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Search results for: METABOLIC DETOXIFICATION
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Metabolic response of cornflower (Centaurea cyanus L.) exposed to tribenuron-methyl: one of the active substances of sulfonylurea herbicides
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30‐Day morbidity and mortality of bariatric metabolic surgery in adolescence during the COVID‐19 pandemic – The GENEVA study
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Chiral Pyrazolo[4,3-e][1,2,4]triazine Sulfonamides—Their Biological Activity, Lipophilicity, Protein Affinity, and Metabolic Transformations
PublicationReferring to our previous laboratory results related to the tyrosinase and urease inhibition by pyrazolo[4,3-e][1,2,4]triazine sulfonamides, we examined here in silico the mechanism of action at the molecular level of the investigated pyrazolotriazine sulfonamides by the molecular docking method. The studied compounds being evaluated for their cytotoxic effect against cancer cell lines (MCF-7, K-562) and for recombinant Abl and...
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Electrochemical simulation of metabolic reduction and conjugation reactions of unsymmetrical bisacridine antitumor agents, C-2028 and C-2053
PublicationElectrochemistry (EC) coupled with analysis techniques such as liquid chromatography (LC) and mass spectrometry (MS) has been developed as a powerful tool for drug metabolism simulation. The application of EC in metabolic studies is particularly favourable due to the low matrix contribution compared to in vitro or in vivo biological models. In this paper, the EC(/LC)/MS system was applied to simulate phase I metabolism of the representative...
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Experiments on damage development in metallic plates subjected to explosions
PublicationW pracy przedstawiono badania eksperymentalne rozwoju zniszczenia płyt metalowych pod wpływem eksplozji. Zaprezentowano opis badan statycznych i dynamicznych na płytach oraz opis badan jednoosiowych. Dla założonego modelu równania konstytutywnego przedstawiono sposób identyfikacji parametrów materiałowych.
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Modeling for Detection of Degraded Zones in Metallic and Composite Structures
PublicationW pracy przedstawiono przegląd metod modelowania uszkodzeń w postaci pęknięć i delaminacji wystepujących w elementach konstrukcyjnych
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Conducting polymer films for biodegradable metallic cardiovascular stents
PublicationIn recent years, there is increasing interest to create biodegradable metallic cardiovascular stents instead of using their permanent form. The most interesting materials for this purpose are iron and its alloys. However, in order to use it in clinical application, their degradation rate and biological performance need to be optimized. One promising solution is coating the metal with conducting polymer films. In this work, short...
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Selective oxidation of metallic single-walled carbon nanotubes
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Oxide Layers Fabricated by Spray Pyrolysis on Metallic Surfaces
Publicationw pracy przedstawiono wyniki badań nad opracowaniem optymalnych warunków przygotowania warstwy stabilizowanego itrem cyrkonu jako prekursora na stali 316L jako podłoża za pomocą pirolizy aerozolowej.
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Machining of the flat surfaces with abrasive-metallic lapping tools.
PublicationPrzedstawiono konstrukcje narzędzi ścierno-metalowych do obróbki powierzchni płaskich na docierarkach jednotarczowych. Przeprowadzono badania wydajności i jakości powierzchni elementów ceramicznych o małych gabarytach.
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Tunable Waveguide Filter with Bow-Tie Metallic Posts.
PublicationBadanie i synteza filtru falowodowego zawiewrającego metalowe rezonatory motylkowe (Bow-Tie). Wykorzystano zmodyfikowaną procedurę iteracyjną i metodę dopasowania rodzajów w celu rozwiązania problemu brzegowego na pojedynczej sekcji filtru i określenie pola rozproszonego od rezonatora motylkowego. Obrót i przemieszczenie opisywane struktury w złączu falowodowym umożliwia zmianę odpowiedzi częstotliwościowych układu. Efekt rotacji...
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The association between irisin and muscle metabolism in different thyroid disorders
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Lipophagy and Lipolysis Status in Lipid Storage and Lipid Metabolism Diseases
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Peroxidative metabolism of fatty acids in the course of tick-borne encephalitis
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Updates on Metabolism in Lactic Acid Bacteria in Light of “Omic” Technologies
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Integrative genomics reveal a role for MCPIP1 in adipogenesis and adipocyte metabolism
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Diamond Nanofilm Normalizes Proliferation and Metabolism in Liver Cancer Cells
PublicationPurpose: Surgical resection of hepatocellular carcinoma can be associated with recurrence resulting from the degeneration of residual volume of the liver. The objective was to assess the possibility of using a biocompatible nanofilm, made of a colloid of diamond nanoparticles (nfND), to fill the side after tumour resection and optimize its contact with proliferating liver cells, minimizing their cancerous transformation. Methods:...
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Folate/homocysteine metabolism and lung cancer risk among smokers
PublicationBackground: Folate and homocysteine are involved in DNA synthesis and methylation processes, which are deregulated during carcinogenesis. Objectives: The aim of this study was to assess the relationship between folate/homocysteine concentrations, the functional polymorphisms of folate/homocysteine genes and lung cancer risk among cigarette smokers. Study design: The study included 132 lung cancer patients and 396 controls from...
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New Chalcones Derivatives With Potent Antitumor Activity And Their Metabolism In Vitro
PublicationChalcone derivatives exhibit a broad range of biological activities, with antioxidant and cytotoxic properties among the most studied. Despite numerous reports on chalcones as cytotoxic, and potentially anticancer agents, very little is know on their actual mechanism of activity. Generally, chalcones are considered as antimitotic agents, which interfere with tubulin assembly.We have recently developed a new class of chalcones with...
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Metabolomic and antioxidant properties of different varieties and origins of Dragon fruit
PublicationDragon fruit has appealed much concern from consumers as a novelty fruit with potent nutritional and medicinal benefits. Dragon fruit quality warrants comprehensive evaluation, based on the contents of pigments and health- promoting natural compounds in different varieties. This study was aimed to evaluate the differences among dragon fruit varieties extracted with methanol–water (CD3OD-D2O) and methanol (CD3OD) by proton nuclear magnetic...
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PREVALENCE OF METABOLIC SYNDROME AMONG PATIENTS WITH SCHIZOPHRENIA FROM LONG CARE UNIT IN FORENSIC PSYCHIATRY PROGRAM: AN OBSERVATIONAL STUDY
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Metabolic Evaluation of Urine from Patients Diagnosed with High Grade (HG) Bladder Cancer by SPME-LC-MS Method
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“Positive Regulation of RNA Metabolic Process” Ontology Group Highly Regulated in Porcine Oocytes Matured In Vitro: A Microarray Approach
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Cross-linking of sodium caseinate-structured emulsion with transglutaminase alters postprandial metabolic and appetite responses in healthy young individuals
PublicationThe physico-chemical and interfacial properties of fat emulsions influence lipid digestion and may affect postprandial responses. The aim of the present study was to determine the effects of the modification of the interfacial layer of a fat emulsion by cross-linking on postprandial metabolic and appetite responses. A total of fifteen healthy individuals (26·5 (sem 6·9) years and BMI 21·9 (sem 2·0) kg/m2) participated in a cross-over...
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Kinetics studies of recrystallization process of metallic catalysts for ammonia synthesis
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Ductile fracture prediction in thin metallic plates subjected to explosions
PublicationPraca dotyczy modelowania zniszczenia ciągłego. Zaprezentowano wyniki eksperymentów przeprowadzonych na płytach metalowych poddanych eksplozjom oraz wyniki jednoosiowych prób laboratoryjnych. Opisano przyjęty model prawa konstytutywnego oraz kryteriów zniszczenia. Przedstawiono identyfikację parametrów materiałowych dla przyjętego modelu. Zaprezentowano model numeryczny oraz wyniki symulacji które następnie porównano z wynikami...
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Comparison of experimental and numerical results on metallic plates subjected to explosions
PublicationA comparative study of dynamic response including damage and rupture processes of thin metallic plates subjected to shockwave impulses - explosions is presented. The results of the finite element numerical analysis are related to experiments. Due to high strain rate during explosions the elasto-viscoplastic Chaboches constitutive law including damage effects has been applied. For the assumed model proper material parameters identification...
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Hybrid quantum-classical approach for atomistic simulation of metallic systems
PublicationThe learn-on-the-fly (LOTF) method [G. Csanyi et al., Phys. Rev. Lett. 93, 175503 (2004)] serves to seamlessly embed quantum-mechanical computations within a molecular-dynamics framework by continual local retuning of the potential's parameters so that it reproduces the quantum-mechanical forces. In its current formulation, it is suitable for systems where the interaction is short-ranged, such as covalently bonded semiconductors....
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Formation of Porous Structure of the Metallic Materials Used on Bone Implants
PublicationResearch on improvement of structure and fabrication methods of the bone implants are carried out for many years. Research are aimed to shape the structures, that will have a Young's modulus value similar to the value of the human bones Young's modulus. Depending on theporosity, Young's moduli can even be tailored to match the modulus of bone closer than solid metals can, thus reducing the problems associated with stress shielding...
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The allergic and irritating reactions to metallic implants with trauma - orthopaedic patients
PublicationThe article presents the analysis of clinical operation complications after the treatment of long bones by mean of ostheosynthesis with the use of metal implants and endoprothesoplastic of hip joints.
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Bandwidth Dependence of the Propagation Channel in Circular Metallic BAN Environments
PublicationIn this paper, the bandwidth dependence of the propagation channel for Body Area Networks (BANs) in circular metallic environments is addressed and models are proposed to evaluate the appropriate short-term fading margins that should be considered as a function of the system bandwidth. The deployment of BANs in metallic indoor environments, such as ships, factories, warehouses and other similar environments, involves additional...
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On fatigue safety of metallic elements under static and dynamic loads.
PublicationGłównym celem monografii było wyznaczenie współczynników bezpieczeństwa i kryteriów projektowych z uwzględnieniem wpływu obciążeń statycznych oraz naprężeń średnich i resztowych na wytrzymałość zmęczeniową przy obciążeniach okresowych i/lub stochastycznych. Uzyskano to za pomocą wyznaczonych naprężeń równoważnych i równania Soderberga. Otrzymano kryteria w postaci zamkniętej i zgodnej z wzorem Milesa na trwałość zmęczeniową oraz...
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Disturbances of magnetic field in surrounding of mobile, metalic plate
PublicationThe uniform magnetic field of the Earth in the surrounding of a mobile, metalic object undergoes deformation by eddy currents. The influence of the moving conducting object on total magnetic field of the Earth depends on the object's shape, position and speed of the changes relative to the magnetic field's vector of the Earth as well as the electric conductivity and the relative magnetic permeability of the material. The disturbances...
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Urinary metabolomic signature of muscle-invasive bladder cancer: A multiplatform approach
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Central carbon metabolism influences fidelity of DNA replication in Escherichia coli
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Vitamin D Metabolism Gene Polymorphisms and Their Associated Disorders: A Literature Review
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Activities of genes controlling sphingolipid metabolism in human fibroblasts treated with flavonoids
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Modulation of expression of genes involved in glycosaminoglycan metabolism and lysosome biogenesis by flavonoids
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Evaluation of bioconcentration and metabolism of diclofenac in mussels Mytilus trossulus - laboratory study
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Lactose and β-Glucosides Metabolism and Its Regulation in Lactococcus lactis: A Review
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Ascorbate and glutathione metabolism in embryo axes and cotyledons of germinating lupine seeds
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Completing Autophagy: Formation and Degradation of the Autophagic Body and Metabolite Salvage in Plants
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Renal Regulation of Calcium-Phosphate Metabolism in Single- and Twin Pregnant Goats
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The II phase metabolism of endogenous and exogenous compounds, including antitumor chemotherapeutics
PublicationThe II phase metabolism, it is a set of metabolism and excretion pathways of endogenous as well as exogenous compounds including xenobiotics. UDP-glucuronyltransferases (UGTs; EC 2.4.1.17) are the most crucial representatives of II phase enzymes, which are responsible for the transformation of bilirubine and bile acids, steroids and thyroid hormones and lipids. Exogenous compounds, including drugs, carcinogens, environmental pollutants...
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The Impact of Different Drying Methods on the Metabolomic and Lipidomic Profiles of Arthrospira platensis
PublicationDrying is an inseparable part of industrial microalgae production. In this work, the impacts of eight different drying methods on the metabolome and lipidome of Arthrospira platensis were investigated. The studied drying methods were freeze drying (FD), sun drying (SD), air drying at 40 and 75 °C (AD′ and AD″), infrared drying at 40 and 75 °C (IRD′ and IRD″), and vacuum drying at 40 and 75 °C (VD′ and VD″). Results gathered by...
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Metabolic Profiling of Jasminum grandiflorum L. Flowers and Protective Role against Cisplatin-Induced Nephrotoxicity: Network Pharmacology and In Vivo Validation
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Hypericum alpestre extract exhibits in vitro and in vivo anticancer properties by regulating the cellular antioxidant system and metabolic pathway of L‐arginine
PublicationConventional treatment methods are not effective enough to fight the rapid increase in cancer cases. The interest is increasing in the investigation of herbal sources for the development of new anticancer therapeutics. This study aims to investigate the antitumor capacity of Hypericum alpestre (H. alpestre) extract in vitro and in vivo, either alone or in combination with the inhibitors of the L‐arginine/polyamine/nitric oxide...
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NADPH-Cytochrome P-450 reductase in strongly involved in activating metabolic transformatios of 9-amino-1-nitroacridine antitumor agents
PublicationCelem pracy było wyjaśnienie roli reduktazy cytochromu P-450 jaką odgrywa ten enzym w przemianach metabolicznych dwóch związków przeciwnowotworowych z grupy pochodnych 1-nitroakrydyny. Zastosowano metodę HPLC do rozdziału metabolitów, a badania struktur przeprowadzono stosując metodę ESI-MS. Wykazano, że badana reduktaza jest zaangażowana bardziej w metabolizm aktywacyjny 1-nitroakrydyn niż metabolizm detoksykacyjny.
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Phase I and phase II metabolism simulation of antitumor-active 2-hydroxyacridinone with electrochemistry coupled on-line with mass spectrometry.
PublicationHere, we report the metabolic profile and the results of associated metabolic studies of 2-hydroxyacridinone (2-OH-AC), the reference compound for antitumor-active imidazo- and triazoloacridinones. Electrochemistry coupled with mass spectrometry was applied to simulate the general oxidative metabolism of 2-OH-AC for the first time. The reactivity of 2-OH-AC products to biomolecules was also examined. The usefulness of the electrochemistry...
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Laser Surface Alloying of Aluminium Alloys with Cu/Fe Metallic Powders
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