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Search results for: immunoglobulin-like domain
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Zastosowanie metody galwanostatycznej do wyznaczania błędu fazy elektrod woltamperometrycznych
PublicationW pracy przeanalizowano właściwości metrologiczne elektrod woltamperometrycznych w dziedzinie częstotliwości. Wykazano, że w przypadku, gdy reakcja elektrochemiczna kontrolowana jest procesem transportu jonów, elektroda woltamperometryczna zachowuje się tak jak przetwornik pomiarowy I rzędu. Jej właściwości metrologiczne opisane są przez czułość, częstotliwość graniczną, błąd amplitudy i błąd fazy. Przeprowadzona analiza pokazała,...
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EMISJA AKUSTYCZNA JAKO SYGNAŁ DIAGNOSTYCZNY ODWZOROWUJĄCY ZMĘCZENIOWE ZUŻYCIE WARSTW ŚLIZGOWYCH PANWI ŁOŻYSK GŁÓWNYCH I KORBOWYCH SILNIKÓW O ZAPŁONIE SAMOCZYNNYM
PublicationW artykule przedstawiono wyniki badań laboratoryjnych, z których wynika, że emisja akustyczna (EA) może być uznana za sygnał diagnostyczny, przydatny do identyfikacji stanu technicznego łożysk głównych i korbowych okrętowych silników o zapłonie samoczynnym. Wykazano w nim bowiem, że parametry emisji akustycznej takie jak: czas rejestracji, energia sygnału, amplituda sygnału, ilość przekroczeń poziomu dyskryminacji, czas narastania,...
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Study of Metrological Properties of Voltammetric Electrodes in the Time Domain
PublicationMetrological properties of voltammetric electrodes, in the situation where on their surface an electrochemical reaction of oxidizing/reduction takes place, were analyzed in this chapter. The properties of electrodes on which a reaction controlled by ion transport process takes place were taken into consideration. Also, it was analyzed how the electrode’s shape and the voltage polarizing the electrode influence this electrode’s...
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IT Business Standards as an Ontology Domain
PublicationThe aim of this paper is to report a selection of Semantic Web aspects pertaining to ontology development activities in the domain of the IT business standard (TOGAF 9) such as formulating competency questions, conceptualization of the domain, resolution of the source knowledge deficiency and applying common design patterns in the OWL formalization. Authors also try to determine target groups that may benefit from such ontology...
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Structure and evolution of the 4-helix bundle domain of Zuotin, a J-domain protein co-chaperone of Hsp70
PublicationThe J-domain protein Zuotin is a multi-domain eukaryotic Hsp70 co-chaperone. Though it is primarily ribosome-associated, positioned at the exit of the 60S subunit tunnel where it promotes folding of nascent polypeptide chains, Zuotin also has off-ribosome functions. Domains of Zuotin needed for 60S association and interaction with Hsp70 are conserved in eukaryotes. However, whether the 4-helix bundle (4HB) domain is conserved remains...
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Multi-domain and Context-Aware Recommendations Using Contextual Ontological User Profile
PublicationRecommender Systems (RS) became popular tools in many Web services like Netflix, Amazon, or YouTube, because they help a~user to avoid an information overload problem. One of the types of RS are Context-Aware RS (CARS) which exploit contextual information to provide more adequate recommendations. Cross-Domain RS (CDRS) were created as a response to the data sparsity problem which occurs when only few users can provide reviews or...
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An analysis of domain-based ship collision risk parameters
PublicationAccording to a lot of contemporary research on ship collision avoidance the classic approach parameters – distance at closest point of approach (DCPA) and time to the closest point of approach (TCPA) – are not sufficient for estimating ship collision risk and for planning evasive manoeuvres. Consequently new measures are introduced, often utilizing the concept of a ship domain. Their drawback, up to this point, was the lack of...
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Assessing Word Difficulty for Quiz-Like Game
PublicationMappings verification is a laborious task. Our research aims at providing a framework for manual verification of mappings using crowdsourcing approach. For this purpose we plan on implementing a quiz like game. For this purpose the mappings have to be evaluated in terms of difficulty to better present texts in respect of game levels. In this paper we present an algorithm for assessing word difficulty. Three approaches...
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Laplace domain BEM for anisotropic transient elastodynamics
PublicationIn this paper, we describe Laplace domain boundary element method (BEM) for transient dynamic problems of three-dimensional finite homogeneous anisotropic linearly elastic solids. The employed boundary integral equations for displacements are regularized using the static traction fundamental solution. Modified integral expressions for the dynamic parts of anisotropic fundamental solutions and their first derivatives are obtained....
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Defining a novel domain that provides an essential contribution to site-specific interaction of Rep protein with DNA
PublicationAn essential feature of replication initiation proteins is their ability to bind to DNA. In this work, we describe a new domain that contributes to a replication initiator sequence-specific interaction with DNA. Applying biochemical assays and structure prediction methods coupled with DNA–protein crosslinking, mass spectrometry, and construction and analysis of mutant proteins, we identified that the replication initiator of the...
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A Framework of a Ship Domain-based Collision Alert System
PublicationThe paper presents a framework of a planned ship collision alert system. The envisaged system is compliant with IMO Resolution MSC.252 (83) “Adoption of the revised performance standards for Integrated Navigation Systems (INS)”. It is based on a ship domain-oriented approach to collision risk and introduces a policy of alerts on dangerous situations. The alerts will include cautions, warnings and alarms, which will be triggered...
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Influence of the Square Wave Voltage on Dynamical Properties of a Flat Voltammetric Electrode in the Time Domain by the Electrochemical Reversible Reaction
PublicationIn this article there is a presentation of the analysis of the polarizing voltage shape influencing dynamic properties of voltammetric electrodes when on their surface reversible reaction takes place in the time domain. The electrode polarization with linearly increasing voltage and with a square component, was analyzed. The analysis that were conducted showed that the voltammetric electrode behaves like a first order transducer....
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Propeller-Like Chirality of Methyl-Tris (2,6-diisopropylphenoxy)Silylsulfide
PublicationTwo new methylsilylsulfides are synthesized. Propeller-like chirality is described for triaryloxysilanethiol and its methyl derivative. S-methylation of the silanethiol lowers the overall symmetry of the unit cell.
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Two-step mechanism of J-domain action in driving Hsp70 function
PublicationJ-domain proteins (JDPs), obligatory Hsp70 cochaperones, play critical roles in protein homeostasis. They promote key allosteric transitions that stabilize Hsp70 interaction with substrate polypeptides upon hydrolysis of its bound ATP. Although a recent crystal structure revealed the physical mode of interaction between a J-domain and an Hsp70, the structural and dynamic consequences of J-domain action once bound and how Hsp70s...
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Domain Reduction in Hybrid Technique for Electromagnetic Wave Scattering Problems
PublicationThis paper proposes a combination of the field matching technique, finite element method and generalized impedance matrix, the main idea of which is to reduce the computational domain by surrounding a scatterer with the smallest convex shape and applying the field matching technique. This approach can be applied for arbitrary shaped scatterers and types of materials and allows for the reduction of the computational domain. In order...
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OSC - domain oriented ontology creation system
PublicationOntologies are, as part of semantic web, a basic component to enrich content available in the Internet with a meaning understandable for computers. In this publication an architecture and functionality of a domain oriented web portal for collaborative creation and storage of ontologies is presented. The system is being created by Gdańsk University of Technology Electronics, Telecommunications and Informatics faculty's Department...
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Chirp-rate estimation of FM signals in the time-frequency domain
PublicationNovel dynamic representations of a complex signal in the time-frequency domain including: a channelized instantaneous complex frequency (CICF), a complex local group delay (CLGD) and a channelized instantaneous chirp-rate (CICR) are introduced. The proposed approach is based on the use of the gradient of the short-time Fourier transform complex phase. An interpretation of the newly-introduced distributions especially of the CICR...
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Sinusoidal Alternating-Current Voltammetry and Metrological Properties of a Flat Voltammetric Electrode in the Time Domain
PublicationIn this paper there were analyzed metrological properties of a flat electrode used to mark ions with the method of sinusoidal alternating-current voltammetry in the situation where on its surface an electrochemical reversible reaction of oxidizing / reduction takes place. The result of the analysis conducted is that such a voltammetric electrode functions like a converter type I. Metrological properties of such an electrode in...
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Long‐time scale simulations of virus‐like particles from three human‐norovirus strains
PublicationThe dynamics of the virus like particles (VLPs) corresponding to the GII.4 Houston, GII.2 SMV, and GI.1 Norwalk strains of human noroviruses (HuNoV) that cause gastroenteritis was investigated by means of long-time (about 30 μs in the laboratory timescale) molecular dynamics simulations with the coarse-grained UNRES force field. The main motion of VLP units turned out to be the bending at the junction between the P1 subdomain (that...
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Two-dimensional hydrogen-like atom in a weak magnetic field
PublicationWe consider a non-relativistic two-dimensional (2D) hydrogen-like atom in a weak, static, uniform magnetic field perpendicular to the atomic plane. Within the framework of the Rayleigh-Schr¨odinger perturbation theory, using the Sturmian expansion of the generalized radial Coulomb Green function, we derive explicit analytical expressions for corrections to an arbitrary planar hydrogenic bound-state energy level, up to the fourth...
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Improvement of Fingerprinting Method based on Hill Cipher by using Frequency Domain
PublicationThe main goal of this paper is to present the advantages of a digital fingerprinting in a frequency domain over a pixel domain, in case of VoD services (Video on Demand). The paper presents basic issues of a multimedia data protection by digital fingerprinting. It also describes threats to embedded fingerprints from both collusion attacks and from a transmission itself. Possible solution was presented on the example of the DCT...
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The noncanonical disulfide bond as the important stabilizing element of the immunoglobulin fold of the Dr fimbrial DraE subunit
PublicationAdhezyny fimbrialne bakterii patogennych stanowią liniowe asocjaty białkowe odpowiedzialne za wiązanie do specyficznych receptorów na powierzchni komórek gospodarza. Biogeneza tych struktur odbywa się przez system sekrecji typu chaperone/usher zakonserwowany pośród bakterii Gram-ujemnych. Powyższe struktury adhezyjne charakteryzują się wysoką odpornością na denaturację i deasocjację, powodowane przez temperaturę lub chemiczne czynniki...
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Dimensionality-Reduced Antenna Modeling with Stochastically Established Constrained Domain
PublicationOver the recent years, surrogate modeling methods have become increasingly widespread in the design of contemporary antenna systems. On the one hand, it is associated with a growing awareness of numerical optimization, instrumental in achieving high-performance structures. On the other hand, considerable computational expenses incurred by massive full-wave electromagnetic (EM) analyses, routinely employed as a major design tool,...
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Two-Stage Variable-Fidelity Modeling of Antennas with Domain Confinement
PublicationSurrogate modeling has become the method of choice in solving an increasing number of antenna design tasks, especially those involving expensive full-wave electromagnetic (EM) simulations. Notwithstanding, the curse of dimensionality considerably affects conventional metamodeling methods, and their capability to efficiently handle nonlinear antenna characteristics over broad ranges of the system parameters is limited. Performance-driven...
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TIME- AND FREQUENCY-DOMAIN QUASI-2D SMALL-SIGNAL MOSFET MODELS
PublicationA novel approach to small-signal MOSFET modeling is presented in this book. As a result, time- and frequency-domain physics-based quasi-2D NQS four-terminal small-signal MOSFET models are proposed. The time-domain model provides the background to a novel DIBL-included quasi‑2D NQS four-terminal frequency-domain small-signal MOSFET model. Parameters and electrical quantities of the frequency-domain model are described by explicit...
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Analysis of Reconstituted Tripartite Complex Supports Avidity-based Recruitment of Hsp70 by Substrate Bound J-domain Protein
PublicationHsp70 are ubiquitous, versatile molecular chaperones that cyclically interact with substrate protein(s). The initial step requires synergistic interaction of a substrate and a J-domain protein (JDP) cochaperone, via its J-domain, with Hsp70 to stimulate hydrolysis of its bound ATP. This hydrolysis drives conformational changes in Hsp70 that stabilize substrate binding. However, because of the transient nature of substrate and JDP...
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Preparation and Characterization of Diamond-like Carbon Coatings for Biomedical Applications—A Review
PublicationDiamond-like carbon (DLC) films are generally used in biomedical applications, mainly because of their tribological and chemical properties that prevent the release of substrate ions, extend the life cycle of the material, and promote cell growth. The unique properties of the coating depend on the ratio of the sp3/sp2 phases, where the sp2 phase provides coatings with a low coefficient of friction and good electrical conductivity,...
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Low-Cost Behavioral Modeling of Antennas by Dimensionality Reduction and Domain Confinement
PublicationBehavioral modeling has been rising in importance in modern antenna design. It is primarily employed to diminish the computational cost of procedures involving massive full-wave electromagnetic (EM) simulations. Cheaper alternative offer surrogate models, yet, setting up data-driven surrogates is impeded by, among others, the curse of dimensionality. This article introduces a novel approach to reduced-cost surrogate modeling of...
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Time-Domain Description of Point-Source Acoustic Wavefields as a Useful Approach in Ultrasonic Techniques
PublicationIn traditional acoustics, field problems are usually treated in the frequency domain, broadband fields being reduced to superposition of harmonic spectrum components. However, this approach is inherently acausal and it is known that in case of arbitrary signals, the distribution-based, time-domain description can be more effective. The present paper is an attempt to expand the time-domain linear systems formalism onto space problems...
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Time-domain description of point-source acoustic wavefields as a useful approach in ultrasonic techniques
PublicationIn traditional acoustics, field problems are usually treated in the frequency domain, broadband fields being reduced to superposition of harmonic spectrum components. However, this approach is inherently acausal and it is known that in case of arbitrary signals, the distribution-based, time-domain description can be more effective. The present paper is an attempt to expand the time-domain linear systems formalism onto space problems...
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Ship domain applied to determining distances for collision avoidance manoeuvres in give-way situations
PublicationShip domain is often used in marine navigation and marine traffic engineering as a safety condition. The basic idea behind those applications is that an encounter of two or more ships can be considered safe if neither of ship domains is intruded by other ships. Research utilising this approach has been documented in numerous works, including publications on optimising collision avoidance manoeuvres performed to fulfil domain-based...
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A ship domain-based model of collision risk for near-miss detection and Collision Alert Systems
PublicationThe paper presents a new model of ship collision risk, which utilises a ship domain concept and the related domain-based collision risk parameters. An encounter is here described by five variables representing: degree of domain violation (DDV), relative speed of the two vessels, combination of the vessels’ courses, arena violations and encounter complexity. As for the first three variables, their values can be directly computed...
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A Hyperdense Semantic Domain for Discontinuous Behavior in Physical System Models
PublicationMultiple time models have been proposed for the formalization of hybrid dynamic system behavior. The superdense notion of time is a well-known time model for describing event-based systems where several events can occur simultaneously. Hyperreals provide a domain for defining the semantics of hybrid models that is elegantly aligned with first principles in physics. This paper discusses the value of both time models and shows how...
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Distributed Inter-Domain Link Capacity Optimization for Inter-Domain IP/MPLS Routing
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Comparison of backscattered sea bottom echo modelling in the acoustic pressure domain and in the intensity domain
PublicationPrzedstawiono dwie metody modelowania rozpraszania wstecznego na dnie morskim: modelowania ciśnienia akustycznego opartego na aproksymacji Kirchhoffa oraz modelowania natężenia echa przy założeniu dominacji rozpraszania niekoherentnego. Porównano i przedyskutowano wyniki w odniesieniu do problemu poszukiwania jak najwłaściwszego opisu zjawiska rozpraszania sygnału akustycznego na dnie.
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Advancements in Diamond-Like Carbon Coatings
PublicationAn essential resource for engineers and scientists in the coatings field, providing an in-depth examination of current and advanced technologies for industrially oriented nanoceramic and nanocomposite coatings
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Multi-objective antenna design by means of sequential domain patching
PublicationA simple yet robust methodology for rapid multiobjective design optimization of antenna structures has been presented. The key component of our approach is sequential domain patching of the design space which is a stencil-based search that aims at creating a path that connects the extreme Pareto-optimal designs, obtained by means of single-objective optimization runs. The patching process yields the initial approximation of the...
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Time domain model of the resonance-based electromagnetic pulses emission system
PublicationIn the literature, the emission properties of the electromagnetic field pulse systems based on high voltage antennas (HVR) have been widely described. In order to increase the emission efficiency by extending duration and increasing amplitude of the impulse it is possible to use a resonance system tuned to the parameters of the signal shaped in the pulse forming circuit. The synthesis of a time-domain simulation model of a complex...
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Relativistic two-dimensional hydrogen-like atom in a weak magnetic field
PublicationA two-dimensional (2D) hydrogen-like atom with a relativistic Dirac electron, placed in a weak, static, uniform magnetic field perpendicular to the atomic plane, is considered. Closed forms of the first- and second-order Zeeman corrections to energy levels are calculated analytically, within the framework of the Rayleigh–Schrödinger perturbation theory, for an arbitrary electronic bound state. The second-order calculations are...
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Swapping Space for Time: An Alternative to Time-Domain Interferometry
PublicationYoung's double-slit experiment [1] requires two waves produced simultaneously at two different points in space. In quantum mechanics the waves correspond to a single quantum object, even as complex as a big molecule. An interference is present as long as one cannot tell for sure which slit is chosen by the object. The more we know about the path, the worse the interference. In the paper we show that quantum mechanics allows for...
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Application of Ontology In the ITIL Domain
PublicationBusiness standards tend to be less formal in description then strict technical norms. Authors of this chapter suggest applying ontological description (powered by the capabilities of the OWL language) to express Information Technology Infrastructure Library (ITIL). One of the goals of this initial study is to determine the usefulness of such semantic model in organizations that adopted or plan to adopt ITIL.
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Hybrid Technique for the EM Scattering Analysis with the Use of Ring Domain Decomposition
PublicationA hybrid technique combining finite-element and mode-matching methods for the analysis of scattering problems in open space is presented here. The main idea is based on impedance matrix descriptions of the boundary surrounding the discrete computational domain and combine it with external field described analytically. The discrete analysis, which is the most time- and memory-consuming, is limited here only to the close proximity...
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A Ship Domain-Based Method of Determining Action Distances for Evasive Manoeuvres in Stand-On Situations
PublicationA ship encounter can be considered safe if neither of ships’ domains (defined areas around ships) is intruded by other ships. Published research on this includes optimising collision avoidancemanoeuvres fulfilling domain-based safety conditions.However, until recently there was no method, using ship’s domain to determine exact moment when a particular collision avoidance manoeuvre can still be successfully performed. The authors...
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Finite-difference time-domain analyses of active cloaking for electrically-large objects
PublicationInvisibility cloaking devices constitute a unique and potentially disruptive technology, but only if they can work over broad bandwidths for electrically-large objects. So far, the only known scheme that allows for broadband scattering cancellation from an electrically-large object is based on an active implementation where electric and magnetic sources are deployed over a surface surrounding the object, but whose ‘switching on’...
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Analytical Expression for the Time-Domain Green's Function of a Discrete Plane Wave Propagating in the 3-D FDTD Grid
PublicationIn this paper, a closed-form expression for the time-domain dyadic Green’s function of a discrete plane wave (DPW) propagating in a 3-D finite-difference time-domain (FDTD) grid is derived. In order to verify our findings, the time-domain implementation of the DPW-injection technique is developed with the use of the derived expression for 3-D total-field/scattered-field (TFSF) FDTD simulations. This implementation requires computations...
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Analytical Expression for the Time-Domain Discrete Green's Function of a Plane Wave Propagating in the 2-D FDTD Grid
PublicationIn this letter, a new closed-form expression for the time-domain discrete Green's function (DGF) of a plane wave propagating in the 2-D finite-difference time-domain (FDTD) grid is derived. For the sake of its verification, the time-domain implementation of the analytic field propagator (AFP) technique was developed for the plane wave injection in 2-D total-field/scattered-field (TFSF) FDTD simulations. Such an implementation of...
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A novel method of local chirp-rate estimation of LFM chirp signals in the time-frequency domain
PublicationIn the paper, novel dynamic representations of a complex signal in the time-frequency domain are introduced. The proposed approach is based on using the gradient of the short-time Fourier transform complex phase. A channelized instantaneous complex frequency (CICF) and a complex local group delay (CLGD) are included in the presented signal representations. An application of the newly-introduced distributions is demonstrated by...
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Toxoplasma gondii: Usefulness of ROP1 recombinant antigen in an immunoglobulin G avidity assay for diagnosis of acute toxoplasmosis in humans
PublicationWyniki zawarte w niniejszej pracy pokazują, iż antygen rekombinantowy ROP1 Toxoplasma gondii może być użyteczny w wykrywaniu wczesnej fazy toksoplazmozy z zastosowaniem testu oznaczania awidności przeciwciał klasy IgG. W przeprowadzonych badaniach wykazano, że specyficzne przeciwciała o niskiej awidności były wykrywane w surowicach pacjentów z wczesną fazą choroby, natomiast przeciwciała o wysokiej awidności lub ich brak notowano...
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Toxoplasma gondii: Recombinant GRA5 antigen for detection of immunoglobulin G antibodies using enzyme-linked immunosorbent assay
PublicationW publikacji po raz pierwszy oszacowano przydatność diagnostyczną antygenu rekombinantowego GRA5 Toxoplasma gondii do serodiagnostyki toksoplazmozy u ludzi. Do celu wykorzystano pulę surowic pochodzącą od 189 pacjentów chorych na toksoplazmozę wczesną, podostrą i przewlekłą oraz od 31 pacjentów zdrowych , które testowano z wykorzystaniem metody ELISA. Specyficzne przeciwciała anty-GRA5 klasy IgG wykryto w 70,9% surowic seropozytywnych....
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Usefulness of Toxoplasma gondii recombinant antigens (GRA1, GRA7 and SAG1) in an immunoglobulin G avidity test for the serodiagnosis of toxoplasmosis
PublicationOpisano wykorzystanie mieszanki trzech antygenów rekombinantowych (GRA1, GRA7 i SAG1) Toxoplasma gondii w serodiagnostyce toksoplazmozy z wykorzystaniem oznaczenia awidności przeciwciał klasy IgG. Zastosowana mieszanka może z powodzeniem zastąpić całkowity lizat antygenów natywnych który obecnie stosowany jest w komercyjnie dostępnych zestawach. Ponadto wykazano, że zastosowane antgeny rekombinantowe różnicują fazy choroby lepiej...