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Search results for: atp synthase
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Molecular dynamics study on the role of solvation water in the adsorption of hyperactive AFP to the ice surface
PublicationUsing computer simulations, the early stages of the adsorption of the CfAFP molecule to the ice surface were analyzed. We found that the ice and the protein interact at least as early as when the protein is about 1 nm away from the ice surface. These interactions are mediated by interfacial solvation water and are possible thanks to the structural ordering of the solvent. This ordering leads to positional preference of the protein...
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Molecular mechanism and energetics of coupling between substrate binding and product release in the F 1 -ATPase catalytic cycle
PublicationF1-ATPase is a motor protein that couples the rotation of its rotary γ subunit with ATP synthesis or hydrolysis. Single-molecule experiments indicate that nucleotide binding and release events occur almost simultaneously during the synthesis cycle, allowing the energy gain due to spontaneous binding of ADP to one catalytic β subunit to be directly harnessed for driving the release of ATP from another rather than being dissipated...
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Hydrophobic derivatives of 2-amino-2-deoxy-D-glucitol-6-phosphate: a newtype of D-glucosamine-6-phosphate synthase inhibitors with antifungal action.
PublicationDokonano syntezy szeregu N-acylowych i estrowych pochodnych 2-amino-2-deok-sy-glucitolo-6-fosforanu (ADGP) i zbadano ich aktywność przeciwgrzybową oraz wobec enzymów zaangażowanych we wczesne etapy biosyntezy chityny w komórkach grzybów. Wszystkie badane pochodne okazały się słabszymi inhibitorami enzymu syntezy GlcN-6-P aniżeli ADGP, ale niektóre z nich wykazywały znacznie wyższą aktywność przeciwgrzybową niż związek macierzysty....
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Fluconazole resistant Candida auris clinical isolates have increased levels of cell wall chitin and increased susceptibility to a glucosamine-6-phosphate synthase inhibitor
PublicationIn 2009 Candida auris was first isolated as fungal pathogen of human disease from ear canal of a patient in Japan. In less than a decade, this pathogen has rapidly spread around the world and has now become a major health challenge that is of particular concern because many strains are resistant to multiple class of antifungal drugs. The lack of available antifungals and rapid increase of this fungal pathogen provides an incentive...
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Endometrial nitric oxide production and nitric oxide synthases in the equine endometrium: Relationship with microvascular density during the estrus cycle
PublicationNitric oxide (NO) plays an important role in angiogenesis and in the regulation of the blood flow. This study was carried out to investigate (i) the effects of endogenous estrogens and progestins and exogenous progesterone (P(4)) (5 ng/ml or 1 microg/ml) or estradiol 17beta (E(2)beta) (50 pg/ml or 1 microg/ml) on in vitro endometrial NO synthesis; (ii) the presence of different isoforms of NO synthase;...
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Syntheses of N-Substituted Thymine Thioacetamides. A Novel Approach to Site Selective Acylation of Diaminoalkanes
PublicationA new series of N-substituted thiocarbamoyl derivs. contg. histamine, tryptamine, and other moieties having at least one amino group attached to an aliph. chain has been synthesized from (1-thyminyl)thioacetamide in good isolated yields (69-86%). N-[2-(4-Imidazolyl)ethyl](1-thyminyl)thioacetamide was hydrolyzed to its amide on prolonged heating in water. Ammonium sulfide (20-22% soln. in water) has found interesting new applications...
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ATR FT-IR H2O spectra of acidic aqueous solutions. Insights about proton hydration
PublicationW artykule podjęto próbę ilościowej analizy widm oscylacyjnych H2O w wodnych roztworach kwasów. Widma H2O dostarczają głównie informacji o stanie strukturalnym cząsteczek wody, wynikającym ze sprzężeń oscylatorów w układzie. Są jednak znacznie trudniejsze w interpretacji niż widma HDO. Widma wodnych roztworów kwasów jednoprotonowych (HCl, HClO4, HPF6) zmierzono posługując się spektroskopią FT-IR w technice osłabionego wewnętrznego...
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Flame retardant effect and mechanism of nanosized NiO as synergist in PLA/APP/CSi-MCA composites
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Ovocystatin Induced Changes in Expression of Alzheimer’s Disease Relevant Proteins in APP/PS1 Transgenic Mice
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Industrial Heritage in sacrifice zones, The potential of Bocamina I & II Thermoelectric in Coronel, Chile
PublicationThis work aims to present the recovery potential of the Chilean Sacrifice Zones, urban areas affected by high amounts of pollution caused by industrial activities. It centers in the case of “Bocamina I & II”, two Thermoelectric based in the city of Coronel, southern Chile. A settlement historically related to the mining processes. These plants operated for decades supplying the national energy...
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Addition of novel benzylmagnesium “ate” complexes of BnR2MgLi type to 2-(thio)pyridones and related compounds
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Different philosophical approaches to estimating missing data in AHP frameworks for uncertainty representation in risk assessments
PublicationAHP (ang. Analytic Hierarchy Process) jest jedną z metod szeroko stosowaną w wieloatrybutowym podejmowaniu decyzji. Zwykle ekspert lub grupa ekspertów jest proszona o wyrażenie swojej subiektywnej opinii o każdej z par wariantów decyzyjnych. Na tej podstawie tworzone są tzw. macierze ocen. Zdarza się często, że macierze takie są niekompletne i wtedy występuje problem brakujących danych. Referat dotyczy wybranych metod ich uzupełnienia.
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VIII polsko - niemieckie kolokwium: PZITS - ATV - DVWK. Eksploatacja i renowacja sieci kanalizacyjnych.
PublicationSprawozdanie z kolejnej, cyklicznej, imprezy polsko - niemieckiej dotyczącej współczesnych zagadnień funkcjonowania sieci kanalizacyjnych.
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Are creative users more apt in reusing and adopting Open Government Data (OGD)? Gender differences
PublicationOpen Government Data (OGD) has been considered as a potent instrument for value creation and innovation by a range of stakeholders. Given that individual ingenuity is a function of individual and environmental factors, it is important to understand how the OGD adoption and usage is a factor of creative performance behaviors (CPB), viz., Problem Identification (PI), Information Search (IS), Idea Generation (IG) and Idea Promotion...
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Methyl jasmonate as a control factor of the synthase squalene gene promoter and ginsenoside production in American ginseng hairy root cultured in shake flasks and a nutrient sprinkle bioreactor
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Endothelial integrity of radial artery grafts harvested by minimally invasive surgery — immunohistochemical studies of CD31 and endothelial nitric oxide synthase expressions: a randomized controlled trial☆
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Human Gb3/CD77 synthase produces P1 glycotope-capped N-glycans, which mediate Shiga toxin 1 but not Shiga toxin 2 cell entry
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The synthesis and biological activity of lipophilic derivatives of bicine conjugated with n3-(4-methoxyfumaroyl)-l-2,3-diaminopropanoic acid(fmdp) - an inhibitor of glucosamine-6-phosphate synthase
PublicationOtrzymano serię pochodnych bicyny połączonych z inhibitorem syntazy glukozamino-6-fosforanu (fmdp)oraz zbadano ich właściwości lipofilowe i aktywność przeciwgrzybową. otrzymane związki charakteryzowały się wyższą llipofilowością niż fmdp. wszystkie otrzymane związki wykazywały także wyższą aktywność przeciwgrzybową niż fmdp.
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Keep It Flexible: Driving Macromolecular Rotary Motions in Atomistic Simulations with GROMACS
PublicationWe describe a versatile method to enforce the rotation of subsets of atoms, e.g., a protein subunit, in molecular dynamics (MD) simulations. In particular, we introduce a “flexible axis” technique that allows realistic flexible adaptions of both the rotary subunit as well as the local rotation axis during the simulation. A variety of useful rotation potentials were implemented for the GROMACS 4.5 MD package. Application to the...
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Syntheses, Structures and Reactivity of Terminal Phosphido Complexes of Iron(II) Supported by a β-Diketiminato Ligand
PublicationWe report the synthesis of the first series of terminal phosphido iron complexes supported by a β‐diketiminato ligand (Dippnacnac) and their catalytic activity in dehydrocoupling of secondary phosphines. Anionic and neutral mono‐ or diphosphido complexes were obtained from the reaction of [(Dippnacnac)FeCl2Li(dme)2] with the R2PLi (R = iPr, tBu, Cy, Ph) phosphides by tuning the stoichiometric ratio, polarity of the solvent, and...
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Quantitative Analysis of Biofilm Formed on Vascular Prostheses by Staphylococcus Epidermidis with Different ica and aap Genetic Status
PublicationOBJECTIVES: This study aims to examine biofilm formed on vascular prostheses by Staphylococcus epidermidis with different ica and aap genetic status, and to evaluate the effect of antibiotic-modified prostheses on bacterial colonization. METHODS: Biofilm formation was determined using fluorescence microscopy imaging. Quantitative analysis was conducted using the biofilm coverage ratio (BCR) calculations. RESULTS: Our investigations...
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Physicochemical Properties and Application of Silica-Doped Biochar Composites as Efficient Sorbents of Copper from Tap Water
PublicationThis article concerns research on new sorption materials based on silica-doped activated carbon. A two-stage synthesis involved pyrolysis of plant material impregnated in a water glass solution , followed by hydrothermal activation of the pyrolysate in KOH solution. The resulting composite can be used as a sorbent in drinking water filters. The proposed method of synthesis enables the design of materials with a surface area...
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Selected mice models based on APP, MAPT and presenilin gene mutations in research on the pathogenesis of Alzheimer’s disease
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Biostability of Tap Water—A Qualitative Analysis of Health Risk in the Example of Groundwater Treatment (Semi-Technical Scale)
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Genetic and pharmacologic proteasome augmentation ameliorates Alzheimer’s-like pathology in mouse and fly APP overexpression models
PublicationThe proteasome has key roles in neuronal proteostasis, including the removal of misfolded and oxidized proteins, presynaptic protein turnover, and synaptic efficacy and plasticity. Proteasome dysfunction is a prominent feature of Alzheimer’s disease (AD). We show that prevention of proteasome dysfunction by genetic manipulation delays mortality, cell death, and cognitive deficits in fly and cell culture AD models. We developed...
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Genetic and pharmacologic proteasome augmentation ameliorates Alzheimer’s-like pathology in mouse and fly APP overexpression models
PublicationThe proteasome has key roles in neuronal proteostasis, including the removal of misfolded and oxidized proteins, presynaptic protein turnover, and synaptic efficacy and plasticity. Proteasome dysfunction is a prominent feature of Alzheimer’s disease (AD). We show that prevention of proteasome dysfunction by genetic manipulation delays mortality, cell death, and cognitive deficits in fly and cell culture AD models. We developed...
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Zastosowanie obserwatora ATO do filtracji wyników estymacji położenia w napędzie z silnikiem PMSM
Publicationreferacie zaproponowano zastosowanie obserwatora ATO (ang. Angle Tracking Observer) do poprawy dokładności odtwarzania położenia kątowego wirnika silnika PMSM (ang. Permanent Magnet Synchronous Motor) za pomocą estymatora fizykalnego. Opracowano dedykowaną, uproszczoną strukturę ATO. Zaproponowano procedurę doboru nastaw wzmocnień obserwatora w oparciu o model symulacyjny. Skuteczność działania ATO potwierdzono badaniami eksperymentalnymi.
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Zastosowanie obserwatora ATO do filtracji wyników estymacji położenia w napędzie z silnikiem PMSM
PublicationW referacie zaproponowano zastosowanie obserwatora ATO (ang. Angle Tracking Observer) do poprawy dokładności odtwarzania położenia kątowego wirnika silnika PMSM (ang. Permanent Magnet Synchronous Motor) za pomocą estymatora fizykalnego. Opracowano dedykowaną, uproszczoną strukturę ATO. Zaproponowano procedurę doboru nastaw wzmocnień obserwatora w oparciu o model symulacyjny. Skuteczność działania ATO potwierdzono badaniami eksperymentalnymi.
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DYSKURS. Pismo Naukowo-Artystyczne ASP we Wrocławiu
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Synthesis and biological activity of novel ester derivatives of N3-(4-metoxyfumaroyl)-(S)-2,3-diaminopropanoic acid containing amide and keto function as inhibitors of glucosamine-6-phosphate synthase
PublicationA short series of novel ester derivatives of N3-4-methoxyfumaroyl-(S)-2,3-diaminopropanoic acid (FMDP) containing amido or keto functions have been designed and synthesized. Their antifungal activity and inhibitory properties toward fungal glucosamine-6-phosphate synthase has also been evaluated. The obtained compounds 11-13 and 15-17 demonstrated good antifunga activity against Candida albicans. Compounds 11-13 displayed also...
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Syntheses, spectroscopic and structural properties of phenoxysilyl compounds: X-ray structures, FT-IR and DFT calculations
PublicationThe reaction of silicon disulfide with alkylphenols leads to tetraphenoxysilane, cyclodisilthiane and silanethiol. The products of the reaction of silicon disulfide with phenols are characterized by FT-IR, NMR, X-ray diffraction and DFT calculations. The intramolecular interactions in the compounds are mainly XH---π (X = C, S) whereas the intermolecular interactions are either very weak CH---π/CH---O contacts found in aryloxysilane...
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Transcriptomics‐Based and AOP‐Informed Structure–Activity Relationships to Predict Pulmonary Pathology Induced by Multiwalled Carbon Nanotubes
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Single-Step Symmetrical Double Alkylation of β,γ-Unsaturated δ-Lactams via Magnesium ‘Ate’ Complexes
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Adaptive Algorithm of a Tap-Changer Controller of the Power Transformer Supplying the Radial Network Reducing the Risk of Voltage Collapse
Publicationhe development of renewable energy, including wind farms, photovoltaic farms as well as prosumer installations, and the development of electromobility pose new challenges for network operators. The results of these changes are, among others, the change of network load profiles and load flows determining greater volatility of voltages. Most of the proposed solutions do not assume a change of the transformer regulator algorithm....
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Human Gb3/CD77 synthase reveals specificity toward two or four different acceptors depending on amino acid at position 211, creating Pk, P1 and NOR blood group antigens
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Syntheses, structures, and chiroptical and magnetic properties of chiral clusters built from Schiff bases: a novel [MnIIMnIII6NaI2] core
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Exhaust Emissions of Gaseous and Solid Pollutants Measured over the NEDC, FTP-75 and WLTC Chassis Dynamometer Driving Cycles
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Using AOP-Wiki to support the ecotoxicological risk assessment of nanomaterials: first steps in the development of novel adverse outcome pathways
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Influence of bulky 3,3′-diphenylalanine enantiomers replacing position 2 of AVP analogues on their conformations: NMR and molecular modeling studies
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Integration of Fuzzy AHP and Fuzzy TOPSIS Methods for Wire Electric Discharge Machining of Titanium (Ti6Al4V) Alloy Using RSM
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AlP compound and P-doping for promotion of electrocatalytic activity of N-doped carbon derived from metal-organic framework
PublicationWater splitting plays a key role in future fuels, where two processes occur - the hydrogen evolution reaction (HER) and the oxygen evolution reaction (OER). Nitrogen-doped carbon derived from...
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T cell Activation Is Driven by an ADP-Dependent Glukosinase Linking Enhanced Glycolysis with Mitochondrial Reactive Oxygen Species Generation
PublicationMitochondria-originating reactive oxygen species control T cell receptor (TCR)-induced gene expression. Here, we show that TCR-triggered activation of ADP-dependent glucokinase (ADPGK), an alternative, glycolytic enzyme typical for Archaea, mediates generation of the oxidative signal. We also show that ADPGK is localized in the endoplasmic reticulum and suggest that its active site protrudes toward the cytosol. The ADPGK-driven...
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Marek Olesz dr hab. inż.
PeopleWydział Elektrotechniki i Automatyki, Prodziekan ds. rozwoju dr hab. inż. Marek Olesz, prof. PG data urodzenia 1966 wykształcenie Politechnika Gdańska, Wydział Elektryczny (1990) stopień / tytuł naukowy doktor habilitowany – Politechnika Gdańska, Wydział Elektrotechniki i Automatyki (2017), doktor – Politechnika Gdańska, Wydział Elektrotechniki i Automatyki (1998) zatrudnienie Politechnika Gdańska: asystent stażysta (1989 –...
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Analysis of the biological stability of tap water on the basis of risk analysis and parameters limiting the secondary growth of microorganisms in water distribution systems
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Studium właściwości, badanie systemu szerokopasmowego dostępu ATM firmy Siemens oraz jego współpracy z wąskopasmowym systemem FASTLINK
PublicationOpracowano metodologię badań systemu szerokopasmowego dostępu ATM współpracującego z wąskopasmowym systemem FASTLINK. Przedstawiono: opis systemu, wyniki badań usług podstawowych, dostępu podstawowego ISDN, łączy cyfrowych: Nx64 kbit/s, 2 Mbit/s. Zaprezentowano opracowane wnioski
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MULTI-CRITERIA INVESTMENT DECISION SUPPORT MODEL USING FUZZY ANALYTIC HIERARCHY PROCESS (F-AHP) METHOD FOR POWER INDUSTRY
PublicationIn this paper, the comparative analysis of two wind farm construction projects was presented. This particular type of analysis is commonly applied before purchasing investment project being in a planning phase by a company interested in its development. Conduction of this type of analysis is prompted by the necessity to take into consideration the requirements of Polish legislation. Comparison of wind farm construction projects...
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Dataset 1 on nitrobenzene degradation after 60 minutes of the ARP at 20 °C
Open Research DataTHis set od date presents a nitrobenzene degradation after 60 minutes of the process at 20 °C - Advanced Reduction Process based on dithionate application.
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Maximum Power Point Technique (MPPT) for PV System Based on Improved Pert and Observe (P&O) Method with PI Controller
PublicationPhotovoltaic power generation system has key rule in electricity production. Although, it is clean renewable energy with unlimited resources but it has some drawbacks in efficiency. In order to maximize the efficiency, PV array must drive at maximum power point. For the reason so, several algorithms are used in PV system to track MPP and reduce the...
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Regioselective Synthesis of 6‐Vinyl‐3,6‐dihydropyridine‐2(1H)‐ones through Simple Addition of a Vinylmagnesium “Ate” Complex to 2‐Pyridones
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First highly effective non-catalytic nitrobenzene reduction in UV/dithionite system with aniline production – Advanced reduction process (ARP) approach
PublicationAdvanced reduction processes (ARPs) are currently intensively investigated as an alternative to Advanced Oxidation Processes (AOPs). The study presents efficient reduction of nitrobenzene under non-catalytic conditions through reaction with free radicals having reductive potential. Effective conversion of nitrobenzene in a model wastewater solution, was obtained for sodium dithionite (SDT)/ dithionite (DTN). The developed process...