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Search results for: BISACRIDINE DERIVATIVES
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Involvement of human glutathione S-transferase M1-1 in the glutathione conjugation of the antitumor unsymmetrical bisacridine derivative C-2028.
Open Research DataUnsymmetrical bisacridines (UAs) are a novel potent class of antitumor-active therapeutics. The aim of this study was to investigate the possible role of human glutathione S-transferase M1-1 (hGSTM1-1) in the glutathione (GSH) conjugation of a representative UA, C‑2028.
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The absorption and fluorescence spectra of C-1305 derivatives (IKE1-IKE8), potential antifungal agents
Open Research DataOptical measurements of C-1305 derivatives (IKE1-IKE8). The absorption spectra were recorded at 300 - 800 nm for solutions with 16 μg / mL derivative concentration. The fluorescence emission spectra were determined at 420-800 nm with the excitation wavelengths 360 or 415 nm for solutions with 1 μg / mL derivative concentration. All measurements were...
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The effect of anthraquinone derivatives on telomerase activity
Open Research DataThe data set contains images of the PCR products obtained from the Telomerase Repeated Amplification Protocol (TRAP). The effect of anthraquinone derivatives (TXT1-TXT9) on telomerase activity was comparatively examined using the following reference compounds: BIBR1532, TMPyP4 and mitoxantrone (MTX).
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The effect of anthraquinone derivatives (C1-C9) on telomerase activity
Open Research DataThe data set contains images of the PCR products obtained from the Telomerase Repeated Amplification Protocol (TRAP). The effect of anthraquinone derivatives (C-C9) on telomerase activity was analyzed using lysates from drug-treatedcancer cell line.
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Non-enzymatic glutathione-mediated conjugation of unsymmetrical bisacridine C-2028 with anticancer activity
Open Research DataThe presented data complement the studies on the interplay between C-2028 (anticancer-active unsymmetrical bisacridine) and the glutathione S-transferase/glutathione (GST/GSH) system.
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NADES propolis extracts - update 2023 and synthesis of derivatives of propolis ingredients
Open Research DataThis dataset contains results of our investigation aiming in determination of antimicrobial potential of the propolis extracts produced with deep eutectic solvents
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Cytotoxicity of anthraquinone derivatives (Compound 1-9) towards H226 cancer cell
Open Research DataThis study presents absorbance values of formazan product (converted from MTT) which corresponds to the cytotoxicity of anthraquinone derivatives (Compound 1-9) towards H226 cancer cells.
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Cytotoxicity of anthraquinone derivatives (Compound 1-9) towards A549 cancer cells
Open Research DataThis study presents absorbance values of formazan product (converted from MTT) which corresponds to the cytotoxicity of anthraquinone derivatives (Compound 1-9) towards A549 cancer cells.
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Cytotoxicity of anthraquinone derivatives (Compound 1-9) towards NHBE normal cells
Open Research DataThis study presents absorbance values of formazan product (converted from MTT) which corresponds to the cytotoxicity of anthraquinone derivatives (Compound 1-9) towards NHBE normal cells.
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Cytotoxicity of anthraquinone derivatives (Compound 1-9) towards H460 cancer cell
Open Research DataThis study presents absorbance values of formazan product (converted from MTT) which corresponds to the cytotoxicity of anthraquinone derivatives (Compound 1-9) towards H460 cancer cells.
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Effect of new bisacridines IKE16, IKE18 and IE10 on the yeast topoisomerase II relaxation activity
Open Research DataThe datasets contain the results of new bisacridines IKE16, IKE18 and IE10 inhibition activity against yeast topoisomerase II. DNA topoisomerases (Topo) are enzymes that catalyze changes in the spatial structure of DNA and play an important role in replication, transcription and recombination. Beyond their normal functions, DNA topo are significant...
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Effect of C-1748 derivatives on the biofilm formation of C. albicans ATCC 10231 cells
Open Research DataThe datasets contain the results of the impact of five C-1748 derivatives (IKE28 - IKE32) on the biofilm formation of Candida albicans strain ATCC 10231 cells. Photographic documentation prepared with the TECAN Spark 10M titration plate reader.
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Effect of C-1748 derivatives on the morphological transformation of C. albicans ATCC 10231 cells
Open Research DataThe datasets contain the results of the impact of five C-1748 derivatives (IKE28 - IKE32) on morphological transformation of Candida albicans strain ATCC 10231 cells. Photographic documentation prepared with the TECAN Spark 10M titration plate reader.
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The absorption and fluorescence spectra of novel bisacridines (IKE15-19, IKE21) and IE10, potential antifungal agents
Open Research DataOptical measurements of novel bisacridines (IKE15-19, IKE21) and IE10 were conducted. The absorption spectra were recorded from 300 to 800 nm. The fluorescence emission spectra were determined with excitation and emission wavelengths described in the file. All measurements were recorded using a multiplate reader, Tecan Spark 10M.
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Determination of the minimum inhibitory concentration of new bisacridines IKE15-19 and IKE21, against yeast strains
Open Research DataThe datasets contain the results of determining the minimum inhibitory concentration of new bisacridines against C. albicans ATCC 10231, C. glabrata ATCC 90030, C. krusei ATCC 6258 and C. parapsilosis ATCC 22019, S. cerevisiae ATCC 9763 and fluconazole resistant C. albicans strains by the modified M27-A3 specified by the CLSI.
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Thermogravimetric analysis (TGA ) and derivative thermogravimetry (DTG) results for potassium citrate
Open Research DataThese data contains thermogravimetric analysis (TGA ) and derivative thermogravimetry (DTG) results for thermal decomposition of potassium citrate.
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Determination of the minimum inhibitory concentration of C-1305 derivatives (IKE1-IKE8) against Candida strains
Open Research DataThe datasets contain the results of determining the minimum inhibitory concentration of acridone derivatives against C. albicans ATCC 10231, C. glabrata ATCC 90030, C. krusei ATCC 6258 and C. parapsilosis ATCC 22019 by the modified M27-A3 specified by the CLSI.
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Determination of the minimum inhibitory concentration of C-1330 derivatives (IKE9-IKE14) against Candida strains
Open Research DataThe datasets contain the results of determining the minimum inhibitory concentration of C-1330 derivatives (IKE9-IKE14) against C. albicans ATCC 10231, C. glabrata ATCC 90030, C. krusei ATCC 6258 and C. parapsilosis ATCC 22019 by the modified M27-A3 specified by the CLSI.
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Study of proapoptotic activity of anthraquinone derivatives towards A549 cancer cells using flow cytometry
Open Research DataThis study presents the fluorescence intensity of Annexin V/7AAD and caspase 3/7 which correspond to the proapoptotic activity of anthraquinone derivatives towards A549 cancer cells.
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IKE1-IKE3 (C-1305 derivatives) inhibitory effect of the Yeast Topoisomerase II relaxation activity
Open Research DataInhibition of Yeast Topoisomerase II were analyzed according to relaxation assay kit from Inspiralis. Briefly, 250 ng of supercoiled pBR322 DNA, 1 mM ATP, 1-200 μM of analyzed compound were mixed with reaction buffer (1 mM Tris-HCl (pH 7.9), 10 mM KCl, 0.5 mM MgCl 2, 0.2 % (v/v) glycerol). The reaction was initiated by the addition of an enzyme, allowed...
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Study of proapoptotic activity of anthraquinone derivatives towards H226 cancer cells using flow cytometry
Open Research DataThis study presents the fluorescence intensity of Annexin V/7AAD and caspase 3/7 which correspond to the proapoptotic activity of anthraquinone derivatives towards H226 cancer cells.
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Uniform expansion estimates in the quadratic map as a function of the parameter, using the “derivative” partition type
Open Research DataThis dataset contains selected results of numerical computations described in the paper "Quantitative hyperbolicity estimates in one-dimensional dynamics" by S. Day, H. Kokubu, S. Luzzatto, K. Mischaikow, H. Oka, P. Pilarczyk, published in Nonlinearity, Vol. 21, No. 9 (2008), 1967-1987, doi: 10.1088/0951-7715/21/9/002.
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Effect of novel bisacridines (IKE16, IKE18, IKE19, IKE21) and IE10 on the biofilm formation of C. albicans ATCC 10231 cells
Open Research DataThe datasets contain the results of the impact of novel bisacridines (IKE16, IKE18, IKE19, IKE21) and IE10 on the biofilm formation of Candida albicans strain ATCC 10231 cells. Photographic documentation prepared with the TECAN Spark 10M titration plate reader.
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Glutathione conjugation of the antitumor-active 1-nitroacridine derivatives compounds C-857 and C-1748 – the major role of glutathione S-transferase M1-1
Open Research DataObjectives: C-857 and C-1748 are antitumor-active agents, monomers of unsymmetrical bisacridine derivatives. The aim of this study was to analyze their glutathione (GSH) conjugation in vitro in the presence of glutathione S-transferase (GST) M1-1.
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Uniform expansion estimates in the quadratic map as a function of the partition size, using the “derivative” partition type
Open Research DataThis dataset contains selected results of numerical computations described in the paper "Quantitative hyperbolicity estimates in one-dimensional dynamics" by S. Day, H. Kokubu, S. Luzzatto, K. Mischaikow, H. Oka, P. Pilarczyk, published in Nonlinearity, Vol. 21, No. 9 (2008), 1967-1987, doi: 10.1088/0951-7715/21/9/002.
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Statement of FUS revenues and costs (in PLN thousand) in the first half of 2020
Open Research DataIn the period from January to June 2020. The fund's expenditure amounted to PLN 130.0 billion, while revenues from premiums and their derivatives amounted to PLN 92.2 billion. As a result, in the first half of this year, the degree of coverage of expenses with revenues from premiums and their derivatives amounted to. the level of 70.9 percent (a decrease...
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Determination of the MIC (minimum inhibitory concentration) of new bisacridines IKE16-19, IKE21 and IE10 against C. glabrata clinical strains
Open Research DataThe datasets contain the results of determining the MIC value (minimum inhibitory concentration) of new bisacridines IKE16-19, IKE21 and IE10 against Candida glabrata clinical strains CZD 310, 373, 377, 513 and collection strain DSM 11226 by the modified M27-A3 specified by the CLSI.
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Indicator of coverage of expenses with income from contributions in the Social Insurance Fund
Open Research DataThe consequences of the COVID-19 pandemic negatively affected the picture of the financial situation of the Social Insurance Fund. In the period from January to June this year. the fund's expenditure amounted to PLN 130.0 billion, while revenues from premiums and their derivatives amounted to PLN 92.2 billion. As a result, in the first half of this...
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Killing kinetics analysis of C-1311 derivative with octaarginine (Compound 1-R8) against Candida albicans
Open Research DataThe datasets contain the results of killing kinetics analysis of imidazoacridinone derivative and fluconazole against C. albicans ATCC 10231. The suspensions of Candida albicans ATCC 10231 cells (500 µL) in RPMI 1640 at cell density of 104 cells /mL were added to 500 µL of RPMI 1640 medium with various concentrations of the compounds, corresponding...
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Determination of the minimum inhibitory concentration of C-1311 derivatives (C-1296, C-1410, Compound 1, Compound 1-R8) against Candida strains
Open Research DataThe datasets contain the results of determining the minimum inhibitory concentration of imidazoacridinone derivatives against C. albicans ATCC 10231, C. glabrata ATCC 90030, C. krusei ATCC 6258 and C. parapsilosis ATCC 22019 and C. albicans clinical strains by the modified M27-A3 specified by the CLSI.
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Investigation of the C-1311 glucuronidation: an electrochemical approach
Open Research DataThis study was undertaken to investigate the glucuronidation of the compound C-1311 (5-diethylaminoethylamino-8-hydroxyimidazoacridinone – the model anticancer acridine derivative) using electrochemistry/mass spectrometry (EC/MS) as a complementary technique to in vitro (liver microsomes) and in silico approaches.
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Revenue of social security contributions (in PLN billion)
Open Research DataIn the period January-September 2020, the expenditure of the Social Insurance Fund amounted to PLN 197.1 billion, and the revenues from contributions and their derivatives - PLN 144.5 billion. As a result, the proceeds covered 73.3 percent. expenses. At that time, the fund received a subsidy from the budget in the amount of PLN 29.3 million.
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The influence of chitosan hydrogels on the morphology of L929 cells
Open Research DataRepresentative image at 20x magnification of L929 cells following 24 h of treatment with chitosan derivatives: chitosan dissolved in carbonic acid, chitosan dissolved in carbonic acid endotoxin free, chitosan dissolved in hydroacetic acid at 1:3 diluent factor. The scale bar is 100 µm; Microscope Olympus IX83, Tokyo, Japan).
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Determination of cytotoxic activity of new bisacridines IKE18, IKE19, IKE21 and IE10 against human kidney HEK-293 (ATCC® CRL-1573™) and liver cells HEPG2 (ATCC® HB-8065™)
Open Research DataThe datasets contain the results of determining in vitro cytotoxic activity of compounds using human cell lines assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, a method that evaluates cell viability by measuring cellular oxidoreductase activity. Initially, cells were seeded in 96-well culture plates and allowed...
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Tax on dividend income and income from investments in equity instruments in selected European Union countries
Open Research DataThe following data contains the information about the capital gains tax in selected EU countries. Capital gain is understood as an increase in the value of capital, e.g. as a result of an increase in the prices of securities held on the stock exchange, units of funds, exchange rate differences or other assets. This profit may be specified in nominal...
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The BDD electrodes wettability modification by anodic polarization treatment
Open Research DataThe dataset contains the raw images, photographs obtained for the contact angle measurement at the surface of the boron-doped diamond (BDD) electrode. The measurements were carried out on after potentiodynamic polarization procedure, at various anodic polarization scan range (no polarization - HTBDD; 1.0 V; 1.4 V; 1.9 V; 2.5 V vs Ag|AgCl, scan rate...
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A Fortran-95 algorithm to solve the three-dimensional Higgs boson equation in the de Sitter space-time
Open Research DataA numerically efficient finite-difference technique for the solution of a fractional extension of the Higgs boson equation in the de Sitter space-time is designed. The model under investigation is a multidimensional equation with Riesz fractional derivatives of orders in (0,1)U(1,2], which considers a generalized potential and a time-dependent diffusion...
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Stochastic intervals for the family of quadratic maps
Open Research DataNumerical analysis of chaotic dynamics is a challenging task. The one-parameter families of logistic maps and closely related quadratic maps f_a(x)=a-x^2 are well-known examples of such dynamical systems. Determining parameter values that yield stochastic-like dynamics is especially difficult, because although this set has positive Lebesgue measure,...
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A collection of directed graphs for the minimum cycle mean weight computation
Open Research DataThis dataset contains definitions of the 16 directed graphs with weighted edges that were described in the following paper: Paweł Pilarczyk, A space-efficient algorithm for computing the minimum cycle mean in a directed graph, Journal of Mathematics and Computer Science, 20 (2020), no. 4, 349--355, DOI: 10.22436/jmcs.020.04.08, URL: http://dx.doi.org/10.22436/jmcs.020.04.08 These...
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The luminescence study of Bi-doped Cs2AgInCl6 double perovskite.
Open Research DataHere, we report a halide precursor acid precipitation method to synthesize Cs2AgIn1−xBixCl6 (x = 0, 0.02, 0.04, 0.08, 0.16, 0.32, 0.64, and 1) microcrystals. Cs2AgInCl6 and Bi derivative double perovskites show broadband white light emission via self-trapped excitons (STEs) and have achieved the highest internal quantum efficiency of up to 52.4% at...
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Non-adiabatic coupling elements between the diatomic silver anion and neutral silver dimer plus continuum electron
Open Research DataThe process of a two-channel decay of the diatomic silver anion (Ag2-), namely the spontaneous electron ejection giving Ag2 + e- and the dissociation leading to Ag- + Ag is theoretically studied. The ground state potential energy curves (PECs) of the neutral silver dimer and anionic silver diatomic molecule are calculated using the single reference...
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Dynamics of S-unimodal maps used in population modeling.
Open Research DataS-unimodal maps are maps of the interval with negative Schwarzian derivative and having only one turning point (such that the map is increasing to the left of the turning point and decreasing to the right of it). Theory of S-unimodal maps is now a well-developed branch of discrete dynamical systems, including famous Singer theorem which implies existence...