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Wyniki wyszukiwania dla: GENOME EDITING
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Female Fabry disease patients and X-chromosome inactivation
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Cell cycle is disturbed in mucopolysaccharidosis type II fibroblasts, and can be improved by genistein
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Molecular cloning and initial characterization of African green monkey (Cercopithecus aethiops) corticotropin releasing factor receptor type 1 (CRF1) from COS-7 cells
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Towards Synthetic and Balanced Digital Government Benchmarking
PublikacjaReliable benchmarking is essential for effective management of the government digitalization efforts. Existing benchmarking instruments generally fail to support this target. One problem is the diversity of instruments, resulting in a split image of digital progress and adding ambiguity to policy decisions. Another problem is disconnect in assessing progress between digital and traditional “analog” governance, lending support to...
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Reshaping of Coastlines as the Beginning of Urban Structures Changes in North Poland
PublikacjaThis article discusses the problem of strategies concerning the processes of re-shaping the Baltic Sea southern coastline applied recently in North Poland. The undertaken research is an attempt to identify the relationship between the modifications of coastline forms and the positive changes of urban structures. It can be seen that these modifications are needed because of the problems of existing shoreline erosion. It can be also...
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Evolutionary Algorithms in MPLS network designing
PublikacjaMPLS technology become more and more popular especially in core networks giving great flexibility and compatibility with existing Internet protocols. There is a need to optimal design such networks and optimal bandwidth allocation. Linear Programming is not time efficient and does not solve nonlinear problems. Heuristic algorithms are believed to deal with these disadvantages and the most promising of them are Evolutionary Algorithms....
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THE PANTOGRAPH AND ITS GEOMETRIC TRANSFORMATIONS - A FORMER POPULAR TOOL FOR COPYING AND SCALING
PublikacjaDevelopment of digital technology has resulted in significant transformations of designer workshops. Computer applications replaced the previously existing tools and methods for drawing up of projects. Professional, sophisticated drawing instruments and tools for manual plotting, as well as basic drawing aids, have gradually fallen into oblivion and become relicts of a bygone era - the objects of collectors' interest. Gdansk University...
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New transition curve adapted to railway operational requirements
PublikacjaThe paper points to the limited possibilities of improving the existing situation in the area of transition curves used in geometrical layouts of the railway track. Difficulties in the practical implementation and maintenance of very small horizontal ordinates of the transition curve and the ordinates of the gradient due to cant in the initial section, appearing on smooth transition curves, were indicated. The main reason for this...
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[Soft Skills] Writing grant application
Kursy Online{mlang pl} Dyscyplina: soft skills Zajęcia obowiązkowe dla doktorantów II roku, Prowadzący: mgr Renata Downar-Zapolska Liczba godzin: 5 Forma zajęć: {mlang} {mlang en} Discipline: soft skills Obligatory course for 2nd-year PhD students Academic teacher: mgr Renata Downar-Zapolska Total hours of training: 5 teaching hours Course type: {mlang}
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[Soft Skills] Writing grant application
Kursy Online{mlang pl} Dyscyplina: soft skills Zajęcia obowiązkowe dla doktorantów II roku, Prowadzący: mgr Renata Downar-Zapolska Liczba godzin: 5 Forma zajęć: online Data:15.06.2023 {mlang} {mlang en} Discipline: soft skills Obligatory course for 2nd-year PhD students Academic teacher: mgr Renata Downar-Zapolska Total hours of training: 5 teaching hours Course type: online Date: 15.06.2023 {mlang}
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Academic writing 2024 Group 2
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Academic writing 2024 Group 1
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Wernsdorf - a biography of an 18th century scholar - transcription, photographs and partial translation
Dane BadawczeThe data set contains the transcription of a large passage of the Latin biography of the eighteenth-century philologist and theologian Gottlieb Wernsdorf (1717-1774), as well as photos of the entire print. A translation from Latin into English and Polish was added to the data set as well (that is, excerpts on the education of both Gottlieb himself,...
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Science of Scientific Writing 23/24
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Project application workshops_Inter PhD_electronics, telecommunications and informatics
Kursy Onlinedisciplinary field: ETI / The aim of the course is to provide the necessary information related to the search for sources of funding for scientific research and development work, with particular emphasis on competitions addressed to young researchers. Procedures for writing grant applications will be presented.
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Project application workshops_InterPhDII_civil and environmental engineering
Kursy Onlinedisciplinary field: WILiŚ / The aim of the course is to provide the necessary information related to the search for sources of funding for scientific research and development work, with particular emphasis on competitions addressed to young researchers. Procedures for writing grant applications will be presented.
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Project application workshops_Inter PhDII_chemistry
Kursy Onlinedisciplinary field: chemistry / The aim of the course is to provide the necessary information related to the search for sources of funding for scientific research and development work, with particular emphasis on competitions addressed to young researchers. Procedures for writing grant applications will be presented.
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Analysis of volatile fraction selected hybrid fruits using chromatographic techniques
PublikacjaAt present, "healthy eating" is gaining in popularity. Many people associate this term with eating plenty of vegetables and fruits. The basic elements influencing the selection of fruit are their appearance and smell. Of course, their origin and impact on human health are also very important. In recent years, exotic fruits have become increasingly accessible, making them gaining popularity, even among Poles. You can also meet plants...
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The fertility rate (TFR) in selected EU countries in 2015
Dane BadawczeThe main reasons for the negative consequences of demographic changes are: natural increase in the life span of the population, decline in fertility and emigration of unusual dimensions.
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Wordventure - cooperative wordnet editor. Architecture for lexical semantic aquisition
PublikacjaThis article presents architecture for acquiring lexical semanticsin a collaborative approach paradigm. The system enablesfunctionality for editing semantic networks in a wikipedia-like style. The core of the system is a user-friendly interface based on interactive graph navigation.It has been used for semantic network presentation,and brings simultaneously modification functionality.
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WordVenture - COOPERATIVE WordNet EDITOR Architecture for Lexical Semantic Acquisition
PublikacjaThis article presents architecture for acquiring lexical semantics in a collaborative approach paradigm. The system enables functionality for editing semantic networks in a wikipedia-like style. The core of the system is a user-friendly interface based on interactive graph navigation. It has been used for semantic network presentation, and brings simultaneously modification functionality.
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Genetyka molekularna - wykład, WCh 2022/23, Biotechnologia II stopień - new
Kursy OnlineCelem kursu jest zapoznanie się z podstawowymi mechanizmami funkcjonowania genomów, regulacji ich aktywności i dziedziczenia, edycją genomu w oparciu o programowane nukleazy (system CRISPR-Cas i prime-editing), metodami wykorzystywanymi do analizy struktury, funkcji genów, skutków zmian mutacyjnych oraz wyłączania ich aktywności (np. TargeTron gene nockout system) oraz technikami in vitro wykorzystywanymi do wprowadzania biomolekuł...
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Genetyka molekularna - wykład, WCh 2023/24, Biotechnologia II stopień
Kursy OnlineCelem kursu jest zapoznanie się z podstawowymi mechanizmami funkcjonowania genomów, regulacji ich aktywności i dziedziczenia, edycją genomu w oparciu o programowane nukleazy (system CRISPR-Cas i prime-editing), metodami wykorzystywanymi do analizy struktury, funkcji genów, skutków zmian mutacyjnych oraz wyłączania ich aktywności (np. TargeTron gene nockout system) oraz technikami in vitro wykorzystywanymi do wprowadzania biomolekuł...
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STUDIES ON THE USE OF TERRESTRIAL LASER SCANNING IN THE MAINTENANCE OF BUILDINGS BELONGING TO THE CULTURAL HERITAGE
PublikacjaWithin the frames of the use of terrestrial laser scanning we find numerous examples of registration of building facilities, including also historical and valuable in their culture. In the case presented in this paper, at the root of the problem there is a preservation of the historic blacksmith’s forge located in Gdansk Orunia. The facility dating from the early nineteenth century was intended to repair involving the complete...
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Studies on the use of terrestrial laser scanning in the maintenance of buildings belonging to the cultural heritage
PublikacjaWithin the frames of the use of terrestrial laser scanning we find numerous examples of registration of building facilities, including also historical and valuable in their culture. In the case presented in this paper, at the root of the problem there is a preservation of the historic blacksmith's forge located in Gdansk Orunia. The facility dating from the early nineteenth century was intended to repair involving the complete...
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Analysis of Transformation Methods of Hydroacoustic and Optoelectronic Data Based on the Tombolo Measurement Campaign in Sopot
PublikacjaMeasurements in the coastal zone are carried out using various methods, including Global Navigation Satellite Systems (GNSS), hydroacoustic and optoelectronic methods. Therefore, it is necessary to develop coordinate transformation models that will enable the conversion of data from the land and marine parts to one coordinate system. The article presents selected issues related to the integration of geodetic and hydrographic data....
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A new division of bacterial UvrA homologues
PublikacjaThe UvrA protein is a DNA-binding and damage-recognition enzyme which participates in the prokaryotic type nucleotide excision repair (NER) pathway. It has recently been noted that some bacterial genomes comprise additional uvrA genes which encode five distinct types of UvrA homologue. We investigated the sequences of over 2400 bacterial genomes and found 130 examples of bacteria containing uvrA 2 genes. The sequence analyses conducted...
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Ligation Mediated PCR methods, their possibilities and limitations
PublikacjaThe application of molecular diagnostics for bacterial strain typing or identifying bacteria at the strain level is of particular importance at present. However, among the many genotyping methods that are currently available, no single one is universally ideal. In this article, we thus review the Ligation Mediated PCR group methods as prospects from which to choose. We discuss different strategies for selecting the amplified PCR...
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New Approaches for Escherichia coli Genotyping
PublikacjaEasy-to-perform, fast, and inexpensive methods of differentiation of Escherichia coli strains beyond the species level are highly required. Herein two new, original tools for genotyping of E. coli isolates are proposed. The first of the developed method, a PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphism) test uses a highly variable fliC gene, encoding the H antigen as a molecular target. The designing...
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Jolanta Łopatowska dr inż.
OsobyJolanta Łopatowska, adiunkt w Katedrze Inżynierii Zarządzania i Jakości na Wydziale Zarzadzania i Ekonomii, jest absolwentką Wydziału Elektroniki PG i Instytutu Organizacji i Projektowania Systemów Produkcyjnych PG oraz doktorem w dyscyplinie nauk ekonomicznych. Jej zainteresowania naukowo-badawcze koncentrują się wokół zaawansowanych organizacyjnie i technologicznie systemów produkcyjnych, ze szczególnym uwzględnieniem procesów...
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The role of epigenetics in regeneration
PublikacjaComplex changes in chromatin structure and at the transcriptional level occur from the creation of a single parental gamete throughout fertilization, embryo development and the life of an adult organism. Epigenetic changes, such as methylation and hydroxymethylation of DNA or histone methylation and acetylation, are an important part of these processes. Epigenetic regulation has an essential influence on gene expression level. DNA...
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Genetyka człowieka, seminarium
Kursy OnlineTematy referatów: 1. Budowa chromosomu i metody badania (metody cytogenetyczne, FISH, CGH) 2. Badanie DNA w medycynie sądowej 3. Genetyczne podstawy odporności immunologicznej 4. Klonowanie zwierząt i ludzi 5. Genetyka nowotworów 6. Katastrofy elektrowni atomowych w Czarnobylu i w Fukushimie a zachorowalność na nowotwory 7. Dziedziczenie epigenetyczne 8. Mikromacierze hybrydyzacyjne w badaniu ekspresji genów, metylacji...
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Analysis of the bulk solid flow during gravitational silo emptying using X-ray and ECT tomography
PublikacjaW pracy przedstawiono wyniki pomiarów zmian koncentracji piasku bezkohezyjnego zachodzących w prostokątnym modelu silosu opróżnianym grawitacyjnie. Pomiary wykonano z zastosowaniem kontynualnego promieniowania rentgenowskiego oraz z użyciem tomografii pojemnościowej. Badania wykonano dla zróżnicowanego zagęszczenia początkowego piasku oraz różnego stopnia szorstkości ścian. Szczególny nacisk położono na zachowanie sie materiału...
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Andrzej Klimczuk
OsobyAndrzej Klimczuk, doktor nauk społecznych w zakresie nauki o polityce publicznej oraz socjolog. Adiunkt w Katedrze Polityki Społecznej Kolegium Ekonomiczno-Społecznego Szkoły Głównej Handlowej w Warszawie. W latach 2002-2009 redaktor i korespondent wydawnictw o grach komputerowych. W latach 2011-2013 wiceprezes Fundacji Laboratorium Badań i Działań Społecznych "SocLab". Ekspert zewnętrzny m.in. Komisji Europejskiej, programu URBACT,...
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Number of tax returns filed by taxpayers who obtain income taxed with a lump sum on income recorded according to sources of income (2011-2015)
Dane BadawczeTaxpayers engaged in non-agricultural business activities benefiting from taxation in the form of a lump sum on recorded income, are required to have and store proofs of purchase of goods, keep a list of fixed assets and intangible assets, records of equipment and, separately for each tax year, a record of revenues. The obligation to keep records of...
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Control of Luminescence by Tuning of Crystal Symmetry and Local Structure in Mn4+ -Activated Narrow Band Fluoride Phosphors
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Hunting for the Magnesium(I) Species: Formation, Structure, andReactivity of some Donor-Free Grignard Compounds
PublikacjaMagnesium bromide radicals have to be prepared as high-temperature molecules and trapped as a metastable solution because a seemingly simple reduction of donor-free Grignard compounds failed. However, the essential role of magnesium(I) species during the formation of Grignard compounds could be demonstrated experimentally.
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Synthesis of Multiwalled Carbon Nanotubes by Catalytic Combustion of Polypropylene
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Enantioselective Gel Phase Synthesis of Metal–Organic Materials
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Pendant Proton-Relays Systematically Tune the Rate and Selectivity of Electrocatalytic Ammonia Generation in a Fe-Porphyrin Based Metal-Organic Framework
PublikacjaElectrocatalytic nitrite reduction (eNO2RR) is a promising alternative route to produce ammonia (NH3). Until now, several molecular catalysts have shown capability to homogeneously reduce nitrite to NH3, while taking advantage of added secondary-sphere functionalities to direct catalytic performance. Yet, realizing such control over heterogeneous electrocatalytic surfaces remains a challenge. Herein, we demonstrate that heterogenization...
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Enantiomeric self-recognition of a facial amphiphile triggered by [{Pd(ONO2)(en)}2]
PublikacjaOpisano syntezę pochodnych glikolurylu tworzących dimeryczne struktury w roztworze wodnym prowadzące do samorozpoznania enancjomerycznego. Struktury te uzyskano dzięki koordynacji do [{Pd(ONO2)(en)}2].
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Supramolecular Assemblies of Hydrogen Bonded Carboxylic Acid Dimers Mediated by Phenyl-Pentafluorophenyl Stacking Interactions.
PublikacjaKwas pentafluorobenzoesowy tworzy heterodimery z kwasami benzoesowym i 2,4,6-trimetylobenzoesowym w wyniku oddziaływań typu pi-pi reszt fenylowych i pentafluorofenylowych. Otrzymane kokryształy wymienionych kwasów z 1,4-bisarylobutadiynami zawierały homodimery tworzone przez cząsteczki kwasów, pomiędzy którymi znajdowały się cząsteczki diarylodiacetylenów.
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Optimization of Hydrogen - Evolving Photochemical Molecular Devices
PublikacjaA molecular photocatalyst consisting of a RuII photocenter, a tetrapyridophenazine bridging ligand, and a PtX2 (X=Cl or I) moiety as the catalytic center functions as a stable system for light-driven hydrogen production. The catalytic activity of this photochemical molecular device (PMD) is significantly enhanced by exchanging the terminal chlorides at the Pt center for iodide ligands. Ultrafast transient absorption spectroscopy...
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Palladium versus Platinum: The Metal in the Catalytic Center of a Molecular Photocatalyst Determines the Mechanism of the Hydrogen Production with Visible Light
PublikacjaTo develop highly efficient molecular photocatalysts for visible light-driven hydrogen production, a thorough understanding of the photophysical and chemical processes in the photocatalyst is of vital importance. In this context, in situ X-ray absorption spectroscopic (XAS) investigations show that the nature of the catalytically active metal center in a (N^N)MCl2 (M=Pd or Pt) coordination sphere has a significant impact on the...
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Topochemical, Single‐Crystal‐to‐Single‐Crystal [2+2] Photocycloadditions Driven by Chalcogen‐Bonding Interactions
PublikacjaThe face-to-face association of (E)-1,2-di(4-pyridyl)ethylene (bpen) molecules into rectangular motifs stabilized for the first time by chalcogen bonding (ChB) interactions is shown to provide photoreactive systems leading to cyclobutane formation through single-crystal-to-single-crystal [2+2] photodimerizations. The chelating chalcogen bond donors are based on original aromatic, ortho-substituted bis(selenocyanato)benzene derivatives...
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Ln2(SeO3)2(SO4)(H2O)2 (Ln=Sm, Dy, Yb): A Mixed‐Ligand Pathway to New Lanthanide(III) Multifunctional Materials Featuring Nonlinear Optical and Magnetic Anisotropy Properties
PublikacjaBottom-up assembly of optically nonlinear and magnetically anisotropic lanthanide materials involving precisely placed spin carriers and optimized metal-ligand coordination offers a potential route to developing electronic architectures for coherent radiation generation and spin-based technologies, but the chemical design historically has been extremely hard to achieve. To address this, we developed a worthwhile avenue for creating...
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Folding‐upon‐repair DNA nanoswitches for monitoring DNA repair enzymes activity
PublikacjaWe demonstrate here a new class of DNA‐based nanoswitches that, upon enzymatic repair, could undergo a conformational change mechanism leading to a change in fluorescent signal. Such folding‐upon‐repair DNA nanoswitches are synthetic DNA sequences containing O6‐methyl‐guanine (O6‐MeG) nucleobases and labelled with a fluorophore/quencher optical pair. The nanoswitches are rationally designed so that only upon enzymatic demethylation...
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[Soft Skills] Academic writing gr. 4
Kursy Online{mlang pl} Dyscyplina: soft skills Zajęcia obowiązkowe dla doktorantów I roku, fakultatywne dla doktorantów II roku Prowadzący: dr Iwona Mokwa-Tarnowska Liczba godzin: 30 Forma zajęć: {mlang} {mlang en} Discipline: soft skills Obligatory course for 1st-year PhD students, facultative for 2nd-year PhD students Academic teacher: dr Iwona Mokwa - Tarnowska Total hours of training: 30 teaching hours Course type: {mlang}
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[Soft Skills] Academic writing gr. 3
Kursy Online{mlang pl} Dyscyplina: soft skills Zajęcia obowiązkowe dla doktorantów I roku, fakultatywne dla doktorantów II roku Prowadzący: dr Iwona Mokwa-Tarnowska Liczba godzin: 30 Forma zajęć: {mlang} {mlang en} Discipline: soft skills Obligatory course for 1st-year PhD students, facultative for 2nd-year PhD students Academic teacher: dr Iwona Mokwa - Tarnowska Total hours of training: 30 teaching hours Course type: {mlang}
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[Soft Skills] Academic writing Group 3
Kursy Online{mlang pl} Dyscyplina: Soft Skills Zajęcia obowiązkowe dla doktorantów I roku Prowadzący: CJO PG Liczba godzin: 30 {mlang} {mlang en} Discipline: Soft Skills Obligatory course for 1st-year PhD students Academic teacher: CJO PG Total hours of training: 30 teaching hours {mlang}