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Wyniki wyszukiwania dla: MICA
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Lactoferricin B Combined with Antibiotics Exhibits Leukemic Selectivity and Antimicrobial Activity
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Proteomic profile of melanoma cell‐derived small extracellular vesicles in patients’ plasma: a potential correlate of melanoma progression
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Changes in the Secretion of Melatonin and Selected Adipokines during the Progression of Parkinson’s Disease—Preliminary Studies
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Essential Oils, Silver Nanoparticles and Propolis as Alternative Agents Against Fluconazole Resistant Candida albicans, Candida glabrata and Candida krusei Clinical Isolates
PublikacjaDevelopment of effective and safe therapeutic treatment of fungal infections remains one of the major challenge for modern medicine. The aim of presented investigation was to analyze the in vitro antifungal activity of selected essential oils, ethanolic extracts of propolis and silver nanoparticles dropped on TiO2 against azole-resistant C. albicans (n = 20), C. glabrata (n = 14) and C. krusei (n = 10) clinical isolates. Among...
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Antibiotic-Based Conjugates Containing Antimicrobial HLopt2 Peptide: Design, Synthesis, Antimicrobial and Cytotoxic Activities
PublikacjaRecent studies have shown that modified human lactoferrin 20−31 fragment, named HLopt2, possesses antibacterial and antifungal activity. Thus, we decided to synthesize and evaluate the biological activity of a series of conjugates based on this peptide and one of the antimicrobials with proven antibacterial (ciprofloxacin, CIP, and levofloxacin, LVX) or antifungal (fluconazole, FLC) activity. The drugs were covalently connected...
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Resource saving by optimization and machining environments for sustainable manufacturing: A review and future prospects
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Molecular epidemiology of Serratia marcescens in two hospitals in Danzig, Poland, over a 5-year period.Molecular epidemiology of Serratia marcescens in two hospitals in Gdańsk, Poland, over a 5-year period.
PublikacjaW pracy badano zmiany populacji Serratia marcescens w ciągu 5 lat w dwóch szpitalach klinicznych Gdańska. Posłużono się wartościami MIC, wynikami typowania genetycznego RAPD-PCR, PFGE i nową metodą ADSRRS-fingerprinting oraz analizą beta-laktamaz o rozszerzonym spektrum substratowym (ESBL). Dzięki określeniu lekowrażliwości na najnowsze antybiotyki beta-laktamowe wykryto fenotypy wykazujące derepresję cefalosporynazy AmpC u 23%...
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Oporność patogennych drożdżaków z rodzaju Candida na chemoterapeutyki przeciwgrzybowe i nowe sposoby jej przełamywania
PublikacjaCelem badania było określenie podatności na leki przeciwgrzybowe izolatów Candida od pacjentów z polskich szpitali oraz określenie mechanizmów oporności na nie. Drugim celem było zbadanie aktywności przeciwgrzybowej produktów naturalnych (olejków eterycznych i propolisów pszczelich) i mechanizmów ich działania. Prawie 20% zebranych izolatów wykazało oporność na flukonazol oraz oporność krzyżową na cztery badane azole. Większość...
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Antimicrobial and surface activity of 1-alkyl-3-methylimidazolium derivatives
PublikacjaWiedza na temat zależności struktura-aktywność umożliwia projektowanie i syntezę nowych kationowych związków amfifilowych ze zoptymalizowaną aktywnością antymikrobową na rzecz przyszłego rozwoju nowych środków dezynfekujących, sanityzujących czy konserwujących. Potrzeba projektowania i identyfikowania nowych związków posiadających właściwości przeciwbakteryjne jest rezultatem pojawienia się bardziej odpornych mikroorganizmów w...
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Effective Drug Concentration and Selectivity Depends on Fraction of Primitive Cells
PublikacjaPoor efficiency of chemotherapeutics in the eradication of Cancer Stem Cells (CSCs) has been driving the search for more active and specific compounds. In this work, we show how cell density-dependent stage culture profiles can be used in drug development workflows to achieve more robust drug activity (IC50 and EC50) results. Using flow cytometry and light microscopy, we characterized the cytological stage profiles of the HL-60-,...
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Epigenetic regulation and regeneration: the search for differentially methylated genes in the MRL mouse
PublikacjaThe MRL mouse is an inbred laboratory strain, which was developed in the 60’s of the 20th century and has been extensively used as a model of lupus erythematosus. The regenerative abilities of the strain were discovered in the 90' when the MRL mouse was shown to close 2 mm hole punches made in the ear pinnae four weeks after injury without scarring. The phenomenon has not been observed in other mouse strains, where the holes...
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David Duenas-Cid
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OECD Guidelines for Micro Statistics on Household Wealth
PublikacjaThis report reflects the contributions of members of the OECD Expert Group on Micro Statistics on Household Income, Consumption and Wealth. Members of the Expert Group included representatives from National Statistical Offices – Bob McColl (Chair, Australia); Alison Hale (Canada); Andre Bustamante and David Niculcar (Chile); Henrik Sejerbo Soerensen (Denmark); Yafit Alfandari (Israel); Shinji Yoshioka (Japan); Sinho Kim...
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Anthra[1,2-d][1,2,3]triazine-4,7,12(3H)-triones as a New Class of Antistaphylococcal Agents: Synthesis and Biological Evaluation
PublikacjaThe development and spread of resistance of human pathogenic bacteria to the action of commonly used antibacterial drugs is one of the key problems in modern medicine. One of the especially dangerous and easily developing antibiotic resistant bacterial species is Staphylococcus aureus. Anthra[1,2-d][1,2,3]triazine-4,7,12(3H)-triones 22–38 have been developed as novel effective antistaphylococcal agents. These compounds have been...
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Linezolid-resistant Enterococcus faecium strains isolated from one hospital in Poland –commensals or hospital-adapted pathogens?
PublikacjaOne of the most pressing problems of enterococci infections is occurring resistance to linezolid, which is an antibiotic used in the treatment of infections caused by vancomycin-resistant strains (VRE). The main objective of our research was to investigate the relationship of 19 linezolid-resistant E. faecium isolates from 18 patients hospitalized at Clinical Hospital in Gdansk (Poland). One of the LZDREF was isolated in 2003...
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Systemic modulation of stress and immune parameters in patients treated for prostate adenocarcinoma by intensity-modulated radiation therapy or stereotactic ablative body radiotherapy
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Antitumor 1-nitroacridine derivative C-1748 induces significant apoptosis in pancreatic cancer cells.
PublikacjaPancreatic cancer is the fifth leading cause of cancer death and has the lowest survival rate of any solid cancer in the industrial countries. The poor prognosis of pancreatic cancer results from its tendency for late presentation, aggressive invasion, early metastasis, and resistance to chemotherapy. Gemcitabine still remains the best chemotherapeutic agent available for the treatment of advanced pancreatic cancer. However, gemcitabine...
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GRA1 protein vaccine confers better immune response compared to codon-optimized GRA1 DNA vaccine
PublikacjaW publikacji oszacowano immunogenność i właściwości protekcyjne szczepionki anty-Toxoplasma gondii opartej na białku rekombinantowym GRA1 oraz dwóch rodzajach szczepionek DNA (plazmidu zawierającego gen kodujący białko GRA1 dzikiego typu oraz modyfikowanego genu kodującego białko GRA1). Uzyskane wyniki sugerują lepsze właściowści immunoprotekcyjne rekombinantowego białka antygenowego niż szczepionek DNA.
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Magnetic nanocomposites for biomedical applications
PublikacjaTissue engineering and regenerative medicine have solved numerous problems related to the repair and regeneration of damaged organs and tissues arising from aging, illnesses, and injuries. Nanotechnology has further aided tissue regeneration science and has provided outstanding opportunities to help disease diagnosis as well as treat damaged tissues. Based on the most recent findings, magnetic nanostructures (MNSs), in particular,...
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Występowanie oraz charakterystyka molekularna oporności na azole wśród klinicznych i środowiskowych izolatów Aspergillus fumigatus
PublikacjaCelem badań prowadzonych w ramach niniejszej pracy doktorskiej było sprawdzenie występowania oporności na azole grzybów A. fumigatus pochodzących z Polski oraz jej molekularna charakterystyka. W toku badań utworzono kolekcję 200 izolatów A. fumigatus pochodzących z różnych miejsc Polski. W skład kolekcji wchodziły izolaty kliniczne, środowiskowe i weterynaryjne. Przynależność gatunkową badanych grzybów potwierdzono metodami diagnostyki...
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Composition and antimicrobial activity of fatty acids detected in the hygroscopic secretion collected from the secretory setae of larvae of the biting midge Forcipomyia nigra (Diptera: Ceratopogonidae)
PublikacjaThe hygroscopic secretion produced by the secretory setae of terrestrial larvae of the biting midge Forcipomyia nigra (Winnertz) was analysed using gas chromatography coupled with mass spectrometry (GC-MS). The viscous secretion is stored at the top of each seta and absorbs water from moist air. GC-MS analyses (four independent tests) showed that the secretion contained 12 free fatty acids, the most abundant of which were oleic...
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Independent Mechanisms Lead to Genomic Instability in Hodgkin Lymphoma: Microsatellite or Chromosomal Instability
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Erratum: Cuceu, C., et al. Independent Mechanisms Lead to Genomic Instability in Hodgkin Lymphoma: Microsatellite or Chromosomal Instability. Cancers 2018, 10, 233
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Dual-Activity Fluoroquinolone-Transportan 10 Conjugates offer alternative Leukemia therapy during Hematopoietic Cell Transplantation
PublikacjaHematopoietic cell transplantation (HCT) is often considered a last resort leukemia treatment, fraught with limited success due to microbial infections, a leading cause of mortality in leukemia patients. To address this critical issue, we explored a novel approach by synthesizing antileukemic agents containing antibacterial substances. This innovative strategy involves conjugating fluoroquinolone antibiotics, such as ciprofloxacin...
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IFI16 Impacts Metabolic Reprogramming during Human Cytomegalovirus Infection
PublikacjaCellular lipid metabolism plays a pivotal role in human cytomegalovirus (HCMV) infection, as increased lipogenesis in HCMV-infected cells favors the envelopment of newly synthesized viral particles. As all cells are equipped with restriction factors (RFs) able to exert a protective effect against invading pathogens, we asked whether a similar defense mechanism would also be in place to preserve the metabolic compartment from HCMV...
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Mohsan Ali Master of Science in Computer Science
OsobyMohsan Ali is a researcher at the University of the Aegean. He won the Marie-Curie Scholarship in 2021 in the field of open data ecosystem (ODECO) to pursue his PhD degree at the University of the Aegean. Currently, he is working on the technical interoperability of open data in the information systems laboratory; this position is funded by ODECO. His areas of expertise are open data, open data interoperability, data science, natural...
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Recent Results from Studies of Electric Discharges in the Mesosphere
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International Expert Consensus Statement
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Metody radiotransmisji w aplikacjach biomedycznych - 2022/2023
Kursy OnlineCelem przedmiotu jest zapoznanie studentów z zagadnieniami dotyczącym systemów i sieci radiokomunikacyjnych w pod kątem możliwych zastosowań w biomedycynie. Plan wykładu Podstawowe pojęcia w telekomunikacji (telekomunikacja, informacja, źródła informacji, sygnał, usługa telekomunikacyjna, system telekomunikacyjny, kanał telekomunikacyjny, sieć telekomunikacyjna). Opis sygnałów analogowych w dziedzinie czasu i częstotliwości;...
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Metody radiotransmisji w aplikacjach biomedycznych - 2023/2024
Kursy OnlineCelem przedmiotu jest zapoznanie studentów z zagadnieniami dotyczącym systemów i sieci radiokomunikacyjnych w pod kątem możliwych zastosowań w biomedycynie. Plan wykładu Podstawowe pojęcia w telekomunikacji (telekomunikacja, informacja, źródła informacji, sygnał, usługa telekomunikacyjna, system telekomunikacyjny, kanał telekomunikacyjny, sieć telekomunikacyjna). Opis sygnałów analogowych w dziedzinie czasu i częstotliwości;...
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Evaluation of the BNT162b2 Covid-19 Vaccine in Children 5 to 11 Years of Age
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Association between use of enhanced recovery after surgery protocols and postoperative complications in colorectal surgery in Europe: The EuroPOWER international observational study
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Introduction to a Culturally Sensitive Measure of Well-Being: Combining Life Satisfaction and Interdependent Happiness Across 49 Different Cultures
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Happiness Maximization Is a WEIRD Way of Living
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Comparability of Raman Spectroscopic Configurations: A Large Scale Cross-Laboratory Study
PublikacjaThe variable configuration of Raman spectroscopic platforms is one of the major obstacles in establishing Raman spectroscopy as a valuable physicochemical method within real-world scenarios such as clinical diagnostics. For such real world applications like diagnostic classification, the models should ideally be usable to predict data from different setups. Whether it is done by training a rugged model with data from many setups...
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Gendered Self-Views Across 62 Countries: A Test of Competing Models
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The International Natural Product Sciences Taskforce (INPST) and the power of Twitter networking exemplified through #INPST hashtag analysis
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Psychometric Properties and Correlates of Precarious Manhood Beliefs in 62 Nations
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Diversity and ethics in trauma and acute care surgery teams: results from an international survey
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Team dynamics in emergency surgery teams: results from a first international survey
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Two years later: Is the SARS-CoV-2 pandemic still having an impact on emergency surgery? An international cross-sectional survey among WSES members
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Correction to: Two years later: Is the SARS-CoV-2 pandemic still having an impact on emergency surgery? An international cross-sectional survey among WSES members
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Long-term safety and efficacy of benralizumab in patients with severe, uncontrolled asthma: 1-year results from the BORA phase 3 extension trial
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Incidence of severe critical events in paediatric anaesthesia (APRICOT): a prospective multicentre observational study in 261 hospitals in Europe
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Surgeons’ practice and preferences for the anal fissure treatment: results from an international survey
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Correction: Surgeons’ perspectives on artificial intelligence to support clinical decision-making in trauma and emergency contexts: results from an international survey
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Time for a paradigm shift in shared decision-making in trauma and emergency surgery? Results from an international survey
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Surgeons’ perspectives on artificial intelligence to support clinical decision-making in trauma and emergency contexts: results from an international survey
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Infected pancreatic necrosis: outcomes and clinical predictors of mortality. A post hoc analysis of the MANCTRA-1 international study
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coMpliAnce with evideNce-based cliniCal guidelines in the managemenT of acute biliaRy pancreAtitis): The MANCTRA-1 international audit
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