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Search results for: FUSION PROTEIN
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Molecular Dynamics Studies on Amyloidogenic Proteins
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Targeting shelterin proteins for cancer therapy.
PublicationAs a global health challenge, cancer prompts continuous exploration for innovative therapies that are also based on new targets. One promising avenue is targeting the shelterin protein complex, a safeguard for telomeres crucial in preventing DNA damage. The role of shelterin in modulating ataxia- telangiectasia mutated (ATM) and ataxia-telangiectasia and Rad3-related (ATR) kinases, key players in the DNA damage response (DDR),...
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THE ARCHİTECTURE AND FASHİON DESİGN – An Examination of the Relationship between Fashion and Architecture Design in light of Technological Advancements
PublicationThe article focuses on the mutual relationship between two seemingly distant fields of art - architecture and fashion design. It describes a common basis for the process of creating art in the approach to both fashion and architecture. The following considerations, which are based on principles of composition, attempt to reach beyond just the form and analyze also context or perception. The article quotes famous creators and depicts...
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Protein overproduction alters exosome secretion in Chinese hamster ovary cells
PublicationDespite the abundance of available cell lines, nearly 70% of all recombinant therapeutic proteins today are produced in Chi-nese hamster ovary (CHO) cells. The impact of protein overproduction on the secretion of exosomes by CHO cells has been investigated here. Increased secretion of extracellular vesicles (EVs) by protein overexpressing CHO cells was demonstrated with protein content assay, nanoparticle tracking analysis, and...
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What makes a group worth dying for? Identity fusion fosters perception of familial ties, promoting self-sacrifice.
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Fusion of DNA-binding domain of Pyrococcus furiosus ligase with TaqStoffel DNA polymerase as a useful tool in PCR with difficult targets
PublicationThe DNA coding sequence of TaqStoffel polymer- ase was fused with the DNA-binding domain of Pyrococcus furiosus ligase. The resulting novel recombinant gene was cloned and expressed in E. coli. The recombinant enzyme was purified and its enzymatic features were studied. The fusion protein (PfuDBDlig-TaqS) was found to have enhanced processivity as a result of the conversion of the Taq DNA polymerase from a relatively low processive...
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Zeta potential and droplet size of n-tetradecane/ethanol (protein) emulsions
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Two-dimensional gel-based serum protein profile of growing piglets
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Relationship between Milk Protein Polymorphism and Selected Cows’ Reproductive Indices
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DSC and electrophoretic studies on protein denaturation of Anodonta woodiana (Lea, 1834)
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Trial Proteomic Qualitative and Quantitative Analysis of the Protein Matrix of Submandibular Sialoliths
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Riboflavin binding protein—Chiral stationary phase: Investigation of retention mechanism
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The Nutritional Value and Biological Activity of Concentrated Protein Fraction of Potato Juice
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Serum Fatty Acid-Binding Protein 4 is Increased in Patients with Psoriasis
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Survivin DEx3 as a biomarker of thyroid cancers: A study at the mRNA and protein level
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CAVER 3.0: A Tool for the Analysis of Transport Pathways in Dynamic Protein Structures
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BALCONY: an R package for MSA and functional compartments of protein variability analysis
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Myotilin, a New Topotecan Resistant Protein in Ovarian Cancer Cell Lines
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C-reactive protein as a diagnostic and prognostic factor in inflammatory bowel diseases
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TOLLIP Protein Expression Predicts Unfavorable Outcome in Renal Cell Carcinoma
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Functional Protein Composition in Femoral Glands of Sand Lizards (Lacerta agilis)
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Simulation of Protein Structure and Dynamics with the Coarse-Grained UNRES Force Field
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Inhibition of protein glycosylation reverses the MDR phenotype of cancer cell lines
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Blind prediction of homo‐ and hetero‐protein complexes: The CASP13‐CAPRI experiment
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Stability of delay induced oscillations in gene expression of Hes1 protein model
PublicationW pracy prezentowana jest matematyczna analiza modelu ekspresji genu białka Hes1. Rozważamy układ równań z dwoma opóźnieniami - w produkcji białka Hes1 oraz jego mRNA. Dowodzimy istnienia i jednoznaczności oraz nieujemności rozwiązań. Pokazujemy istnienie dokładnie jednego dodatniego stanu stacjonarnego. Wykazujemy, że stabilność stanu stacjonarnego zależy od sumy opóźnień. Podajemy warunek dostateczny na wystąpienie bifurkacji...
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Novel primosomal protein B from thermophilic bacterium Thermoanerobacter tengcongensis
PublicationWe report the identification and characterization of theprimosomal protein B (PriB) from thermophilic bacteriumThermoanerobacter tengcongensis (TtePriB). It is the largestknown bacterial PriB protein consisting 216 amino acidresidues with a calculated molecular mass of 25 kDa. Surprisingly,it is functional as monomer containing two single-stranded DNA binding domain (OB-fold) and it is thecompletely new kind structure of SSB protein....
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Effect of Functionalization of Carbon Nanotubes with Psychosine on Complement Activation and Protein Adsorption
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Water-mediated influence of a crowded environment on internal vibrations of a protein molecule
PublicationThe influence of crowding on the protein inner dynamics is examined by putting a single protein molecule close to one or two neighboring protein molecules. The presence of additional molecules influences the amplitudes of protein fluctuations. Also, a weak dynamical coupling of collective velocities of surface atoms of proteins separated by a layer of water is detected. The possible mechanisms of these phenomena are described....
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Mathematical analysis of a generalised p53-Mdm2 protein gene expression model
PublicationWe propose the generalisation of the p53-Mdm2 protein gene expression model introduced by Monk (2003). We investigate the stability of a unique positive steady state and formulate conditions which guarantee the occurrence of the Hopf bifurcation. We show that oscillatory behaviour can be caused not only by time lag in protein transcription process, but also can be present in the model without time delay. Moreover, we investigate...
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Impact of AlphaFold on structure prediction of protein complexes: The CASP15‐CAPRI experiment
PublicationWe present the results for CAPRI Round 54, the 5th joint CASP-CAPRI protein assembly prediction challenge. The Round offered 37 targets, including 14 homodimers, 3 homo-trimers, 13 heterodimers including 3 antibody–antigen complexes, and 7 large assemblies. On average 70 CASP and CAPRI predictor groups, including more than 20 automatics servers, submitted models for each target. A total of 21 941 models submitted by these groups...
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Evolution towards simplicity in bacterial small heat shock protein system
PublicationEvolution can tinker with multi-protein machines and replace them with simpler single-protein systems performing equivalent functions in an equally efficient manner. It is unclear how, on a molecular level, such simplification can arise. With ancestral reconstruction and biochemical analysis, we have traced the evolution of bacterial small heat shock proteins (sHsp), which help to refold proteins from aggregates using either two...
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A coarse‐grained approach to NMR ‐data‐assisted modeling of protein structures
PublicationThe ESCASA algorithm for analytical estimation of proton positions from coarse-grained geometry developed in our recent work has been implemented in modeling protein structures with the highly coarse-grained UNRES model of polypeptide chains (two sites per residue) and nuclear magnetic resonance (NMR) data. A penalty function with the shape of intersecting gorges was applied to treat ambiguous distance restraints, which automatically...
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Modified Peptide Molecules As Potential Modulators of Shelterin Protein Functions; TRF1
PublicationIn this work, we present studies on relatively new and still not well-explored potential anticancer targets which are shelterin proteins, in particular the TRF1 protein can be blocked by in silico designed "peptidomimetic" molecules. TRF1 interacts directly with the TIN2 protein, and this protein-protein interaction is crucial for the proper functioning of telomere, which could be blocked by our novel modified peptide molecules....
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Changes in mussel Mytilus galloprovincialis protein profile as a reaction of water pollution
PublicationW pracy przedstawiono zmiany w profilu białkowym małża Mytilus galloprovincialis jako odpowiedź na zanieczyszczenia wody. Określono pojemność przeciwutleniającą z wykorzystaniem testu TEAC. Stwierdzono różnice w poziomie inhibicji w białku pochodzącym od małży zebranych z regionów zanieczyszczonych w stosunku do małży pochodzących z regionów czystych.Zawartość cynku i kadmu w białkach małży pochodzących z regionów zanieczyszczonych...
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POLAND European Union
PublicationThe International Society of City and Regional Planners (ISOCARP) took an initiative to illustrate the processes of the spatial development of the member countries in the International Manual of Planning Practice (IMPP). The innovative aspect of this unique source of information is to emphasize the relationship between the planning system and its application in practice. The book consists of a concise synthesis of planning systems...
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Vision guided robot gripping systems
PublicationW rozdziale omawia się robotycki system wykorzystujący kamery streo. System taki zastępuje pracę człowieka przy przenoszeniu obiektów wielkowymiarowych (teoretycznie nieograniczonych) w przestrzeni trójwymiarowej. W rozważaniach uwzględniono pinholową kamerę (bezsoczewkową z bardzo małą aperturą/otworem) oraz prosty model zniekształcenia soczewkowego. Podano wartości poszczególnych parametrów. Zastosowano dwie konwencje notacyjne...
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Fashion communication research: A way ahead
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Digital Fashion Competences: A Longitudinal Study
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Polish Experience of Implementing Vision Zero
PublicationPurpose of Review The aim of this study is to present an outline and the principles of Poland’s road safety strategic programming as it has developed over the last 25 years since the first Integrated Road Safety System with a strong focus on Sweden’s “Vision Zero”. Recent Findings Countries that have successfully improved road safety have done so by following strategies centred around the idea that people are not infallible and...
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Vision-based motion analysis of kitesurfer
PublicationKitesurfing is a relatively recent phenomenon with raising popularity worldwide – a recently developed extreme water sport considered a high-risk injury sport. It combines elements of several other sports, in particular sailing, surfing, windsurfing, wakeboarding, and snowboarding. The main purpose of authors’ research in the present paper is to use a vision system technique for measuring a kitesurfer’s body movements in order...
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New applications of sound and vision engineering
PublicationMultimedia, Sound & Vision Engineering are relatively new fields within the area of science and technology, but teaching and research in this area has been carried out at Gdansk University of Technology (Gdansk, Poland) for nearly 5 decades. Current project carried-out in the Multimedia Systems Department are in the scope of the paper.
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Erosion of privacy in computer vision systems
PublicationW pracy przedstawiono problemy, które mogą wystąpić, gdy technologia komputerowego wzroku zostanie zaimplementowana w urządzeniach wykorzystywanych w codziennym życiu. Przeprowadzono także dyskusję socjologicznych konsekwencji stosowania biometrii, automatycznego śledzenia ruchu i interpretacji obrazu. Omówiono też problemy wynikające z połączenia komputerowego wzroku z możliwościami oferowanymi przez Internet.
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Novel TG‐FGFR1 and TRIM33‐NTRK1 transcript fusions in papillary thyroid carcinoma
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Acetate-Induced Disassembly of Spherical Iron Oxide Nanoparticle Clusters into Monodispersed Core−Shell Structures upon Nanoemulsion Fusion
PublicationIt has been long known that the physical encapsulation of oleic acid-capped iron oxide nanoparticles (OA−IONPs) with the etyltrimethylammonium (CTA+) surfactant induces the formation of spherical iron oxide nanoparticle clusters (IONPCs). However, the behavior and functional properties of IONPCs in chemical reactions have been largely neglected and are still not well-understood. Herein, we report an unconventional ligand-exchange...
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The measurement of conformational stability of proteins adsorbed on siloxanes
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Molecular basis of TRF proteins and their interactions with peptides
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1.21 Computation of Structure, Dynamics, and Thermodynamics of Proteins
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Coarse-Grained Models of Proteins: Theory and Applications
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Computational techniques for efficient conformational sampling of proteins
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Proprotein Convertase Subtilisin/Kexin Type 9, Angiopoietin-Like Protein 8, Sortilin, and Cholesteryl Ester Transfer Protein—Friends of Foes for Psoriatic Patients at the Risk of Developing Cardiometabolic Syndrome?
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