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Search results for: LIP
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Novel Biodegradable Potato Starch-based Compositions as Candidates in Packaging Industry, Safe for Marine Environment
PublicationAbout 70 % of our planet’s surface is covered by seas and oceans to which even 10 million tons of waste go every year. It makes these places the largest global landfills, containing up to 90 % of plastic waste. In this article we present the results of research on novel starch-based compositions expected to be more safe for the marine environment. For these purpose biopolymers such as, thermoplastic starch (TPS), polylactide (PLA)...
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The Influence of PEG on Morphology of Polyurethane Tissue Scaffold
PublicationIn this study, polyurethanes (PU) were synthesized from oligomeric dihydroxy(etylene-butylene adipate), poly(ethylene glycol) (PEG), hexamethylene diisocyanate (HDI), 1,4-butanediol (BDO) as chain extender and stannous octoate as catalyst. PEG due to its hydrophilic character influences physical and chemical properties of PU. For testing were used PU having the following weigh contents of PEG: 0%, 7%, and 14%. Porous scaffolds...
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Encapsulation of Amikacin into Microparticles Based on Low-Molecular-Weight Poly(lactic acid) and Poly(lactic acid-co-polyethylene glycol)
PublicationThe aim of this study was to fabricate novel microparticles (MPs) for efficient and long-term delivery of amikacin (AMI). The emulsification method proposed for encapsulating AMI employed low-molecular-weight poly(lactic acid) (PLA) and poly(lactic acid-co-polyethylene glycol) (PLA−PEG), both supplemented with poly(vinyl alcohol) (PVA). The diameters of the particles obtained were determined as less than 30 μm. Based on an in-vitro...
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Structure determination of UL49.5 transmembrane protein from bovine herpesvirus 1 by NMR spectroscopy and molecular dynamics
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Akademia Muzyczna im. Karola Lipińskiego we Wrocławiu
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Monocyte Chemoattractant Protein-Induced Protein 1 (MCPIP1) Enhances Angiogenic and Cardiomyogenic Potential of Murine Bone Marrow-Derived Mesenchymal Stem Cells
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Intra- and intersubunit changes accompanying thermal activation of the HtrA2(Omi) protease homotrimer
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The LA Loop as an Important Regulatory Element of the HtrA (DegP) Protease from Escherichia coli
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Temperature-induced changes of HtrA2(Omi) protease activity and structure
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Slurry Surfacing Mixes on the Basis of Bitumen Modified with Phenol-Cresol-Formaldehyde Resin
PublicationSlow-breaking monophase cationic bitumen emulsions have been produced on the basis of bitumen modified with phenol-cresol-formaldehyde resin (PhCR-F). Bitumen emulsions were used as a binder for thin-layer coatings with slurry surfacing mixes (SSM). Physical and technical parameters of modified and unmodified emulsions were determined and analyzed. The optimal compositions of SSM were selected according to the breaking criterion....
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Polyurethane porous scaffolds (PPS) for soft tissue regenerative medicine applications
PublicationTissue engineering requires suitable polymeric scaffolds, which act as a physical support for regenerated tissue. A promising candidate might be polyurethane (PUR) scaffold, due to the ease of the PUR properties design, which can be adjusted directly to the intended purpose. In this study, we report a successful fabrication of porous polyurethane scaffolds (PPS) using solvent casting/particulate leaching technique combined with...
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The role of the LB structural loop and its interactions with the PDZ domain of the human HtrA3 protease
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Electrochemical sensing platform based on screen-printed carbon electrode modified with plasma polymerized acrylonitrile nanofilms for determination of bupropion
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Texture or Linker? Competitive Patterning of Receptor Assembly toward Ultra-Sensitive Impedimetric Detection of Viral Species at Gold-Nanotextured Titanium Surfaces
PublicationIn this work, we study the electrodes with a periodic matrix of gold particles pattered by titanium dimples and modified by 3-mercaptopropionic acid (MPA) followed by CD147 receptor grafting for specific impedimetric detection of SARS-CoV-2 viral spike proteins. The synergistic DFT and MM/MD modeling revealed that MPA adsorption geometries on the Au–Ti surface have preferential and stronger binding patterns through the carboxyl...
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Surface-enhanced Raman scattering (SERS) and tip-enhanced Raman scattering (TERS) in label-free characterization of erythrocyte membranes and extracellular vesicles at the nano-scale and molecular level
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Enantioselective sensing of (S)-Thalidomide in blood plasma with a chiral naphthalene diimide derivative
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Valuable natural products from marine and freshwater macroalgae obtained from supercritical fluid extracts
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Investigation of the Effects of Primary Structure Modifications within the RRE Motif on the Conformation of Synthetic Bovine Herpesvirus 1‐Encoded UL49.5 Protein Fragments
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Insightful studies of AuCu nanostructures deposited on Ti platform: Effect of rapid thermal annealing on photoelectrochemical activity supported by synchrotron radiation studies
PublicationIn this work, we present the influence of annealing atmospheres during rapid thermal annealing (40◦C/s) on nanostructured Ti platforms modified by 10 nm layer of AuCu alloy obtained via magnetron sputtering. The AuCu/Ti platform annealed under hydrogen atmosphere exhibits the best photoelectrochemical activity under visible light, i.e. 27 times higher photocurrent than for pure Ti dimpled platform, and the lowest reflectance with minimum...
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Optimization of parallel implementation of UNRES package for coarse‐grained simulations to treat large proteins
PublicationWe report major algorithmic improvements of the UNRES package for physics-based coarse-grained simulations of proteins. These include (i) introduction of interaction lists to optimize computations, (ii) transforming the inertia matrix to a pentadiagonal form to reduce computing and memory requirements, (iii) removing explicit angles and dihedral angles from energy expressions and recoding the most time-consuming energy/force terms...
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Biochemical properties of the HtrA homolog from bacterium Stenotrophomonas maltophilia
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Artificial intelligence for biomedical engineering of polysaccharides: A short overview
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Polymer biodegradable coatings as active substance release systems for urological applications
PublicationCatheter-associated urinary tract infections are the result of catheterization of the bladder. The risk of infection is directly proportional to the length of the bladder catheterization. Bacteria cells have the ability to adhere and create the biofilm on the surface of catheter materials. Bacteria’s biofilm is an extremely beneficial environment of existence for microorganisms. Microorganisms that are an integral part of the biofilm...
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Mechanical Properties of Bio-Composites Based on Epoxy Resin and Nanocellulose Fibres
PublicationThe aim of our research was to investigate the effect of a small nanocellulose (NC) addition on an improvement of the mechanical properties of epoxy composites. A procedure of chemical extraction from pressed lignin was used to obtain nanocellulose fibers. The presence of nanoparticles in the cellulose pulp was confirmed by FTIR/ATR spectra as well as measurement of nanocellulose particle size using a Zetasizer analyzer. Epoxy...
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Bifunctional Opioid/Melanocortin Peptidomimetics for Use in Neuropathic Pain: Variation in the Type and Length of the Linker Connecting the Two Pharmacophores
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Transparent TiO2 nanotubes supporting silver sulfide for photoelectrochemical water splitting
PublicationDifferences between photoelectrochemical and electrochemical activity were thoroughly investigated for the oxygen evolution reaction mediated by Ag2S deposited on two types of ordered titania substrates. Titanium dioxide nanotubes were fabricated by anodization of magnetron sputtered Ti films on ITO-coated glass substrates or directly from Ti foil. Further, Ag2S deposition on the nanotubes was carried out using successive ionic...
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Artificial intelligence for biomedical engineering of polysaccharides: A short overview.
PublicationThe advent of computer-aided concepts and cognitive algorithms, along with fuzzy sets and fuzzy logic thoughts, supported the idea of ‘making computers think like people’ (Lotfi A. Zadeh, IEEE Spectrum, 21 (26–32), 1984). Such a school of thought enabled the sophistication of mission-oriented...
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Polyurethane based hybrid ciprofloxacin-releasing wound dressings designed for skin engineering purpose
PublicationPurpose Even in the 21st century, chronic wounds still pose a major challenge due to potentially inappropriate treatment options, so the latest wound dressings are hybrid systems that enable clinical management, such as a hybrid of hydrogels, antibiotics and polymers. These wound dressings are mainly used for chronic and complex wounds, which can easily be infected by bacteria. Materials and methods Six Composite Porous Matrices...
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Processing of Polyester-Urethane Filament and Characterization of FFF 3D Printed Elastic Porous Structures with Potential in Cancellous Bone Tissue Engineering
PublicationThis paper addresses the potential of self-made polyester-urethane filament as a candidate for Fused Filament Fabrication (FFF)-based 3D printing (3DP) in medical applications. Since the industry does not provide many ready-made solutions of medical-grade polyurethane filaments, we undertook research aimed at presenting the process of thermoplastic polyurethane (TPU) filament formation, detailed characteristics, and 3DP of specially...
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Composite Polyurethane-Polylactide (PUR/PLA) Flexible Filaments for 3D Fused Filament Fabrication (FFF) of Antibacterial Wound Dressings for Skin Regeneration
Publicationhis paper addresses the potential application of flexible thermoplastic polyurethane (TPU) and poly(lactic acid) (PLA) compositions as a material for the production of antibacterial wound dressings using the Fused Filament Fabrication (FFF) 3D printing method. On the market, there are medical-grade polyurethane filaments available, but few of them have properties required for the fabrication of wound dressings, such as flexibility...
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Tailor-Made Polysaccharides for Biomedical Applications
PublicationPolysaccharides (PSAs) are carbohydrate-based macromolecules widely used in the biomedical field, either in their pure form or in blends/nanocomposites with other materials. The relationship between structure, properties, and functions has inspired scientists to design multifunctional PSAs for various biomedical applications by incorporating unique molecular structures and targeted bulk properties. Multiple strategies, such as...
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9,9′-bifluorenylidene derivatives as novel hole-transporting materials for potential photovoltaic applications
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Kinematyka i dynamika maszyn, Wykład, Mechanika i Budowa Maszyn, Inżynierskie, sem3, zima 22/23 (PG_00055380)
e-Learning CoursesZapoznanie studenta z najważniejszymi pojęciami teorii mechanizmów i maszyn. Przeglądu rodzajów mechanizmów. Wprowadzenie pojęć analizy strukturalnej. Prezentacja wybranych metod wyznaczania położeń, prędkości i przyspieszeń. Prezentacja metod dynamiki mechanizmów. Wprowadzenie do zagadnień drgań swobodnych i wymuszonych układów dyskretnych.
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Teoria mechanizmów i dynamika maszyn, W, Mechatronika, Inżynierskie, sem4, lato 21/22 (PG_00008954
e-Learning CoursesZapoznanie studenta z najważniejszymi pojęciami teorii mechanizmów i maszyn. Przeglądu rodzajów mechanizmów. Wprowadzenie pojęć analizy strukturalnej. Prezentacja wybranych metod wyznaczania położeń, prędkości i przyspieszeń. Prezentacja metod dynamiki mechanizmów. Wprowadzenie do zagadnień drgań swobodnych i wymuszonych układów dyskretnych.
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Układy Wieloczłonowe - Wykład, sem.02, zima 22/23 (PG:00057034)
e-Learning CoursesNa wykładzie poruszane są kwestie dynamiki układów brył połączonych przy pomocy węzłów (par kinematycznych). Istotą zagadnienia jest występowanie dużych przemieszczeń i dużych obrotów brył. Prowadzi to do pojawienia się nieliniowości. Dodatkowym utrudnieniem jest pojawienie się przestrzennego ruchu brył, oraz konieczność radzenia sobie z bardzo rozbudowanymi układami elementów. Poszukiwany jest uniwersalny algorytm działań prowadzących...
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Mechanika, ACiR, lato 2021/22, (PG_00047526)
e-Learning CoursesZapoznanie studentów z niezbędną wiedzą dotyczącą modelowanie w mechanice, głównymi pojęciami itwierdzeniami statyki. Wprowadzenie metod modelowania tarcie posuwistego i oporów toczenia. Zapoznaniez relacjami naprężenia- odkształcenia, oraz z pojęciami naprężenia dopuszczalne elementów rozciąganych,ściskanych, zginanych i skręcanych. Prezentacja metod wyznaczania naprężeń oraz linii ugięcia belek,układy statycznie niewyznaczalne....
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Mechanika analityczna, lato 2021/22, PG_00050046
e-Learning CoursesOpis położenia, prędkości i przyspieszenia punktu oraz bryły i układu brył w ruchu dowolnym. Drgania własne i wymuszone układów o 1 i o wielu stopniach swobody. Więzy i ich reakcje, równania więzów. Współrzędne uogólnione. Przemieszczenia przygotowane. Zasada prac przygotowanych. Siły uogólnione. Ogólne równanie dynamiki analitycznej. Zasady mechaniki analitycznej do opisu dynamiki układu punktów i brył w układach z więzami....
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Układy Wieloczłonowe - Wykład, sem.02, zima 23/24 (PG:00057034)
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Kinematyka i dynamika maszyn, Wykład, Mech&Bud.Masz, Inżynierskie, sem3, zima 24/25 (PG_00055380)
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Metody obliczeniowe w dynamice maszyn, W+P, Mechatronika/Mgr, sem.1, lato 22/23, (PG_00057022)
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Mechanika (PG_00047526),W+C, ACiR, sem 4, wiosna, 2023/24
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Układy wieloczłonowe, Wykład, Mechatronika, Magisterskie, sem2, zima 24/25 (PG_00057034)_kopia
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Kinematyka i dynamika maszyn, Wykład, Mechatronika, Inżynierskie, sem3, zima 24/25 (PG_00055405)
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Metody obliczeniowe w dynamice maszyn, Wykład, Mechatronika, Magisterskie, sem1, wiosna 23/24 (PG_00057022)
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Układy wieloczłonowe, Wykład, Mechatronika, Magisterskie, sem2, zima 24/25 (PG_00057034)
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Metody obliczeniowe w dynamice maszyn, W+P, Mechatronika/Mgr, sem.1, lato 21/22, (PG_00057022)
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Kinematyka i dynamika maszyn, Wykład, Mechanika i Budowa Maszyn, Inżynierskie, sem3, zima 23/24 (PG_00055380)
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Kinematyka i dynamika maszyn, Wykład, Mechatronika, Inżynierskie, sem3, zima 23/24 (PG_00055405)
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Dynamics of Oxidative Damage at Early Stages of Estrogen-dependant Carcinogenesis
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Ambulatory blood pressure and long-term risk for atrial fibrillation
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