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Detection of circulating tumor cells by means of machine learning using Smart-Seq2 sequencing
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Aggressive Phenotype of Cells Disseminated via Hematogenous and Lymphatic Route in Breast Cancer Patients
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Lipid mediators involved in the oxidative stress and antioxidant defence of human lung cancer cells
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Ultrastructural study of neoplastic cells in Macoma balthica (Bivalvia) from the Gulf of Gdansk (Poland).
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CYP3A4 overexpression enhances the cytotoxicity of the antitumor triazoloacridinone derivative C-1305 in CHO cells
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Glioma cells showing IDH1 mutation cannot be propagated in standard cell culture conditions
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Sulforaphene, an isothiocyanate present in radish plants, inhibits proliferation of human breast cancer cells
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IL-22 modulates inflammatory properties of human primary aortic smooth muscle cells
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Spectroscopic Signature of Red Blood Cells in a D-Galactose-Induced Accelerated Aging Model
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Effect of GO-Fe3O4 and rotating magnetic field on cellular metabolic activity of mammalian cells
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Adoptive Cell Therapy—Harnessing Antigen-Specific T Cells to Target Solid Tumours
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Cation-ordered perovskite-type anode and cathode materials for solid oxide fuel cells
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Proteomic profiling of exosomes derived from pancreatic beta-cells cultured under hyperglycemia
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Similarities and Differences in the Protein Composition of Cutaneous Melanoma Cells and Their Exosomes Identified by Mass Spectrometry
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Graphene-encapsulated iron nanoparticles as a non-viral vector for gene delivery into melanoma cells
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MIX2: A Novel Natural Multi-Component Modulator of Multidrug-Resistance and Hallmarks of Cancer Cells
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The modulatory effect of green tea catechin on drug resistance in human ovarian cancer cells
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Synthesis of New Hydrazone Derivatives and Evaluation of their Efficacy as Proliferation Inhibitors in Human Cancer Cells
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Anticancer properties of ester derivatives of betulin in human metastatic melanoma cells (Me-45)
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Comparison of different digestion methods for proteomic analysis of isolated cells and FFPE tissue samples
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Evaluating the Role of Circulating Dendritic Cells in Methimazole-Treated Pediatric Graves’ Disease Patients
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Regulatory B Cells Involvement in Autoimmune Phenomena Occurring in Pediatric Graves’ Disease Patients
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Evaluating the Role of Circulating Dendritic Cells in Methimazole-Treated Pediatric Graves’ Disease Patients
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New conjugates of tuftsin and muramyl dipeptide as stimulators of human monocytes-derived dendritic cells
PublikacjaMuramyl dipeptide (MDP) and tuftsin are known biologically active compound displaying a significant influence on various cell populations of innate immune response. MDP, as a fragment of bacterial cell wall, stimulates not only macrophages and monocytes, but also dendritic cells. In contrast, little is known about tuftsin influence on these cells. Therefore it seemed vital to access whether tuftsin or its derivatives conjugated...
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Investigation of catalytic layers on anode for solid oxide fuel cells operating with synthetic biogas
PublikacjaIn this paper solid oxide fuel cells operating with dry synthetic biogas have been examined. In order to increase their stability the layers of CuO-CeO2, Cu1.3Mn1.7O4 and Y0.08Sr0.92Ti0.8Fe0.2O3 -δ have been deposited on the Ni-YSZ anode site. These layers should catalyze the internal biogas reforming and prevent the carbon deposition on the anode site. It has been found that CuO-CeO2 and Cu1.3Mn1.7O4 catalysts led to an increase...
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Design considerations for compact microstrip resonant cells dedicated to efficient branch-line miniaturization
PublikacjaA conventional compact microstrip resonant cell (CMRC)has been thoroughly investigated to enhance its slow-wave properties and subsequently ensure an efficient miniaturization of a microstrip circuit. The geometry of a classic CMRC has been improved in terms of slowwave effect in two progressive steps: (i) a single-element topology has been replaced with a double-element one and (ii) a high-impedance section has been refined by...
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The influence of different expression of CYP3A4 izoenzymes on metabolic pathway derivatives in human hepatoma cells
PublikacjaCelem przeprowadzonych badań było określenie różnic w metabolizmie pochodnych C-857 i C-1748 w komórkach ludzkiego nowotworu wątroby HepG2 oraz określenie wpływu na ich biotransformację w podwyższonej ekspresji izoenzymu CYP3A4 w tejże linii. Uzyskane wyniki wskazały, że związek C-857, jak również C-1748 metabolizuje w komórkach HepG2 oraz Hep3A4 do wielu reaktywnych, niestabilnych metabolitów. Różnice w biotransformacji były bardzo...
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Fabrication methods of porous perovskite type ceramics for Solid Oxide Fuel Cells (SOFCs)
PublikacjaPublikacja opisuje metody wytwarzania porowatych materiałów ceramicznych o strukturze perowskitu.
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Induction of apoptosis by triazoloacridinone derivative - C-1533 in HL60 and MOLT4 human leukemia cells.
PublikacjaPrzeprowadzone badania miały na celu określenie zdolności triazoloakrydonu C-1533 do indukcji śmierci komórek nowotworowych MOLT4 i HL60 na drodze apoptozy. Badanie zjawiska apoptozy przeprowadzono z wykorzystaniem techniki cytofluorymetrii przepływowej, mikroskopii fluorescencyjnej i elektroforezy agarozowej. Badania wykazały, że zarówno w komórkach MOLT4 jak i HL60, spadek mitochondrialnego potencjału błonowego oraz translokacja...
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Strategies for overcoming ABC-transporters-mediated multidrug resistance (MDR) of tumor cells. Review
PublikacjaOporność wielolekowa (MDR) nowotworów jest główną przyczyną niepowodzeń w chemoterapii przeciwnowotworowej. Jest ona wynikiem nadprodukcji w komórkach opornych transporterów białkowych z nadrodziny ABC, eksportujących cytostatyk z komórki, których działanie uniemożliwia utrzymanie terapeutycznego stężenia leku. W publikacji dokonano przeglądu różnych strategii przeciwdziałania zjawisku MDR. Strategie te dotyczą zarówno kontroli...
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Multimodal analysis of traction forces and the temperature dynamics of living cells with a diamond-embedded substrate
PublikacjaCells and tissues are constantly exposed to chemical and physical signals that regulate physiological and pathological processes. This study explores the integration of two biophysical methods: traction force microscopy (TFM) and optically detected magnetic resonance (ODMR) to concurrently assess cellular traction forces and the local relative temperature. We present a novel elastic substrate with embedded nitrogen-vacancy microdiamonds...
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Interstrand crosslinking of DNA in tumor and fibroblast cells by C-1311 (Symadex) and other imidazoacridinones
PublikacjaImidazoakrydony, w tym pochodna C-1311 znajdująca się w pierwszej fazie badań klinicznych prowadzonych przez firmę Xanthus Life Sciences, należą do grupy bardzo aktywnych związków przeciwnowotworowych zsyntetyzowanych w Katedrze Technologii Leków i Biochemii PG. Za pomocą zmodyfikowanej metody Parsons'a wykazaliśmy, że C-1311 indukuje w sposób zależny od stężenia międzyłańcuchowe wiązania sieciujące w komórkach różnych nowotworów...
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Detection of circulating tumor cells by means of machine learning using Smart-Seq2 sequencing
PublikacjaCirculating tumor cells (CTCs) are tumor cells that separate from the solid tumor and enter the bloodstream, which can cause metastasis. Detection and enumeration of CTCs show promising potential as a predictor for prognosis in cancer patients. Furthermore, single-cells sequencing is a technique that provides genetic information from individual cells and allows to classify them precisely and reliably. Sequencing data typically...
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Development of iron doped strontium titanates as oxygen electrode for solid oxide fuel cells
PublikacjaProducing efficient solid oxide fuel cells (SOFC) without the use of harmful elements is one of the current challenges. Increasing the safety of people and reducing production costs is possible, among others, thanks to the use of iron doped strontium titanates as porous oxygen electrodes. In this thesis, the results of research on iron doped strontium titanates as potential oxygen electrodes for SOFC are presented. The research...
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Tetrahydroquinolinone derivatives exert antiproliferative effect on lung cancer cells through apoptosis induction
PublikacjaThe anticancer properties of quinolones is a topic of interest among researchers in the scientific world. Because these compounds do not cause side effects, unlike the commonly used cytostatics, they are considered a promising source of new anticancer drugs. In this work, we designed a brief synthetic pathway and obtained a series of novel 8-phenyltetrahydroquinolinone derivatives functionalized with benzyl-type moieties at position...
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CYP3A4 overexpressin enhances the cytotoxicity of the antitumor triazoloacridinone derivative C-1305 in CHO cells
PublikacjaW pracy badano wpływ nadekspresji izoenzymu CYP3A4 na cytotoksyczność i odpowiedź komórkową indukowaną przez przeciwnowotworową pochodną triazoloakrydonu w modelowym układzie komórek CHO: dzikego typu, z nadekspresją reduktazy cytochromu P450 (CHO-HR) oraz z koekspresją reduktazy i izoenzymu CYP3A4 (CHO-HR-3A4). Wykazano, że komórki CHO wykazywały różną wrażliwość na badany związek, a linia CHO-HR okazała się najbardziej wrażliwa,...
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Expression of goose parvovirus whole VP3 protein and its epitopes in Escherichia coli cells
PublikacjaThe aim of this study was the expression of goose parvovirus capsid protein (VP3) and its epitopes in Escherichia coli cells. Expression of the whole VP3 protein provided an insufficient amount of protein. In contrast, the expression of two VP3 epitopes (VP3ep4, VP3ep6) in E. coli, resulted in very high expression levels. This may suggest that smaller parts of the GPV antigenic determinants are more efficiently expressed than the...
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Transcriptomic Effects of Estrogen Starvation and Induction in the MCF7 Cells. The Meta-analysis of Microarray Results
PublikacjaEstrogen is one of the most important signaling molecules which targets a number of genes. Estrogen levels regulate cell proliferation and a plethora of metabolic processes, which may interfere with a range of medical conditions and drug metabolism. The MCF7 breast cancer cell line, expressing the estrogen receptor α, is a well-studied model of cellular answer to estrogen. The aim of this study was to characterize transcriptomic...
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Immunophenotyping and transcriptional profiling of in vitro cultured human adipose tissue derived stem cells
PublikacjaAdipose-derived stem cells (ASCs) have become an important research model in regenerative medicine. However, there are controversies regarding the impact of prolonged cell culture on the ASCs phenotype and their differentiation potential. Hence, we studied 10 clinical ASCs replicates from plastic and oncological surgery patients, in six-passage FBS supplemented cultures. We quantified basic mesenchymal cell surface marker transcripts...
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Artificial intelligence-based imaging analysis of stem cells: a systematic scoping review protocol
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Self-assemblies of novel magnesium porphyrins mimicking natural chlorosomal bacteriochlorophylls
PublikacjaSelf-assembling porphyrins are promising materials to mimic natural bacteriochlorophylls c, d, or e encountered in the chlorosomes of photosynthetic bacteria. We have studied four novel magnesium porphyrins mimicking this chlorosomal antenna system. In contrast to previous articles reporting synthetic Zn-porphyrins, our studies focus on porphyrins with Mg as the central atom, which mimic more closely the natural bacteriochlorophylls....
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The Environmental Benefits of Photovoltaic Systems: The Impact on the Environment in the Production of Photovoltaic Systems: With a Focus on Metal Recovery
PublikacjaGreenhouse gases (GHGs) such as carbon dioxide, nitrous oxide and methane, trap heat and energy, thus preventing solar radiation from escaping back into space. As the quantity of greenhouse gases in the atmosphere increases so does the trapped heat and corresponding global temperature. As a result, storms become more violent, droughts more prevalent, glaciers melt, and sea levels rise, to name but a few effects of a rapidly changing...
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Analysis of induction of DNA DSBs on telomeres in A549 cells
Dane BadawczeData consist of an analysis of DNA DSBs on telomeres. A549 were treated with compounds (TXT4, MTX, DMSO) at IC90 concentration for the indicated time. Images were acquired with an LSM 800 inverted laser scanning confocal microscope (Carl Zeiss; Dresden, Germany) equipped with an Airyscan detector using a ×63 1.4 NA Plan Apochromat objective (Carl Zeiss)....
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The analysis of the expression of hTERT in anthraquinone-treated NSCLC cells
Dane BadawczeThe datasets showcase an analysis of hTERT relative gene expression in NSCLC cells treated with anthraquinone, quantified as fold change compared to DMSO-treated control cells, using the comparative CT method.
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Hybrid P3HT: PCBM/GaN nanowire/Si cascade heterojunction for photovoltaic application
PublikacjaPoly(3-hexylthiophene) (P3HT) and phenyl-C61-butyric acid methyl ester (PCBM) are commonly used for the fabrication of organic photovoltaics (OPV). Efficiency limitations of OPVs could be circumvented by incorporation of inorganic nanostructures into organic blends. Again, integration of organic solar cells with well-developed silicon photovoltaic technology is ultimately desirable. In present work, GaN nanowires with diameters...
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Sebastian Molin dr hab. inż.
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The structure of electricity production in Poland (data as at the end of 2010)
Dane BadawczeThe energy market in Poland is characterized primarily by the use of only one raw material for the production of electricity. In 2010, as much as 91.4% of electricity was produced on the basis of hard coal or lignite. Therefore, the remaining sources used for the production of electricity participated in the production of electricity to a small extent....
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Structural changes of water caused by non-electrolytes: Volumetric and compressibility approach for urea-like analogues
PublikacjaHydration of thiourea (TU), hydroxyurea (HU, hydroxycarbamide), acetone (AC, 2-propanone) and dimethyl sulfoxide (DMSO) has been investigated with the help of the volumetric and compression measurement. The apparent molar volumes and the apparent molar isentropic (adiabatic) compression have been calculated from the density and speed of sound data at temperatures ranging from 288.15 to 308.15 K at atmospheric pressure (0.1 MPa)....
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Aqueous Extracts of Selected Potentilla Species Modulate Biological Activity of Human Normal Colon Cells
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The influence of extracts from Rubus caesius leaves on human colon carcinoma cells cultured in vitro
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