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Wyniki wyszukiwania dla: TARGETS
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Molecular Targets for Anticandidal Chemotherapy
PublikacjaA relatively small number of anticandidal chemotherapeutics used in clinical practice is at least in part consequence of a limited number of their molecular targets: ergosterol in the membrane, lanosterol demethylase, b(1!3) glucan synthase, and DNA/RNA biosynthesis. Much more potential novel targets have been revealed by the comparative genomic studies identifying essential genes unique for Candida albicans or resulted from recognition...
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Servo tracking of targets at sea
PublikacjaW artykule przedstawiono propozycje systemu sterowania układem śledzącym umieszczonym na okręcie. Przedstawiono dynamikę błędów śledzenia obiektu we współrzędnych LOS (ang., Line - Of - Sight). Zostało wykazane, że regulacja błędów śledzenia LOS jest możliwa przy pomocy sprzężenia feed-forward od prędkości śledzonego obiektu. Ponieważ prędkość ta nie jest mierzalna zastosowano filtr Kalmana w celu jej estymacji. Ponieważ problem...
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Enzymes of the lysine biosynthetic pathway as targets for antifungals ?
PublikacjaSystemic infections caused by human pathogenic fungi in immunocompromized patients continue to be one of the important clinical problems. Limited availability of safe and efficacious antifungal chemotherapeutics and emerging resistance to existing drugs stimulates search for novel molecular targets for antifungals. The α-aminoadipate pathway (AAP) of L-lysine biosynthesis is unique in fungi and thus has been so far considered...
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New possible pharmacological targets for statins and ezetimibe
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Biologics-Targets & Therapy
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BIOINFO Drug targets
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Psoriasis-Targets and Therapy
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Molecular targets for antifungals in amino acid and protein biosynthetic pathways
PublikacjaFungi cause death of over 1.5 million people every year, while cutaneous mycoses are among the most common infections in the world. Mycoses vary greatly in severity, there are long-term skin (ringworm), nail or hair infections (tinea capitis), recurrent like vaginal candidiasis or severe, life-threatening systemic, multiorgan infections. In the last few years, increasing importance is attached to the health and economic problems...
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TRF1 and TRF2: pioneering targets in telomere-based cancer therapy
PublikacjaThis article presents an in-depth exploration of the roles of Telomere Repeat-binding Factors 1 and 2 (TRF1 and TRF2), and the shelterin complex, in the context of cancer biology. It emphasizes their emerging significance as potential biomarkers and targets for therapeutic intervention. Central to the shelterin complex, TRF1 and TRF2 are crucial in maintaining telomere integrity and genomic stability, their dysregulation often...
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Optimization of multiple model neural tracking filter for marine targets
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Flavonoid biosynthetic pathways in plants: Versatile targets for metabolic engineering
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New Peptide Based Fluconazole Conjugates with Expanded Molecular Targets
PublikacjaInfections of Candida spp. etiology are frequently treated with azole drugs. Among azoles, the most widely used in the clinical scenario remains fluconazole (FLC). Promising results in treatment of dangerous, systemic Candida infections demonstrate the advantages of combined therapies carried out with combinations of at least two different antifungal agents. Here, we report five conjugates composed of covalently linked FLC and...
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The Doppler effect in a bistatic system for determining the position of moving targets
PublikacjaThe article presents the theoretical analysis and the results of numerical calculations of the Doppler effect it occurs in a system designed to determine the position and speed of a moving target. The transmitter is the source of the signal and it emits a sinusoidal, acoustic and continuous wave. Signal reflected off a moving target is received by four hydrophones. Based on the signals, four Doppler shifts are determined and inserted...
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The Extracellular Bacterial HtrA Proteins as Potential Therapeutic Targets and Vaccine Candidates
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Multisensor Tracking of Marine Targets - Decentralized Fusion of Kalman and Neural Filters
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Track-to-track fusion in tracking of multiple targets in clutter - a comparative study.
PublikacjaPrzedstawiono i porównano algorytmy rozproszone wyznaczania trajektorii obiektów dynamicznych na podstawie danych z wielu źródeł. Rozważono przypadek, w którym dane dotyczące pozycji obiektów są zakłócone przez dodatkowe fałszywe wykrycia niezwiązane z obserwowanymi obiektami. Algorytmy rozproszone i centralne to dwie podstawowe klasy algorytmów służące do wyznaczania trajektorii obiektów dynamicznych na podstawie danych z wielu...
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Endothelial dysfunction due to eNOS uncoupling: molecular mechanisms as potential therapeutic targets
PublikacjaNitric oxide (NO) is one of the most important molecules released by endothelial cells, and its antiatherogenic properties support cardiovascular homeostasis. Diminished NO bioavailability is a common hallmark of endothelial dysfunction underlying the patho‑ genesis of the cardiovascular disease. Vascular NO is synthesized by endothelial nitric oxide synthase (eNOS) from the substrate L‑arginine (L‑Arg), with tetrahydrobiopterin...
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Lessons from application of the UNRES force field to predictions of structures of CASP10 targets
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Trajectory planning in collision situations at sea by evolutionary computation - experiments with moving targets
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EXPERT OPINION ON THERAPEUTIC TARGETS
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Breast Cancer-Targets and Therapy
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Lung Cancer-Targets and Therapy
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Infectious Disorders - Drug Targets
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Conditions for Multiple Acquisition of Echoes from Stationary Targets in Successive Transmissions of Active Sonars
PublikacjaIn echolocation, the highest possible number of contacts with a detected target is clearly decisive on the possibilities of echo processing to optimise the estimation of distinctive characteristics of the observed target. In hydrolocation, the slow propagation of acoustic waves in water reduces the number of contacts of echosounders and sonars with detected targets. The article considers model conditions for acquiring multiple...
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TIME-OF-FLIGHT DIFFERENTIAL ELECTRON SCATTERING FROM MOLECULAR TARGETS: BENCHMARK CROSS SECTIONS
PublikacjaWe report time-of-flight differential cross section (DCS) measurements for the electron impact excitation transition in H2. In this work, agreement between available theory and experiment is excellent overall, and marks a transition in electron molecule scattering where differential scattering of excitation is found to be in such precise agreement. We also prove that the newly built apparatus can be used for accurate measurement...
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Studies of kicking of three targets – does sex differentiate the velocity of the taekwondo front kick?
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Blood pressure and LDL-cholesterol targets for prevention of recurrent strokes and cognitive decline in the hypertensive patient
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Treatment of high blood pressure in elderly and octogenarians: European Society of Hypertension statement on blood pressure targets
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The Non-Lantibiotic Bacteriocin Garvicin Q Targets Man-PTS in a Broad Spectrum of Sensitive Bacterial Genera
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Synthesis, crystal structure and spectroscopic characterization of new anionic iridium(III) complexes and their interaction with biological targets
PublikacjaThe synthesis and characterisation of new anionic iridium(II) complexes (NH4)2[IrCl4(κ2N,N’-H2biim)]2 · 5H2O (1) and ((CH3)2NH2)[IrCl4(κ2N,N’-PyBIm)] · H2O (2) are presented in this article. Spectroscopic methods (1H, 13C and 15N NMR, FTIR, UV-Vis) were used to characterize these new complexes. Solid-state structural analysis (SC-XRD) of complexes 1 and 2 shows a slightly distorted octahedral geometry of Ir(III) ions, which is...
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CURRENT CANCER DRUG TARGETS
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Blood and Lymphatic Cancer-Targets and Therapy
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Cardiovascular and Hematological Disorders - Drug Targets
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Diabetes Metabolic Syndrome and Obesity-Targets and Therapy
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Neutrophil proteinase 3 and dipeptidyl peptidase I (cathepsin C) as pharmacological targets in granulomatosis with polyangiitis (Wegener granulomatosis)
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Use of the UNRES force field in template-assisted prediction of protein structures and the refinement of server models: Test with CASP12 targets
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Fusion of DNA-binding domain of Pyrococcus furiosus ligase with TaqStoffel DNA polymerase as a useful tool in PCR with difficult targets
PublikacjaThe DNA coding sequence of TaqStoffel polymer- ase was fused with the DNA-binding domain of Pyrococcus furiosus ligase. The resulting novel recombinant gene was cloned and expressed in E. coli. The recombinant enzyme was purified and its enzymatic features were studied. The fusion protein (PfuDBDlig-TaqS) was found to have enhanced processivity as a result of the conversion of the Taq DNA polymerase from a relatively low processive...
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Endocrine Metabolic & Immune Disorders-Drug Targets
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Structure of single KL0–, double KL1–, and triple KL2 − ionization in Mg, Al, and Si targets induced by photons, and their absorption spectra
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Piperine Targets Different Drug Resistance Mechanisms in Human Ovarian Cancer Cell Lines Leading to Increased Sensitivity to Cytotoxic Drugs
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How do sterols determine the antufungal activitiy of amphotericin B? Free energy of binding between the drug and its membrane targets.
PublikacjaAmphotericin B (AmB) is a well-known polyene antibiotic used to treat systemic fungal infections. It is commonly accepted that the presence of sterols in the membrane is essential for the AmB biological activity, that is, for the formation of transmembrane ion channels. The selective toxicity of AmB for fungal cells is attributed to the fact that it is more potent against fungal cell membranes containing ergosterol than against...
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Similarities and differences in d6 low-spin ruthenium, rhodium and iridium half-sandwich complexes: synthesis, structure, cytotoxicity and interaction with biological targets
PublikacjaIn this paper, we discussed the similarities and diferences in d6 low-spin half-sandwich ruthenium, rhodium and iridium complexes containing 2,2′-biimidazole (H2biim). Three new complexes, {[RuCl(H2biim)(η6 -p-cymene)]PF6}2·H2O (1), [(η5 - Cp)RhCl(H2biim)]PF6 (2), and [(η5 -Cp)IrCl(H2biim)]PF6 (3), were fully characterized by CHN, X-ray difraction analysis, UV–Vis, FTIR, and 1 H, 13C and 15N NMR spectroscopies. The complexes exhibit...
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Designing Atomic Resonance Conditions for $^{93m}$Mo Isomer Depletion Via Nuclear Excitation by Electron Capture in a Beam-based Scenario for Selected Targets
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CO2 Capture by Virgin Ivy Plants Growing Up on the External Covers of Houses as a Rapid Complementary Route to Achieve Global GHG Reduction Targets
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CURRENT DRUG TARGETS
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CNS & Neurological Disorders-Drug Targets
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Complexation of Bioelements and Toxic Metals by Polyphenolic Compounds - Implications for Health
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Protective Effect of Aronia Melanocarpa Polyphenols on Cadmium Accumulation in the Body: A Study in a Rat Model of Human Exposure to this Metal
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Aqueous Extracts of Selected Potentilla Species Modulate Biological Activity of Human Normal Colon Cells
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New Insights into Dietary Supplements Used in Sport: Active Substances, Pharmacological and Side Effects
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