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Search results for: OPIOID GROWTH FACTOR
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Opioid Growth Factor and its Derivatives as Potential Non-toxic Multifunctional Anticancer and Analgesic Compounds
PublicationIn this paper, we review the structure-activity relationship of OGF and its analogues. We highlight also OGF derivatives with analgesic, immunomodulatory activity and the ability to penetrate the blood-brain barrier and may be used as safe agents enhancing chemotherapy efficacy and improving quality of life in cancer patients. The reviewed papers indicate that Met-enkephalin and its analogues are interesting candidates for the...
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CRH functions as a growth factor/cytokine in the skin
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Vascular endothelial growth factor (VEGF)-C - a potent risk factor in children diagnosed with stadium 4 neuroblastoma.
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Vascular endothelial growth factor C—a potent risk factor in childhood acute lymphoblastic leukaemia: an immunocytochemical approach
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Insulin-like growth factor type 2 is better than insulin-like growth factor type 1 a survival marker in patients after acute decompensation of heart failure
PublicationIntroduction:A decreased IGF-1 has been found in heart failure (HF). There are no reports assessing IGF-2 in HF, although in vitro study has shown, that IGF-2 stimulates cardiomyocyte proliferation more than IGF-1. The study aim was to compare the IGF-1 and IGF-2 concentration depending on HF exacerbation and annual survival.Material and methods:Among 75 patients hospitalized...
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Anticancer imidazoacridinone C-1311 inhibits hypoxia-inducible factor-1α (HIF-1α), vascular endothelial growth factor (VEGF) and angiogenesis
PublicationAntitumor imidazoacridinone C-1311 is a DNA-reactive topoisomerase II and FLT3 receptor tyrosine kinase inhibitor. Here, we demonstrate the mechanism of C-1311 inhibitory action on novel targets: hypoxia-inducible factor-1α (HIF-1α), vascular-endothelial growth factor (VEGF), and angiogenesis. In a cell-free system, C-1311 prevented HIF-1α binding to an oligonucleotide encompassing a canonical hypoxia-responsive element (HRE),...
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CD105 and placental growth factor – Potent prognostic factors in childhood acute lymphoblastic leukaemia
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Triazolopeptides Inhibiting the Interaction between Neuropilin-1 and Vascular Endothelial Growth Factor-165
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DNA-reactive anticancer imidazoacridinone C-1311 is a new inhibitor of hypoxia-inducible factor 1 alpha, vascular endothelial growth factor and tumor angiogenesis
PublicationHypoxia-inducible factor 1 (HIF-1) plays a critical role for tumor adaptation to hypoxia and promotes angiogenesis. Antitumor imidazoacridinone C-1311 is a DNA reactive topoisomerase II and FLT3 receptor tyrosine kinase inhibitor selected for phase II clinical trials for breast cancer. Here, we demonstrate the new mechanism of C-1311 action involving HIF-1a, vascular endothelial growth factor (VEGF) and angiogenesis as additional...
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The influence of a synthetic growth hormone‐releasing hormone analogue G11 and opioid peptide biphalin on selected fibroblasts parameters relevant to wound healing
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Angiopoietin-like growth factor-derived peptides as biological activators of adipose-derived mesenchymal stromal cells
PublicationAdipose-derived mesenchymal stromal cells (AD-MSCs) are an essential issue in modern medicine. Extensive preclinical and clinical studies have shown that mesenchymal stromal/stem cells, including AD-MSCs, have specific properties (ability to differentiate into other cells, recruitment to the site of injury) of particular importance in the regenerative process. Ongoing research aims to elucidate factors supporting AD-MSC culture...
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The expression of Platelet-derived Growth factor receptors (PDGFRs) and their correlation with overall survival of patients with ovarian cancer
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Evaluation of differences in expression pattern of three isoforms of the transforming growth factor beta in patients with lumbosacral stenosis
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Structure-activity relationship study of tetrapeptide inhibitors of the Vascular Endothelial Growth Factor A binding to Neuropilin-1
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Effect of psoriasis activity and topical treatment on plasma epidermal growth factor (EGF) and its soluble receptor (sEGFR)
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Effect of psoriasis activity on epidermal growth factor (EGF) and the concentration of soluble EGF receptor in serum and plaque scales
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Nephrotic syndrome unfavorable course correlates with downregulation of podocyte vascular endothelial growth factor receptor (VEGFR)-2
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Development of a Peptide Derived from Platelet-Derived Growth Factor (PDGF-BB) into a Potential Drug Candidate for the Treatment of Wounds
PublicationObjective: This study evaluated the use of novel peptides derived from platelet-derived growth factor (PDGF-BB) as potential wound healing stimulants. One of the compounds (named PDGF2) was subjected for further research after cytotoxicity and proliferation assays on human skin cells. Further investigation included evaluation of: migration and chemotaxis of skin cells, immunological and allergic safety, the transcriptional analyses...
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Does Porcine Oocytes Maturation in Vitro is Regulated by Genes Involved in Transforming Growth Factor Beta Receptor Signaling Pathway?
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A study on the protection of methionine and the reduction of methionine sulfoxide in methionine-containing analogues of the growth-modeling factor Gly-His-Lys
PublicationThe protection of methionine and the reduction of methionine sulfoxide in methionine-containing analogues of Gly-His-Lys are described. The peptides were synthesized by a solid-phase method using the standard Fmoc procedure. Simultaneous deprotection of the peptide side chain and liberation from the resin were achieved using an appropriate TFA cocktail. The TFA cocktail was selected to minimize oxidation of the methionine residue....
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Vascular endothelial growth factor (VEGF-C1)-dependent inflammatory response of podocytes in nephrotic syndrome glomerulopathies in children: an immunohistochemical approach
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Design, synthesis and in vitro biological evaluation of a small cyclic peptide as inhibitor of vascular endothelial growth factor binding to neuropilin-1
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Branched pentapeptides as potent inhibitors of the vascular endothelial growth factor 165 binding to Neuropilin-1: Design, synthesis and biological activity
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Prenatal stress affects insulin-like growth factor-1 (IGF-1) level and IGF-1 receptor phosphorylation in the brain of adult rats
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Conformational latitude – activity relationship of KPPR tetrapeptide analogues toward their ability to inhibit binding of vascular endothelial growth factor 165 to neuropilin‐1
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Extracellular matrix metalloproteinase inducer (EMMPRIN) expression correlates positively with active angiogenesis and negatively with basic fibroblast growth factor expression in epithelial ovarian cancer
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Effect of Manual Therapy Compared to Ibuprofen on Primary Dysmenorrhea in Young Women—Concentration Assessment of C-Reactive Protein, Vascular Endothelial Growth Factor, Prostaglandins and Sex Hormones
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The impact of prenatal stress on insulin-like growth factor-1 and pro-inflammatory cytokine expression in the brains of adult male rats: The possible role of suppressors of cytokine signaling proteins
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Structure-activity relationship study of a small cyclic peptide H-c[Lys-Pro-Glu]-Arg-OH: a potent inhibitor of Vascular Endothelial Growth Factor interaction with Neuropilin-1
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Applications of the regenerative capacity of platelets in modern medicine
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Wybrane elementy projektowania budynków wielofunkcyjnych stanowiących miejskie centra logistyczne
PublicationCelem artykułu jest przedstawienie wybranych aspektów dotyczących projektowania budynków wielofunkcyjnych stanowiących miejskie centra logistyczne. Centrum logistyczne lokalizowane w obszarze zurbanizowanym jest formalnie obiektem, który ma na celu zaspokojenie wielu potrzeb funkcjonalnych względem potencjalnych użytkowników. Miejskie centrum logistyczne stanowi swego rodzaju system, którego podstawą jest sprawna obsługa procesów...
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Preprzedsiębiorczość
PublicationKsiążka składa się z czterech rozdziałów, poprzedzonych wstępem i zwieńczonych częścią podsumowującą całość. Rozdział pierwszy nakreśla tło dla dalszych rozważań. W rozdziale tym wyodrębniono trzy zasadnicze ujęcia: ujęcie ekonomiczne, ujęcie psychologiczne oraz socjologiczno-kulturowe. W dalszej części tego rozdziału przeanalizowano związki między przedsiębiorczością a wzrostem gospodarczym. Wskazano także mniej znane kierunki...
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Fentanyl Structure as a Scaffold for Opioid/Non-Opioid Multitarget Analgesics
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Crystal growth of CsCl-type Yb0.24Sn0.76Ru
PublicationWzrost kryształów o stechiometrii Yb0.24Sn0.76Ru został przeprowadzony metodą topnikową. Kryształy poddano badaniom dyfrakcyjnym a także mikroskopii elektornowej. Yb0.24Sn0.76Ru krystalizuje w sześciennej strukturze typu chlorku cezu (CsCl).
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Crystal growth of CsCl-type Yb0.24Sn0.76Ru
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Stress-opioid interactions: a comparison of morphine and methadone
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Buprenorphine – the unique opioid adjuvant in regional anesthesia
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Verification of baffle factor for straight pipe flow
PublicationDuring the water disinfection devices designing, it is often assumed that the baffle factor for a straight pipe reactors is equal to one. It would be possible only for the plug flow, which is a simplified model of the flow and does not appear in real situations. The paper contains an equation which enables calculation of the real value of the baffle factor for the pipe flow.
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Within- and between-person factor structure of the Oldenburg Burnout Inventory: Analysis of a diary study using multilevel confirmatory factor analysis
PublicationThe study examined the factor structure of burnout, as measured with the Oldenburg Burnout Inventory. The participants were 235 employees of a public administration agency who assessed their burnout online for 10 consecutive working days. Two models were tested with multilevel confirmatory factor analysis, assuming the same one or two-factor structure at the within- and between-person levels. Both models showed a reasonable fit...
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Share of the wage factor in national income – selected aspects
PublicationThe aim of this study is to examine changes in the share of the wage factor in national income, in selected EU countries against labour productivity and investment rates reflecting changes in capital-labour relations, indicated by researchers as determinants of change of the share of the wage factor in national income. The scope of the study includes a review of literature devoted to the issue of wage factor share in national income...
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Evaluation of bacterial strains for developing effective plant growth promoting strain on chickpea growth and physico chemical properties of soil
PublicationThe study was intended to isolate and characterize the plant growth-promoting properties. A collection of microbial consortia called plant growth-promoting microorganisms (PGPM) work to increase crop growth and yield through a variety of direct mechanisms, including as nitrogen fixation, phosphate solubilization, synthesis of PGH, ammonia, and siderophore, as well as indirect mechanisms. The aim of the study was to evaluate the...
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The role of resilience in explaining hotel growth: A fuzzy-set QCA approach
PublicationPurpose: Due to the detrimental effects of the recent pandemic on the hotel sector, hotel resilience research and its impact on hotel recovery have received lots of academic attention. However, a sustainable perspective on hotel resilience, as an approach for investigating its impact on long-term hotel growth, has been largely overlooked in the hospitality resilience literature. Therefore, this paper aims to address the research...
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Deposition and growth of thin ceramic films
Publication: Thin ceramic films play an important role in modern technology. One of the more utilized methods of deposition of ceramic films is spin coating. In this paper we investigate optimal deposition parameters for LaNi0.6Fe0.4O3−δ thin layers spin coated from a polymeric precursor. The quality of the obtained layers is checked using scanning electron microscopy. Additionally, we investigate the growth of grains in ceramic films annealed at...
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How much is Impact Factor worth?
PublicationThe purpose of this work is to present an aspect of counting citations, which is correlated to the Impact Factor, very important for journals in scientific communication, and provides information about the position of a scientific journal in a particular research area. Sometimes citations don’t count in a research output, e.g. if an article is published in a predatory journal. Those journals ...
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RAMAN DIAGNOSTICS OF CVD DIAMOND GROWTH
PublicationDevelopment of Raman spectroscopic system for diagnostics of growth of diamond and BDD (Boron- Doped-Diamond) thin films during μPA CVD (Microwave Plasma Assisted Chemical Vapour Deposition) process is described. Raman studies of such films were carried out as in-situ monitoring of film deposition as ex-situ measurements conducted for a sample outside the reaction vessel after manufacturing process. Modular system for the in-situ...
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Clarke duality for Hamiltonian systems with nonstandard growth
PublicationWe consider the existence of periodic solutions to Hamiltonian systems with growth conditions involving G-function. We introduce the notion of symplectic G-function and provide relation for the growth of Hamiltonian in terms of certain constant CG associated to symplectic G-function G. We discuss an optimality of this constant for some special cases. We also provide applications to the Φ-laplacian type systems.
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Gαi-derived peptide binds the µ-opioid receptor
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Molecular dynamics of fentanyl bound to μ-opioid receptor
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Smart Urban Growth - Myth or New Paradigm?
PublicationArtykuł prezentuje wizję 'smart growth' na przykładzie miast regionu morza Bałtyckiego.
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Multi-factor fuzzy sets decision system forecasting consumer insolvency risk
PublicationThe objective of this study is to develop a multi-factor decision system predicting insolvency risk for natural persons with the use of fuzzy sets. Considering that the financial situation of households is affected by various endogenous and exogenous factors, the main assumption of this study is that the system for predicting financial difficulties should not be limited to the use of only a few financial variables concerning consumers,...