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Search results for: epigenetic drugs
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Issues in the development of new combinations of blood pressure lowering drugs
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The Effect of Antihypertensive Drugs on NADH in Newly Diagnosed Primary Hypertension
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Akrydyny jako związki aktywne przeciwnowotworowo = Acridines as antitumor drugs
PublicationAkrydyny należą do grupy policyklicznych związków heteroaromatycznych. Wykazują szeroki zakres aktywności biologicznej obejmujący aktywność przeciwpierwotniakową, przeciwbakteryjną,przeciwwirusową i przeciwnowotworową. Pochodne akrydyny o działaniu przeciwnowotworowym wykazują zróżnicowany mechanizm działania na poziomie molekularnym. Z uzyskanych dotychczas danych wynika, że jednym z podstawowych etapów działania jest tworzenie...
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Poszukiwanie nowych leków immunosupresyjnych = Quest for new immunosuppressive drugs
PublicationNiniejsza praca przeglądowa dotyczy znanych leków immunosupresyjnych, a także nowych związków o potencjalnym zastosowaniu klinicznym. Wybrane pochodne przedstawiono z uwzględnieniem mechanizmu ich działania oraz metod otrzymywania.
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Inhibitors of glucosamine-6-phosphate synthase as potential antifungal drugs.
PublicationPrzedstawiono stan obecny i perspektywy zastosowania inhibitorów enzymu syntazy GlcN-6-P jako leków skutecznych w leczeniu grzybic układowych. Używając metod modelowania molekularnego zaprojektowano struktury inhibitorów enzymu należących do dwóch grup strukturalnych: analogów glutaminy oraz analogów stanu przejściowego reakcji katalizowanej przez enzym. Opracowano metody syntezy pochodnych zoptymalizowanych inhibitorów, wykazujących...
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Characteristic profiles of DNA epigenetic modifications in colon cancer and its predisposing conditions—benign adenomas and inflammatory bowel disease
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Comparison of the Absolute Level of Epigenetic Marks 5-Methylcytosine, 5-Hydroxymethylcytosine, and 5-Hydroxymethyluracil Between Human Leukocytes and Sperm1
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Are 8-oxoguanine (8-oxoGua) and 5-hydroxymethyluracil (5-hmUra) oxidatively damaged DNA bases or transcription (epigenetic) marks?
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Marine Drugs
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Introduction of a multiplex amplicon sequencing assay to quantify DNA methylation in target cytosine markers underlying four selected epigenetic clocks
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Changes in Epigenetic Patterns Related to DNA Replication in Vicia faba Root Meristem Cells under Cadmium-Induced Stress Conditions
PublicationExperiments on Vicia faba root meristem cells exposed to 150 µM cadmium chloride (CdCl2) were undertaken to analyse epigenetic changes, mainly with respect to DNA replication stress. Histone modifications examined by means of immunofluorescence labeling included: (1) acetylation of histone H3 on lysine 56 (H3K56Ac), involved in transcription, S phase, and response to DNA damage during DNA biosynthesis; (2) dimethylation of histone...
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DRUGS IN R&D
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Drugs and Alcohol Today
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Clinical Cancer Drugs
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Drugs and Therapy Perspectives
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INVESTIGATIONAL NEW DRUGS
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Journal of Psychoactive Drugs
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Journal of Drugs in Dermatology
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Fentanyl and its derivatives as a group of new psychoactive substances (designer drugs)
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Expression of alternatively spliced variants of the Dclk1 gene is regulated by psychotropic drugs
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Assessment of sleep disorders and use of psychoactive drugs among Polish students
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New data on antihypertensive drugs and risk of cancer: should we worry?
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TIME to face the reality about evening dosing of antihypertensive drugs in hypertension
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Chemical Biology & Drug Design
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Environmentally Oriented Models and Methods for the Evaluation of Drug x Drug Interaction Effects
PublicationThis detailed review compares known and widely used methods for drug interaction estimation, some of which now have historical significance. Pharmaceutical application has been noted as far back as several thousand years ago. Relatively late in the 20th century, however, researchers became aware that their fate and metabolism, which still remain a great challenge for environmental analysts and risk assessors. For the patient’s...
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A review on computer‐aided chemogenomics and drug repositioning for rational COVID ‐19 drug discovery
PublicationApplication of materials capable of energy harvesting to increase the efficiency and environmental adaptability is sometimes reflected in the ability of discovery of some traces in an environment―either experimentally or computationally―to enlarge practical application window. The emergence of computational methods, particularly computer-aided drug discovery (CADD), provides ample opportunities for the rapid discovery and development...
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Interaction of selected drugs with food in the group of patients over 60 years of age
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Studies of human and veterinary drugs' fate in environmental solid samples- analytical problems.
PublicationW różnych ośrodkach naukowych na całym świecie trwają prace nad poznaniem losu środowiskowego zanieczyszczeń z grupy farmaceutyków. Obecność pozostałości farmaceutycznych w poszczególnych elementach środowiska stanowi nowe wyzwanie zarówno z punktu widzenia technologii oczyszczania wód i ścieków jak i analityków, których zadaniem jest opracowanie nowych metodyk analitycznych. W publikacji przedstawiono problemy z jakimi stykają...
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European Society of Hypertension Working Group on Obesity: obesity drugs and cardiovascular outcomes
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Detrimental effects of chemotherapeutics and other drugs on the endothelium: A call for endothelial toxicity profiling
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The Comparison Between the Calculated and HPLC-Predicted Lipophilicity Parameters for Selected Groups of Drugs
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Activity evaluation of some psychoactive drugs with the application of QSAR/QSPR modeling methods
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Stable and degradable microgels linked with cystine for storing and environmentally triggered release of drugs
PublicationEnvironmentally sensitive, degradable microgels based on poly(N-isopropylacrylamide) (pNIPA) crosslinked with the diacryloyl derivative of cystine (BISS) were synthesized by applying surfactant-free emulsion polymerization. pNIPA contributed the sensitivity to temperature to the microgels and the cross-linker made them degradable and sensitive to pH. The morphology of the microgels was investigated by using scanning and transmission...
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Impact of selected drugs and their binary mixtures on the germination of Sorghum bicolor (sorgo) seeds
PublicationThe aim of this study was to assess the toxicological potential of binary drug mixtures and individual drugs under different pH conditions with different inorganic ion additions on the germination of Sorghum bicolor (sorgo) seeds. To assess whether the given drug mixtures were more phytotoxic than the individual compounds, concentration addition (CA) and independent action (IA) approaches were applied to estimate the predicted...
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The role of glucuronidation in drug resistance
PublicationThe final therapeutic effect of a drug candidate, which is directed to a specific molecular target strongly depends on its absorption, distribution, metabolism and excretion (ADME). The disruption of at least one element of ADME may result in serious drug resistance. In this work we described the role of one element of this resistance: phase II metabolism with UDP-glucuronosyltransferases (UGTs). UGT function is the transformation...
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In vivo evidence of ascorbate involvement in the generation of epigenetic DNA modifications in leukocytes from patients with colorectal carcinoma, benign adenoma and inflammatory bowel disease
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Cancer stem cells and escape from drug-induced premature senescence in human lung tumor cells: implications for drug resistance and in vitro drug screening models
PublicationBadania z użyciem modelu komórek nowotworu płuc A549 wykazały, że komórki te po traktowaniu lekami uszkadzającymi DNA zatrzymują proliferację i wchodzą w stan starzenia komórkowego. Jednak post-inkubacja tych komórek prowadzi do powrotu do stanu proliferacji małej frakcji komórek. Wykazaliśy, że frakcja ta związana jest z obecnością komórek pierwotnych nowotworu w populacji komórek A549. Powrót do stanu proliferacji komóek A549...
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Electroanalytical and spectroscopic procedures for examination of interactions between double stranded DNA and intercalating drugs
PublicationPrzedstawiono metodę elektrochemicznego opisu oddziaływań dsDNA ze związkiem biologicznie czynnym w warunkach, w których zarówno badany związek jak i cząsteczka DNA są w roztworze elektrolitu. Opracowano warunki pomiaru, gdzie ani związek, ani DNA nie adsorbuje na elektrodzie. Wykazano, podobnie jak podczas badania innymi metodami, że oddziaływania są dwojakiego rodzaju: elektrostatyczne i poporzez interkalację.
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Postmortem analysis of human bone marrow aspirate - Quantitative determination of SSRI and SNRI drugs
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Clinical Relevance of Gut Microbiota Alterations under the Influence of Selected Drugs—Updated Review
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Non-steroidal anti-inflammatory drugs are safe with respect to the transcriptome of human dermal fibroblasts
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Development of potential candidate reference materials for drugs in bottom sediment, cod and herring tissues
PublicationRegular use of a reference material and participation in a proficiency testing program can improve the reliability of analytical data. This paper presents the preparation of candidate reference materials for the drugs metoprolol, propranolol, carbamazepine, naproxen, and acenocoumarol in freshwater bottom sediment and cod and herring tissues. These reference materials are not available commercially. Drugs (between 7 ng/g and 32...
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Monosubstituted hydrazone β-cyclodextrin derivatives for pH-sensitive complex formation with aromatic drugs
PublicationA new and convenient synthetic pathway was developed to produce monosubstituted cyclodextrins with high yields. Each of the β-cyclodextrin derivatives described in this work has an aromatic substituent connected with cyclodextrin core by a pH-sensitive hydrazone linker and a carbon chain. Carbon chains differ in lengths having one or three carbon atoms. The correlation between water solubility and linker length was determined using...
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Integration of protein tethering in a rapid and label-free SERS screening platform for drugs of abuse
PublicationSurface enhanced Raman spectroscopy (SERS) has emerged as a promising technique for the rapid and ultrasensitive detection of molecular species such as drugs of abuse in biofluids. Yet, it remains a significant challenge to create a viable screening tool for multiple drug classes, owing to the lack of affinity of certain species for the SERS substrate and to the matrix interference in complex media. Here we report a protein tethering...
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Effect of chemical structure on complexation efficiency of aromatic drugs with cyclodextrins: The example of dibenzazepine derivatives
PublicationIt is widely believed that the hydrophobic effect governs the binding of guest molecules to cyclodextrins (CDs). However, it is also known that high hydrophobicity of guest molecules does not always translate to the formation of stable inclusion complexes with CDs. Indeed, a plethora of other factors can play a role in the efficiency of guest–CD interactions, rendering structure-based prediction of the complexation efficiency with...
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Application of BiOClnBrm photocatalyst to cytostatic drugs removal from water; mechanism and toxicity assessment
PublicationThe photocatalytic activity of series of BiOClnBrm photocatalysts toward degradation and mineralization of the cytostatic drugs 5-fluorouracil (5-FU) and imatinib mesylate (IMA) both singly and in their mixture under simulated solar and visible light irradiation has been investigated. Screening test revealed that among BiOClnBrm photocatalysts synthesized by a solvothermal method, the one with molar 1.3Cl/0.7Br ratio was the most...
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Clinical Epigenetics
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Druga edycja Konferencji Inżynierii Oprogramowania beIT
PublicationW dniach 18–20 marca 2016 roku na Wydziale Elektroniki, Telekomunikacji i Informatyki odbyła się II Konferencja Inżynierii Oprogramowania beIT. Podobnie jak pierwszą edycję Konferencji beIT, tegoroczne spotkanie zorganizowało Koło Naukowe Zarządzanie IT przy wsparciu Katedry Inżynierii Oprogramowania, WETI oraz JM Rektora PG. Do przeprowadzenia 15 warsztatów, 4 sesji dyskusyjnych round tables oraz 5 wykładów organizatorzy zaprosili...
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ANTI-CANCER DRUGS
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Antimicrobial molecular nanocarrier–drug conjugates
PublicationMany antimicrobial drugs are poorly active against pathogenic microbes causing intracellular infections, such as Mycobacterium tuberculosis or Plasmodium falciparum. On the other hand, several known antimicrobial agents are not effective enough because of their limited cellular penetration. A common feature of both challenges is the inability of an active agent to cross the biological membrane(s). One of the possible approaches...