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Wyniki wyszukiwania dla: reductive metabolism
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Diabetes Metabolic Syndrome and Obesity-Targets and Therapy
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Diabetes & Metabolic Syndrome-Clinical Research & Reviews
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Endocrine Metabolic & Immune Disorders-Drug Targets
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Romanian Journal of Diabetes, Nutrition and Metabolic Diseases
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Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry
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New Gene Markers for Metabolic Processes and Homeostasis in Porcine Buccal Pouch Mucosa during Cells Long Term-Cultivation—A Primary Culture Approach
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Comparative Analysis of Metabolic Variations, Antioxidant Profiles and Antimicrobial Activity of Salvia hispanica (Chia) Seed, Sprout, Leaf, Flower, Root and Herb Extracts
PublikacjaThe purpose of this study was to evaluate the phytochemical profiles of the seeds, sprouts, leaves, flowers, roots and herb of Salvia hispanica and to demonstrate their significant contribution to antioxidant and antimicrobial activities. Applied methods were: HPLC-DAD coupled with post-column derivatization with ABTS reagent, untargeted metabolomics performed by LC-Q-Orbitrap HRMS, and two-fold micro-dilution broth method, which...
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Novel 2-alkythio-4-chloro-N-[imino(heteroaryl)methyl]benzenesulfonamide Derivatives: Synthesis, Molecular Structure, Anticancer Activity and Metabolic Stability
PublikacjaA series of novel 2-alkythio-4-chloro-N-[imino-(heteroaryl)methyl]benzenesulfonamide derivatives, 8–24, were synthesized in the reaction of the N-(benzenesulfonyl)cyanamide potassium salts 1–7 with the appropriate mercaptoheterocycles. All the synthesized compounds were evaluated for their anticancer activity in HeLa, HCT-116 and MCF-7 cell lines. The most promising compounds, 11–13, molecular hybrids containing benzenesulfonamide...
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Octanoic Acid—An Insecticidal Metabolite of Conidiobolus coronatus (Entomopthorales) That Affects Two Majors Antifungal Protection Systems in Galleria mellonella (Lepidoptera): Cuticular Lipids and Hemocytes
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Effect of nitrogen doping on TiOxNythin film formation at reactive high-power pulsed magnetron sputtering
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Możliwości sterowania mocą bierną elektrowni wiatrowej : Reactive power control methods in wind parks
PublikacjaReferat poświęcony jest zagadnieniu sterowania mocą bierną w elektrowniach wiatrowych. W pierwszej części referatu opisano tło problemu sterowania mocą bierną w parkach wiatrowych, podano powody, dla których moc bierna powinna podlegać regulacji oraz zarysowano metody, które mogą być do niej użyte. W celu sprawdzenia proponowanych metod kompensacji, zbudowano model matematyczny elektrowni wiatrowej, którego poszczególne elementy...
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Phyto-mediated photocatalysis: a critical review of in-depth base to reactive radical generation for erythromycin degradation
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Effects of different hydraulic models on predicting longitudinal profiles of reactive pollutants in activated sludge reactors
PublikacjaW pracy przedstawiono wpływ dyspersji na prognozowanie stężeń azotu amonowego w komorach osadu czynnego w oczyszczalni ścieków Gdańsk-Wschód. W tym celu wykorzystano jednowymiarowe równanie adwekcji-dyspersji z członem źródłowym (szybkością nitryfikacji). Współczynnik dyspersji został wyznaczony na podstawie pomiarów znacznika fluoroscencyjnego. Model został zweryfikowany w oparciu o pomiary stężeń azotu w 6 sekcjach komory tlenowej...
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Grafting and reactive extrusion technologies for compatibilization of ground tyre rubber composites: Compounding, properties, and applications
PublikacjaChemical modification of ground tyre rubber (GTR) to compatibilize it with the matrix is a well-known approach. Based on our recent review of the surface etching methods used in GTR modification, the purpose of the current work is to take a deeper look into more advanced methods such as grafting and reactive extrusion. While grafting is more efficient in achieving compatibility, however, it usually involves multi-step synthesis...
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Reactive Sintering of Ground Tire Rubber (GTR) Modified by a Trans-Polyoctenamer Rubber and Curing Additives
PublikacjaThe proposed method of ground tire rubber (GTR) utilization involves the application of trans-polyoctenamer rubber (TOR), a commercially available waste rubber modifier. The idea was to investigate the influence of various curing additives (sulfur, N-cyclohexyl-2-benzothiazole sulfenamide (CBS), dibenzothiazole disulfide (MBTS) and di-(2-ethyl)hexylphosphorylpolysulfide (SDT)) on curing characteristics, physico-mechanical, thermal,...
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Fast Multi-Objective Optimization of Narrow-Band Antennas Using RSA Models and Design Space Reduction
PublikacjaComputationally efficient technique for multi-objective design optimization of narrow-band antennas is presented. In our approach, the corrected low-fidelity antenna model (obtained through coarse-discretization EM simulations) is enhanced using frequency scaling and response correction, sampled, and utilized to obtain a fast response surface approximation (RSA) antenna surrogate. The RSA model is constructed in the reduced design space....
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Rola i znaczenie wiedzy w przedsiębiorstwie funkcjonującym wg zasad koncepcji total productive maintenance
PublikacjaW opracowaniu zaprezentowano rosnące znaczenie wiedzy w przedsiębiorstwie funkcjonującym wg zasad koncepcji Total Productive Maintenance (TPM) Skupiono się na kluczowych zagadnieniach dotyczących istniejących rozwiązań i zastosowania koncepcji TPM w przedsiębiorstwie produkcyjnym. Koncepcje tą zestawiono w porównaniu z tzw. tradycyjnym podejściem utrzymania ruchu występującym jeszcze w wielu przedsiębiorstwach. Przedstawiono...
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Immunoscore, circulating tumor cells and human-derived organoids as potential predictive tools in personalized cancer medicine
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Liver fatty acid-binding protein might be a predictive marker of clinical response to systemic treatment in psoriasis
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Analysis of Let-7 Family miRNA in Plasma as Potential Predictive Biomarkers of Diagnosis for Papillary Thyroid Cancer
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Instrumented end notched flexure - Crack propagation and process zonemonitoring Part II: Data reduction and experimental
PublikacjaA mode II instrumented end notched flexure three point bending (ENF) adhesion test is described. The adhesive joint consists of two aluminium alloy (AW7075-T6) plates bonded with a structural epoxy adhesive (Hysol EA 9395™). Strain gauges are attached to the outer surface (backface) of the substrates in the lengthwise direction to measure local surface strain during crack propagation. Simultaneously, load/displacement measurements...
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The influence of road transport on the activities of glutathione reductase, glutathione peroxidase, and glutathione-S-transferase in equine erythrocytes
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Automatic Adjustment of Integration Time in the NIR Camera for Calibrated Temperature Measurement during Inductive Heating Processes
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Impact of Feature Selection Methods on the Predictive Performance of Software Defect Prediction Models: An Extensive Empirical Study
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Sustained Sympathetic and Blood Pressure Reduction 1 Year After Renal Denervation in Patients With Resistant Hypertension
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Selection of Methods of Surface Texture Characterisation for Reduction of the Frequency-Based Errors in the Measurement and Data Analysis Processes
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Interactions of Nitroaromatic Compounds with the Mammalian Selenoprotein Thioredoxin Reductase and the Relation to Induction of Apoptosis in Human Cancer Cells
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Two-electron reduction of quinones by Enterobacter cloacae NAD(P)H:nitroreductase: quantitative structure-activity relationships
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Rola i znaczenie wiedzy w przedsiębiorstwie funkcjonującym wg zasad koncepcji total productive maintenance
PublikacjaW opracowaniu zaprezentowano rosnące znaczenie wiedzy w przedsiębiorstwie funkcjonującym wg zasad koncepcji Total Productive Maintenance (TPM) Skupiono się na kluczowych zagadnieniach dotyczących istniejących rozwiązań i zastosowania koncepcji TPM w przedsiębiorstwie produkcyjnym. Koncepcje tą zestawiono w porównaniu z tzw. tradycyjnym podejściem utrzymania ruchu występującym jeszcze w wielu przedsiębiorstwach. Przedstawiono główne...
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Robust continuous-time controller design via structural Youla-Kučera parameterization with application to predictive control.
PublikacjaPraca dotyczy projektowania ciągłoczasowego sterowania liniowymi układami SISO o niepewnych parametrach w celu uzyskania nominalnej i odpornej stabilności oraz nominalnej i odpornej jakości regulacji. Specyficzne zastosowanie koncepcji parametryzacji Youli-Kučery (YK) prowadzi do nowego zastosowania obserwatorowych struktur sterowania. Metoda ta została połączona z nominalną strategią uogólnionego sterowania predykcyjnego CGPC,...
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Modeling of a Quasi-Resonant DC Link Inverter Dedicated to Common-Mode Voltage and Ground Current Reduction
PublikacjaIn this paper, the modeling methodology of the AC drive system with a Parallel Quasi-Resonant DC Link Inverter (PQRDCLI) is described. A presented modeling approach is an attractive tool used for the effective evaluation of a common-mode (CM) voltage and grounds current reduction methods. Designed models of inverter, induction machine (IM), and cable are simple, thus the methods for parameter extraction are not complicated. Verification...
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Globalized Knowledge-Based Simulation-Driven Antenna Miniaturization Using Domain-Confined Surrogates and Dimensionality Reduction
PublikacjaDesign of contemporary antenna systems encounters multifold challenges, one of which is a limited size. Compact antennas are indispensable for the new fields of application such as inter-net of things or 5G/6G mobile communication. Still, miniaturization generally undermines elec-trical and field performance. When attempted through numerical optimization, it turns into a constrained problem with costly constraints requiring electromagnetic...
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Mutual Coupling Reduction in Antenna Arrays Using Artificial Intelligence Approach and Inverse Neural Network Surrogates
PublikacjaThis paper presents a novel approach to reduce undesirable coupling in antenna arrays using custom-designed resonators and inverse surrogate modeling. To illustrate the concept, two stand-ard patch antenna cells with 0.07λ edge-to-edge distance are designed and fabricated to operate at 2.45 GHz. A stepped-impedance resonator is applied between the antennas to suppress their mutual coupling. For the first time, the optimum values...
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COMPARISON OF PREDICTIVE METHODS FOR FLOW BOILING HEAT TRANSFER IN CONVENTIONAL CHANNELS AND MINICHANNELS – THE EFFECT OF REDUCED PRESSURE
PublikacjaIn the paper are presented the results of follow on studies from [1]–[3] using authors own model to predict heat transfer coefficient during flow boiling. The model has been tested against a large selection of experimental data collected from various researchers to investigate the sensitivity of the in-house developed model. The collected experimental data came from various studies from literature and were conducted for the full...
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Comparison of predictive methods for flow boiling heat transfer in conventional channels and minichannels - the effect of reduced pressure
PublikacjaIn the paper are presented the results of follow on studies from [1]–[3] using authors own model to predict heat transfer coefficient during flow boiling. The model has been tested against a large selection of experimental data collected from various researchers to investigate the sensitivity of the in-house developed model. The collected experimental data came from various studies from literature and were conducted for the full...
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Structure and thermoelectric properties of Cs-Bi-Te alloys fabricated by different routes of reduction of oxide reagents
PublikacjaCesium-bismuth-telluride polycrystalline materials were fabricated using a cost-effective method based on a reduction of oxide reagents, leading to a production of a material with good thermoelectric properties. Several samples with various initial stoichiometry were prepared by melting of oxide powders at 1050 °C, quenching, milling to powders and then reducing in pure hydrogen at 400 °C. Another concept was to obtain the CsBi4Te6...
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Graphene hydrogels with embedded metal nanopatricles as efficient catalysts in 4-nitrophenol reduction and methylene blue decolorization
PublikacjaSynthesis and characterization of the graphene hydrogels with three different metallic nanoparticles, that is Au, Ag and Cu, respectively is presented. Synthesized in a one-pot approach graphene hydrogels with embedded metallic nanoparticles were tested as heterogeneous catalysts in a model reaction of 4-nitrophenol reduction. The highest activity was obtained for graphene hydrogel with Cu NPs and additional reaction of methylene...
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Influence of reduction process on the structural and mechanical properties of (Pb,Bi)-(Si,Ge)-O oxide glasses
PublikacjaThe effect of the reduction process in H2 at 380 °C on the microstructure and elemental composition of a glass Bi0.4Pb0.2Si0.4Ox has been investigated. It has been shown that after reduction a clearly separated top layer with a thickness of approx. 50 µm was formed on the surface of the sample. This layer is depleted of oxygen and has higher electrical conductivity than the interior of the glass. It has also been found that some...
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Applying Fuzzy Logic of Expert Knowledge for Accurate Predictive Algorithms of Customer Traffic Flows in Theme Parks
PublikacjaThis study analyzes two forecasting models based on the application of fuzzy logic and evaluates their effectiveness in predicting visitor expenditure and length of stay at a popular theme park. The forecasting models are based on a set of more than 600 decision rules constructed in the form of a complex series of IF-THEN statements. These algorithms store expert knowledge. A descriptive instrument that records the individual visitor's...
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Discrete-time predictive control design based on overparameterized delay-plant models and identified cancellation order.
PublikacjaPraca dotyczy uogólnionego sterowania predykcyjnego (GPC) obiektami opisanymi dyskretnoczasowymi modelami CARIMA z uproszczeniami (nieminimalnych, przeparametryzowanych) oraz o niezerowym opóźnieniu transportowym. Optymalne sterowanie predykcyjne wyznacza się na podstawie minimalnowariancyjnego oszacowania przyszłej odpowiedzi sterowanego obiektu. Poprzez analizę warunków rozwiązywalności zadania syntezy sterownika GPC, sformułowano...
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Detoxification of the tricyclic antidepressant opipramol and its analog – IS-noh by UGT enzymes before and after activation by phase I enzymes in rat liver microsomes
PublikacjaThe present studies were carried out to evaluate the simultaneous one-pot metabolism of opipramol (IS-opi) and analog (IS-noh) by phase I and phase II enzymes present in rat liver microsomes (RLM) as an alternative to separate testing with recombinant enzymes. This approach allows for more time-saving and cost-effective screening of the metabolism of newly discovered drugs. We also considered that the lack of results for phase...
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Electrical conductivity relaxation measurements - oxidation and reduction of BaCe0.6Zr0.2Y0.1Tb0.1O3-δ
Dane BadawczeThe dataset consists of 2 main catalogs: measurements performed for oxidation/reduction in dry conditions and in humid conditions. For Electrical Conductivity Relaxation (ECR) measurements, platinum reversible electrodes were applied in a four-probe arrangement and the sample was measured in the ProboStat™ measurement system. The ECR measurements were...
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Analysis of the properties of the YSTF ceramics materials before and after reduction
Dane BadawczeThe valence of titanium in reduced YSTF ceramics materials was investigated. Ceramics were reduced by annealing in a hydrogen atmosphere. For comparison unreduced sample was also measured. Valance state was measured by XPS method.
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Wyniki sulfammox (SRAO)
Dane BadawczeTwo granular sequencing batch reactors were operated for 160 days under anammox conditions, comparing the Anammox process and Sulfate Reduction Ammonium Oxidation process. The study aimed to investigate whether increasing the concentration of SO42- could enhance N removal rates under anaerobic conditions, and whether SO42- reduction and anammox processes...
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Metabolic transformation of antitumor acridinone C-1305 but not C-1311 via selective cellular expression of UGT1A10 increases cytotoxic response: implications for clinical use.
PublikacjaThe acridinone derivates C-1305 and C-1311 are promising antitumor agents with high activity against several experimental cellular and tumor models and which are under evaluation in pre-clinical and early phase clinical trials. Recent evidence from our laboratories has indicated that both compounds were conjugated by several UGT isoforms with the most active being extrahepatic UGT1A10. The present studies were designed to test...
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Mass spectrometry based identification of geometric isomers during metabolic stability study of a new cytotoxic sulfonamide derivatives supported by quantitative structure-retention relationships
PublikacjaA set of 15 new sulphonamide derivatives, presenting antitumor activity have been subjected to a metabolic stability study. The results showed that besides products of biotransformation, some additional peaks occurred in chromatograms. Tandem mass spectrometry revealed the same mass and fragmentation pathway, suggesting that geometric isomerization occurred. Thus, to support this hypothesis, quantitative structure-retention relationships...
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Correspondances en Metabolismes Hormones Diabetes et Nutrition
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NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
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An Approach to Data Reduction for Learning from Big Datasets: Integrating Stacking, Rotation, and Agent Population Learning Techniques
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Structure and thermoelectric properties of Te/Ag/Ge/Sb (TAGS) materials obtained by reduction of melted oxide substrates
PublikacjaThe Ge0.77Ag0.1Sb0.13Te1alloy was fabricated by a novel two step route. For that purpose firstly the oxide reagents were melted at high temperature and quenched into pellets. After that pellets were milled to the powder and then reduced in hydrogen at various temperatures and for various periods of time. Energy dispersive X-ray analysis indicated the possibility of successful fabrication of stoichiometric thermoelectric materials...