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Search results for: AD MODELS
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Genetic and pharmacologic proteasome augmentation ameliorates Alzheimer’s-like pathology in mouse and fly APP overexpression models
PublicationThe proteasome has key roles in neuronal proteostasis, including the removal of misfolded and oxidized proteins, presynaptic protein turnover, and synaptic efficacy and plasticity. Proteasome dysfunction is a prominent feature of Alzheimer’s disease (AD). We show that prevention of proteasome dysfunction by genetic manipulation delays mortality, cell death, and cognitive deficits in fly and cell culture AD models. We developed...
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Genetic and pharmacologic proteasome augmentation ameliorates Alzheimer’s-like pathology in mouse and fly APP overexpression models
PublicationThe proteasome has key roles in neuronal proteostasis, including the removal of misfolded and oxidized proteins, presynaptic protein turnover, and synaptic efficacy and plasticity. Proteasome dysfunction is a prominent feature of Alzheimer’s disease (AD). We show that prevention of proteasome dysfunction by genetic manipulation delays mortality, cell death, and cognitive deficits in fly and cell culture AD models. We developed...
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Procognitive activity of nitric oxide inhibitors and donors in animal models
PublicationNitric oxide is a small gaseous molecule that plays important roles in the majority of biological functions. Impairments of NO-related pathways contribute to the majority of neurological disorders, such as Alzheimer’s disease (AD), and mental disorders, such as schizophrenia. Cognitive decline is one of the most serious impairments accompanying both AD and schizophrenia. In the present study, the activities of NO donors, slow (spermine...
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Modifications to the anaerobic digestion model no. 1 (ADM1) for enhanced understanding and application of the anaerobic treatment processes – A comprehensive review
PublicationAnaerobic digestion (AD) is a promising method for the recovery of resources and energy from organic wastes. Correspondingly, AD modelling has also been developed in recent years. The International Water Association (IWA) Anaerobic Digestion Model No. 1 (ADM1) is currently the most commonly used structured AD model. However, as substrates become more complex and our understanding of the AD mechanism grows, both systematic and specific...
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Missing Puzzle Pieces in Dementia Research: HCN Channels and Theta Oscillations
PublicationIncreasing evidence indicates a role of hyperpolarization activated cation (HCN) channels in controlling the resting membrane potential, pacemaker activity, memory formation, sleep, and arousal. Their disfunction may be associated with the development of epilepsy and age-related memory decline. Neuronal hyperexcitability involved in epileptogenesis and EEG desynchronization occur in the course of dementia in human Alzheimer’s Disease...
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Empirical evaluation of reading techniques for UML models inspection
PublicationArtykuł przedstawia eksperyment, w ramach którego porównane zostały trzy techniki czytania (ad hoc, UML-HAZOP oraz podejście scenariuszowe) zastosowane do inspekcji modeli obiektowych. UML-HAZOP jest techniką czytania wywodzącą się z dziedziny systemów krytycznych, związanych z bezpieczeństwem. W publikacji opisano technikę UML-HAZOP oraz jej różne warianty wykorzystane w eksperymencie. Przedstawiono projekt, sposób przeprowadzenia...
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Dynamic fracture of brittle shells in a space-time adaptive isogeometric phase field framework
PublicationPhase field models for fracture prediction gained popularity as the formulation does not require the specification of ad-hoc criteria and no discontinuities are inserted in the body. This work focuses on dynamic crack evolution of brittle shell structures considering large deformations. The energy contributions from in-plane and out-of-plane deformations are separately split into tensile and compressive components and the resulting...
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Keratinocyte-derived small extracellular vesicles supply antigens for CD1a-resticted T cells and promote their type 2 bias in the context of filaggrin insufficiency
PublicationIntroduction: Exosome-enriched small extracellular vesicles (sEVs) are nanosized organelles known to participate in long distance communication between cells, including in the skin. Atopic dermatitis (AD) is a chronic inflammatory skin disease for which filaggrin (FLG) gene mutations are the strongest genetic risk factor. Filaggrin insufficiency affects multiple cellular function, but it is unclear if sEV-mediated cellular communication...
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Integration of natural and artificial intelligence in production systems
PublicationIntegration processes play an increasingly important role in modern economy, and seriously co-decide about the effectiveness of the company. Integration phase occurs in the system life cycle by preceding the final stages of its implementation and activation. In turn, used in software engineering (SE) iteration-evolutionary models, such as spiral model make that the integration activities can occur in varying degrees in all phases...
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SMAQ - A Semantic Model for Analitical Queries
PublicationWhile the Self-Service Business Intelligence (BI) becomes an important part of organizational BI solutions there is a great need for new tools allowing to construct ad-hoc queries by users with various responsibilities and skills. The paper presents a Semantic Model for Analytical Queries – SMAQ allowing to construct queries by users familiar with business events and terms, but being unaware of database or data warehouse concepts...
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Jerzy Konorski dr hab. inż.
PeopleJerzy Konorski received his M. Sc. degree in telecommunications from Gdansk University of Technology, Poland, and his Ph. D. degree in computer science from the Polish Academy of Sciences, Warsaw, Poland. In 2007, he defended his D. Sc. thesis at the Faculty of Electronics, Telecommunications and Informatics, Gdansk University of Technology. He has authored over 150 papers, led scientific projects funded by the European Union,...
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Expedited Metaheuristic-Based Antenna Optimization Using EM Model Resolution Management
PublicationDesign of modern antenna systems heavily relies on numerical opti-mization methods. Their primary purpose is performance improvement by tun-ing of geometry and material parameters of the antenna under study. For relia-bility, the process has to be conducted using full-wave electromagnetic (EM) simulation models, which are associated with sizable computational expendi-tures. The problem is aggravated in the case of global optimization,...
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Theory versus experiment for vacuum Rabi oscillations in lossy cavities. II. Direct test of uniqueness of vacuum
PublicationThe paper continues the analysis of vacuum Rabi oscillations we started in part I [Phys. Rev. A 79, 033836 (2009)]. Here we concentrate on experimental consequences for cavity QED of two different classes of representations of harmonic-oscillator Lie algebras. The zero-temperature master equation, derived in part I for irreducible representations of the algebra, is reformulated in a reducible representation that models electromagnetic...
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Auditory Display Applied to Research in Music and Acoustics . Obrazowanie dźwiękowe w muzyce i akustyce.
PublicationThis paper presents a relationship between Auditory Display (AD) and the domains of music and acoustics. First, some basic notions of the Auditory Display area are shortly outlined. Then, the research trends and system solutions within the fields of music technology, music information retrieval and music recommendation and acoustics that are within the scope of AD are discussed. Finally, an example of AD solution based on gaze...
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Ruting w sieciach sensorowych typu ad hc
PublicationW artykule przedstawiono zagadnienia dotyczące rutingu w nowoczesnych sieciach sensorowych typu ad hoc.Omówiono tematykę rutingu w mobilnych sieciach komputerowych typu ad hoc (podział i opis najbardziej popularnych protokołów rutingu). Scharakteryzowano cechy sieci sensorowych ad hoc i wymagania jakie stawiają procesom rutingu. Przedstawiono czynniki wpływające na wydajność rutingu w nowoczesnej sieci czujników i oceniono przydatność...
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BADANIA SYMULACYJNE SIECI AD HOC Z WIELODOSTĘPEM TDMA
PublicationW referacie przedstawiono budowę i działanie protokołu komunikacji sieci Ad Hoc z wielodostępem TDMA. Zaprezentowano wyniki badań symulacyjnych transmisji w sieci Ad Hoc pracującej w oparciu o ten protokół. Symulowana sieć składa się ze stacji bazowych i terminali ruchomych znajdujących się w samochodach, samolotach i na statkach.
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Ultraszerokopasmowe pomiary odległości w systemie lokalizacyjnym
PublicationW artykule przedstawiono adaptacyjną metodę alokacji strumieni danych w radiowych sieciach ad hoc. Badania skupiono wokół dynamicznej zmiany przepływności w kanale radiowym pomiędzy węzłami wieloskokowej sieci ad hoc. Wyniki pomiarów pozwoliły określić m.in. rzeczywisty czas rekonfiguracji urządzeń, opóźnienia w transmisji danych i zysk uzyskany dzięki użyciu zaproponowanej metody alokacji strumieni danych.
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Implementacja adaptacyjnej metody alokacji strumieni danych w radiowych sieciach ad hoc
PublicationW artykule przedstawiono adaptacyjną metodę alokacji strumieni danych w radiowych sieciach ad hoc. Badania skupiono wokół dynamicznej zmiany przepływności w kanale radiowym pomiędzy węzłami wieloskokowej sieci ad hoc. Wyniki pomiarów pozwoliły określić m.in. rzeczywisty czas rekonfiguracji urządzeń, opóźnienia w transmisji danych i zysk uzyskany dzięki użyciu zaproponowanej metody alokacji strumieni danych.
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Kontrola przekazywania pakietów w mobilnych sieciach ad hoc opartych na rutingu geograficznym
PublicationW pracy opisano zagadnienia rutingu w sieciach mobilnych ad hoc, z szczególnym zwróceniem uwagi na protokoły geograficzne. Pokrótce scharakteryzowano tą grupę oraz zaproponowano rozwiązanie, oparte na koncepcji mechanizmów reputacyjnych, które umożliwia kontrolę niekooperacyjnych zachowań węzłów ze względu na przekazywanie pakietów w sieci mobilnej ad hoc opartej na typowym protokole geograficznym.
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Efekty egoistycznych ataków na poziomie mac w sieciach ad hoc o topologii wieloskokowej
PublicationStacje sieci ad hoc mogą manipulować parametrami dostępu do medium transmisyjnego dla osiągnięcia nienależnie wysokiej jakości usług. Dla środowiska sieci ad hoc o topologii wieloskokowej rozważane są ataki na mechanizmy odłożenia transmisji i klasyfikacji ruchu, przeprowadzane zarówno w stosunku do przepływów źródłowych jak i tranzytowych. Wyniki pozwalają wstępnie ocenić efekty takich ataków oraz skuteczność mechanizmów obronnych.
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Investigating the disease- modifying properties of sclerotiorin in Alzheimer's therapy using acetylcholinesterase inhibition
PublicationAlzheimer's disease (AD) is a progressive neurodegenerative disorder caused due to the damage and loss of neurons in specific brain regions. It is the most common form of dementia observed in older people. The symptoms start with memory loss and gradually cause the inability to speak and do day-to-day activities. The cost of caring for those affected individuals is huge and is probably beyond most developing countries capability....
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Butyrylcholinesterase signal sequence self-aggregates and enhances amyloid fibril formation in vitro
PublicationAlzheimer’s disease (AD) pathogenesis has been attributed to extracellular aggregates of amyloid β (Aβ) plaques and neurofibrillary tangles in the human brain. It has been reported that butyrylcholinesterase (BChE) also accumulates in the brain Aβ plaques in AD. We have previously found that the BChE substitution in 5′UTR caused an in-frame N-terminal extension of 41 amino acids of the BChE signal peptide. The resultant variant...
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Stanowisko do badania adaptacyjnego doboru parametrów interfejsu radiowego sieci ad hoc
PublicationW artykule przedstawiono stanowisko do badania opracowanej metody adaptacyjnej konfiguracji interfejsu radiowego sieci ad hoc. Badania skupiono wokół dynamicznej zmiany przepływności łącza radiowego do komunikacji pomiędzy węzłami w wieloskokowej sieci doraźnej. Wyniki pomiarów umożliwilły określenie m.in. rzeczywistego czasu rekonfiguracji urządzeń, czy opóźnienia transmisji danych. Przedstawiono również badania opracowanej warstwy...
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Stanowisko do badania adaptacyjnego doboru parametrów interfejsu radiowego sieci ad hoc
PublicationW artykule przedstawiono stanowisko do badania opracowanej metody adaptacyjnej konfiguracji interfejsu radiowego sieci ad hoc. Badania skupiono wokół dynamicznej zmiany przepływności łącza radiowego do komunikacji pomiędzy węzłami w wieloskokowej sieci doraźnej. Wyniki pomiarów umożliwilły określenie m.in. rzeczywistego czasu rekonfiguracji urządzeń, czy opóźnienia transmisji danych. Przedstawiono również badania opracowanej warstwy...
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Biochemical assays of intensified methane content in biogas from low-temperature processing of waste activated sludge
PublicationAnaerobic digestion (AD) is implemented as an important ‘waste to energy’ approach for converting organic-rich byproducts such as sewage sludge into biogas and nutrient-rich digestate. Sewage sludge consists of primary sludge and waste activated sludge (WAS), and low biodegradability of WAS limits methane production. This study presents the influence of the low-temperature pretreatment (LT-PT) of WAS on the efficiency of AD. Different...
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Biomass in biogas production: Pretreatment and codigestion
PublicationGlobally, there is increasing awareness that the implementation of ‘waste to energy’ technology is one of the best means to achieve sustainable energy development. The most popular approach is the conversion of organic-rich compounds into clean and renewable products by anaerobic digestion (AD). Biogas can be produced from agricultural residues, municipal/industrial biowastes, and sustainable biomass, especially materials that...
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Neurochemical changes underlying cognitive impairment in olfactory bulbectomized rats and the impact of the mGlu5-positive allosteric modulator CDPPB
PublicationThe olfactory bulbectomized (OBX) rat model is a well-established model of depression in which antidepressant drugs reverse deficits in the passive avoidance test 14 days after administration. Recently, the olfactory bulbectomized rat model has been proposed to be a model of Alzheimer’s disease (AD), and the available data indicate similarities between the changes that typically occur in AD and those observed in OBX animals. In...
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Józef Woźniak prof. dr hab. inż.
PeopleProfessor Józef Woźniak received his M.Sc., Ph.D. and D.Sc. degrees in electronics and telecommunications from the Faculty of Electronics, Gdańsk University of Technology (GUT), Poland, in 1971, 1976 and 1991, respectively. In January 2002 he became a full professor. In 1993 he was elected Associate Dean of the Faculty of Electronics and in 1994 he was he was appointed a Professor at GUT. Simultaneously, from October 1994 till...
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Analiza zagrożeń bezpieczeństwa i rodzajów ataków w bezprzewodowych sieciach Ad hoc
PublicationW referacie przedstawiono opis zagrożeń i słabych punktów pod względem bezpieczeństwa transmisji w sieciach Ad hoc. Opisano również rodzaje ataków w metody wykrywania włamań do tego rodzaju sieci.
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The Impact of Different Drying Methods on the Metabolomic and Lipidomic Profiles of Arthrospira platensis
PublicationDrying is an inseparable part of industrial microalgae production. In this work, the impacts of eight different drying methods on the metabolome and lipidome of Arthrospira platensis were investigated. The studied drying methods were freeze drying (FD), sun drying (SD), air drying at 40 and 75 °C (AD′ and AD″), infrared drying at 40 and 75 °C (IRD′ and IRD″), and vacuum drying at 40 and 75 °C (VD′ and VD″). Results gathered by...
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Ad hoc routing protocols - security objectives, threats and solution
PublicationZaprezentowano przykładowe strategie routingu stosowane w bezprzewodowych sieciach ad-hoc z transmisją wieloetapową. Dokonanao przegladu protokołow routingu, zidentyfikowano podstawowe typy ataków i zagrożenia integralności i poufności transmisji w sieciach bezprzewodowych. Przedstawiono przykładowe rozwiazania algorytmów routingu.
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Data-Centric Dempster-Shafer Theory-Based Selfishness Thwarting via Trust Evaluation in MANETs and WSNs
PublicationPrzedstawiono ramy wymiany informacji reputacyjnej pomiędzy terminalami sieci mobilnej ad hoc lub sensorowej, prowadzące do efektywnej lokalizacji terminali egoistycznych i jednocześnie zapobiegające skutkom fałszywych rekomendacji. Integrację miar zaufania i rekomendacji reputacyjnych oparto na teorii Dempstera-Shafera.
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O07 Filaggrin insufficiency renders keratinocyte-derived small extracellular vesicles capable of affecting CD1a-mediated T-cell responses and promoting allergic inflammation
PublicationThe association between FLG loss-of-function mutations and the development of atopic dermatitis (AD) indicates that filaggrin is critical to skin barrier function; the mutations are also linked to additional allergic manifestations, but it is unknown how the skin may influence inflammation in distant tissues. Here we investigated the impact of filaggrin insufficiency on keratinocyte-derived exosome-enriched small extracellular...
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Specific Binding of Cholesterol to the Amyloid Precursor Protein: Structure of the Complex and Driving Forces Characterized in Molecular Detail
PublicationC99 is the C-terminal membrane-bound fragment of the amyloid precursor protein that is cleaved by γ-secretase to release Aβ peptides, the hallmark of Alzheimer’s disease (AD). Specific interactions of C99 with cholesterol have been proposed to underlie the recognized role of cholesterol in promoting amyloidogenesis. By using molecular dynamics simulations, we studied cholesterol binding to C99 in a lipid bilayer. We determined...
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Wireless LAN with noncooperative anonymous stations: QOS provisioning via war of attrition
PublicationMAC-layer QoS provision necessitates an admission scheme to grant a requested QoS notwithstanding subse-quent requests. For an ad hoc WLAN with anonymous stations, we assume a degree of power awareness to propose a session- rather than frame-level bidding for bandwidth. Next we analyze the underlying Bayesian war of attrition game.
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The Transmission Protocol of Sensor Ad Hoc Networks
PublicationThis paper presents a secure protocol for a radio Ad Hoc sensor network. This network uses the TDMA multiple access method. The transmission rate on the radio channel is 57.6 kbps. The paper presents the construction of frames, types of packets and procedures for the authentication, assignment of time slots available to the node, releasing assigned slots and slots assignment conflict detection.
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Dempster-shafer theory-based trust and selfishness evaluation in mobile ad hoc networks
PublicationThe paper addresses the problem of selfishness detec-tion in mobile ad hoc networks. It describes an approach based on Dempster-Shafer theory of evidence. Special attention is paid to trust evaluation and using it as a metric for coping with (weighted) recommendations from third-party nodes. Efficiency and robustness of the pre-sented solution is discussed with an emphasis on resil-iency to false recommendations.
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The secure transmission protocol of sensor Ad Hoc network
PublicationThe paper presents a secure protocol of radio Ad Hoc sensor network. This network operates based on TDMA multiple access method. Transmission rate on the radio channel is 57.6 kbps. The paper presents the construction of frames, types of packets and procedures for the authentication, assignment of time slots available to the node, releasing assigned slots and slots assignment conflict detection.
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A reactive algorithm for deducing nodal forwarding behavior in a multihop ad-hoc wireless network in the presence of errors
PublicationA novel algorithm is presented to deduce individual nodal forwarding behavior from standard end-to-end acknowledgments. The algorithm is based on a well-established mathematical method and is robust to network related errors and nodal behavior changes. The proposed solution was verified in a network simulation, during which it achieved sound results in a challenging multihop ad-hoc network environment.
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Distributed reputation system for multihop mobile ad hoc networks
PublicationZaproponowano system reputacyjny dla bezprzewodowej sieci rozległej ad hoc, pozwalający stacjm sieci zachować tzw. anonimowość pakietową oraz odróżniać zachowania niekoperacyjne od efektów przeciążenia sieci. Zastosowano generację miar reputacyjnych przy wykorzystaniu mechanizmu lokalnego nasłuchiwania (watchdog). Przeprowadzono symulacyjne badania odporności tego systemu na obecność stacji niewspółpracujących.
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AUDITORY DISPLAY FROM THE MUSIC TECHNOLOGY PERSPECTIVE . Obecność wirtualnego środowiska dźwiękowego w technologiach muzycznych
PublicationThis paper presents some applications of Auditory Displays (AD) in the domain of music technology. First, the scope of music technology and auditory display areas are shortly outlined. Then, the research trends and system solutions within the fields of music technology, music information retrieval and music recommendation are discussed. Finally, an example of an auditory display that facilities music annotation process based on...
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Metryki reputacji w sieciach mobilnych ad hoc
PublicationDla przeciwdziałania niepoprawnym zachownaiom węzłów w sieciach mobilnych ad hoc projektuje się systemy reputacyjne, ściśle współpracujące z mechanizmami routingu i przekazywania pakietów. W pracy przedyskutowano zasady wyznaczania wartości reputacji w kilku znanych systemach. Efekty różnych metod wyznaczania reputacji zilustrowano przy pomocy prostych eksperymentów symulacyjnych.
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Nodal cooperation equilibrium analysis in multi-hop wireless ad hoc networks with a reputation system
PublicationMotivated by the concerns of cooperation security, this work examines selected principles of state-of-the-art reputation systems for multi-hop ad hoc networks and their impact upon optimal strategies for rational nodes. An analytic framework is proposed and used for identification of effective cooperation-enforcement schemes. It is pointed out that optimum rather than high reputation can be expected to be sought by rational nodes.
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Investigation of the influence of capilary effect on operation of the loop heat pipe
PublicationIn the paper presented are studies on the inestigation of the capillary forces effect inducted in the porous structure of a loop heat pipe using water and ethanol ad test fluids. The potential application of such effects is for example in the evaporator of the domestic micro-CHP unit, where the reduction of pumping power could be obtained. Preliminary analysis of the results indicates water as having the best potential for developing...
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Discouraging Traffic Remapping Attacks in Local Ad Hoc Networks
PublicationQuality of Service (QoS) is usually provided in ad hoc networks using a class-based approach which, without dedicated security measures in place, paves the way to various abuses by selfish stations. Such actions include traffic remapping attacks (TRAs), which consist in claiming a higher traffic priority, i.e., false designation of the intrinsic traffic class so that it can be mapped onto a higher-priority class. In practice, TRAs...
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Synthesis and Cholinesterase Inhibitory Activity of N-Phosphorylated /N-Tiophosphorylated Tacrine
PublicationNovel phosphorus and thiophosphorus tacrine derivatives were designed, synthesized and their biological activity and molecular modeling was investigated as a new potential anti-Alzheimer's disease (AD) agents. All new synthesized compound exhibited lower toxicity against neuroblastoma cell line (SH-SY5Y) in comparison with tacrine. Two analogues in the series, 7 and 9, demonstrated lack of cytotoxicity against hepatocellular cells...
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Effective Data-Centric Reputation Systems for MANETs: A Novel Evaluation Framework
PublicationZaprezentowano datacentryczny system reputacyjny dla sieci bezprzewodowej ad hoc z transmisją wieloskokową oraz metodę jego oceny opartą na wskaźniku efektywności. Wskaźnik ten odzwierciedla wymienność pomiędzy odróżnialnością węzłów egoistycznych od pozostałych oraz stopniem wykazywanego przez nie egoizmu. Dla przyjętego modelu sieci przedyskutowano analitycznie znaczenie znajomości tras i metryk reputacyjnych przez węzły.
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Resilient Routing in Communication Networks
PublicationThis important text/reference addresses the latest issues in end-to-end resilient routing in communication networks. The work highlights the main causes of failures of network nodes and links, and presents an overview of resilient routing mechanisms, covering issues related to the Future Internet (FI), wireless mesh networks (WMNs), and vehicular ad-hoc networks (VANETs). For each of these network architectures, a selection of...
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Protokół transmisji sensorowej sieci Ad Hoc
PublicationW referacie zaprezentowano protokół radiowej sieci sensorowej Ad Hoc. Sieć ta pracuje w oparciu o metodę wielodostępu TDMA. Szybkość transmisji w kanale radiowym wynosi 57,6 kb/s. W referacie przedstawiono budowę ramek, rodzaje pakietów oraz procedury przypisania wolnych szczelin czasowych do węzła, zwalniania przypisanych szczelin i wykrywania konfliktów przyporządkowania szczelin.
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Analiza porównawcza wybranych hierarchicznych algorytmów trasowania w sieciach ad hoc
PublicationW referacie przybliżono ogólną zasadę działania algorytmów hierarchicznych stosowanych w sieciach ad hoc. Szczegółowo omówiono dwa hierarchiczne protokoły trasowania: Cluster Based Routing Protocol oraz Zone Routing Protocol. Osobny punkt referatu poświęcono analizie porównawczej obu protokołów. W podsumowaniu przeanalizowano zasadność zastosowania wspomnianych protokołów w Zautomatyzowanym Systemie Radarowego Nadzoru Polskich...