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Search results for: ibuprofen and its metabolites
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An automatic system for identification of random telegraph signal (RTS) noise in noise signals
PublicationIn the paper the automatic and universal system for identification of Random Telegraph Signal (RTS) noise as a non-Gaussian component of the inherent noise signal of semiconductor devices is presented. The system for data acquisition and processing is described. Histograms of the instantaneous values of the noise signals are calculated as the basis for analysis of the noise signal to determine the number of local maxima of histograms...
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Acridinone antitumor agents, C-1305 and C-1299 are metabolized rather by flavin-containing monooxygenases and UDP-glucuronosyltransferases than cytochromes P450
PublicationStwierdzono, że to monooksygenazy flawinowe, a nie enzymy cytochromu P450, są głównymi enzymami frakcji mikrosomalnej, odpowiedzialnymi za detoksyfikacyjny metabolizm dwóch badanych pochodnych triazoloakrydonu. Dodatkowo C-1305 ulega sprzęganiu w czasie drugiej fazy metabolizmu z kwasem glukuronowym do postaci O-glukuronidu
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CTS-Clinical and Translational Science
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ETS Research Report Series
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Phase I and phase II metabolism simulation of antitumor-active 2-hydroxyacridinone with electrochemistry coupled on-line with mass spectrometry.
PublicationHere, we report the metabolic profile and the results of associated metabolic studies of 2-hydroxyacridinone (2-OH-AC), the reference compound for antitumor-active imidazo- and triazoloacridinones. Electrochemistry coupled with mass spectrometry was applied to simulate the general oxidative metabolism of 2-OH-AC for the first time. The reactivity of 2-OH-AC products to biomolecules was also examined. The usefulness of the electrochemistry...
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Topographic AFM imaging of the leaf surface with magnification of details of its morphological structure
Open Research DataTopographic imaging of the leaf surface with magnification of details of its morphological structure. Measurements in semi-contact mode. NTEGRA Prima (NT-MDT) device. NSG 01 probe.
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Marek Kubale prof. dr hab. inż.
PeopleDetails concerning: Qualifications, Experiences, Editorial boards, Ph.D. theses supervised, Books, and Recent articles can be found at http://eti.pg.edu.pl/katedra-algorytmow-i-modelowania-systemow/Marek_KubaleGoogle ScholarSylwetka prof. Marka Kubalego Prof. Marek Kubale pracuje na Wydziale ETI Politechniki Gdańskiej nieprzerwanie od roku 1969. W tym czasie napisał ponad 150 prac naukowych, w tym ponad 40 z listy JCR. Ponadto...
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Estimation of the aluminum salt effect on homopolymerization of acrylamide and its copolymerization with acrylic acid by DSC
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Apoptosis induction in C32 human melanoma cells by Jasione montana and its main phytoconstituents
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In vitro evaluation of the effect of Bidens tripartita extract and its main constituents on the intestine contractility
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Composition of the Essential Oil of Bidens tripartita L. Roots and Its Antibacterial and Antifungal Activities
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Chemometric analysis of UV-Vis spektra of associated forms of Amphotericin B and its derivatives
PublicationPrzedmiotem badań był proces agregacji nowych pochodnych antybiotyku polienowego Amfoterycyny B. Do śledzenia procesu agregacji wykorzystano spektroskopię absorpcyjną w zakresie widzialnym i bliskiego nadfioletu. Zastosowanie zaawansowanych technik chemometrycznych pozwoliło na dogłębną analizę agregacji tych pochodnych, co pozwoliło na wyciągniecie następujacych wniosków: i) w przypadku wszystkich pochodnych przy stężeniach poniżej...
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Empirical Analysis of Forest Penalizing Attribute and Its Enhanced Variations for Android Malware Detection
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Coexpression of human chorionic gonadotropin beta subunit and its receptor in nontrophoblastic gynecological cancer
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Antimicrobial and antioxidant activities of Cinnamomum cassia essential oil and its application in food preservation
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Forced degradation studies of ivabradine and in silico toxicology predictions for its new designated impurities
PublicationAll activities should aim to eliminate genotoxic impurities and/or protect the API againstdegradation. There is a necessity to monitor impurities from all classification groups,hence ivabradine forced degradation studies were performed. Ivabradine was provedto be quite durable active substance, but still new and with insufficient stability data.Increased temperature, acid, base, oxidation reagents and...
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Seasonal differences in the content of phenols and pigments in thalli of freshwater Cladophora glomerata and its habitat
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Revelations About Carotid Body Function Through its Pathological Role in Resistant Hypertension
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Health Risk Assessment of Exposure to Nitrates in Drinking Water Depending on the Source of Its Origin
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Cadmium in edible plants from Silesia, Poland, and its implications for health risk in populations
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Plants of the Genus Terminalia: An Insight on Its Biological Potentials, Pre-Clinical and Clinical Studies
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Sunshine duration and its variability in the main ridge of the Karkonosze Mountains in relation to with atmospheric circulation
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The covalent and non-covalent conjugation of graphene oxide with hydroxycamptothecin in hyperthermia for its anticancer activity
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Gypsum dehydration in cement and its impact on air-void structure in air-entrained concrete
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Potential pitfalls of propofol target controlled infusion delivery related to its pharmacokinetics and pharmacodynamics
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An analysis and evaluation of the WeFold collaborative for protein structure prediction and its pipelines in CASP11 and CASP12
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The effect of the type of substrate and its surface treatment on the pull-off strength of gypsum plasters
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Role of Myeloid-derived suppressor cell (MDSC) in autoimmunity and its potential as a therapeutic target
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Effect of Chitosan Deacetylation on Its Affinity to Type III Collagen: A Molecular Dynamics Study
PublicationThe ability to form strong intermolecular interactions by linear glucosamine polysaccharides with collagen is strictly related to their nonlinear dynamic behavior and hence bio-lubricating features. Type III collagen plays a crucial role in tissue regeneration, and its presence in the articular cartilage affects its bio-technical features. In this study, the molecular dynamics methodology was applied to evaluate the effect of...
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The Role and Importance of a Footbridge Suspended over a Highway in the Opinion of Its Users—Trabzon (Turkey)
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Territorial Extrapolation of Basic Data as a Solution of the Problem of Its Deficiency during Mass Appraisal
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The role of the LB structural loop and its interactions with the PDZ domain of the human HtrA3 protease
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Eveningness and its possibility of predicting burnout symptoms among physicians and nurses – preliminary results
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Associations of ESR1 and ESR2 gene polymorphisms with metabolic syndrome and its components in postmenopausal women
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Solvent effects on fluorescence properties of protochlorophyll and its derivatives with various porphyrin side chains
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Precise regulation of defect concentration in MOF and its influence on photocatalytic overall water splitting
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Nanosized zinc, epigenetic changes and its relationship with DMBA induced breast cancer in rats
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Impact of Euro 2012 on the Pomeranian Region and Its Small and Medium Enterprises in Terms of Competitiveness
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Adaptive Method of Raster Images Compression and Examples of Its Applications in the Transport Telematic Systems
PublicationThe paper presents a concept and exemplary application of an adaptive method of compression of raster images which may be applied, i.a. in ITS systems. The described method allows to improve the efficiency of systems belonging to ITS category, which require transmission of large volumes of image data through telecommunications networks. The concept of the adaptive method of compression of raster images described in the paper uses...
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The potential of historical railway infrastructure, possibilities of its adaptation on the examples of railway water towers
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Dielectric properties of modified graphene oxide filled polyurethane nanocomposites and its correlation with rheology
PublicationThis study aims at investigating the dynamic mechanical, dielectric and rheological properties of reinforced polyurethane (PU) nanocomposites containing hydrophilic graphene oxide (GO) and/or hydrophobic modified graphene oxide (mGO) sheets. The organic modification of GO was performed with 4,4′-methylenebis (phenyl isocyanate) (MDI) and the samples were prepared by solvent mixing. We found that addition of mGO provides a more...
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User-generated images and its impact on consumer-based brand equity and on purchase intention
PublicationResearchers and brand managers have limited knowledge of the effects that different types of user-generated content (UGC) have on consumers’ perception of brands and behavior. In this study we investigated 301 authors of a specific category of UGC, i.e., user-generated images (UGI) on a social networking site to confirm the relationships of four drivers reported in literature (co-creation, empowerment, community, and self-concept)...
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BIODIVERSITY OF YEASTS ISOLATED FROM CAVES OF THE POLISH TATRA MOUNTAINS, AND ITS BIOTECHNOLOGICAL POTENTIAL
PublicationMost of the Earth’s biosphere is permanently or periodically exposed to temperatures below 5°C. Cold habitats harbor a wide diversity of psychrophiles. For many years Antarctica has been the geographic area preferred for studying the diversity and properties of cold-adapted microorganisms. However, the non-Antarctic habitats like Himalayas or Alps are also extensively explored. The Tatra Mountains are Europe’s second-highest massif...
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Expression of Deinococcus geothermalis Trehalose Synthase Gene in Escherichia coli and Its Enzymatic Properties
PublicationA novel trehalose synthase gene from Deinococcus geothermalis (DSMZ 11300) containing 1,692 bp reading-frame encoding 564 amino acids was amplified using PCR. The gene was ligated into pET30Ek/LIC vector and expressed after isopropyl alfa-D-thiogalactopyranoside induction in Escherichia coli BL21(DE3)pLysS. The recombinant trehalose synthase (DgeoTreS) containing a His6 tag at the C-terminus was purified by metal affinity chromatography...
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Investigation of Noise-Induced Instabilities in Quantitative BiologicalSpectroscopy and Its Implications for Noninvasive Glucose Monitoring
PublicationPrzedstawiono sposób oceny błędów jakie pojawiają się przy estymacji poziomu glukozy we krwi za pomocą pomiarów widm Ramana. Zastosowano nieliniowy algorytm regresji według maszyny wektorów nośnych. Określono jak na wyznaczenie stężenia glukozy we krwi wpływają błędy pomiarów widmach Ramana oraz błędów pomiaru referencyjnego stężenia glukozy podczas etapu kalibracji modelu (etapu uczenia algorytmu maszyny wektorów nośnych). Określono...
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A method of supporting client-provider cooperation in software acquisition processes and its evaluation criteria
PublicationArtykuł przedstawia metodę Wspomagania Interakcji KLienta i Dostawcy Oprogramowania (WIKLIDO). Metoda ta została zpowodzeniem zastosowana w dwóch studiach przypadków w komercyjnych projektach pozyskiwania oprogramowania. Artykuł wyjaśnia w jaki sposób metoda wykorzystuje środki modelowania do usystematyzowania interakcji pomiędzy klientem i dostawcą oprogramowania. Przedstawia również w jaki sposób wykorzystano podejście GQM (ang....
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Salt stress vs. salt shock - the case of sugar beet and its halophytic ancestor
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Electrophoretically deposited titanium and its alloys in biomedical engineering: Recent progress and remaining challenges
PublicationOver the past decade, titanium implants have gained popularity as the number of performed implantation operations has significantly increased. There are a number of methods for modifying the surface of biomaterials, which are aimed at extending the life of titanium implants. The developments in this field in recent years have required a comprehensive discussion of all the properties of electrophoretically deposited coatings on...
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Influence of Surface Laser Treatment on Mechanical Properties and Residual Stresses of Titanium and its Alloys
PublicationSurface modification of the titanium and its alloys used in implantology with a long-pulse laser can change the surface topography, but it also leads to changes in the stress sign and magnitude in the resulting subsurface layer. The presented research was aimed at evaluating the state of stress after laser remelting with the Nd:YAG laser of pre-etched titanium alloys Ti6Al4V and Ti13Nb13Zr and pure titanium. The obtained surface...
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The critical rotational speed of circular saw: simple measurement method and its practical implementations.
PublicationProducenci pił tarczowych są zobligowani do podawania ich dopuszczalnych prędkości obrotowych. Jednakże, umieszczane przez nich prędkości na piłach są często bliskie prędkościom krytycznym lub je przewyższają. Przecinanie takimi narzędziami może być więc niebezpieczne dla obsługującego. Praca przedstawia prostą metodologię wyznaczania prędkości obrotowych krytycznych pił tarczowych. Badania były prowadzone z wykorzystaniem technik...