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Search results for: PARP-1
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Journal of Experimental Zoology Part A-Ecological and Integrative Physiology
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Journal of Neurological Surgery Part B-Skull Base
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Energy Sources Part B-Economics Planning and Policy
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SURFACE COATINGS INTERNATIONAL PART B-COATINGS TRANSACTIONS
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Rocznik Muzeum "Górnośląski Park Etnograficzny w Chorzowie"
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Navigator-Subsidios para a Historia Maritima do Brasil
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Journal of Experimental Zoology Part A-Ecological Genetics and Physiology
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TRANSPORTATION RESEARCH PART E-LOGISTICS AND TRANSPORTATION REVIEW
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Energy Sources Part A-Recovery Utilization and Environmental Effects
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Structural Evolution and Effect of the Neighboring Cation on the Photoluminescence of Sr(LiAl 3 ) 1− x (SiMg 3 ) x N 4 :Eu 2+ Phosphors
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Spectrofluorometrical Determination of Vitamin B 1 in Different Matrices Using Box‐Behnken Designed Pipette Tip Solid Phase Extraction by a Carbon Nanotube Sorbent
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Selektywne chłodzenie mózgu noworodka po Niedotlenieniu okołoporodowym. Część 1. Medyczne fakty oraz przegląd dostępnych rozwiązań systemów selektywnego chłodzenia mózgu
PublicationMózg ludzki jest organem delikatnym, dlatego tak ważne jest zadbanie o to, aby już w momencie przyjścia na świat noworodek miał zapewnioną, w razie konieczności możliwość minimalizacji uszkodzeń neurologicznych, spowodowanych niedotlenieniem okołoporodowym. Niedotlenienie to w dramatyczny sposób zaburza homeostazę mózgu, który jako organ najbardziej energochłonny potrzebuje najwięcej tlenu. Zapoczątkowane brakiem tlenu procesy...
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Dendron to Central Core S1–S1 and S2–Sn (n>1) Energy Transfers in Artificial Special Pairs Containing Dendrimers with Limited Numbers of Conformations
PublicationTwo dendrimers consisting of a cofacial free-base bisporphyrin held by a biphenylene spacer and functionalized with 4-benzeneoxomethane (5-(4-benzene)tri-10,15,20-(4-n-octylbenzene)zinc(II)porphyrin) using either five or six of the six available meso-positions, have been synthesized and characterized as models for the antenna effect in Photosystems I and II. The presence of the short linkers, -CH2O-, and long C8H17 soluble side...
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OPINIA NAUKOWO-TECHNICZNA Południowa Obwodnica Gdańska Ocena rozwiązań konstrukcyjnych elementów posadowienia Estakady WE-1 w ciągu Południowej Obwodnicy Gdańska.
PublicationPrzedmiotem opracowania jest ocena rozwiązań konstrukcyjnych oraz analiza wyników badań statycznych i testów dynamicznych nośności pali prefabrykowanych w podporach Estakady WE-1.
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<p>Potential effects of microbial air quality on the number of new cases of diabetes type 1 in children in two regions of Poland: a pilot study</p>
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Seeking the Factors Predisposing to Local Skin Inflammatory State Development in Children with Type 1 Diabetes (T1DM) Treated with Continuous Subcutaneous Insulin Infusion (CSII)
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Incidence trends for childhood type 1 diabetes in Europe during 1989–2003 and predicted new cases 2005–20: a multicentre prospective registration study
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Comparative field test for measurement of PM10 dust in atmospheric air using gravimetric (reference) method and b-absorption method (Eberline FH 62-1)
PublicationThe paper presents the results of a field test carried out in Gdansk region between 01-01-2010 and 31-12-2010 in order to demonstrate equivalence of the Eberline FH 62-1 sampler to the reference gravimetric method of suspended PM10 dust measurement. The differences in PM10 dust concentration provided by both methods have been discussed for different seasons of the year. A method of estimation of the correction factors/correction...
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Induction of G2/M phase arrest and apoptosis of human pancreatic cancer BxPC-3 cells by potenet antitumor 1-nitroacridine derivative C-1748
PublicationPancreatic ductal adenocarcinoma (PDA) is among the most lethal human cancers, in part because it is insensitive to many chemotherapeutic drugs. Gemcitabine still remains the best chemotherapeutic agent available for the treatment of advanced pancreatic cancer. However, gemcitabine treatment results in only a marginal survival advantage. Thus, there is a strong need for the continuous development of novel therapeutic agents...
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Identification of 1H‐indene‐(1, 3, 5, 6)‐tetrol derivatives as potent pancreatic lipase inhibitors using molecular docking and molecular dynamics approach
PublicationPancreatic lipase is a potential therapeutic target to treat diet-induced obesity in humans, as obesity-related diseases continue to be a global problem. Despite intensive research on finding potential inhibitors, very few compounds have been introduced to clinical studies. In this work, new chemical scaffold 1H-indene-(1,3,5,6)-tetrol was proposed using knowledge-based approach, and 36 inhibitors were derived by modifying its...
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Risk factors for chronic kidney disease do not influence the serum levels of asymmetric dimethylarginine in HIV-1-infected patients without significant renal disease
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The acid strength of the HClO4/n(AlF3) and HClO4/n(SbF5) (n = 1–3) Lewis–Brønsted superacids containing the excess of the Lewis acid component
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In Vitro Effect of 3D Plates Used for Surgical Treatment of Condylar Fractures on Prostaglandin E2 (PGE2) and Thromboxane B2 (TXB2) Concentration in THP-1 Macrophages
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DNA-reactive anticancer imidazoacridinone C-1311 is a new inhibitor of hypoxia-inducible factor 1 alpha, vascular endothelial growth factor and tumor angiogenesis
PublicationHypoxia-inducible factor 1 (HIF-1) plays a critical role for tumor adaptation to hypoxia and promotes angiogenesis. Antitumor imidazoacridinone C-1311 is a DNA reactive topoisomerase II and FLT3 receptor tyrosine kinase inhibitor selected for phase II clinical trials for breast cancer. Here, we demonstrate the new mechanism of C-1311 action involving HIF-1a, vascular endothelial growth factor (VEGF) and angiogenesis as additional...
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Raport z badań podczas próbnego obciążenia wiaduktu kolejowego w km 165,161 LK nr 14 - konstrukcja w torze nr 1
PublicationW pracy przedstawiono metodykę pomiarów i wyniki badań podczas próbnego obciążenia wiaduktu kolejowego w km 165,161 LK nr 14.. Sformułowano wnioski i wydano pinie dotyczącą rzeczywistej pracy konstrukcji i warunków dalszej eksploatacji obiektu.
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New potent steroid sulphatase inhibitors based on 6-(1-phenyl-1H-1,2,3-triazol-4-yl)naphthalen-2-yl sulphamate derivatives
PublicationIn the present work, we report a new class of potent steroid sulphatase (STS) inhibitors based on 6-(1-phenyl-1H-1,2,3-triazol-4-yl)naphthalen-2-yl sulphamate derivatives. Within the set of new STS inhibitors, 6-(1-(1,2,3-trifluorophenyl)-1H-1,2,3-triazol-4-yl)naphthalen-2-yl sulphamate 3L demonstrated the highest activity in the enzymatic assay inhibiting the STS activity to 7.98% at 0.5 µM concentration. Furthermore, to verify...
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Error analysis of calculating average d-q current components using Regular Sampling and Park transformation in FOC drives
PublicationIn electric drives using voltage source inverters, motor currents contain ripple component resulting from pulse-width modulated (PWM) voltage. The frequency range of the ripples is much higher than the bandwidth of current control. Therefore the control is performed on the basis of a fundamental current component, i.e. average value with the averaging time being the PWM period. In majority of cases the average current is measured...
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Cień Boga w ogrodzie filozofa. Parc de La Villette w Paryżu w kontekście filozofii chôry
PublicationKsiążka „Cień Boga w ogrodzie filozofa. Parc de La Villette w Paryżu w kontekście filozofii chôry” przedstawia filozoficzne dyskusje, jakie towarzyszyły projektowaniu rozległego parku w paryskiej dzielnicy La Villette. Na teoretyczne założenia parku złożyły się teksty Bernarda Tschumiego, w których kwestionował on tradycyjne sposoby tworzenia dzieła architektury postulując w zamian zastosowanie długiego szeregu...
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<title>Data transmission optical link for LLRF TESLA project part I: hardware structure of OPT0 module</title>
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<title>Cavity simulator and controller for VUV free electron laser SIMCON 2.1, part II: functional blocks</title>
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FPGA implementation of reverse residue conversion based on the new Chinese Remainder Theorem II- Part II,- Experimantal results
PublicationW pracy opisano realizację sprzętową konwertera z systemu resztowego do systemu binarnego. Konwerter jest oparty na nowej formie chińskiego twierdzenia o resztach CRT II. Teoretyczne aspekty takiej konwersji przedstawiono w części I. Implementację konwertera wykonano w środowisku Xilinx FPGA. Zaprezentowano ogólną architekturę konwertera, a także opisano realizację wybranych bloków. Podano ilość koniecznych zasobów sprzętowych...
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Influence of pitting corrosion on fatigue and corrosion fatigue of ship and offshore structures. Part II: Load - pit crack interaction
PublicationIn the paper has been discussed influence of stresses on general corrosion rate and corrosion pit nucleation and growth rate, whose presence has been questioned by some authors but accepted by most of them. Influence of pit walls roughness on fatigue life of a plate suffering pit corrosion and presence of so called "non damaging" pits which never lead to initiation of fatigue crack, has been presented. Possibility of prediction...
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Conformational studies of vasopressin and mesotocin using NMR spectroscopy and molecular modelling methods. Part II: studies in the SDS micelle
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Experimental and numerical investigation of crosstalk effect in coupled coplanar waveguides - part i: bi-mode coupled line representation
PublicationW pracy przedstawiono analizę zjawiska przesłuchu w strukturze sprzężonych falowodów koplanarnych. Analiza wykorzystując metodę przestrzeni widmowej i bazując na dwurodzajowym modelu pary linii sprzężonych uwzględnia efekty dyspersji obserwowane w zakresie wysokich częstotliwośći. Przedyskutowano zagadnienie sposobu definicji impedancji charakterystycznych dla prowadzonych rodzajów pola. Wyniki modelowania numerycznego potwierdzono...
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Recommendations of the Polish Psychiatric Association regarding the treatment of affective disorders in women of childbearing age. Part II: Bipolar disorder
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Fatigue strength determination of ship structural joints. Part I - Analytical methods for determining fatigue strength of ship tructures
PublicationSpectacular accidents at sea which have happened for a few last years show that hull structures of contemporary sea-going ships are not perfect and must be systematically improved. Fatigue strength is one of the groups of strength problems which affect design of contemporary ship's structures and greatly contribute in their improvement process. In this paper several approaches to estimation of fatigue life of hull structural...
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The synthesis, x-ray structure and metal cation complexation properties of colored crown with two heterocyclic residues as a part of macrocycle
PublicationZsyntezowano nowy eter koronowy zawierający ugrupowanie azowe, resztę pirolu i pirydyny w pierścieniu makrocyklicznym. Badano zdolność kompleksowania kationów metali w acetonitrylu oraz mieszaninę acetonitryl-woda. Do pomiarów wykorzystano spektrofotometrię UV-Vis. Ustalono strukturę krystalograficzną otrzymanego związku.
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Exhaust gas temperature measurements in diagnostic examination of naval gas turbine engines. Part I: Steady-state processes
PublicationThe article presents a possible method of detecting failures in the flow section and supply system of a naval gas turbine engine based on the exhaust gas temperature measured behind the gas generator. This temperature is a basic diagnostic parameter use for evaluating the technical state of the turbine engine in operation, and is monitored during engine start-ups, accelerations and decelerations of rotor units, and steady-load...
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Exhaust gas temperature measurements in diagnostic examination of naval gas turbine engines. Part III. Diagnostic and operating tolerances
PublicationThe third part of the article presents a method for detecting failures of the automatic engine control system with the aid of an exhaust gas temperature setter, specially designed and machined for this purpose. It also presents a procedure of identifying the operating tolerances and determining the diagnostic tolerances for the exhaust gas temperature recorded in the naval turbine engine during the start-up and acceleration processes....
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Impact of Volcanic Eruptions on the Occurrence of PAHs Compounds in the Aquatic Ecosystem of the Southern Part of West Spitsbergen (Hornsund Fjord, Svalbard)
PublicationThe paper presents changes in concentration levels of dioxin-like compounds that can be observed over the course of four study seasons in water samples collected from the Arctic watershed of Svalbard. The conducted analysis involved anthropogenic and natural factors that may affect the concentration of PAHs in the study samples of water. An attempt is made to indicate the emission source of the compounds being deposited and to...
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Influence of gas turbine controller adjustment on propulsion system behaviour in high sea conditions. Part 2. The simulation investigations.
PublicationDo badań przyjęto układ napędowy okrętowy z turbinami gazowymi napędzającymi poprzez przekładnię mechaniczną zębatą śrubę okrętową o zmiennym skoku.Przy użyciu programu komputerowego Matlab i jego nakładki Simulink wykonano symulację dynamiki układu napędowego statku pracującego na wzburzonym morzu.Zbadano wpływ nastaw i typu regulatora na pracę układu. Porównano nastawy układu regulacyjnego układu napędowego dla pracy...
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3D calculations of aerodynamic forces causing self-excited vibrations of turbine rotor systems. Part II: Pressure forces
PublicationPrzedstawiono wyniki badań numerycznych sił generowanych w uszczelnieniu nadbandażowym stopnia turbinowego przeprowadzone metodą Fluent. Uwzględniono niecentryczne położenie osi wirnika względem osi korpusu. Rozpatrzono bandaże o różnej geometrii. Niektóre wyniki zweryfikowano doświadczalnie.
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Miniaturized solid phase extraction techniques for different kind of pollutants analysis: State of the art and future perspectives – PART 2
PublicationDetermination of pollutants present in environmental samples at a low concentration level very often requires the analytical protocol that includes analytes isolation and/or enrichment prior to the final quantification. Miniaturized SPE offers an interesting alternative to LLE. Nowadays, many types of sorbents are available and can be used as selective materials for extraction of varied analytes in different kinds of samples. The...
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Low-temperature synthesis of zeolite from perlite waste — Part I: review of methods and phase compositions of resulting products
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Effect of Oyster Mushroom Addition on Improving the Sensory Properties, Nutritional Value and Increasing the Antioxidant Potential of Carp Meat Burgers
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Horizontal velocity field derived from EPN and ASG-EUPOS satellite data on the example of south-western part of Poland
PublicationPresently the determination of the velocity field in the global reference frame is possible by using different space techniques and dense terrestrial networks from global to local and regional scales. However, the reliability of such determinations is strongly limited by the restricted number of unmodeled effects. Some of them are periodic (atmospheric or hydrological effects), some instantaneous (natural or man-made seismicity)...
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Determination of the Theoretical and Actual Working Volume of a Hydraulic Motor—Part II (The Method Based on the Characteristics of Effective Absorbency of the Motor)
Publication: In this article, the second method of determination of the theoretical and actual working volume of a hydraulic motor is described. The proposed new method is based on the characteristics of effective absorbency of the motor. The effective absorbency has been defined as the ratio of flow rate in a motor to the rotational speed of the motor’s shaft. It has been shown that the effective absorbency is a nonlinear function of the...
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Dylematy polskiej polityki kursowej w dobie globalizacji. W: Wewnętrzne i zewnętrzne determinanty procesów decyzyjnych w zarządzaniu finansami przed-siębiorstw. Monografia Katedry Finansów nr 1. Gdańsk: Kated. Finan. Wydz.Zarz. i Ekon. P. Gdań.**2003 s. 107-118, 1 rys. 3 tab. bibliogr. 21 poz.
PublicationArtykuł prezentuje kwestię doboru odpowiedniej polityki kursowej w dobie globalizacji. Jest w nim również dokonana analiza możliwych rozwiazań kur- sowych w Polsce na drodze do Unii Gospodarczej i Walutowej.
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Comparison of Absorbed and Intercepted Fractions of PAR for Individual Trees Based on Radiative Transfer Model Simulations
PublicationThe fraction of absorbed photosynthetically active radiation (fAPAR) is a key parameter for estimating the gross primary production (GPP) of trees. For continuous, dense forest canopies, fAPAR, is often equated with the intercepted fraction, fIPAR. This assumption is not valid for individual trees in urban environments or parkland settings where the canopy is sparse and there are well-defined tree crown boundaries. Here, the distinction...
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Managing the security vulnerabilities of critical systems and hazardous plants
PublicationRozdział poświęcono aktualnym problemom zarządzania ochroną obiektów podwyższonego ryzyka jako ważnych systemów infrastruktury krytycznej. Zarządzanie odpornością na ataki takich obiektów jest oparte na ocenach ryzyka. Podkreśla się, że występują ważne instalacje i systemy wymagające specjalnej uwagi i zabezpieczeń, szczególnie systemy kontroli dostępu do sterowni i urządzeń komunikacji. Opisuje się przykładowe technologie ochrony....