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The Combination of Beta-Blockers and ACE Inhibitors Across the Spectrum of Cardiovascular Diseases
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Procedura powiadamiania o śmierci pacjenta —“In Person, In Time…”
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Discovering the mechanisms of strain-dependent response of Staphylococcus aureus to photoinactivation: Oxidative stress toleration, endogenous porphyrin level and strain's virulence
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Nanosecond pulsed electric fields (nsPEFs) impact and enhanced Photofrin II® delivery in photodynamic reaction in cancer and normal cells
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Do bacteria isolated from ICU patients ‘ESKAPE’ antibiotic treatment? In vitro susceptibility of the Enterobacteriaceae family to tigecycline
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CARDINAL REGENERATIVE FEATURES OF THE MRL MOUSE — AN UPDATE
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Susceptibility to tigecycline of Acinetobacter baumannii strains isolated from intensive care unit patients
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Pre-clinical evaluation of 1-nitroacridine derived chemotherapeutic agent that has preferential cytotoxic activity towards prostate cancer
PublikacjaPraca zawiera wyniki badań przedklinicznych pochodnej 1-nitroakrydyny C-1748 wobec komórek ludzkiego raka prostaty CaP in vitro, jak i przeszczepialnego na zwierzęta. W oparciu o fosforylację histonu H2AX jako markera podwójnych cięć DNA wykazano, że C-1748 jest bardziej aktywny w komórkach CaP niż HL60. Zidentyfikowano poza tym receptor androgenny (AR) jako cel molekularny badanego związku. W doświadczeniach na zwierzętach stwierdzono...
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Comparison of propofol-ketamine versuspropofol-remifentanil in children anaesthetized for gastroscopy
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Triage during the COVID-19 pandemic
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Human UDP-Glucuronosyltransferases: Effects of altered expression in breast and pancreatic cancer cell lines.
PublikacjaIncreased aerobic glycolysis and de novo lipid biosynthesis are common characteristics of invasive cancers. UDP-glucuronosyltransferases (UGTs) are phase II drug metabolizing enzymes that in normal cells possess the ability to glucuronidate these lipids and speed their excretion; however, de-regulation of these enzymes in cancer cells can lead to an accumulation of bioactive lipids, which further fuels cancer progression. We hypothesize...
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Prenatally Evolving Ectopia Cordis with Successful Surgical Treatment
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Anticancer imidazoacridinone C-1311 inhibits hypoxia-inducible factor-1α (HIF-1α), vascular endothelial growth factor (VEGF) and angiogenesis
PublikacjaAntitumor imidazoacridinone C-1311 is a DNA-reactive topoisomerase II and FLT3 receptor tyrosine kinase inhibitor. Here, we demonstrate the mechanism of C-1311 inhibitory action on novel targets: hypoxia-inducible factor-1α (HIF-1α), vascular-endothelial growth factor (VEGF), and angiogenesis. In a cell-free system, C-1311 prevented HIF-1α binding to an oligonucleotide encompassing a canonical hypoxia-responsive element (HRE),...
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Cardinal regenerative features of the MRL mouse
PublikacjaIn this review, we discuss recent studies relating to major features of adult MRL mouse biology that contribute to the regenerative responses seen. These include an increased inflammatory cell profile, a unique glycolytic metabolic state typically found during embryogenesis, and a cell cycle phenotype of DNA damage and G2/M arrest. These traits have been found in other mammalian and non-mammalian regenerative systems. How these...
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Ball milling induced borophene flakes fabrication
PublikacjaTo fill the knowledge gap for borophene, as the youngest member of the two-dimensional (2D)nanomaterials family, a facile, cost effective, scalable and reproducible fabrication route is still stronglyrequired. Among so far studied techniques the potential of pure mechanical processes such as ballmilling is not explored yet. Therefore, in this contribution, we explore the efficiency...
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Pemphigus vulgaris - Female, 46 - Tissue image [9140730014118821]
Dane BadawczeThis is the histopathological image of SKIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Abnormal cytological findings - Female, 46 - Cell image [50407300202761]
Dane BadawczeThis is the histopathological image of CERVIX UTERI cell sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Environmental failure of dental biomaterials
PublikacjaW pracy przedstawiono problematykę związaną z zagadnieniem trwałości biomateriałów stomatologicznych. Scharakteryzowano kryteria doboru materiałów i na przykładzie koron stomatologicznych pokazano wyniki oceny prawidłowości doboru w oparciu o metodę elementów skończonych. Przedstawiono wyniki weryfikacji doświadczalnej i wskazano na możliwości wykorzystania tej metody do konstruowania odpornych na zniszczenie koron metalowo-ceramicznych.
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Effect Of Resveratrol And Quercetin On Telomerase Regulation In Cancer Cells And Their Anti-Cancer Potential
PublikacjaTelomeres and telomerase are nowadays one on targets for anticancer therapy. Telomerase is expressed in ~90% of human cancer cell lines and tumor specimens, whereas its enzymatic activity is not detectable in most human somatic cells. Was found that some dietary compounds can modulate telomerase activity in cancer cells. This review summarizes the current knowledge about the effects of resveratrol and quercetin on telomerase regulation...
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Thermal stability analysis of poly(lactic acid)-carbon black-nanodiamond composite
Dane BadawczeThis dataset contains thermal stability tests carried out on new 3D printing-dedicated composites with poly-lactic acid (PLA), carbon black (CB) and nanodiamond fillers. Two types of nanodiamonds were studied: detonation nanodiamonds (DND) and boron-doped carbon nanowalls (BCNW). The investigated techniques include: thermogravimetric analysis (TGA)...
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Phosphinoborinium cation: a synthon for cationic B-P bond systems
PublikacjaHerein, we report access to phosphinoborinium cations via heterolytic cleavage of the boron-bromide bond in bromophosphinoborane. The product of the reaction was isolated as a dimeric dication possessing a planar P2B2 core. Activation of C-H and C-P bonds in the dication led to formation of the borinium-phosphaborene adduct. Reactivity studies revealed that title cation exhibits ambiphilic properties and intramolecular frustrated...
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Screening of predicted synergistic multi-target therapies in glioblastoma identifies new treatment strategies
PublikacjaAbstract Background IDH-wildtype glioblastoma (GBM) is a highly malignant primary brain tumor with a median survival of 15 months after standard of care, which highlights the need for improved therapy. Personalized combination therapy has shown to be successful in many other tumor types and could be beneficial for GBM patients. Methods We performed the largest drug combination screen to date in GBM, using a high-throughput effort...
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Muramyl dipeptide-based analogs as potential anticancer compounds: Strategies to improve selectivity, biocompatibility, and efficiency
PublikacjaAccording to the WHO, cancer is the second leading cause of death in the world. This is an important global problem and a major challenge for researchers who have been trying to find an effective anticancer therapy. A large number of newly discovered compounds do not exert selective cytotoxic activity against tumorigenic cells and have too many side effects. Therefore, research on muramyl dipeptide (MDP) analogs has attracted interest...
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Anna Lisowska-Oleksiak prof. dr hab.
OsobyAnna Lisowska-Oleksiak, born in 1952, has been working at GUT since 1977. Currently is employed at the Faculty of Chemistry as a full professor. She was employed as a research assistant at the University of St Andrews in the group of C. A. Vincent and P.G. Bruce (1991-1994). She completed a two-month research internship in CEA Grenoble (2011). Anna Lisowska-Oleksiak obtained her MSc in chemistry at Nicolaus Copernicus University...
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Inhibition of T-type calcium channel disrupts Akt signaling and promotes apoptosis in glioblastoma cells.
PublikacjaGlioblastoma multiforme (GBM) are brain tumors that are exceptionally resitant to both radio- and chemotherapy regimens and novel approaches to treatment are needed. T-type calcium channels are one type of low voltage-gated channel (LVCC) involved in embryonic cell proliferation and differentiation; however they are often over-expressed in tumors, including GBM. In this study, we found that inhibition of T-type Ca channels in GBM...
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Future of medicine: personalized oncology
PublikacjaUnderstanding genetic and epigenetic mechanisms of tumorigenesis allows identifying many vital mutations affected the formation of various malignancies. This led to the discovery of a new therapeutic approach, based on molecular mechanisms in the world of medicine, which is called personalized medicine (PM). This review aims to outline the state of the art of the personalized medicine in treatment, taking into account anti-cancer...
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Michał Tomasz Kucewicz dr
OsobyMichal Kucewicz was born in 1986 in Gdansk. In 2005 he completed International Baccalaureate programme in Topolowka (III High School in Gdańsk). Thanks to the G. D. Fahrenheit scholarship, he moved to the United Kingdom to study neuroscience. He received his Bachelor’s and Master’s degree from the Cambridge University, and his doctoral degree from the University of Bristol specializing in electrophysiology of memory and cognitive...
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Realizacja inwestycji społecznych w Polsce w kontekście założeń polityki społecznej Unii Europejskiej
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Justyna Woroń mgr
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Uniformity of Thermoluminescence and Optically Stimulated Luminescence Signals Over the Length of Doped LiMgPO4 Crystal Rods Grown by Micro-Pulling-Down Method
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Cahiers Critiques de Therapie Familiale et de Pratiques de Reseaux
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Poland: Quality Monitoring of Therapeutic Processes in a Small Treatment Center for Children
PublikacjaThis article presents the case of the first ISO 9001:2000-certified small healthcare organization (the Center for Therapy and Rehabilitation) providing therapeutic and rehabilitation services for disabled children in Northern Poland. Elements of the process-oriented healthcare quality system implementation, initial benefits, and the organization's quality system structure and process descriptions are described. Particular attention...
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Rehabilitation device supporting active and passive upper limb exercises
PublikacjaThis article presents a mechatronic solution for rehabilitation devices supporting active and passive exercises in persons with motor dysfunctions of the upper limbs in the area of the elbow and shoulder joints. A planar positioner integrated with original software and a control system, served as the basis for creating the present solution. Bellman’s programming method was applied to optimize the motion trajectory of the planar...
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WIMiO - Oceanotechnika i Projektowanie i budowa jachtów - Matematyka II sem.2 2021/2022 (J.Woroń)
Kursy OnlineKurs z ćwiczeń do przedmiotu "Matematyka II" przeznaczony dla studentów Wydziału Inżynierii Mechanicznej i Okrętownictwa na kierunku Oceanotechnika i Projektowanie i budowa jachtów w roku akademickim 2021/2022 (semestr letni).
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WILiŚ- Transport sem.1 - Matematyka I 2022/2023 (J.Woroń)
Kursy OnlineKurs z ćwiczeń do przedmiotu "Matematyka I" przeznaczony dla studentów Wydziału Inżynierii Lądowej i Środowiska na kierunku Transport (grupa 1) w roku akademickim 2022/2023 (semestr zimowy).
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WILiŚ - Transport gr. 1 - Matematyka II sem.2 2022/2023 (J.Woroń)
Kursy OnlineKurs z ćwiczeń do przedmiotu "Matematyka II" przeznaczony dla studentów Wydziału Inżynierii Lądowej i Środowiska na kierunku Transport (grupa dziekańska 1) w roku akademickim 2022/2023 (semestr letni).
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WILiŚ - IS gr. 1 i 2 - Matematyka II sem.2 2021/2022 (J.Woroń)
Kursy OnlineKurs z ćwiczeń do przedmiotu "Matematyka II" przeznaczony dla studentów Wydziału Inżynierii Lądowej i Środowiska specjalności Inżynieria sanitarna (grupy dziekańske 1 i 2) w roku akademickim 2021/2022 (semestr letni).
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WILiŚ - IS gr. 1 i 2 - Matematyka II sem.2 2022/2023 (J.Woroń)
Kursy OnlineKurs z ćwiczeń do przedmiotu "Matematyka II" przeznaczony dla studentów Wydziału Inżynierii Lądowej i Środowiska specjalności Inżynieria sanitarna (grupy dziekańske 1 i 2) w roku akademickim 2022/2023 (semestr letni).
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WIMiO - Oceanotechnika - Matematyka II sem.2 2022/2023 (J.Woroń)
Kursy OnlineKurs z ćwiczeń do przedmiotu "Matematyka II" przeznaczony dla studentów Wydziału Inżynierii Mechanicznej i Okrętownictwa na kierunku Oceanotechnika w roku akademickim 2022/2023 (semestr letni).
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WEiA - Et gr.3 - Matematyka I 2023/2024 (J.Woroń)
Kursy OnlineKurs z ćwiczeń do przedmiotu "Matematyka I" przeznaczony dla studentów Wydziału Wydziału Elektrotechniki i Automatyki na kierunku Elektrotechnika (grupa dziekańska 3) w roku akademickim 2023/2024 (semestr zimowy).
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WIMiO - OiKM gr. 1 i 2 - Matematyka II 2023/2024 (J.Woroń)
Kursy OnlineKurs z ćwiczeń do przedmiotu "Matematyka II" przeznaczony dla studentów Wydziału Inżynierii Mechanicznej i Okrętownictwa na kierunku Okręty i Konstrukcje Morskie (grupy 1 i 2) w roku akademickim 2023/2024 (semestr letni).
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WILiŚ - IS gr. 2 i 3 - Matematyka II sem.2 2023/2024 (J.Woroń)
Kursy OnlineKurs z ćwiczeń do przedmiotu "Matematyka II" przeznaczony dla studentów Wydziału Inżynierii Lądowej i Środowiska specjalności Inżynieria sanitarna (grupy dziekańske 2 i 3) w roku akademickim 2023/2024 (semestr letni).
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WEiA - Et gr. 3 - Matematyka II 2023/2024 (J.Woroń)
Kursy OnlineKurs z ćwiczeń do przedmiotu "Matematyka II" przeznaczony dla studentów Wydziału Elektrotechniki i Automatyki na kierunku Elektrotechnika (grupa dziekańska 3) w roku akademickim 2023/2024 (semestr letni).
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Mechanism-based inactivation of human cytochrome P450 1A2 and 3A4 isoenzymes by antitumor triazoloacridinone C-1305.
Publikacja5-Dimethylaminopropylamino-8-hydroxytriazoloacridinone, C-1305, is a promising antitumor therapeutic agent with high activity against several experimental tumors. It was determined to be a potent and selective inhibitor of liver microsomal and human recombinant cytochrome P450 (CYP) 1A2 and 3A4 isoenzymes. Therefore, C-1305 might modulate the effectiveness of other drugs used in multidrug therapy. The objective of this study was...
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Biomarkers of alcohol consumption in body fluids - possibilities and limitations of application in toxicological analysis
PublikacjaEthyl alcohol is the most popular legal drug, but its excessive consumption causes social problems. Despite many public campaigns against alcohol use, car accidents, instances of aggressive behaviour, sexual assaults and deterioration in labor productivity caused by inebriated people is still commonplace. Fast and easy diagnosis of alcohol consumption is required in order to introduce proper and effective therapy, and is crucial...
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Diagnosis of preeclampsia in women with diabetic kidney disease
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Specjalistyczne laboratorium techniki wysokich napięć. Materiały pomocnicze.P. Gdań. [online] [dostęp 30.12.2003]. Dostępny w World Wide Web: http:// www.ely.pg.gda.pl/wnae/index1.html) [84 s.]
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Dilemmas associated with the implementation of quality management systems in Polish smaller health care units
PublikacjaThe article presents the considerations and recommendations for the implementation of the process-oriented quality management systems (QMS) in small health care units. As an example, the unit providing services for children with disabilities (therapy and rehabilitation) localized in northern part of Poland have been selected. The essential elements of the implementation of the quality system, taking into account the objectives...
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Physicochemical studies (BET) of nanoparticles used for 3D printable conductive composites
Dane BadawczeThis dataset contains physico-chemical examination of fillers used to fabricate new 3D printing-dedicated composites with poly-lactic acid (PLA), carbon black (CB) and nanodiamond fillers. Geometric surface area of the nanoparticles was studied by Brunauer–Emmett–Teller (BET) adsorption/desorption isotherms. Investigated samples: CB Ensaco 250G, detonation...
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Dynamic Nanoimpedance Characterization of the Atomic Force Microscope Tip-Surface Contact
PublikacjaNanoimpedance measurements, using the dynamic impedance spectroscopy technique, were carried out during loading and unloading force of a probe on three kinds of materials of different resistivity. These materials were: gold, boron-doped diamond, and AISI 304 stainless steel. Changes of impedance spectra versus applied force were registered and differences in the tip-to-sample contact character on each material were revealed. To...