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Novel NK1R-Targeted 68Ga-/177Lu-Radioconjugates with Potential Application against Glioblastoma Multiforme: Preliminary Exploration of Structure–Activity Relationships
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Molecular docking studies towards development of novel Gly-Phe analogs for potential inhibition of Cathepsin C (dipeptidyl peptidase I).
PublikacjaCathepsin C is a cysteine protease required for activation of various pro-inflammatory serine proteases and, essentially, is of interest as a therapeutic target. Cathepsin C coordinate system was employed as a model to study the interaction of some already available inhibitors of Cathepsin C. Compounds containing Gly-Phe fragment with functional groups at its ends were designed by knowledge based approach. Using AutoDock and...
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Structure and Stability Characterization of Natural Lake Pigments Made from Plant Extracts and Their Potential Application in Polymer Composites for Packaging Materials
PublikacjaNatural dyes were extracted from various plant sources and converted into lake pigments based on aluminum and tin. Three different plants (weld, Persian berries, and Brazilwood) were chosen as representative sources of natural dyes. High-performance liquid chromatography (HPLC) and triple-quadrupole mass spectrometry (QqQ MS) were used to identify dyestuffs in the raw extracts. The natural dyes and lake pigments were further characterized...
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Scheelite-Type Wide-Bandgap ABO4 Compounds (A = Ca, Sr, and Ba; B = Mo and W) as Potential Photocatalysts for Water Treatment
PublikacjaIn the present study, alkaline-earth metal scheelite-type compounds ABO4 (A = Ca, Sr, Ba, B = Mo, W) synthesized by a hydrothermal method were systematically studied. The as-obtained photocatalysts were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller surface area analysis (BET), UV–Vis diffuse reflectance spectroscopy (DR/UV-Vis), photoluminescence, and thermoluminescence (TL)...
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Chemical Composition of Atmospheric Air in Nemoral Scots Pine Forests and Submountainous Beech Forests: The Potential Region for the Introduction of Forest Therapy
PublikacjaStudies show that forests are one of the main recreational destinations. This can be explained by their beneficial effects on the health of their visitors, which can be attributed to compounds from the terpene group. The aim of this research was to determine the chemical composition of air in the interiors of Nemoral Scots pine forests and submountainous beech forests, with the determination of compounds of the terpene group. Samples...
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The new type of [Zr6(μ3-O)4 (μ3-OH)4] cluster core: Crystal structure and spectral characterization of [Zr6O4(OH)4(OOCR)12] (R = Bu^t^,C(CH3)2Et)
PublikacjaSześciojądrowe oxo karboksylowe kompleksy cyrkonu(IV) zostały otrzymane z Zr(OR')4 i odpowiednich kwasów organicznych HOOCR (R=t-Bu, CMe2Et) w stosunku molowym 1:2. Struktury krystaliczne dwóch związków o wzorze [Zr6O4(OH)4(OOCR)12] (1 dla R=t-Bu i 2 dla R=-CMe2Et) zostały rozwiązane w grupie przestrzennej R-3. Substancje zostały przebadane termograwimetrycznie (TGA/DTA) oraz przy użyciu spektroskopii w podczerwieni ze zmienną...
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Manganese(II) tri-tert-butoxysilanethiolate complexes with imidazole based coligands. A neutral complex with four independent ligands and MNOS2 core (M=Mn) related to the liver alcohol dehydrogenase catalytic center (M=Zn)
PublikacjaReakcja silanotiolanu manganu(II) z imidazolem oraz dwiema jego metylowymi pochodnymi prowadzi do uzyskania kompleksów heteroleptycznych o różnym typie. Gdy do syntez wykorzystano 2-metyloimidazol uzyskano związek zawierający w komórce elementarnej dwie różniące się od siebie cząsteczki, powiązane wiązaniami wodorowymi typu N-H…S. W jednej z tych molekuł centralny atom manganu jest skoordynowany z czterema ligandami: dwoma podstawnikami...
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The absorption and fluorescence spectra of C-1305 derivatives (IKE1-IKE8), potential antifungal agents
Dane BadawczeOptical measurements of C-1305 derivatives (IKE1-IKE8). The absorption spectra were recorded at 300 - 800 nm for solutions with 16 μg / mL derivative concentration. The fluorescence emission spectra were determined at 420-800 nm with the excitation wavelengths 360 or 415 nm for solutions with 1 μg / mL derivative concentration. All measurements were...
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Smooth muscle tumor of uncertain malignant potential - Female, 10 - Tissue image [5170730021247121]
Dane BadawczeThis is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Smooth muscle tumor of uncertain malignant potential - Female, 10 - Tissue image [5170730021246131]
Dane BadawczeThis is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Smooth muscle tumor of uncertain malignant potential - Female, 10 - Tissue image [5170730021242491]
Dane BadawczeThis is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Smooth muscle tumor of uncertain malignant potential - Female, 10 - Tissue image [5170730021246271]
Dane BadawczeThis is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Smooth muscle tumor of uncertain malignant potential - Female, 10 - Tissue image [5170730021243701]
Dane BadawczeThis is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Smooth muscle tumor of uncertain malignant potential - Female, 10 - Tissue image [5170730021247401]
Dane BadawczeThis is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Smooth muscle tumor of uncertain malignant potential - Female, 10 - Tissue image [5170730021241571]
Dane BadawczeThis is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Smooth muscle tumor of uncertain malignant potential - Female, 10 - Tissue image [5170730021243311]
Dane BadawczeThis is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Smooth muscle tumor of uncertain malignant potential - Female, 10 - Tissue image [5170730021242361]
Dane BadawczeThis is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Smooth muscle tumor of uncertain malignant potential - Female, 10 - Tissue image [5170730021248921]
Dane BadawczeThis is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Smooth muscle tumor of uncertain malignant potential - Female, 10 - Tissue image [5170730021245961]
Dane BadawczeThis is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Smooth muscle tumor of uncertain malignant potential - Female, 10 - Tissue image [5170730021246081]
Dane BadawczeThis is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Smooth muscle tumor of uncertain malignant potential - Female, 10 - Tissue image [5170730021241011]
Dane BadawczeThis is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Smooth muscle tumor of uncertain malignant potential - Female, 10 - Tissue image [5170730021246111]
Dane BadawczeThis is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Smooth muscle tumor of uncertain malignant potential - Female, 10 - Tissue image [5170730021244491]
Dane BadawczeThis is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Smooth muscle tumor of uncertain malignant potential - Female, 10 - Tissue image [5170730021245751]
Dane BadawczeThis is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Executing Multiple Simulations in the MERPSYS Environment
PublikacjaThe chapter investigates the steps necessary to perform a simulation instance in the MERPSYS environment and discusses potential limitations in case when vast numbers of simulations are required. An extended architecture is proposed which includes a JMS-based simulation queue and multiple distributed simulators, overcoming the potential bottlenecks. The chapter introduces also methods for preparing suites of multiple simulations...
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Electrochemical characterization of Prussian blue type nickel hexacyanoferrate redox mediator for potential application as charge relay in dye-sensitized solar cells
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Isolation and characterization of stable nanofiber from turmeric spent using chemical treatment by acid hydrolysis and its potential as antimicrobial and antioxidant activities
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Beach Gravels as a Potential Lithostatistical Indicator of Marine Coastal Dynamics: The Pogorzelica–Dziwnów (Western Pomerania, Baltic Sea, Poland) Case Study
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Effects of lightning and sprites on the ionospheric potential, and threshold effects on sprite initiation, obtained using an analog model of the global atmospheric electric circuit
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Optimization of the UNRES Force Field by Hierarchical Design of the Potential-Energy Landscape. 1. Tests of the Approach Using Simple Lattice Protein Models
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Shape-Depended Biological Properties of Ag3PO4 Microparticles: Evaluation of Antimicrobial Properties and Cytotoxicity in In Vitro Model—Safety Assessment of Potential Clinical Usage
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Synthesis of 7-oxo-7h-naphto[1,2,3-de]quinoline derivatives as potential anticancer agents active on multidrug resistant cell lines
PublikacjaOpierając się na naszym wcześniejszym stwierdzeniu, że tetracykliczne analogi antrachinonów z wbudowanym pierścieniem pirydynowym wykazują aktywną cytotoksyczność względem komórek z indukowaną opornością, przeprowadzono syntezę pochodnych 7-oxo-7h-nafto[1,2,3-de]chinoliny (3, 6-8, 10-12, 14,15 i 18) posiadających jeden lub dwa zasadowe łańcuchy boczne i różne podstawniki w pierścieniu pirydynowym, związków o potencjalnym działaniu...
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Copper(II) Complexes with 1-(Isoquinolin-3-yl)heteroalkyl-2-ones: Synthesis, Structure and Evaluation of Anticancer, Antimicrobial and Antioxidant Potential
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Assessment of High-Temperature Oxidation Properties of 316L Stainless Steel Powder and Sintered Porous Supports for Potential Solid Oxide Cells Applications
PublikacjaIn this work, oxidation properties of austenitic 316L stainless steel powder and sintered porous support were investigated at the temperature range of ~600-750 °C for 100 hours in ambient air. Oxidation kinetics was determined by continuous thermogravimetry and analyzed employing parabolic rate law. It was observed that oxidation leads to the formation of an oxide scale, with substantial oxidation occurring at ≥ 650 °C in the powder....
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Unlocking the biosynthetic potential of Penicillium roqueforti for hyperproduction of the immunosuppressant mycophenolic acid: Gamma radiation mutagenesis and response surface optimization of fermentation medium
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On the rising extra storage capacity of ultra-small Fe3O4particles functionalized with HCS and their potential as high-performance anode material for electrochemical energy storage
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Electrochemical Charakterization of Prussian blue type nickel hexacyanoferrate redox mediator for potential application as charge relay in dye-sensitized solar cells
PublikacjaMateriał nieorganiczny o mieszanym przewodnictwie elektronowo jonowym jakim jest heksacyjanożelazian (II,III) niklu (II) (NiHCF) rozpatrywany był jako potencjalny przenośnik ładunku w ogniwach słonecznych sensybilizowanych pigmentem (DSSC). Stwierdzono, że reakcje redoksowe NiHCF są szybkie i odwracalne nie tylko w obecności elektrolitu wspomagającego ale również w stanie stałym. Użyteczność NiHCF zbadana została za pomocą tradycyjnego...
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Potential of nanocomposites of zero valent copper and magnetite with Eleocharis dulcis biochar for packed column and batch scale removal of Congo red dye
PublikacjaThe current study is the first attempt to prepare nanocomposites of Eleocharis dulcis biochar (EDB) with nano zero-valent Copper (nZVCu/EDB) and magnetite nanoparticles (MNPs/EDB) for batch and column scale sequestration of Congo Red dye (CR) from synthetic and natural water. The adsorbents were characterized with advanced analytical techniques. The impact of EDB, MNPs/EDB and nZVCu/EDB dosage (1–4 g/L), pH (4–10), initial concentration...
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Aneta Łuczkiewicz prof. dr hab. inż.
OsobyProwadzę badania nad zdolnościami adaptacyjnymi mikroorganizmów oraz możliwością ich wykorzystania do wspomagania procesów technologicznych. Łączę inżynierię środowiska z elementami inżynierii biomedycznej i materiałowej. Interesują mnie nowatorskie metody detekcji mikroorganizmów istotnych klinicznie w środowisku wodnym (tzw. epidemiologia oparta na ściekach) oraz zaawansowane i praktyczne rozwiązania w sektorze gospodarki wodnej....
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Dynamic Electrochemical Impedance Spectroscopy (DEIS) as a Tool for Analyzing Surface Oxidation Processes on Boron-Doped Diamond Electrodes
PublikacjaSurface oxidation processes play a key role in understanding electrochemical properties of boron-doped diamond (BDD) electrodes. The type of surface termination groups, which create the potential window of electrolytic water stability or hydrophobicity, influences such properties. In this study the kinetics of oxidation process under anodic polarization were studied in situ by means of Dynamic Electrochemical Impedance Spectroscopy...
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Serce dzielnicy w stanie embrionalnego rozwoju - śrómieście reurbanizowanego wielkiego osiedla w polskim mieście metropolitalnym = Heart of the districts in embrional faze of development -city core structures for the large scale housing in Polish metropolitan city
PublikacjaW ostatnich 10 latach obserwowana jest intensyfikacja procesu uzupełniania zabudowy śródmieścia Gdańska. Jest to z jednej strony kontynuacja odbudowy historycznego centrum miasta, z drugiej zaś rewitalizacja dzielnic o przewadze zabudowy z początku wieku obejmująca śródmiejskie tereny powojskowe i poprzemysłowe m.in dawnej Stoczni Gdańskiej, koszaty we Wrzeszczu. Liczne komercyjne projekty prowadzą do istotnych dogęszczeń funcjami...
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Multilocular cystic renal neoplasm of low malignant potential - Male, 42 - Tissue image [617073002674451]
Dane BadawczeThis is the histopathological image of KIDNEY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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The absorption and fluorescence spectra of novel bisacridines (IKE15-19, IKE21) and IE10, potential antifungal agents
Dane BadawczeOptical measurements of novel bisacridines (IKE15-19, IKE21) and IE10 were conducted. The absorption spectra were recorded from 300 to 800 nm. The fluorescence emission spectra were determined with excitation and emission wavelengths described in the file. All measurements were recorded using a multiplate reader, Tecan Spark 10M.
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Multilocular cystic renal neoplasm of low malignant potential - Male, 42 - Tissue image [6170730026743851]
Dane BadawczeThis is the histopathological image of KIDNEY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Multilocular cystic renal neoplasm of low malignant potential - Male, 42 - Tissue image [6170730026745981]
Dane BadawczeThis is the histopathological image of KIDNEY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Multilocular cystic renal neoplasm of low malignant potential - Male, 42 - Tissue image [6170730026749991]
Dane BadawczeThis is the histopathological image of KIDNEY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Cathodic Protection System of the Spiral Classifier at the KGHM Polska Miedź S.A. Ore Concentration Plant—Case Study of Commissioning and Control of Operating Parameters
PublikacjaThe project involved designing, constructing and commissioning a cathodic protection system for a selected spiral classifier operating at the KGHM Polska Miedź S.A. Ore Concentration Plant (O/ZWR). The authors developed a concept and assumptions regarding the corrosion protection of a large industrial device using a cathodic protection system with an external power source. Pre-project studies included conducting a trial polarization...
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Peptide dendrimers as antifungal agents and carriers for potential antifungal agent—N3‐(4‐methoxyfumaroyl)‐(S)‐2,3‐ diaminopropanoic acid—synthesis and antimicrobial activity
PublikacjaA series of peptide dendrimers and their conjugates with antimicrobial agent FMDP (N3‐(4‐methoxyfumaroyl)‐(S)‐2,3‐diamino‐propanoic acid) were synthesized. The obtained compounds were tested for the antibacterial and antifungal activity. All novel dendrimers displayed much better activity against the tested strains than FMDP itself. Moreover, their conjugates with FMDP also exhibited antimicrobial activity. The most promising molecules...
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Ultrasound assisted synthesis of 3-alkynyl substituted 2-chloroquinoxaline derivatives: their in silico assessment as potential ligands for N-protein of SARS-CoV-2
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Potential of Serum Proteome Patterns Analysis by MALDI-TOF Mass Spectrometry for Prediction of Acute Radiation Injury Response in Head and Neck Cancers Patients
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