN: 1942-7611

• CNS DRUG REVIEWS

  Czasopisma

  ISSN: 1527-3458

• Journal of Drug Delivery

  Czasopisma

  ISSN: 2090-3014 , eISSN: 2090-3022

• DRUG DISCOVERY TODAY

  Czasopisma

  ISSN: 1359-6446 , eISSN: 1878-5832

• DRUG RESISTANCE UPDATES

  Czasopisma

  ISSN: 1368-7646 , eISSN: 1532-2084

• Current Drug Safety

  Czasopisma

  ISSN: 1574-8863 , eISSN: 2212-3911

• BIOINFO Drug targets

  Czasopisma

  ISSN: 2249-1759

• Drug Metabolism and Pharmacokinetics

  Czasopisma

  ISSN: 1347-4367 , eISSN: 1880-0920

• Current Drug Therapy

  Czasopisma

  ISSN: 1574-8855 , eISSN: 1065-7630

• JOURNAL OF DRUG ASSESSMENT

  Czasopisma

  ISSN: 1369-9474 , eISSN: 2155-6660

• DRUG AND ALCOHOL REVIEW

  Czasopisma

  ISSN: 0959-5236 , eISSN: 1465-3362

• Drug and Therapeutics Bulletin

  Czasopisma

  ISSN: 0012-6543

• Drug Discovery World

  Czasopisma

  ISSN: 1469-4344

• Drug Metabolism Letters

  Czasopisma

  ISSN: 1872-3128

• Drug Delivery Letters

  Czasopisma

  ISSN: 2210-3031

• WHO Drug Information

  Czasopisma

  ISSN: 1010-9609

• Drug Invention Today

  Czasopisma

  ISSN: 0975-7619

• Drug Delivery System

  Czasopisma

  ISSN: 0913-5006

• Contemporary Drug Problems

  Czasopisma

  ISSN: 0091-4509

• Drug Development and Registration

  Czasopisma

  ISSN: 2305-2066 , eISSN: 2658-5049

• JOURNAL OF DRUG TARGETING

  Czasopisma

  ISSN: 1061-186X , eISSN: 1029-2330

• Medicine in Drug Discovery

  Czasopisma

  eISSN: 2590-0986

• PHARMACOEPIDEMIOLOGY AND DRUG SAFETY

  Czasopisma

  ISSN: 1053-8569 , eISSN: 1099-1557

• Drug Evaluation Research

  Czasopisma

  ISSN: 1674-6376

• JOURNAL OF DRUG EDUCATION

  Czasopisma

  ISSN: 0047-2379 , eISSN: 1541-4159

• JOURNAL OF DRUG ISSUES

  Czasopisma

  ISSN: 0022-0426 , eISSN: 1945-1369