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- Publikacje 268 wyników po odfiltrowaniu
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- Dane Badawcze 69 wyników po odfiltrowaniu
Wyniki wyszukiwania dla: IMPLANTY ORTOPEDYCZNE
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DNA-reactive anticancer imidazoacridinone C-1311 is a new inhibitor of hypoxia-inducible factor 1 alpha, vascular endothelial growth factor and tumor angiogenesis
PublikacjaHypoxia-inducible factor 1 (HIF-1) plays a critical role for tumor adaptation to hypoxia and promotes angiogenesis. Antitumor imidazoacridinone C-1311 is a DNA reactive topoisomerase II and FLT3 receptor tyrosine kinase inhibitor selected for phase II clinical trials for breast cancer. Here, we demonstrate the new mechanism of C-1311 action involving HIF-1a, vascular endothelial growth factor (VEGF) and angiogenesis as additional...
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Experimental database of 3D lattice structure scaffolds testing
Dane BadawczeDataset contains results of validation (experimental testing) of 3D lattice scaffolds proposed in the paper "Mathematical approach to design 3D scaffolds for the 3D printable bone implant". There are presented three series of experimental testing for each of seven tested scaffolds:
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Forming of the gap in tendon sutures with an anchor without a pin
Dane BadawczeThe main objective of the all study was to assess the load capacity of a new implant device for knotless tendon anastomosis. During this series of experiments the gap formation process between the fronts of the connected tendons was observed. Tendons from fresh swine legs (commercially available) served as the biological material. The tendon juncture...
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Forming of the gap in tendon sutures with an anchor with a pin
Dane BadawczeThe main objective of the all study was to assess the load capacity of a new implant device for knotless tendon anastomosis. During this series of experiments the gap formation process between the fronts of the connected tendons was observed. Tendons from fresh swine legs (commercially available) served as the biological material. The tendon juncture...
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Maximum forces in tendon connections for an anchor with a pin in the full sample experiment
Dane BadawczeThe main objective of the all study was to assess the load capacity of a new implant device for knotless tendon anastomosis. During this series of experiments the load capacity of the anchoring element with a pin (see figure 1) was examined. Tendons from fresh swine legs (commercially available) served as the biological material. All samples were subjected...
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Hip endhoprothesis development using rapid prototyping methods
PublikacjaIntegrated product development based on Rapid Prototyping methods, connected with computer aided 3D design and computer aided engineering enables fast and full new product verification and validation. A case study derived from clinical and technological practice using hip implant construction is also included.
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Electrochemically assisted deposition of hydroxyapatite on Ti6Al4V substrates covered by CVD diamond films — Coating characterization and first cell biological results
PublikacjaAlthough titaniumand its alloys are widely used as implant material for orthopedic and dental applications they show only limited corrosion stability and osseointegration in different cases. The aim of the presented research was to develop and characterize a novel surface modification system from a thin diamond base layer and a hydroxyapatite (HAp) top coating deposited on the alloy Ti6Al4V widely used for implants in contact with bone....
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Skłonność złączy wykonanych pod wodą do tworzenia pęknięć zimnych
PublikacjaPrzedmiotem pracy jest analiza stanu wiedzy dotyczącej skłonności do tworzenia peknięć zimnych złączy wykonanych pod wodą. Omówiono wpływ warunków spawania na czynniki będące przyczyną pękania. Przedstawiono wyniki badań złączy ze stali o podwyższonej wytrzymałości metodą implant.
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Nanotubular oxide layers and hydroxyapatite coatings on porous titanium alloy Ti13Nb13Zr
PublikacjaThe surface condition of an implant has a significant impact on response occurring at the implant-biosystem border. The knowledge of physical-chemical and biological processes allows for targeted modification of biomaterials to induce a specified response of a tissue. The present research was aimed at development of technology composing of obtaining the nanotube oxide layers on a porous titanium alloy Ti13Nb13Zr, followed by the...
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Structural changes of bacterial cellulose due to incubation in conditions simulating human plasma in the presence of selected pathogens
PublikacjaBacterial nanocellulose (BNC) is a natural biomaterial with a wide range of medical applications. However, it cannot be used as a biological implant of the circulatory system without checking whether it is biodegradable under human plasma conditions. This work aimed to investigate the BNC biodegradation by selected pathogens under conditions simulating human plasma. The BNC was incubated in simulated biological fluids with or...
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Maximum forces in tendon connections for an anchor without pin in the single-side sample experiment
Dane BadawczeThe main objective of the all study was to assess the load capacity of a new implant device for knotless tendon anastomosis. During this series of experiments the load capacity of the anchoring element without a pin (see figure 1) was examined. Tendons from fresh swine legs (commercially available) served as the biological material. All samples were...
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Maximum forces in tendon connections for an anchor with pin in the single-side sample experiment
Dane BadawczeThe main objective of the all study was to assess the load capacity of a new implant device for knotless tendon anastomosis. During this series of experiments the load capacity of the anchoring element with a pin (see figure 1) was examined. Tendons from fresh swine legs (commercially available) served as the biological material. All samples were subjected...
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Maximum forces in tendon connections for the Kessler suture in the single-side sample experiment
Dane BadawczeThe main objective of the all study was to assess the load capacity of a new implant device for knotless tendon anastomosis. During this series of experiments the load capacity of the traditional two-strand Kessler sutures (3-0 sutures) was examined. Tendons from fresh swine legs (commercially available) served as the biological material. All samples...
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Warstwy z polimerów przewodzących dla biodegradowalnych metalicznych materiałów na implanty
ProjektyProjekt realizowany w Katedra Inżynierii Biomedycznej zgodnie z porozumieniem UMO-2016/23/N/ST5/00346 z dnia 2017-09-08
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Surface modifications of ti and its alloys
PublikacjaThis article reviews the various surface modification techniques pertaining to titanium and titanium alloys including physical treatment, mechanical treatment, and chemical and electrochemical treatment. The proper surface modification expands the use of titanium and its alloys in the biomedical field for long-term implants retaining the excellent properties of substrate material and improving the specific surface properties required...
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Effect of welding conditions on susceptibility to cold cracking of underwater welded joints
PublikacjaPrzedstawiono wybrane aspekty spawalności stali przy spawaniu pod wodą metodą lokalnej komory suchej. Zwrócono szczególną uwagę na skłonność do tworzenia peknięć zimnych w SWC. Przy pomocy planowania doświadczeń określono ilościowy wpływ parametrów spawania na naprężenia krytyczne z próby implant.
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BJS-03 DO WE NEED FIXATION OF THE MESH IN LAPAROENDOSCOPIC TECHNIQUES FOR M3 INGUINAL DEFECTS? AN EXPERIMENTAL STUDY
PublikacjaThe authors conducted a research experiment to verify the hypothesis that it is possible to preserve the mesh in the operating field in large direct hernias (M3) without the need to use fixing materials. The results showed that mesh fixation is not the only alternative to preventing recurrence in complex defects and that the type of implant seems to be a key factor from the point of view of mechanics and biophysics.
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The Setting Time of Polyether Impression Materials after Contact with Conventional and Experimental Gingival Margin Displacement Agents
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Self-Organized Nanotubular Oxide Layers on Ti and Ti Alloys
PublikacjaTo improve bioactivity of titanium and titanium, the implant surface modification by formation of self-organized TiO2 nanotube arrays with electrochemical techniques is presented. The influence of electrolyte composition and deposition parameters during anodization is characterized. The enhancement of phosphates deposition by titanium nanotubular structure is discussed. The calcium phosphate ceramics is shown to be uniformly deposited...
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Serous adenocarcinoma, NOS - Female, 70 - Tissue image [6100730023422231]
Dane BadawczeThis is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Malignant neoplasm of unspecified ovary - Female, 66 - Tissue image [9020730024813581]
Dane BadawczeThis is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Serous adenocarcinoma, NOS - Female, 70 - Tissue image [6100730023424461]
Dane BadawczeThis is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Wpływ implantacji jonowej na wybrane właściwości użytkowe stopu Ti-13Nb-13Zr w aspekcie zastosowania na elementy trące w endoprotezach stawu biodrowego
PublikacjaOgraniczeniem stosowania stopów tytanu na implanty długookresowe, które podlegają obciążeniom zmiennym jest, oprócz zjawiska metalozy, ich stosunkowo niska odporność na zużycie poprzez tarcie. Zachodzące procesy zużycia tribologicznego na powierzchniach współpracujących elementów pary trącej ograniczają żywotność sztucznych stawów, co najczęściej jest przyczyną operacji rewizyjnych, wskutek obluzowania się elementów nośnych endoprotezy...
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Effects of electrophoretic deposition times and nanotubular oxide surfaces on properties of the nanohydroxyapatite/nanocopper coating on the Ti13Zr13Nb alloy
PublikacjaLoad-bearing implants are developed with a particular emphasis placed on an application of ceramic hydroxyapatite coatings in order, to enhance the bioactivity of titanium implants and to shorten the healing time. Therefore, thin, fully crystalline coatings that are, highly adhesive, hydrophilic and demonstrating antibacterial properties are ly looked for. The aim of this research was to develop and characterize the properties...
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Mechanical Behavior of Bi-Layer and Dispersion Coatings Composed of Several Nanostructures on Ti13Nb13Zr Alloy
PublikacjaTitanium implants are commonly used because of several advantages, but their surface modification is necessary to enhance bioactivity. Recently, their surface coatings were developed to induce local antibacterial properties. The aim of this research was to investigate and compare me-chanical properties of three coatings: multi-wall carbon nanotubes (MWCNTs), bi-layer composed of an inner MWCNTs layer and an outer TiO2 layer, and...
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Linear Micropolar Elasticity Analysis of Stresses in Bones Under Static Loads
PublikacjaWe discuss the finite element modeling of porous materials such as bones using the linear micropolar elasticity. In order to solve static boundary-value problems, we developed new finite elements, which capture the micropolar behavior of the material. Developed elements were implemented in the commercial software ABAQUS. The modeling of a femur bone with and without implant under various stages of healing is discussed in details
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Malignant neoplasm of unspecified ovary - Female, 66 - Tissue image [9020730024813501]
Dane BadawczeThis is the histopathological image of COLON tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Malignant neoplasm of unspecified ovary - Female, 66 - Tissue image [9020730024819901]
Dane BadawczeThis is the histopathological image of UTERUS, NOS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Serous adenocarcinoma, NOS - Female, 70 - Tissue image [6100730023439261]
Dane BadawczeThis is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Serous adenocarcinoma, NOS - Female, 70 - Tissue image [6100730023432971]
Dane BadawczeThis is the histopathological image of CORPUS UTERI tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Serous adenocarcinoma, NOS - Female, 70 - Tissue image [6100730023431521]
Dane BadawczeThis is the histopathological image of CORPUS UTERI tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Analiza możliwości zastosowania planowania badań do określania skłonności do tworzenia pęknięć zimnych.
PublikacjaW pracy przedstawiono rozważania na temat możliwości zastosowania teorii planowania badań do określania skłonności do tworzenia pęknięć na zimno badanej metodą implant. Opisano wady i zalety wybranych planów badań z uwzględnieniem kryteriów realizowalności, informatywności i efektywności. Szczególną uwagę zwrócono na trudności związane z zastosowaniem planowania badań do zagadnień spawalniczych.
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Fuzzy reasoning system design and assessment of load-bearing endoprostheses and their fabrication processes
PublikacjaZaproponowano piec zastosowan podejscia rozumowania rozmytego do rozwiazania problemów w dziedzinie biomechanikioraz inzynierii biomateriałów. Obejmuja one: (A) oszacowanie maksymalnych naprezen kontaktowych działajacych naendoproteze, (B) zaprojektowanie procesu spiekania dla otrzymania porowatego implantu, (C) opracowanie planu utleniania wcelu otrzymania struktury nanorurkowej na stopach Ti, (D) oraz (E) zaprojektowanie osadzania...
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Characteristics of silver-dopped carbon nanotube coating destined for medical applications
PublikacjaCarbon nanotubes are materials demonstrating outstanding mechanical, chemical, and physical properties and are considered coatings of titanium implants. The present research is aimed to characterize the microstructure and properties of the multi-wall carbon nanotubes (MWCNTs) layer decorated with silver nanoparticles (Ag NPs) on the Ti13Nb13Zr alloy destined for long-term implants. The electrophoretic deposition of coatings...
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Malignant neoplasm of unspecified ovary - Female, 66 - Tissue image [9020730024817641]
Dane BadawczeThis is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Adenocarcinoma, NOS - Female, 76 - Tissue image [4080730010648641]
Dane BadawczeThis is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: VS200 Olympus slide scanner (20x magnification) and saved to DICOM format.
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Malignant neoplasm of unspecified ovary - Female, 66 - Tissue image [9020730024814211]
Dane BadawczeThis is the histopathological image of COLON tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Tubular adenocarcinoma - Male, 70 - Tissue image [5170730007435211]
Dane BadawczeThis is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Malignant neoplasm of unspecified ovary - Female, 66 - Tissue image [902073002481151]
Dane BadawczeThis is the histopathological image of CORPUS UTERI tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Malignant neoplasm of unspecified ovary - Female, 66 - Tissue image [9020730024815271]
Dane BadawczeThis is the histopathological image of RETROPERITONEUM AND PERITONEUM tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Malignant neoplasm of unspecified ovary - Female, 66 - Tissue image [902073002481261]
Dane BadawczeThis is the histopathological image of COLON tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Malignant neoplasm of unspecified ovary - Female, 66 - Tissue image [9020730024811081]
Dane BadawczeThis is the histopathological image of CORPUS UTERI tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Adenocarcinoma, metastatic, NOS - Female, 76 - Tissue image [408073001064341]
Dane BadawczeThis is the histopathological image of STOMACH tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: VS200 Olympus slide scanner (20x magnification) and saved to DICOM format.
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Skłonność do tworzenia pęknięć zimnych złączy spawanych ze stali o podwyższonej wytrzymałości wykonanych pod wodą.
PublikacjaW pracy przedstawiono zagadnienie spawalności stali 18G2A w odniesieniu do spawania pod wodą metodą lokalnej komory suchej. Zaprezentowano wyniki badań skłonności do tworzenia pęknięć zimnych metodą implant. Ustalono, że podczas spawania pod wodą stal 18G2A cechuje się zwiększoną wrażliwością na tworzenie się pęknięć zimnych w porównaniu ze spawaniem w środowisku powietrznym.
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Implant przegrody nosowej
Wynalazki -
Wytwarzanie i charakterystyka inteligentnych, czułych na zmianę pH, powłok kompozytowych na implanty.
ProjektyProjekt realizowany w Wydział Mechaniczny zgodnie z porozumieniem DEC-2019/03/X/ST5/00243 z dnia 2019-10-23
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Wpływ modyfikacji laserowej stopu Ti13Nb13Zr na mikrostrukturę powłok hydroksyapatytowych
PublikacjaDotychczasowe badania powierzchni wszczepów tytanowych dla chirurgii kostnej wykazały, że osteointegracja na powierzchniach rozwiniętych jest znacznie szybsza niż na powierzchniach gładkich, co za tym idzie chropowatość powierzchni implantu ma bardzo duży wpływ na adhezję składników środowiska biologicznego. W artykule przedstawiono wstępne wyniki badań dotyczące wpływu chropowatości powierzchni stopu Ti13Nb13Zr o bardzo małym...
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Electrophoretically deposited titanium and its alloys in biomedical engineering: Recent progress and remaining challenges
PublikacjaOver the past decade, titanium implants have gained popularity as the number of performed implantation operations has significantly increased. There are a number of methods for modifying the surface of biomaterials, which are aimed at extending the life of titanium implants. The developments in this field in recent years have required a comprehensive discussion of all the properties of electrophoretically deposited coatings on...
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Anticancer imidazoacridinone C-1311 inhibits hypoxia-inducible factor-1α (HIF-1α), vascular endothelial growth factor (VEGF) and angiogenesis
PublikacjaAntitumor imidazoacridinone C-1311 is a DNA-reactive topoisomerase II and FLT3 receptor tyrosine kinase inhibitor. Here, we demonstrate the mechanism of C-1311 inhibitory action on novel targets: hypoxia-inducible factor-1α (HIF-1α), vascular-endothelial growth factor (VEGF), and angiogenesis. In a cell-free system, C-1311 prevented HIF-1α binding to an oligonucleotide encompassing a canonical hypoxia-responsive element (HRE),...
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Adenocarcinoma, metastatic, NOS - Female, 76 - Tissue image [4080730010643691]
Dane BadawczeThis is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: VS200 Olympus slide scanner (20x magnification) and saved to DICOM format.