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Search results for: METABOLIC DETOXIFICATION
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The Rate of Improvement in Metabolic Control in Children with Diabetes Mellitus Type 1 on Insulin Glargine Depends on Age
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Metabolic Profiles of New Unsymmetrical Bisacridine Antitumor Agents in Electrochemical and Enzymatic Noncellular Systems and in Tumor Cells
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Primary mediastinal B-cell lymphoma – metabolic and anatomical features in 18FDG-PET/CT and response to therapy
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Perturbations of the hepatic proteome behind the onset of metabolic disorders in mouse offspring developed following embryo manipulation
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Cardiovascular, anthropometric, metabolic and hormonal profiling of normotensive women with polycystic ovary syndrome with and without biochemical hyperandrogenism
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Emerging Role of Adenylate Kinase 4 as a Metabolic Player Regulating Cellular Hypoxic Responses in Pulmonary Cells
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Effects of Low Concentration of Selected Analgesics and Successive Bioaugmentation of the Activated Sludge on Its Activity and Metabolic Diversity
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Metabolic Profiles of New Unsymmetrical Bisacridine Antitumor Agents in Electrochemical and Enzymatic Noncellular Systems and in Tumor Cells
PublicationNew unsymmetrical bisacridines (UAs) demonstrated high activity not only against a set of tumor cell lines but also against human tumor xenografts in nude mice. Representative UA compounds, named C-2028, C-2045 and C-2053, were characterized in respect to their physicochemical properties and the following studies aimed to elucidate the role of metabolic transformations in UAs action. We demonstrated with phase I and phase II enzymes...
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Sustainable nitrogen removal in anammox-mediated systems: Microbial metabolic pathways, operational conditions and mathematical modelling
PublicationAnammox-mediated systems have attracted considerable attention as alternative cost-effective technologies for sustainable nitrogen (N) removal from wastewater. This review comprehensively highlights the importance of understanding microbial metabolism in anammox-mediated systems under crucial operation parameters, indicating the potentially wide applications for the sustainable treatment of N-containing wastewater. The partial...
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Proteomic and Metabolomic Changes in Psoriasis Preclinical and Clinical Aspects
PublicationSkin diseases such as psoriasis (Ps) and psoriatic arthritis (PsA) are immune-mediated inflammatory diseases. Overlap of autoinflammatory and autoimmune conditions hinders diagnoses and identifying personalized patient treatments due to different psoriasis subtypes and the lack of verified biomarkers. Recently, proteomics and metabolomics have been intensively investigated in a broad range of skin diseases with the main purpose...
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Peroxidative metabolism of arachidonic acid in the course of Lyme arthritis
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Retained features of embryonic metabolism in the adult MRL mouse
PublicationThe MRL mouse is an inbred laboratory strain that was derived by selective breeding in 1960 from the rapidly growing LG/J (Large) strain. MRL mice grow to nearly twice the size of other commonly used mouse strains, display uncommonly robust healing and regeneration properties, and express later onset autoimmune traits similar to Systemic Lupus Erythematosis. The regeneration trait (heal) in the MRL mouse maps to 14-20 quantitative...
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Metabolomic Signature of Early Vascular Aging (EVA) in Hypertension
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Alternative Lactose Catabolic Pathway in Lactococcus lactis IL1403
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Melatonin: A Cutaneous Perspective on its Production, Metabolism, and Functions
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Pathways and products for the metabolism of vitamin D3 by cytochrome P450scc
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Vascular Aging and Damage in Patients with Iron Metabolism Disorders
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Unbalanced Sphingolipid Metabolism and Its Implications for the Pathogenesis of Psoriasis
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Parametric imaging in dynamic glucose metabolism studies in brain
PublicationArtykuł analizuje badania dynamiczne 18FDG-PET, które służą do estymacji metabolizmu glukozy w mózgu. Zbadano w nim wpływ zakłóceń na wyznaczanie interesującego nas parametru LCMRGlc.
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Metabolism of antitumour agent 1-nitroacridine derivative, C-1748 in pancreatic cancer cell lines
PublicationPancreatic cancer has the highest mortality rate of all major cancers because of limited treatment options. Surgical removal of the tumour is possible only in its early stage, nevertheless the asymptomatic development very often makes unable an accurate diagnose. In the case of metastatic pancreatic cancer only chemotherapy, mainly with gemcitabine, can be offered to patients. However, common resistance towards gemcitabine imposes...
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The metabolic profiles of pterin compounds as potential biomarkers of bladder cancer—Integration of analytical-based approach with biostatistical methodology
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Metabolic response of cornflower (Centaurea cyanus L.) exposed to tribenuron-methyl: one of the active substances of sulfonylurea herbicides
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30‐Day morbidity and mortality of bariatric metabolic surgery in adolescence during the COVID‐19 pandemic – The GENEVA study
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Role of adenylate kinase 4 as a new metabolic regulator of pulmonary artery smooth muscle cells under hypoxia
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Electrochemical simulation of metabolic reduction and conjugation reactions of unsymmetrical bisacridine antitumor agents, C-2028 and C-2053
PublicationElectrochemistry (EC) coupled with analysis techniques such as liquid chromatography (LC) and mass spectrometry (MS) has been developed as a powerful tool for drug metabolism simulation. The application of EC in metabolic studies is particularly favourable due to the low matrix contribution compared to in vitro or in vivo biological models. In this paper, the EC(/LC)/MS system was applied to simulate phase I metabolism of the representative...
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Chiral Pyrazolo[4,3-e][1,2,4]triazine Sulfonamides—Their Biological Activity, Lipophilicity, Protein Affinity, and Metabolic Transformations
PublicationReferring to our previous laboratory results related to the tyrosinase and urease inhibition by pyrazolo[4,3-e][1,2,4]triazine sulfonamides, we examined here in silico the mechanism of action at the molecular level of the investigated pyrazolotriazine sulfonamides by the molecular docking method. The studied compounds being evaluated for their cytotoxic effect against cancer cell lines (MCF-7, K-562) and for recombinant Abl and...
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Tunable Waveguide Filter with Bow-Tie Metallic Posts.
PublicationBadanie i synteza filtru falowodowego zawiewrającego metalowe rezonatory motylkowe (Bow-Tie). Wykorzystano zmodyfikowaną procedurę iteracyjną i metodę dopasowania rodzajów w celu rozwiązania problemu brzegowego na pojedynczej sekcji filtru i określenie pola rozproszonego od rezonatora motylkowego. Obrót i przemieszczenie opisywane struktury w złączu falowodowym umożliwia zmianę odpowiedzi częstotliwościowych układu. Efekt rotacji...
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Machining of the flat surfaces with abrasive-metallic lapping tools.
PublicationPrzedstawiono konstrukcje narzędzi ścierno-metalowych do obróbki powierzchni płaskich na docierarkach jednotarczowych. Przeprowadzono badania wydajności i jakości powierzchni elementów ceramicznych o małych gabarytach.
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Experiments on damage development in metallic plates subjected to explosions
PublicationW pracy przedstawiono badania eksperymentalne rozwoju zniszczenia płyt metalowych pod wpływem eksplozji. Zaprezentowano opis badan statycznych i dynamicznych na płytach oraz opis badan jednoosiowych. Dla założonego modelu równania konstytutywnego przedstawiono sposób identyfikacji parametrów materiałowych.
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Modeling for Detection of Degraded Zones in Metallic and Composite Structures
PublicationW pracy przedstawiono przegląd metod modelowania uszkodzeń w postaci pęknięć i delaminacji wystepujących w elementach konstrukcyjnych
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Selective oxidation of metallic single-walled carbon nanotubes
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Conducting polymer films for biodegradable metallic cardiovascular stents
PublicationIn recent years, there is increasing interest to create biodegradable metallic cardiovascular stents instead of using their permanent form. The most interesting materials for this purpose are iron and its alloys. However, in order to use it in clinical application, their degradation rate and biological performance need to be optimized. One promising solution is coating the metal with conducting polymer films. In this work, short...
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Oxide Layers Fabricated by Spray Pyrolysis on Metallic Surfaces
Publicationw pracy przedstawiono wyniki badań nad opracowaniem optymalnych warunków przygotowania warstwy stabilizowanego itrem cyrkonu jako prekursora na stali 316L jako podłoża za pomocą pirolizy aerozolowej.
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Peroxidative metabolism of fatty acids in the course of tick-borne encephalitis
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The association between irisin and muscle metabolism in different thyroid disorders
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Updates on Metabolism in Lactic Acid Bacteria in Light of “Omic” Technologies
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Integrative genomics reveal a role for MCPIP1 in adipogenesis and adipocyte metabolism
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Lipophagy and Lipolysis Status in Lipid Storage and Lipid Metabolism Diseases
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Folate/homocysteine metabolism and lung cancer risk among smokers
PublicationBackground: Folate and homocysteine are involved in DNA synthesis and methylation processes, which are deregulated during carcinogenesis. Objectives: The aim of this study was to assess the relationship between folate/homocysteine concentrations, the functional polymorphisms of folate/homocysteine genes and lung cancer risk among cigarette smokers. Study design: The study included 132 lung cancer patients and 396 controls from...
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New Chalcones Derivatives With Potent Antitumor Activity And Their Metabolism In Vitro
PublicationChalcone derivatives exhibit a broad range of biological activities, with antioxidant and cytotoxic properties among the most studied. Despite numerous reports on chalcones as cytotoxic, and potentially anticancer agents, very little is know on their actual mechanism of activity. Generally, chalcones are considered as antimitotic agents, which interfere with tubulin assembly.We have recently developed a new class of chalcones with...
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Metabolomic and antioxidant properties of different varieties and origins of Dragon fruit
PublicationDragon fruit has appealed much concern from consumers as a novelty fruit with potent nutritional and medicinal benefits. Dragon fruit quality warrants comprehensive evaluation, based on the contents of pigments and health- promoting natural compounds in different varieties. This study was aimed to evaluate the differences among dragon fruit varieties extracted with methanol–water (CD3OD-D2O) and methanol (CD3OD) by proton nuclear magnetic...
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Diamond Nanofilm Normalizes Proliferation and Metabolism in Liver Cancer Cells
PublicationPurpose: Surgical resection of hepatocellular carcinoma can be associated with recurrence resulting from the degeneration of residual volume of the liver. The objective was to assess the possibility of using a biocompatible nanofilm, made of a colloid of diamond nanoparticles (nfND), to fill the side after tumour resection and optimize its contact with proliferating liver cells, minimizing their cancerous transformation. Methods:...
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International Journal of Osteoporosis and Metabolic Disorders
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Clinical Immunology, Endocrine and Metabolic Drugs
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Current Opinion in Endocrine and Metabolic Research
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Metabolic Evaluation of Urine from Patients Diagnosed with High Grade (HG) Bladder Cancer by SPME-LC-MS Method
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“Positive Regulation of RNA Metabolic Process” Ontology Group Highly Regulated in Porcine Oocytes Matured In Vitro: A Microarray Approach
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PREVALENCE OF METABOLIC SYNDROME AMONG PATIENTS WITH SCHIZOPHRENIA FROM LONG CARE UNIT IN FORENSIC PSYCHIATRY PROGRAM: AN OBSERVATIONAL STUDY
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Cross-linking of sodium caseinate-structured emulsion with transglutaminase alters postprandial metabolic and appetite responses in healthy young individuals
PublicationThe physico-chemical and interfacial properties of fat emulsions influence lipid digestion and may affect postprandial responses. The aim of the present study was to determine the effects of the modification of the interfacial layer of a fat emulsion by cross-linking on postprandial metabolic and appetite responses. A total of fifteen healthy individuals (26·5 (sem 6·9) years and BMI 21·9 (sem 2·0) kg/m2) participated in a cross-over...
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On fatigue safety of metallic elements under static and dynamic loads.
PublicationGłównym celem monografii było wyznaczenie współczynników bezpieczeństwa i kryteriów projektowych z uwzględnieniem wpływu obciążeń statycznych oraz naprężeń średnich i resztowych na wytrzymałość zmęczeniową przy obciążeniach okresowych i/lub stochastycznych. Uzyskano to za pomocą wyznaczonych naprężeń równoważnych i równania Soderberga. Otrzymano kryteria w postaci zamkniętej i zgodnej z wzorem Milesa na trwałość zmęczeniową oraz...