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Search results for: CELL HYPOXIA
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Potent antidiuretic agonists, deamino-vasopressin and desmopressin, and theirinversoanalogs: NMR structure and interactions with micellar and liposomic models of cell membrane
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Artificial Intelligence-Based Weighting Factor Autotuning for Model Predictive Control of Grid-Tied Packed U-Cell Inverter
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Antiproliferative Activity of Double Point Modified Analogs of 1,25-Dihydroxyvitamin D2 Against Human Malignant Melanoma Cell Lines
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Geldanamycin-Induced Osteosarcoma Cell Death Is Associated with Hyperacetylation and Loss of Mitochondrial Pool of Heat Shock Protein 60 (Hsp60)
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An insertion/deletion polymorphism of the dihydrofolate reductase (DHFR) gene is associated with serum and red blood cell folate concentrations in women
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Tumor infiltrating lymphocyte signature is associated with single nucleotide polymorphisms and predicts survival in esophageal squamous cell carcinoma patients
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Expression of Osteoblast-Specific Factor 2 (OSF-2, Periostin) Is Associated with Drug Resistance in Ovarian Cancer Cell Lines
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PTPRK Expression Is Downregulated in Drug Resistant Ovarian Cancer Cell Lines, and Especially in ALDH1A1 Positive CSCs-Like Populations
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Monitoring T-Cell Responses in Translational Studies: Optimization of Dye-Based Proliferation Assay for Evaluation of Antigen-Specific Responses
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LC-PDA-MS and GC-MS Analysis of Scorzonera hispanica Seeds and Their Effects on Human Breast Cancer Cell Lines
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Update on the molecular pathogenesis and clinical treatment of Mantle Cell Lymphoma (MCL): minutes of the 9th European MCL Network conference
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Acalabrutinib in relapsed or refractory mantle cell lymphoma (ACE-LY-004): a single-arm, multicentre, phase 2 trial
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Induced Pluripotent Stem Cell (iPSC)–Derived Extracellular Vesicles Are Safer and More Effective for Cardiac Repair Than iPSCs
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Characterization of the interactions between human high-molecular-mass kininogen and cell wall proteins of pathogenic yeasts, Candida tropicalis
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Changes in subcellular localization of visfatin in human colorectal HCT-116 carcinoma cell line after cytochalasin B treatment
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Vanadium toxicity in chickpea (Cicer arietinum L.) grown in red soil: Effects on cell death, ROS and antioxidative systems
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Novel Nystatin A1 derivatives exhibiting low host cell toxicity and antifungal activity in an in vitro model of oral candidosis
PublicationOpportunistic oral infections caused by Candida albicans are frequent problems in immunocompromised patients. Management of such infections is limited due to the low number of antifungal drugs available, their relatively high toxicity and the emergence of antifungal resistance. Given these issues, our investigations have focused on novel derivatives of the antifungal antibiotic Nystatin A1, generated by modifications at the amino...
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9,10-Dioxoanthracenyldithiocarbamates effectively inhibit the proliferation of non-small cell lung cancer by targeting multiple protein tyrosine kinases
PublicationAnthraquinones have attracted considerable interest in the realm of cancer treatment owing to their potent anticancer properties. This study evaluates the potential of a series of new anthraquinone derivatives as anticancer agents for non-small-cell lung cancer (NSCLC). The compounds were subjected to a range of tests to assess their cytotoxic and apoptotic properties, ability to inhibit colony formation, pro-DNA damage functions,...
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Discussion on 3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibitors reduce human pancreatic cancer cell invasion and metastasis
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Calculation of silicon cell temperature of loaded photovoltaic module based on thermal coefficients for different weather conditions of Northern Poland
PublicationWydajność obciążonego modułu fotowoltaicznego zależy silnie od natężenia promieniowania słonecznego, temperatury otoczenia, prędkości wiatru i temperatury wewnętrznej składowych ogniw fotowoltaicznych. Sprawność konwersji fotowoltaicznej spada istotnie wraz z e wzrostem temperatury złącza p-n. Pomiar tej temperatury jest niemożliwy i oblicza się ją w oparciu o mierzoną wartość temperatury przedniej lub tylnej powierzchni modułu...
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T cell Activation Is Driven by an ADP-Dependent Glukosinase Linking Enhanced Glycolysis with Mitochondrial Reactive Oxygen Species Generation
PublicationMitochondria-originating reactive oxygen species control T cell receptor (TCR)-induced gene expression. Here, we show that TCR-triggered activation of ADP-dependent glucokinase (ADPGK), an alternative, glycolytic enzyme typical for Archaea, mediates generation of the oxidative signal. We also show that ADPGK is localized in the endoplasmic reticulum and suggest that its active site protrudes toward the cytosol. The ADPGK-driven...
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Antitumor DNA-Damaging C-1748 is a New Inhibitor of Autophagy that Triggers Apoptosis in Human Pancreatic Cancer Cell Lines
PublicationDespite the enormous progress that has been made over the past decades in diagnosis, treatment and prevention of many types of tumors, survival rates in pancreatic cancer still remain poor. Pancreatic cancer is one of the most malignant and chemoresistant tumors and the profound mechanism supporting these phenomena is the constitutively activated prosurvival autophagy. The antitumor 1-nitroacridine derivative C-1748 belongs to...
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Result of the 6-min walk test is an independent prognostic factor of surgically treated non-small-cell lung cancer
PublicationPathological tumour, node and metastasis (TNM) stage remains the most significant prognostic factor of non-small-cell lung cancer (NSCLC). Meanwhile, age, gender, pulmonary function tests, the extent of surgical resection and the presence of concomitant diseases are commonly used to complete the prognostic profile of the patient with early stage of NSCLC. The aim of this study is to assess how the result of a 6-min walk test (6MWT)...
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Genotoxicity of selected pharmaceuticals, their binary mixtures, and varying environmental conditions – study with human adenocarcinoma cancer HT29 cell line
PublicationPharmaceutical residues are present in the environment in mixtures and their adverse effects may also result from interactions that occur between compounds. Studies presented in this work focus on genotoxicity of pharmaceuticals from different therapeutic groups in mixtures and in individual solutions impacted with different environmental conditions assessed using comet assay (alkaline approach). Binary mixtures of pharmaceuticals...
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Low temperature processed MnCo2O4 and MnCo1.8Fe0.2O4 as effective protective coatings for solid oxide fuel cell interconnects at 750 °C
PublicationIn this study two materials, MnCo2O4 and MnCo1.8Fe0.2O4 are studied as potential protective coatings for Solid Oxide Fuel Cell interconnects working at 750 °C. First powder fabrication by a modified Pechini method is described followed by a description of the coating procedure. The protective action of the coating applied on Crofer 22 APU is evaluated by following the area specific resistance (ASR) of the scale/coating for 5500...
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Mission impossible for cellular internalization: When porphyrin alliance with UiO-66-NH2 MOF gives the cell lines a ride
PublicationIs it possible to accelerate cell internalization by hybridization of nanomaterials? Herein we support the realization of using metal-organic frameworks (MOFs) with the assistance of rigid porphyrin structure (H2TMP) aimed at drug loading, drug release, relative cell viability, and targeted in vitro drug delivery. There are several MOFs, i.e., UiO-66-NH2 (125 ± 12.5 nm), UiO-66-NH2 @H2TMP (160 ± 14 nm), UiO-66-NH2 @H2TMP@DOX, and...
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Spectroscopic investigations into degradation of polymer membranes for fuel cells applications
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Manufacture of photovoltaic cells with hybrid organic–inorganic bulk heterojunction
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Impact of TiO2 Nanostructures on Dye-Sensitized Solar Cells Performance
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Proteomic Analysis of Proton Beam Irradiated Human Melanoma Cells
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Badania elementów metalowych w celu określenia procesu wytwarzania
PublicationWykonano badania metalograficzne elementów metalowych w celu określenia technologii ich wykonania. Sformułowano wnioski.
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Recycling and Reuse Treatment Technologies for Photovoltaic Cells and Modules - a Review
PublicationŚredni czas życia modułów fotowoltaicznych wynosi obecnie ponad 25 lat. Dla Europy oczekuje się rozpoczęcia okresu końca życia modułów montowanych na skalę masową w 2040 r. - szacuje się wzrost odpadów pochodzących z modułów PV do 33 500 ton. Zagospodarowanie wycofanych z użytku elementów systemów PV może stać się problemem w związku z ciągle rosnącą produkcją modułów fotowoltaicznych. Mogą i powinny być one poddane recyklingowi,...
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Changes in bacterial cells induced by high pressure at subzero temperature
PublicationW publikacji przedstawiono wyniki badań dotyczące zmian jakie zachodzą w komórkach bakterii Escherichia coli po działaniu wysokiego ciśnienia w ujemnej temperaturze. Stwierdzono, że w wyniku działania ciśnienia 193 MPa zachodzącą zmiany w błonie cytoplazmatycznej i ścianie komórkowej bakterii. W tych warunkach następowała prawie całkowita utrata wewnątrzkomórkowego ATP z komórek badanych szczepów znajdujących się w fazie logarytmicznej....
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Metal Supported Solid Oxide Fuel Cells - Selected Aspects
PublicationW artykule przedstawiono wyniki badań nad tlenkowymi ogniwami paliwowymi zbudowanymi na stalowym interkonektorze.
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Knowledge Management Challenges in Collaborative Design of a Virtual Call Centre
PublicationThis paper presents the analysis of knowledge management issues for an user interface consulting project relevant during the development of a Virtual Call Centre. Experiences gathered by the team of designers and team of usability consultants have been described and evaluated from the knowledge management viewpoint. A concept of a knowledge-based system, potentially supporting usability consulting in subsequent IT projects has...
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Fabrication and characterization of anode supported solid oxide fuel cells
PublicationW tej pracy, napylanie aerozolowe zawiesiny proszków jest oceniane jako metoda osadzania cienkich elektrolitów tlenkowych ogniw paliwowych. Metoda ta jest tania, prosta i mam zalety w stosunku do szeroko stosowanej metody sitodruku. Wpływ parametrów osadzania: stężenie zawiesiny, ciśnienie robocze są w artykule omawiane.
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The author's technology for the recovery of materials from the silicon photovoltaic cells
PublicationOdzyskanie czystego krzemu z uszkodzonych lub wycofanych z eksploatacji modułów PV może prowadzić do korzyści ekonomicznych i ekologicznych. Ze względu na wysokie wymagania jakościowe, dotyczące odzyskiwanego krzemu, procesy chemiczne są najważniejszym etapem w recyklingu ogniw PV. W artykule przedstawiono przykłady i możliwości odzyskania materiałów ze zużytych lub uszkodzonych ogniw fotowoltaicznych z krystalicznego krzemu oraz...
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Experimental Validation of the Chemical Recycling of Crystalline Silicon Solar Cells
PublicationW ostatnich latach systemy fotowoltaiczne stają się bardzo popularne na całym świecie jako korzystne dla środowiska rozwiązanie problemów energetycznych. Zagadnienie zagospodarowania zużytych elementów systemów fotowoltaicznych, których ilość w przyszłości może być znaczna, nie zostało do tej pory opracowane. Konieczne jest znalezienie optymalnej metody recyklingu i ponownego wykorzystania wycofanych z użycia elementów składowych...
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Design of standard cells library for UMC L130E FSG process
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N6-methyladenosine regulates the stability of RNA:DNA hybrids in human cells
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Regulated Proenkephalin Expression in Human Skin and Cultured Skin Cells
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Clinical Relevance of Circulating Tumor Cells in Prostate Cancer Management
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Sulforaphane inhibits growth of phenotypically different breast cancer cells
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Photoinduced Operation by Absorption of the Chalcogenide Nanocrystallite Containing Solar Cells
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Comprehensive investigation of capacitive deionization cells by response surface methodology
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The role of phoenixin in the proliferation and migration of ectopic epithelial cells in vitro
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Przedsiębiorstwo na rynku, jego cele i determinanty funkcjonowania
PublicationW pracy przedstawiono cele przedsiębiorstwa w kontekście zmian, związanych z funkcjonowanie firmy w warunkach urynkowienia gospodarki. Wskazano determinanty realizacji celów, w szczególności konieczność zapewnienia finansowania dla zróźnicowanych celów przedsiębiorstwa.
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Sex-dependent membranopathy in stored human red blood cells
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Dark current characteristics of single crystalline silicon solar cells.
PublicationW pracy przedstawiono wpływ szkodliwych rezystancji na parametry pracy krzemowych ogniw fotowoltaicznych. W tym celu wyznaczono ciemne charakterystyki prądowo-napięciowe. W celu opisu własności elektrycznych ogniw zastosowano model jedno- i dwu-diodowy. Wyznaczono współczynniki nieidealności charakterystyki i rezystancję szeregową w całym zakresie temperatur pracy ogniw fotowoltaicznych dla zastosowań naziemnych. Wyznaczona za...
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Call Processing Performance in a Multidomain IMS/NGN with Asymmetric Traffic
PublicationIn this paper we continue our research using the previously proposed analytical traffic model of a multidomain Next Generation Network (NGN), which is standardized for delivering multimedia services based on the IP Multimedia Subsystem (IMS). The aim of the model is to assess mean Call Set-up Delay (CSD) and mean Call Disengagement Delay (CDD), which are standardized call processing performance parameters. The output variables...