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Search results for: axonal regrowth
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Antitumor Activity of Triazine Mimic Antibiotics for DNA-binding Implications (Impressive Activity in Vitro Against a Variety of Tumor Types in the NCI-60 Screen): NSC 710607 To Fight HCT-116 Human Colon Carcinoma Cell Lines in Vivo Using the Hollow Fiber Assay and Xenograft Mouse Models
PublicationPurpose Successful clinical applications of DNA-directed selective cytotoxic agents disrupt the vital replication/transcription processes and ultimately lead to cancer cell death. This study aimed to examine the growth screen of two lead triazine compounds in a number of cell lines and xenografts and to develop anticancer agents with noncovalent binding affinity bringing fewer side effects. Methods The NCI initial hollow...
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Chemical and biological characterization of Ocimum basilicum L. phenolic extract and essential oil derived through ultrasound and microwave-assisted extraction techniques
PublicationPlant-derived bioactive molecules are increasingly utilized in food processing as natural additives, driven by a growing interest in healthier lifestyles. This trend has spurred industries to reformulate products to meet the demands of health-conscious consumers. This study investigates the phenolic extract and essential oil of O. basilicum L. obtained via ultrasound-assisted extraction and microwave-assisted extraction, respectively. Characterization...
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RAGE as a Novel Biomarker for Prostate Cancer: A Systematic Review and Meta-Analysis
PublicationThe receptor for advanced glycation end-products (RAGE) has been implicated in driving prostate cancer (PCa) growth, aggression, and metastasis through the fueling of chronic inflammation in the tumor microenvironment. This systematic review and meta-analysis summarizes and analyzes the current clinical and preclinical data to provide insight into the relationships among RAGE levels and PCa, cancer grade, and molecular effects....
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Acid-aided epoxy-amine curing reaction as reflected in epoxy/Fe3O4 nanocomposites: Chemistry, mechanism, and fracture behavior
PublicationThis work seeks to answer the question whether or not the presence of acid functional groups accelerate epoxyamine curing reaction. Epoxy/Fe3O4 nanocomposite was considered as a case, where discussions are based on chemistry, mechanism behind curing reactions and fracture behavior influenced by acid assistance to crosslinking. Fe3O4 magnetic nanoparticles (MNPs) with nanosilica decorative layer (B-MNP) were synthesized and subsequently...
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Thriving in multicultural workplace
PublicationThriving at work is defined as the psychological state that links both a sense of vitality and learning. The vitality component of thriving may be seen as positive energy, while learning enhances a sense of competence and efficacy. Thriving sheds new light on individual psychological functioning and the experience of growth in the work context. Thriving at work promotes growth through playing an active role in interaction with...
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Natural fish oil improves the differentiation and maturation of oligodendrocyte precursor cells to oligodendrocytes in vitro after interaction with the blood–brain barrier
PublicationThe blood–brain barrier (BBB) tightly controls the microenvironment of the central nervous system (CNS) to allow neurons to function properly. Additionally, emerging studies point to the beneficial effect of natural oils affecting a wide variety of physiological and pathological processes in the human body. In this study, using an in vitro model of the BBB, we tested the influence of natural fish oil mixture (FOM) vs. borage oil...
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Enhanced Visible Light Active WO3 Thin Films Toward Air Purification: Effect of the Synthesis Conditions
PublicationTaking into consideration, our current environmental situation in the world people should face with growing problem of air and water pollution. Heterogeneous photocatalysis is highly promising tool to improve both, air and water quality through decomposition/mineralization of contaminations directly into harmless CO2 and H2O under ambient conditions. In this contribution we focused on the synthesis of self-assembly WO3 thin films...
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Transport deficiency is the molecular basis of Candida albicans resistance to antifungal oligopeptides
Publication(FMDP), an inhibitor of glucosamine-6-phosphate synthase, exhibited growth inhibitory activity against Candida albicans, with minimal inhibitory concentration values in the 0.05–50 mg/L range. Uptake by the peptide permeases was found to be the main factor limiting an anticandidal activity of these compounds. Di- and tripeptide containing FMDP (F2 and F3) were transported by Ptr2p/Ptr22p peptide transporters (PTR) and FMDP-containing...
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Reprezentation of mechanic hysteresis in a railway track using the Preisach model
PublicationThis paper presents an implementation of the classic scalar Preisach model to describe the hysteresis phenomenon created in a railway track subjected to lateral (in the horizontal plane) displacements. The principles of the Preisach theory and the scalar mathematical model of the mechanical hysteresis that is based on statistically distributed modified hysteresis operators are briefly presented. This article presents the characteristic...
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Stabilizing forces in trapezoidal sheeting used as a part of the bracing system
PublicationIn the analysis of bracing systems imperfections of the restrained elements should be considered. According to EC3 this effect can be calculated by means of the equivalent stabilizing force, which replaces (in simplified way) initial bow imperfection of the braced element. However, alternative suggestions of the equivalent stabilizing force calculations can be also found in the literature. In this paper segment of the pitched roof...
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Density functional LCAO calculations of vibrational modes and phonon density of states in the strained single-layer phosphorene
PublicationThe paper presents an investigation of phosphorene under axial strain on the phonon density of states and vibrational modes. The studies were performed by means of density functional theory (DFT) within the linear combination of atomic orbitals (LCAO). The strained models were constructed using optimised supercell techniques. The vibrational mode spectra were estimated for strains applied for both the zigzag and armchair directions...
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Edgewise Compressive Behavior of Composite Structural Insulated Panels with Magnesium Oxide Board Facings
PublicationEdgewise compression response of a composite structural insulated panel (CSIP) with magnesium oxide board facings was investigated. The discussed CSIP is a novel multifunctional sandwich panel introduced to the housing industry as a part of the wall, floor, and roof assemblies. The study aims to propose a computational tool for reliable prediction of failure modes of CSIPs subjected to concentric and eccentric axial loads. An advanced...
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Stabilizing forces in trapezoidal sheeting used as a part of the bracing system
PublicationIn the analysis of bracing systems imperfections of the restrained elements should be considered. According to EC3 this effect can be calculated by means of the equivalent stabilizing force, which replaces (in simplified way) initial bow imperfection of the braced element. However, alternative suggestions of the equivalent stabilizing force calculations can be also found in the literature. In this paper segment of the pitched roof...
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The role of investments in economic development
PublicationIn the modern world, one may observe diversification of economies of given countries. Many of them, considered to be less developed,are aspiring to diminish the gap between them and well developed countries, one of such countries is Poland, which is trying hard to boots its competitive position in the worldwide market and achieve the constant and well-balanced development. It can be attained by building knowledge economy. Therefore,...
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Can Grand Design Doctrines Go Well with Locally Reinvented Urbanisms? Notes from Polish Cities in Transition
PublicationThe text explores how New Urbanism ideas, a comprehensive global design doctrine, transgress into the context of Polish planning practice. New Urbanism is considered through the perspective of the decentralization of a discussion on a planning policy and a modernization of a State, resulting form its post-Socialist urban change. In the text, New Urbanism is understood as a neotraditionalist movement i.e. drawing from the pre-modernist...
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Zachowania przedsiębiorcze a otoczenie instytucjonalne - mechanizmy
PublicationIn this paper the ways in which entrepreneurial behaviour is manifested in insti-tutional contexts of different quality is presented. Taken the assumption of Baumol that the supply of entrepreneurs in each economy is constant, and that there are changes in the share of productive and unproductive entrepreneurship in this supply, it is emphasized that the quality of institutional framework determines the outco-mes of entrepreneurship...
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Mobility Management Solutions for IP Networks Comparative Analysis of IP-based Mobility Protocols and Handover Algorithms Invited Paper
PublicationA rapid growth of IP-based networks and services hascreated a vast collection of resources and functionalities availableto users by means of a uniform method of access offered by the IPprotocol. At the same time, advances in the design of mobileelectronic devices allowed them to reach a utility levelcomparable to desktop computers, while still retaining theirmobility advantage. Unfortunately, the base IP protocol does notperform...
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Integration of inertial sensors and GPS system data for underwater navigation
PublicationThe Inertial Navigation System (INS) is usually employed to determine the position of an underwater vehicles, like Remotely Operated Vehicles (ROV) and, more recently, Autonomous Underwater Vehicle (AUV). The accuracy of the position provided by the INS, which uses accelerometers and gyroscopes, deteriorates with time. An external aiding sources such as the Global Positioning System (GPS) can be employed to reduce the error growth...
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The influence of applying supplementary web plates on structural joint moment resistance and rotational stiffness
PublicationContinual trend to simplify structural elements and find less time-consuming solutions on construction site as well as inevitable increase in labour costs determine for instance elimination of those technological steps that are difficult to automation. Welding additional reinforcements and web stiffeners is a great example of such a step. The method presented in EN 1993-1-8 [8] is a result of long-term studies focused on calculating...
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Influence of Wood Moisture on Strength and Elastic Modulus for Pine and Fir Wood Subjected to 4-point Bending Tests
PublicationThe main purpose of this research paper was to determine the influence of the wood moisture on the strength and elastic modulus of pine and fir wood specimens subjected to the 4-point bending tests. Six bending tests for each wood species and for two different moisture level have been performed. Then, the advanced statistical analysis of the results has been carried out. On the basis of the obtained results, it has been noted that...
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The Creation of an Antimicrobial Coating on Contact Lenses by The Use of Nanocopper
PublicationThe aim of the research was to creation an antimicrobial coating on contact lens and examine the ability of copper nanoparticles to decrease microbial adhesion and prevent the growth of bacteria. The creation was based on the immersion method in solution with dispersed nanoparticles of copper at concentration 200 pm. There were evaluated follows factors: time of immersion and base to dispersed nanoparticles. Three solutions: ethyl...
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Au nanoparticles identifiction with the use of AFM Volta potential mapping
Open Research DataThe specific physical, chemical and electrochemical electrical properties of gold nanoparticles have led to their extensive use as high-performance chemical and biochemical sensors. The described properties relate to surface plasmon resonance, fluorescence quenching or enhancement, high electrical conductivity and light scattering. The described nanoparticles...
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“Shadow” vs. “Phase 3D” method within endoscopic examinations of marine engines
PublicationA visual investigation of surfaces creating internal, working spaces of marine combustion engines by means of specialized view-finders so called endoscopes is at present almost a basic method of technical diag-nostics. The surface structure of constructional material is visible during investigations like through the magnifying glass (usually with a precisely determined magnification), which makes possible a detection, recognition...
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Wireless Networks as an Infrastructure for Mission-Critical Business Applications
PublicationDespite the dynamic growth of wireless network systems, their pres-ence in business-support infrastructure has been limited. In the article we provide an overview of generic corporate network architecture and examine usefulness of available wireless network solutions in such systems. Following this overview we analyze new wireless network architecture which currently undergoes standardization process - wireless mesh. It can result...
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3D polypyrrole structures as a sensing material for glucose detection
PublicationIn this work, 3D polypyrrole (PPy) structures as material for glucose detection is proposed. Polypyrrole was electrochemically polymerized on platinum screen-printed electrode from an aqueous solution of lithium perchlorate and pyrrole. The growth mechanism of such PPy structures was studied by ex-situ scanning electron microscopy. Preliminary studies show that studied here PPy film is a good candidate as a sensing material for...
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Global value chains, wages, employment and labour production in China: A regional approach
PublicationIn this study we analyse the relationship of trade and global value chains (GVCs) to the labour market in 31 Chinese provinces for 25 sectors, by means of a system of structural equations. We firstly distinguish between provincial value chains (PVCs) and interprovincial value chains (PRVCs) in order to outline their distribution and evolution over time. Then, we investigate to what extent participation in GVCs, PVCs and PRVCs –...
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Digitalization and digital skills development patterns. Evidence for European countries
PublicationThis chapter contextualizes the digitalization process and the digital skills concept. It discusses the very process of technology diffusion, emphasizing several unique features of digital technologies that make them globally available. Next, it turns to the digital skills concept, clarifying how and why they reshape the societal and economic landscape. It also briefly addresses the digital divide and skill-biased technological...
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Antifungal Activity of Homoaconitate and Homoisocitrate Analogs
PublicationThirteen structural analogs of two initial intermediates of the L-alpha-aminoadipate pathway of L-lysine biosynthesis in fungi have been designed and synthesized, including fluoro- and epoxy-derivatives of homoaconitate and homoisocitrate. Some of the obtainedcompounds exhibited at milimolar range moderate enzyme inhibitory properties against homoaconitase and/or homoisocitrate dehydrogenase of Candida albicans. The structural...
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The Impact of EU Funds on the Development of Business Environment Institutions – Research Results in Pomeranian Voivodeship in Poland
PublicationThe paper presents the main findings of the research conducted to assess the impact of EU funds on development of business environment infrastructure in Pomeranian Voivodeship in Poland, and – indirectly – on the growth of the innovation capacity of Pomeranian entrepreneurs. The research shows that support of ROP PV 2007-2013 contributed to the creation of multifunctional business infrastructure throughout the Pomorskie Voivodship,...
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Influence of pitting corrosion on fatigue and corrosion fatigue of ship and offshore structures. Part II: Load - pit crack interaction
PublicationIn the paper has been discussed influence of stresses on general corrosion rate and corrosion pit nucleation and growth rate, whose presence has been questioned by some authors but accepted by most of them. Influence of pit walls roughness on fatigue life of a plate suffering pit corrosion and presence of so called "non damaging" pits which never lead to initiation of fatigue crack, has been presented. Possibility of prediction...
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Performance analysis of mobility protocols and handover algorithms for IP-based networks
PublicationA rapid growth of IP-based networks and services has created the vast collection of resources and functionality available to users by means of a universal method of access - an IP protocol. At the same time, advances in design of mobile electronic devices have allowed them to reach utility level comparable to stationary, desktop computers, while still retaining their mobility advantage. Following this trend multiple extensions...
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Antifungal dipeptides incorporating an inhibitor of homoserine dehydrogenase
PublicationThe antifungal activity of 5‐hydroxy‐4‐oxo‐L‐norvaline (HONV), exhibited under conditions mimicking human serum, may be improved upon incorporation of this amino acid into a dipeptide structure. Several HONV‐containing dipeptides inhibited growth of human pathogenic yeasts of the Candida genus in the RPMI‐1640 medium, with minimal inhibitory concentration values in the 32 to 64 μg mL−1 range. This activity was not affected by multidrug...
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Spatial Evolution of the European Container Ports’ System in Perspective of the Location Theory
PublicationThe maritime container terminal is nowadays a spatially incoherent object. From the functional point of view it ends, where their most external components are located. The process of location splitting of container terminals is a new phase of their discrete growth. The external container facilities are being built to improve effectivness of the logistic chain in the hinterland. The new components of container terminals have very...
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Polyurethanes as a Potential Medical-Grade Filament for Use in Fused Deposition Modeling 3D Printers – a Brief Review
PublicationThe possibility of using 3D printing technology (3DP) in medical field is a kind of revolution in health care. This has contributed to a rapid growth in demand for 3D printers, whose systems and materials are adapted to strict medical requirements. In this paper, we report a brief review of polyurethanes as a potential medical-grade filament for use in Fused Deposition Modeling (FDM) 3D printer technology. The advantages of polyurethanes...
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Fractional Calculus Evaluation of Hyaluronic Acid Crosslinking in a Nanoscopic Part of Articular Cartilage Model System
PublicationThis work presents a study of the mechanism of physical crosslinking of hyaluronic acid in the presence of common phospholipids in synovial joint organ systems. Molecular dynamic simulations have been executed to understand the formation of hyaluronan networks at various phospholipid concentrations. The results of the simulations suggest that the mechanisms exhibit subdiffusion characteristics. Transportation quantities derive...
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PUBLIC SOURCES OF FINANCE FOR CULTURE AS AN ELEMENT OF CULTURAL SECURITY IN POLAND
PublicationCulture is an important element of the country, playing an important role both for its security and the economy. It cannot be only seen as a cost-creating sector, but may be a significant factor in economic development. For this to happen, it is necessary to create a system of financing this economic sector. This article’s aim is to analyze the use of funds from public sources in Poland to finance culture-related activities. The...
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Corrosion Study of Ceria Protective Layer Deposited by Spray Pyrolysis on Steel Interconnects
PublicationSingle fuel cells and electrolysis cells are assembled into stacks using interconnects in order to increase power and gas production capacity. The most common choice for the interconnect material is stainless steel. It has good electrical and mechanical properties and is also cost effective. One of the problems when using steel is the formation of a thermally grown oxide scale during use which has a lower electrical conductivity...
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Czynniki wzrostu zatrudnienia w mikro przedsiębiorstwach – czy chcieć znaczy móc?
PublicationDotychczasowe badania nad wzrostem małych i średnich przedsiębiorstw, prowadzone od wielu lat zarówno na świecie jak i w Polsce nie przyniosły odpowiedzi na pytanie jakie czynniki na to zjawisko wpływają. W artykule przedstawiono pokrótce podejścia badawcze wykorzystywane w badaniu czynników wzrostu. W oparciu o przeprowadzone w 2009 i 2012 roku badania panelowe w Województwie Pomorskim, przeanalizowano wpływ czynników związanych...
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Effect of bio-polyol molecular weight on the structure and properties of polyurethane-polyisocyanurate (PUR-PIR) foams
PublicationThe increasing interest in polyurethane materials has raised the question of the environmental impact of these materials. For this reason, the scientists aim to find an extremely difficult balance between new material technologies and sustainable development. This work attempts to validate the possibility of replacing petrochemical polyols with previously synthesized bio-polyols and their impact on the structure and properties...
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Assestment of the anti-cancer activity of the copper complexes with imidazole and pivalato ligands
PublicationDespite the development of science and technology progress so far there have not been found effective drugs for cancer. Many coordination compounds were investigated due to their antitumor potential. The most known cis-diamminedichloroplatinum(II) is used as anti-cancer therapeutic agent. The copper complexes are the coordination compounds possessing anti-tumour properties. Their capability to kill cancer cells is mainly linked...
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Electrical characterization of diamond/boron doped diamond nanostructures for use in harsh environment applications
PublicationThe polycrystalline boron doped diamond (BDD) shows stable electrical properties and high tolerance for harsh environments (e.g. high temperature or aggressive chemical compounds) comparing to other materials used in semiconductor devices. In this study authors have designed electronic devices fabricated from non-intentionally (NiD) films and highly boron doped diamond structures. Presented semiconductor devices consist of highly...
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The relationship between standard reduction potentials of catechins and biological activities involved in redox control
PublicationRedox homeostasis involves factors that ensure proper function of cells. The excess reactive oxygen species (ROS) leads to oxidative stress and increased risk of oxidative damage to cellular components. In contrast, upon reductive stress, insufficient ROS abundance may result in faulty cell signalling. It may be expected that dietary antioxidants, depending on their standard reduction potentials (E°), will affect both scenarios....
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Influence of B/N co-doping on electrical and photoluminescence properties of CVD grown homoepitaxial diamond films
PublicationBoron doped diamond (BDD) has great potential in electrical, and electrochemical sensing applications. The growth parameters, substrates, and synthesis method play a vital role in the preparation of semiconducting BDD to metallic BDD. Doping of other elements along with boron (B) into diamond demonstrated improved efficacy of B doping and exceptional properties. In the present study, B and nitrogen (N) co-doped diamond has been...
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Impact response of novel layered two stage fibrous composite slabs with different support type
PublicationThe performance of novel Layered Two Stage Fibrous Composite slabs (LTSFC) was pioneered under falling mass collisions using a combined experimental and numerical study. Such LTSFC slabs consist of three layers with and without the insertion of glass fibre mesh between the layers. LTSFC techniques were used to fabricate the composite slabs with three layers including 3%, 1.5%, and 3% of fibre content for the top, middle, and...
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Heavy metal accumulation and distribution in Phragmites australis seedlings tissues originating from natural and urban catchment
PublicationThe retention of heavy metal (HM) was studied in root and rhizomes (BLG), stems (ST), and leaves (LF) of Phragmites australis (common reed) seedlings collected from different locations, differing in the scale of anthropogenic interference. The analysis includes the reference samples of sediments in uncontaminated lake Garczonki and contaminated roadside ditch in Cieplewo. The concentrations of Zn, Cu, Pb, Cd, Ni, and Cr were analyzed...
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Stability evaluation of the marine propulsion unit mechanical system bymeans of vibrations measurements and their analysis.
PublicationIn paper selected issues concerning vibration diagnosis of the mechanical system within marine propulsion units have been given. The analysis of vibration parameters was carried out on the basis of experimental examinations of a real object in which an exceedance of the allowable vibration's level had been observed. In the beginning, the vibration apparatus being on laboratory equipment of the Department of Ship Power Plants of...
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Stability evaluation of the marine propulsion unit's mechanical system by means of vibration measurements and their analysis
PublicationIn this paper selected issues concerning vibration diagnosis of the mechanical system within marine propulsion units have been given. The analysis of vibration parameters was carried out on the basis of experimental examinations of a real object in which an exceedance of the allowable vibration's level had been observed. In the beginning, the vibration apparatus being on laboratory equipment of the Department of Ship Power Plants...
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The effect of macro polymer fibres length and content on the fibre reinforced concrete
PublicationThe paper presents studies of a ready-mix concrete containing polymer fibres of three different lengths: 24, 38 and 54 mm. The performed tests allowed to determine the effect of fibre volume fraction and length on the concrete strength. The basic parameters of concrete mixture (consistency, air content and bulk density) were identified. Fibre reinforced concrete belongs to a group of composite materials. The polymer fibres are...
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A Geometrically Simple Compact Wideband Circularly Polarized Antenna
PublicationA compact broadband wide-slot circular polarization (CP) antenna is proposed. An inverted L-shape parasitic strip at the open end of a microstrip line extension and a slot modification is applied to attain wideband CP. The advantage of this technique is simplicity which makes it readily re-designable for different frequency bands. To demonstrate the concept, three designs working at different frequencies are obtained. The redesign...
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Parametric Study on a Performance of a Small Counter-Rotating Wind Turbine
PublicationA small Counter-Rotating Wind Turbine (CRWT) has been proposed and its performancehas been investigated numerically. Results of a parametric study have been presented in this paper.As parameters, the axial distance between rotors and a tip speed ratio of each rotor have been selected.Performance parameters have been compared with reference to a Single Rotor Wind Turbine (SRWT).Simulations were carried out with Computational Fluids...