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Wyniki wyszukiwania dla: pharmaceuticals wastewaters
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Solubility Characteristics of Acetaminophen and Phenacetin in Binary Mixtures of Aqueous Organic Solvents: Experimental and Deep Machine Learning Screening of Green Dissolution Media
PublikacjaThe solubility of active pharmaceutical ingredients is a mandatory physicochemical characteristic in pharmaceutical practice. However, the number of potential solvents and their mixtures prevents direct measurements of all possible combinations for finding environmentally friendly, operational and cost-effective solubilizers. That is why support from theoretical screening seems to be valuable. Here, a collection of acetaminophen...
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Problematyka dotycząca zapewnienia fotostabilności substancji leczniczych w postaciach leku
PublikacjaUV and visible radiation may influence on the stability of some active pharmaceutical ingredients and in a consequence destabilizes such medicinal products, causes changesin its physicochemical properties also with negative pharmacological and sometimes even toxic effects. For this reason it is important to conduct the routine testing photostability. The knowledge of chemistry and technology as well as some methods of...
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Determination of API content in a pilot-scale blending by near-infrared spectroscopy as a first step method to process line implementation
PublikacjaNear infrared (NIR) spectroscopy was used for estimation of powder blend homogeneity and manufacturing control of a medicinal product powder mixture containing active pharmaceutical ingredient (API). Aiming at initiating a Process Analytical Technology (PAT) activity, the first step was a stationary mode atline evaluation. In this, the content of pharmaceutical active compound in the powder mixtures intended to the direct tabletting...
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Using On-line Measurement by Electronic Nose and Computer Simulations for Real-time Control at WWTP
PublikacjaContinuous investigation of wastewater quality can be carried out by a device called an e-nose. One important feature of the proposed real-time control system for WWTP is that using on-line measurements by e-nose together (Figure 1) with technological sets picked on this basis by means of computer models, it is possible to change treatment process parameters, depending on the current quality of wastewater. It can be used for the...
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Distillation cleanup preceded gc determination of short-chain monocarboxylic acids in aqueous and solid samples of wastewater origin = Oznaczanie krótkołańcuchowych kwasów monokarboksylowych w próbkach wodnych i stałych pochodzących z oczyszczalni ścieków z wykorzystaniem chromatografii gazowej poprzedzonej destylacją
PublikacjaShort-chain monocarboxylic acids (SCMAs) (C2-C5) formed in the process of aerobic biodegradation of larger organic molecules should often be monitored to optimize wastewater biological treatment and study the processes of converting organic waste matter into methane, etc. Gas chromatography (GC) seems a method of choice for such a task. Majority of samples require clean up before they can be injected into GC system. In this work...
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The evaluation of COD fractionation and modeling as a key factor for appropriate optimization and monitoring of modern cost-effective activated sludge systems
PublikacjaA study was conducted to characterize the raw wastewater entering a modern cost effective municipal WWTP in Poland using two approaches; 1) a combination of modeling and carbonaceous oxygen demand (COD) fractionation using respirometric test coupled with model estimation (RTME) and 2) flocculation/filtration COD fractionation method combined with BOD measurements (FF-BOD). It was observed that the particulate fractions of COD obtained...
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Self-Association of Amphotericin B: Spontaneous Formation of Molecular Structures Responsible for the Toxic Side Effects of the Antibiotic
PublikacjaAmphotericin B (AmB) is a lifesaving antibiotic used to treat deep-seated mycotic infections. Both the pharmaceutical activity and highly toxic side effects of the drug rely on its interaction with biomembranes, which is governed by the molecular organization of AmB. In the present work we present detailed analysis of self-assembly of AmB molecules in different environments, interesting from the physiological standpoint, based...
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Recent advances on the removal of phosphorus in aquatic plant-based systems
PublikacjaPhosphorus (P) is a vital nutrient for the ecosystems and its excess in wastewater streams leads to some environmental issues such as extensive algae growth (eutrophication). Phytoremediation is a green technology that is based on the combined actions of plants and their associated microbial groups to remove and transfer the toxic compounds in surface water, groundwater and soil. Aquatic plants are widely used for the remediation...
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The microbial community, its biochemical potential, and the antimicrobial resistance of Enterococcus spp. in Arctic lakes under natural and anthropogenic impact (West Spitsbergen)
PublikacjaThe sustainable management of small human communities in the Arctic is challenging. In this study, both a water supply system (Lake 1) under the natural impact of a bird-nesting area, and a wastewater receiver (Lake 2) were analysed in the vicinity of the Polish Polar Station on West Spitsbergen. Microbial community composition, abundance and activity were assessed in samples of the treated wastewater, lake water and sediments...
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The Correlation between Physical Crosslinking and Water-Soluble Drug Release from Chitosan-Based Microparticles
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Hydrogel Delivery System Containing Calendulae flos Lyophilized Extract with Chitosan as a Supporting Strategy for Wound Healing Applications
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The Chitosan-Based System with Scutellariae baicalensis radix Extract for the Local Treatment of Vaginal Infections
PublikacjaScutellarie baicalensis radix, as a flavone-rich source, exhibits antibacterial, antifungal, an-tioxidant, and anti-inflammatory activity. It may be used as a therapeutic agent to treat various
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Recent Advances in Polymer-Based Vaginal Drug Delivery Systems
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Photoprotection and Antiaging Activity of Extracts from Honeybush (Cyclopia sp.)—In Vitro Wound Healing and Inhibition of the Skin Extracellular Matrix Enzymes: Tyrosinase, Collagenase, Elastase and Hyaluronidase
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In Vitro Biological Evaluation of Aprepitant Based 177Lu-Radioconjugates
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The Stimulating Effect of Rosmarinic Acid and Extracts from Rosemary and Lemon Balm on Collagen Type I Biosynthesis in Osteogenesis Imperfecta Type I Skin Fibroblasts
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Tuning of the Anti-Breast Cancer Activity of Betulinic Acid via Its Conversion to Ionic Liquids
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Nanoemulsion Structural Design in Co-Encapsulation of Hybrid Multifunctional Agents: Influence of the Smart PLGA Polymers on the Nanosystem-Enhanced Delivery and Electro-Photodynamic Treatment
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Effective Targeting of Colon Cancer Cells with Piperine Natural Anticancer Prodrug Using Functionalized Clusters of Hydroxyapatite Nanoparticles
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Abdominoplasty Skin-Based Dressing for Deep Wound Treatment—Evaluation of Different Methods of Preparation on Therapeutic Potential
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New Peptide Based Fluconazole Conjugates with Expanded Molecular Targets
PublikacjaInfections of Candida spp. etiology are frequently treated with azole drugs. Among azoles, the most widely used in the clinical scenario remains fluconazole (FLC). Promising results in treatment of dangerous, systemic Candida infections demonstrate the advantages of combined therapies carried out with combinations of at least two different antifungal agents. Here, we report five conjugates composed of covalently linked FLC and...
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pH-Responsive Drug Delivery Nanoplatforms as Smart Carriers of Unsymmetrical Bisacridines for Targeted Cancer Therapy
PublikacjaSelective therapy and controlled drug release at an intracellular level remain key challenges for effective cancer treatment. Here, we employed folic acid (FA) as a self-navigating molecule in nanoconjugates containing quantum dots (QDs) and β-cyclodextrin (β-CD) for the delivery of antitumor unsymmetrical bisacridine compound (C-2028) to lung and prostate cancers as well as normal cells. The bisacridine derivative can form the...
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Synergistic Effects of Propolis Combined with 2-Phenoxyethanol and Antipyretics on the Growth of Staphylococcus aureus
PublikacjaThe present investigation aimed to assess the combinational effect of commonly usedantipyretics and antiseptics with ethanolic extracts of propolis (EEPs) on the growth inhibition ofStaphylococcus aureus. The broth microdilution checkerboard assay revealed synergistic interactionsbetween all investigated antipyretics, namely acetylsalicylic acid, ibuprofen, and acetaminophen,with EEPs samples. The values of the fractional inhibitory...
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Spectroscopic evaluation on pseudopolymorphs of sodium naproxen
PublikacjaThis paper demonstrates the assessment of vibrational spectroscopy methods such as middle infrared, near infrared and Raman spectroscopy (FTIR, FT-NIR, Raman) for the identification of pseudopolymorphic forms of a model active pharmaceutical ingredient (API) - sodium naproxen (NpxNa). NpxNa, in the form of three different pseudopolymorphs, was investigated by methods dedicated for solid state characterization: DSC (differential...
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Biopolymers and Their Composites for Drug Delivery: A Brief Review
PublikacjaIn recent years, excipient development has become a core area of research in pharmaceutical drug delivery because it influences the formulation development and drug delivery process in various ways. Polymeric drug delivery systems have been of great interest for controlled delivery as they show the great advantage in drug delivery systems because of optimized drug loading and releasing property. Then, the side effects of synthetic...
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Reliability and efficiency of pollution removal during long-term operation of a one-stage constructed wetland system with horizontal flow
PublikacjaThe paper presents the results of a study of the reliability and efficiency of pollutant removal during long term operation of a one-stage constructed wetland system with horizontal flow. The flow rate of the wastewater treatment plant was 1.2 m3·d-1 during the research period. Physical and chemical analyses of raw wastewater and treated effluent were carried out in the years 1997–2010 (14 years). During this study period, 56 series...
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Characteristic and specificity of protease activity of thermophilic bacteria Meiothermus ruber
PublikacjaThe primary purpose of research was to establish the possibility of using thermophilic bacteria Meiothermus ruber as a source of proteolytic enzymes. The main reason of searching new proteases is their commercial value especially in production of detergents, food, pharmaceuticals, leather, diagnostics or waste management. The development of this type processes will be possible by utilization of enzymes which have unique characteristics...
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Monitoring Lead Concentration in the Surrounding Environmental Components of a Lead Battery Company: Plants, Air and Effluents—Case Study, Kenya
PublikacjaLead (Pb) pollution from smelters and lead–acid battery has become a serious problem worldwide owing to its toxic nature as a heavy metal. Stricter regulations and monitoring strategies have been formulated, legislated and implemented in various parts of the world on heavy metal usage. Developed countries such as the USA and in Europe largely operate within the set standards, however, developing countries such as Kenya, Nigeria...
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Distribution of volatile organohalogen compounds in petrochemical plant water streams
PublikacjaThe study assesses halogenated volatile organic compound concentrations in the water and wastewaterstreams of a petrochemical plant. Water samples were collected at 11 sampling points during 5 samplingcampaigns. The samples were collected from the oil dewaxing unit and in the wastewater treatmentplant. Dichloromethane and 1,2-dichloroethane were the most frequently determined compounds. Tetrachloroethenewas also detected at the...
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Wpływ dodatku odcieków składowiskowych do oczyszczanych ścieków komunalnych na wielkość frakcji ChZT
PublikacjaManaging landfill leachate is one of the most important problems with maintaining landfills. The aim of this study was to determine the influence on COD fraction of landfill leachate addition from 0,5% to 5% to raw wastewater. The results of this study show that soluble inert COD in wastewater and mixture wastewater with landfill leachate constituted the smallest percentage of total COD. Nonetheless this fraction (soluble inert...
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The process generation of WWTP models for optimization of activated sludge systems
PublikacjaThe objective of water and wastewater utilities, which are responsible for optimization of wastewater treatment plant operation, is threefold: environmental protection, saving money, and mitigation of pollutant emissions, both to water and air. The performed study aimed to assess the process generation of WWTP models that improve activated sludge systems operation, by means of new developed Mantis2 model. This model accounts for...
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The efficiency and technological reliability of biogenic compounds removal during long-term operation of a one-stage subsurface horizontal flow constructed wetland
PublikacjaThe paper presents the results of a study of the efficiency and technological reliability of total nitrogen and total phosphorus removal during long term operation of a one-stage constructed wetland system with subsurface horizontal wastewater flow. The flow rate of the wastewater treatment plant was 1.2m3/d during the research period. Physical and chemical analyses of raw wastewater and treated effluent were carried out in the...
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Comparative Study of Balancing SRT by Using Modified ASM2d in Control and Operation Strategy at Full-Scale WWTP
PublikacjaDetailed knowledge on the composition of the influent going into the wastewater treatment system is essential for the development of a reliable computer model. In the context of WWTPs (wastewater treatment plants), the wastewater characteristics are not only important for activated sludge system modelling, but also have an impact on the appropriate control of single unit operations. The aim of this study was to evaluate the concepts...
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Porównanie efektywności biologicznego usuwania związków biogennych w procesach MUCT i A2/O na przykładzie oczyszczalni w Gdańsku
PublikacjaThis paper presents a comparison of the efficiency of nutrient removal in two different technological systems functioning in WWTP in Gdansk. The upgrade was necessary in order to adjust the parameters of wastewater treatment to more stringent requirements for Total Nitrogen removal (Total Nitrogen concentration < 10 mg/L). Since 2012 the biological treatment line has operated based on modified A2/O process instead of MUCT process....
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Strategy towards the use of ultrafiltration and reverse osmosis for industrial water recovery and reuse as part of the Green Deal Implementation
PublikacjaIn line with the European Parliament’s Resolution of February 10th, 2021 on the new action plan for a closed economy, most of the activities undertaken in the wastewater treatment process should focus on the search for new technologies that use wastewater as a source of water and nutrients. The paper reviews the concept of water reuse in industrial installations, with special emphasis on the use of membrane technologies for this...
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Adaptive stochastic and hybrid nonlinear optimization algorithms for improving the effectiveness of the biological processes at WWTP
PublikacjaWastewater treatment plays an important factor in the modern world. Insufficient treatment may result in environmental pollution which can further lead to disasters and diseases. However, processes that take place inside wastewater treatment plants (WWTP) are highly complex in nature, therefore it is difficult to design an efficient, optimal control system. The problem regarding biochemical reactions inside Sequential Batch Reactor...
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Nanoparticles: Taking a Unique Position in Medicine
PublikacjaThe human nature of curiosity, wonder, and ingenuity date back to the age of humankind. In parallel with our history of civilization, interest in scientific approaches to unravel mechanisms underlying natural phenomena has been developing. Recent years have witnessed unprecedented growth in research in the area of pharmaceuticals and medicine. The optimism that nanotechnology (NT) applied to medicine and drugs is taking serious...
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THERMAL ANALYSIS AND DESIGN OF HYBRID MICROCHANNEL -MICROJET TEST PROBE
PublikacjaAccurate control of cooling parameters is required in ever wider range of technical applications. It is known that reducing the flow hydraulic diameter to an increase in the economy of cooling and improves its quality (Mikielewicz and Muszyński 2009). Present study describes research results related to the design and construction of the test stand for hybrid microjet- microchannel cooling modules study, which may be applied in...
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Recovery of Anammox Biomass at Short Hydraulic Retention Time in a MBR Reactor
PublikacjaThe anammox system has been consider as an economical option for treating high concentration of nitrogen and poor in biodegradable orgaednic carbon wastewaters. This process is attractive option compared with conventional nitrogen removal because it provides a significant saving in aeration and organic addition for denitrification. The anammox technology has been applied mostly for concentrated nitrogenous wastewater containing...
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Novel hierarchical nonlinear control algorithm to improve dissolved oxygen control in biological WWTP
PublikacjaWastewater treatment is a problem known to humankind for centuries. The quality of treated sewage determines the condition of reservoirs around the world. Control of such a complex and nonlinear system as a wastewater treatment plant requires thorough knowledge of the process. The paper presents a hierarchical control system of a Sequencing Batch Reactor (SBR) in Wastewater Treatment Plant (WWTP) taking into account a model based...
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DETERMINATION OF SURFACTANTS IN ENVIRONMENTAL SAMPLES - PART I. CATIONIC COMPOUNDS = Oznaczanie Surfaktantów W Próbkach Środowiskowych. Część I. Związki Kationowe
PublikacjaCompounds from the group of cationic surfactants are widely applied in household, industrial, cleaning, disinfectant, cosmetic and pharmaceutical products as their specific properties (antimicrobial, emulsifying, anticorrosion, softening). After use, cationic surfactants are disposed to wastewater-treatment plants and finally with effluent water to surface waters due to their incomplete degradation. Moreover, they can freely circulate...
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Synthesis, characteristics, and photocatalytic activity of zinc oxide nanoparticles stabilized on the stone surface for degradation of metronidazole from aqueous solution
PublikacjaAbstract Background: The presence of antibiotics such as metronidazole in wastewater even at low concentrations requires searching for a suitable process such as advanced oxidation process (AOP) to reduce the level of pollutants to a standard level in water. Methods: In this study, zinc oxide (ZnO) nanoparticles were synthesized by thermal method using zinc sulfate (ZnSO4) as a precursor, then, stabilized on stone and was used...
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Treatment Wetlands in Rural Areas of Poland for Baltic Sea Protection
PublikacjaWater and wastewater management, especially in rural areas, greatly affects loads of nutrients discharged to the Baltic Sea. In Poland, this management is unbalanced because of the dispersed development and in many locations construction of sewerage system is uneconomic or even impossible. For this reason, a significant part of sewage from single-family houses in rural areas must be discharged into domestic sewage systems. The...
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Biological activities of leaf extracts from selected Kalanchoe species and their relationship with bufadienolides content
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Natural Deep Eutectic Solvents as Agents for Improving Solubility, Stability and Delivery of Curcumin
PublikacjaPurpose Study on curcumin dissolved in natural deep eutectic solvents (NADES) was aimed at exploiting their beneficial properties as drug carriers. Methods The concentration of dissolved curcumin in NADES was measured. Simulated gastrointestinal fluids were used to determine the concentration of curcumin and quantum chemistry computations were performed for clarifying the origin of curcumin solubility enhancement in NADES. Results NADES...
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Biodegradable Poly(ester-urethane) Carriers Exhibiting Controlled Release of Epirubicin
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SEWAGE SYSTEM CONCEPT FOR KAMIEŃ VILLAGE IN THE COMMUNE OF SZEMUD
PublikacjaThe aim of this thesis is to solve a disturbing problem, which is illegal sewage discharge, without any previous treatment in a village Kamień, Szemud commune, Poland, by developing a multivariate sewerage system concept. The introduction submits the theory concerning the division of sewer systems as well as the wastewater treatment’s level. Moreover, there is also the problem of rural sanitation presented and main locality –...
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Comparison of Two Nonlinear Predictive Control Algorithms for Dissolved Oxygen Tracking Problem at WWTP
PublikacjaThe wastewater treatment plant is classified as a complex system, due to its nonlinear dynamics, large uncertainty of disturbance inputs, multiple time scales in the internal process dynamics, and multivariable structure. The aeration process, in turn, is an important and expensive part of wastewater treatment plant operation. All operating parameters of the aeration in biological processes are to be precisely controlled to provide...
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Thermally activated persulfate-based Advanced Oxidation Processes — recent progress and challenges in mineralization of persistent organic chemicals: a review
PublikacjaThermally activated persulfate (TAP) finds application in Advanced Oxidation Processes for the removal of pollutants from contaminated water and soil. This paper reviewed the various cases of TAP in the environmental remediation. The pollutants such as individual pharmaceuticals, biocides, cyclic organic compounds, and dyes are considered in this review. It is interesting to note that most of the organic compounds undergo complete...
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Hybrid constructed wetlands for the National Parks in Poland - a case study, requirements, dimensioning, preliminary results
PublikacjaWater and wastewater management, especially in rural areas, greatly affects loads of nutrients discharged to the Baltic Sea. In Poland, this management is unbalanced because of the dispersed development and in many locations con struction of sewerage system is uneconomic or even impossible. For this reason, a significant part of sewage from single-family houses in rural areas must be discharged into domestic sewage systems. The...