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Wyniki wyszukiwania dla: biological%20activity
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Disorder of Biological Quality and Autophagy Process in Bovine Oocytes Exposed to Heat Stress and the Effectiveness of In Vitro Fertilization
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Comparison of 2D and 3D culture models in the studies of the biological response induced by unsymmetrical bisacridines in cancer cells
PublikacjaMulticellular tumor spheroids are a good tool for testing new anticancer drugs, including those that may target cancer stem cells (CSCs), responsible for cancer progression, metastasis, and recurrence. Therefore, following the initial evaluation of the impact of antitumor unsymmetrical bisacridines (UAs) on lung and colon cancer cells using traditional monolayer cultures, I extended my investigations and applied the spherical model....
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Functional Interfaces, Biological Pathways, and Regulations of Interferon-Related DNA Damage Resistance Signature (IRDS) Genes
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A stochastic approach for the solution of single and multi – objective optimisation problems of biological processes in sequencing batch reactor
PublikacjaThis paper investigates the impact of implementing single and multi-optimisation solutions on the biological treatment process in a sequencing batch reactor (SBR). The research is based on a case study of the water resource recovery facility (WRRF) in Swarzewo, Northern Poland. The paper introduces the adaptive extremum seeking control (ESC) method for dissolved oxygen (DO) concentration control and places it in a layered control structure....
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UNRES-GPU for Physics-Based Coarse-Grained Simulations of Protein Systems at Biological Time- and Size-Scales
PublikacjaThe dynamics of the virus like particles (VLPs) corresponding to the GII.4 Houston, GII.2 SMV, and GI.1 Norwalk strains of human noroviruses (HuNoV) that cause gastroenteritis was investigated by means of long-time (about 30 μs in the laboratory timescale) molecular dynamics simulations with the coarse-grained UNRES force field. The main motion of VLP units turned out to be the bending at the junction between the P1 subdomain (that...
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Synthesis and biological evaluation of fluorinated 3-phenylcoumarin-7-O-sulfamate derivatives as steroid sulfatase inhibitors
PublikacjaIn the present work, we report the initial results of our study on a series of 3-phenylcoumarin sulfamate-based compounds containing C-F bonds as a novel inhibitors of steroid sulfatase (STS). The new compounds are potent STS inhibitors, possessing more than 10 times higher inhibitory potency than coumarin-7-O-sulfamate. In the course of our investigation, compounds 2b and 2c demonstrated the highest inhibitory effect in the enzymatic...
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HPLC-coupled post-column derivatization aims at characterization and monitoring of plant phytocomplexes, not at assessing their biological properties
PublikacjaTwo recent decades of research identified a number of environmental factors as well as mechanisms leading to pathogenic processes in the human organism. A common factor in pathogenesis of many diseases is oxidative stress, a condition in which the production of damaging reactive oxygen species (ROS), present in the body as an inevitable consequence of respiration and exacerbated by the inflammatory response and by exogenous factors...
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Biological study on carboxymethylated (1→3)-α-d-glucans from fruiting bodies of Ganoderma lucidum
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A policy view: gaps and weaknesses of substitution between biological products in law and economics dimension: the example of insulin
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Multiregional PI control strategy for dissolved oxygen and aeration system control at biological wastewater treatment plant
PublikacjaThe dissolved oxygen is a key parameter for biological processes at wastewater treatment plant. The dissolved oxygen tracking problem is one of the most complex and fundamental issue of biological processes. The paper proposes a new multiregional control strategy for dissolved oxygen tracking problem. The aeration system is included in overall control structure. The control mechanism within the operating point area is based on...
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Recent developments in biological sample testing methods for the confirmation of gestational exposure to tobacco smoke anddrugs of abused
PublikacjaSubstance use is most prevalent in reproductive-aged people also by women during pregnancy. In national prevalence surveys among women aged 15 to 44 years, 10.8 % of women reported using alcohol during pregnancy, 17 % reported smoking during pregnancy, and 4.4 % reported abusing any illicit substances during pregnancy. Virtually all illegal drugs, such as heroin and cocaine, pose dangers to a pregnant woman. Legal substances, such...
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Biological responses to environmental contamination. How can metal pollution impact signal honesty in avian species?
PublikacjaEnvironmental pollution, for example with metals, can significantly affect the ecosystem balance leading to severe changes. Biologically active pigments are relevant for the appearance and condition of birds. Melanin and carotenoid particles are the most frequently deposited pigments in avian integument. They are responsible for the majority of colors of bird plumage. The phenotypic expression can be affected by metal contamination....
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The role of slowly biodegradable organic compounds in a full-scale biological nutrient removal activated sludge systems
PublikacjaThe aim of this study was to determine the immediate effects of slowly biodegradable substrates on the denitrification capability and phosphate release/uptake interactions for a full-scale biomass process from two large wastewater treatment plants (WWTPs) located in the cities of Gdansk and Gdynia (northern Poland). Since it is hard to distinguish the slowly biodegradable substrate in a direct way, a novel procedure based on batch...
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Stable nanoconjugates of transferrin with alloyed quaternary nanocrystals Ag–In–Zn–S as a biological entity for tumor recognition
PublikacjaOne way to limit the negative effects of anti-tumor drugs on healthy cells is targeted therapy employing functionalized drug carriers. Here we present a biocompatible and stable nanoconjugate of transferrin anchored to Ag-In-Zn-S quantum dots modified with 11-mercaptoundecanoic acid (Tf-QD) as a drug carrier versus typical anticancer drug, doxorubicin. Detailed investigations of Tf-QD nanoconjugates without and with doxorubicin...
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Synthesis, crystal structure and spectroscopic characterization of new anionic iridium(III) complexes and their interaction with biological targets
PublikacjaThe synthesis and characterisation of new anionic iridium(II) complexes (NH4)2[IrCl4(κ2N,N’-H2biim)]2 · 5H2O (1) and ((CH3)2NH2)[IrCl4(κ2N,N’-PyBIm)] · H2O (2) are presented in this article. Spectroscopic methods (1H, 13C and 15N NMR, FTIR, UV-Vis) were used to characterize these new complexes. Solid-state structural analysis (SC-XRD) of complexes 1 and 2 shows a slightly distorted octahedral geometry of Ir(III) ions, which is...
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Glutathione-mediated conjugation of anticancer drugs: an overview of reaction mechanisms and biological significance for drug detoxification and bioactivation.
PublikacjaThe effectiveness of many anticancer drugs depends on the creation of specific metabolites that may alter their therapeutic or toxic properties. One significant route of biotransformation is a conjugation of electrophilic compounds with reduced glutathione, which can be non-enzymatic and/or catalyzed by glutathione-dependent enzymes. Glutathione usually combines with anticancer drugs and/or their metabolites to form more polar...
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Biological and antibacterial properties of chitosan-based coatings with AgNPs and CuNPs obtained on oxidized Ti13Zr13Nb titanium alloy
PublikacjaDespite numerous studies, the antibacterial efficiency and cytotoxicity of chitosan-based coatings with nanometals need further studies. The purpose of this research was to determine the biological properties of chitosan coatings implemented with either silver nanoparticles (AgNPs) or copper nanoparticles (CuNPs), that were electrophoretically deposited on electrochemically oxidized Ti13Zr13Nb alloy. The SEM tests were used to...
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Acta Biologica Cracoviensia Series Zoologia
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Revista Argentina de Antropologia Biologica
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ACTA BIOLOGICA CRACOVIENSIA SERIES BOTANICA
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BULLETIN OF THE GEOLOGICAL SOCIETY OF FINLAND
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ZOOLOGICAL JOURNAL OF THE LINNEAN SOCIETY
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Journal of the Geological Society of Korea
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BULLETIN OF THE GEOLOGICAL SOCIETY OF DENMARK
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Biologically Inspired Cognitive Architectures
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Bulletin of the Geological Society of Malaysia
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Geological Society Special Publication
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Geological Field Trips and Maps
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Geological Research in Moravia and Silesia
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GEOLOGICAL SOCIETY OF AMERICA BULLETIN
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International Journal of Zoological Research
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HUMAN AND ECOLOGICAL RISK ASSESSMENT
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Review of the Bulgarian Geological Society
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Ecological Engineering and Environmental Technology
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PROCEEDINGS OF THE YORKSHIRE GEOLOGICAL SOCIETY
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International Journal of Urological Nursing
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Socio-Ecological Practice Research
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JOURNAL OF THE GEOLOGICAL SOCIETY OF INDIA
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U.S. Geological Survey Circular
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Ecological Engineering and Environmental Technology
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Bulletin of the Geological Survey of Finland
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A design concept of fire protection system for an ecological floating dock
PublikacjaW artykule przedstawiono możliwe do wystąpienia na doku pływającym zagrożenie pożarowe oraz projekt koncepcyjny systemu zabezpieczenia przeciwpożarowego. Projekt ten obejmuje: istalację gaśniczą wodno-hydrantową i pianową do ochrony pokładu głównego oraz instalację CO2 do ochrony siłowni, rozdzielni elektrycznej i tunelu kablowego, a także instalację wykrywania i sygnalizacji pożaru.
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Scuffing resistance of DLC-coated gears lubricated with ecological oil
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Ecological trends in machining as a key factor in sustainable production – A review
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Zinc(II) complexation by some biologically relevant pH buffers
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Ecological correlates of the popularity of birds and butterflies in Internet information resources
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The idea of a geothermal power station working in national geological conditions.
PublikacjaPrzedstawiono koncepcję elektrowni geotermalnej pracującej w krajowych warunkach geologicznych. Przeprowadzono analizę obiegu Clausiusa-Rankine'a i na tej podstawie dobrano parametry obiegu na czynnik niskowrzący - izobutan. Określono główne wymiary urządzeń do realizacji technicznej takiej elektrowni. Przeprowadzono uproszczoną analizę ekonomiczną takiej inwestycji.
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Pro-ecological technology of wood sawing with circular saw blades
PublikacjaW niniejszym artykule opisano możliwości materiało- i energooszczędnego przecinania piłami tarczowymi. Przedstawiono również przykłady efektów zastosowania proekologicznych technologii przecinania w przemyśle.
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Axiological Dimension of Consumption in the Context of Sustainable Development and Environmental Ethics
PublikacjaPodjęta próba odpowidzi na pytanie, w jaki sposób krytyka konsumpcjonizmu i modelowanie wzorów eko-konsumpcji odwołują się do koncepcji zrownoważonego rozwoju i etyki środowiskowej.Przedstawiona argumentacja na rzecz tezy, że holistycznie ujęty zrownoważony rozwoj oraz wyzwania na rzecz cywilizacyjnej zmiany w kierunku paradygmatu ekologizmu mogą być zrealizowane poprzez przesunięcie ontologiczne...
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Sources of inspiration in designing ecological buildings. If not Pinterest than what?
PublikacjaEfficiency of ecological measures for sustainable architecture depends greatly upon the moment in which it is defined as essential, and how early it can be applied during the design concept stage. The following article refers to inspiration, the initial stage of the design and means to combine it with substantial knowledge regarding ecological architecture. Means, such as computer programs...