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Search results for: ANTITUMOR DRUGS
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Effect of antitumor compounds on the yeast topoisomerase II relaxation activity
Open Research DataThe datasets contain results of antitumor compounds* (known inhibitors of human topoisomerase alpha II) inhibitory activity against yeast topoisomerase II. DNA topoisomerases (Topo) are enzymes that catalyze changes in the spatial structure of DNA and play an important role in replication, transcription and recombination. Beyond their normal functions,...
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Paracetamol in Friction Ridge Skin Raman Spectra - Paracetamol Reference and from drugs 2023
Open Research DataRaman scatter spectra for paracetamol from different drugs and paracetamol reference.
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Acetaminophen in Friction Ridge Skin Raman Spectra - acetaminophen (paracetamol) Reference and from drugs 2023
Open Research DataRaman spectra for acetaminophen (paracetamol) from different drugs and paracetamol reference.
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Results of modeling of pharmaceuticals mixtures toxicity with deviation ratio and best-fit functions models using Aliivibrio fischeri bacterium as model organism
Open Research DataThe research was concerned with verifying the impact of mixtures of nine pharmaceuticals against a selected organism, i.e., the bacterium Aliivibrio fischeri. A. fisheri is used as a model organism in the monitoring of acute toxicity in environmental and reference samples in Microtox® systems. Tested pharmaceuticals, namely: diclofenac (sodium salt),...
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Involvement of human glutathione S-transferase M1-1 in the glutathione conjugation of the antitumor unsymmetrical bisacridine derivative C-2028.
Open Research DataUnsymmetrical bisacridines (UAs) are a novel potent class of antitumor-active therapeutics. The aim of this study was to investigate the possible role of human glutathione S-transferase M1-1 (hGSTM1-1) in the glutathione (GSH) conjugation of a representative UA, C‑2028.
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Glutathione conjugation of the antitumor-active 1-nitroacridine derivatives compounds C-857 and C-1748 – the major role of glutathione S-transferase M1-1
Open Research DataObjectives: C-857 and C-1748 are antitumor-active agents, monomers of unsymmetrical bisacridine derivatives. The aim of this study was to analyze their glutathione (GSH) conjugation in vitro in the presence of glutathione S-transferase (GST) M1-1.
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Accidents, victims and risk levels on regional roads in pomorskie voivodeship, 2017-2019 - Alcohol and drug accidents
Open Research DataData contain risk classification on regional roads (voivodeship roads) in pomorskie voivodeship in 2017-2019, risk group: Offenders under influence of alcohol or drug - driver or pedestrian. Measures used to assess the level of risk are (5 classes low, low to medium, medium, medium to high, high):
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Detailed results of shaping personnel risk factors in enterprise C
Open Research DataThe data presents the shape of all the researched personnel risk factors in the C enterprise (which was tested by the author). Further considerations should be started with the presentation of the synthesis of the obtained results, which is presented in this research data.
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Detailed results of shaping personnel risk factors in enterprise A
Open Research DataThe data presents the shape of all the researched personnel risk factors in the A enterprise (which was tested by the author). Further considerations should be started with the presentation of the synthesis of the obtained results, which is presented in this research data.
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Results of modeling of pharmaceuticals mixtures toxicity with deviation ratio and best-fit functions models using Saccharomyces cerevisiae yeast as model organism
Open Research DataThe research was concerned with verifying the impact of binary mixtures of nine pharmaceuticals against a selected organism, i.e., the yeast Saccharomyces cerevisiae. S cerevisiae is used as a model organism in the monitoring of endocrine disruptors in environmental and reference samples in Xenometrix® systems - XenoScreen®. Tested pharmaceuticals,...
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Results of pharmaceuticals mixtures toxicity on inhibition of bioluminescence of Vibrio fischeri (Microtox)
Open Research DataThe research was concerned with verifying the impact of mixtures of nine pharmaceuticals against a selected organism, i.e., the bacterium Aliivibrio fischeri. A. fisheri is used as a model organism in the monitoring of acute toxicity in environmental and reference samples in Microtox® systems. Tested pharmaceuticals, namely: diclofenac (sodium salt),...
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The effect of anthraquinone derivatives (C1-C9) on telomerase activity
Open Research DataThe data set contains images of the PCR products obtained from the Telomerase Repeated Amplification Protocol (TRAP). The effect of anthraquinone derivatives (C-C9) on telomerase activity was analyzed using lysates from drug-treatedcancer cell line.
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Near-Infrared III Nanophosphorswith Cr3+Ni2+ Energy Transfer for Bioimaging
Open Research DataIn the biomedical field, the use of fluorescence imaging in the second near-infrared (NIR-II) region is growing rapidly because it imparts the advantages of reduced autofluorescence and low photon scattering. The advantage of reduced scattering is that it increases penetration depth in vivo and improves imaging clarity. Herein, this work uses mesoporous...
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Polyacrylamide substrate viscosity impact on temozolomide activity in glioblastoma cells by flow cytometry and rheological measurements
Open Research DataDataset includes raw data on cell lines LN-229 and LN-18 treated with temozolomide measured by flow cytometry, rheometry and cell projections. It also includes calculations necessary for creation of figures and conclusions based on those figures in the publication titiled: "Substrate viscosity impairs temozolomide-mediated inhibition of glioblastoma...
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Impact of binary mixtures of Irgasan (triclosan) and Diclofenac on endocrine processes of the model organism Saccharomyces Cerevisiae (using XenoScreen YES/YAS test)
Open Research DataThe XenoScreen YES/YAS reagents and methodology is given in Kudłak et al. (2019) and in details in electronic supplementary material.
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Results of the effect of mixtures of ketoprofen with three cations on the germination of Sorghum bicolor (sorghum) seeds
Open Research DataThe research data includes an attempt to verify whether the addition of cations (sodium, ammonium and potassium) at levels found in the environment would affect the toxicity of pharmaceuticals to Sorghum Bicolor grain. Ion concentrations were selected based on studies of water samples collected in water bodies receiving wastewater from wastewater treatment...
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Results of the effect of mixtures of ketoprofen with three anions on the germination of Sorghum bicolor (sorghum) seeds
Open Research DataThe research data includes an attempt to verify whether the addition of anions (bromide, chloride and fluoride) at levels found in the environment would affect the toxicity of pharmaceuticals to Sorghum Bicolor grain. Ion concentrations were selected based on studies of water samples collected in water bodies receiving wastewater from wastewater treatment...
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The effect of pH change of ketoprofen solutions on the germination of Sorghum bicolor (sorghum) seeds
Open Research DataIn these studies, an attempt was also made to determine whether (and, if so, to what extent) the change in pH affects the toxicity of ketoprofen will affect the germination of Sorghum bicolor (sorghum) seeds. As reported by Kudlak B, Wieczerzak M, Yotova G, Tsakovski S, Simeonov V, Namieśnik J (2016) Environmental risk assessment of Polish wastewater...
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The mechanism of internalization study of QDgreen−CD−FA−C−2028 conjugate at IC80 value to cancer (H460, Du-145, and LNCaP) and normal (MRC-5 and PNT1A) cells
Open Research DataThe influence of different endocytosis inhibitors on the internalization of QDgreen−CD−FA−C−2028 conjugate at IC80 value in cancer (H460, Du-145, and LNCaP) and normal (MRC-5 and PNT1A) cells. First, the cells were preincubated with: drug-free medium (no inhibitor), at 4 °C, 5 µM Cytochalasin D, 30 µM Amiloride, 80 µM Dynasore, 25 µM Pitstop 2 and 1.5...
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Clinical situations text database for Polish language
Open Research DataDataset contains a database of anonymized texts in Polish for the purposes of building a medical speech corpus, for clinical situations in the following areas: medical interview, interview and description of the result of an oncological examination, description of a radiological examination, description of a pathomorphological examination, description...
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A set of data constituting the basis for the publication entitled "Mitochondria dysfunction is one of the causes of diclofenac toxicity in the green alga Chlamydomonas reinhardtii"
Open Research DataNon-steroidal anti-inflammatory drugs (NSAIDs), such as diclofenac (DCF), form a significant group of environmental contaminants. When the toxic effects of DCF on plants are analyzed, authors often focus on photosynthesis, whilemitochondrial respiration is usually overlooked. Therefore, an in vivo investigation of plant mitochondria functioning under...