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Search results for: WSKAŹNIK OEE
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Interplay between Structure and Charge as a Key to Allosteric Modulation of Human 20S Proteasome by the Basic Fragment of HIV-1 Tat Protein
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The interaction between cuticle free fatty acids (FFAs) of the cockroaches Blattella germanica and Blatta orientalis and hydrolases produced by the entomopathogenic fungus Conidiobolus coronatus
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Structural Model of the Bilitranslocase Transmembrane Domain Supported by NMR and FRET Data
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Impact of selected amino acids of HP0377 (Helicobacter pylori thiol oxidoreductase) on its functioning as a CcmG (cytochrome c maturation) protein and Dsb (disulfide bond) isomerase
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Diet influences the bacterial and free fatty acid profiles of the cuticle of Galleria mellonella larvae
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The type of blood used to feed Aedes aegypti females affects their cuticular and internal free fatty acid (FFA) profiles
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ZMYND10 - Mutation Analysis in Slavic Patients with Primary Ciliary Dyskinesia
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Harman and norharman, metabolites of entomopathogenic fungus Conidiobolus coronatus (Entomopthorales), disorganize development of Galleria mellonella (Lepidoptera) and affect serotonin-regulating enzymes
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Conidiobolus coronatus induces oxidative stress and autophagy response in Galleria mellonella larvae
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Predictive Factors of Late Venous Aortocoronary Graft Failure: Ultrastructural Studies
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Bayesian multilevel model of micro RNA levels in ovarian-cancer and healthy subjects
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In vitro screening of 65 mycotoxins for insecticidal potential
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Cuticular fatty acids of Galleria mellonella (Lepidoptera) inhibit fungal enzymatic activities of pathogenic Conidiobolus coronatus
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Promising effects of xanthine oxidase inhibition by allopurinol on autonomic heart regulation estimated by heart rate variability (HRV) analysis in rats exposed to hypoxia and hyperoxia
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Structural Analysis of a Peptide Fragment of Transmembrane Transporter Protein Bilitranslocase
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Can cornelian cherry mask bitter taste of probiotic chocolate? Human TAS2R receptors and a sensory study with comprehensive characterisation of new functional product
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Phylogenetic Placement and Taxonomy of the Genus Hederorkis (Orchidaceae)
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Taxonomic Position and Phylogeny of the Genus Vargasiella (Orchidaceae, Vandoideae) Based on Molecular and Morphological Evidence
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New Biochemical Insights into the Mechanisms of Pulmonary Arterial Hypertension in Humans
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The effect of light conditions on the content of selected active ingredients in anatomical parts of the oyster mushroom (Pleurotus ostreatus L.)
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Cardiovascular risk and response to lipid lowering therapy in patients with HIV infection according to different recommendations
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A comparison of the effects of monotherapy with rosuvastatin, atorvastatin or ezetimibe versus combination treatment with rosuvastatin-ezetimibe and atorvastatin-ezetimibe on the integrity of vascular endothelial cells damaged by oxidized cholesterol
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Development and biological evaluation of Ti6Al7Nb scaffold implants coated with gentamycin-saturated bacterial cellulose biomaterial
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Biochemical properties of thyroid peroxidase (TPO) expressed in human breast and mammary-derived cell lines
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Air pollution in the places of Betula pendula growth and development changes the physicochemical properties and the main allergen content of its pollen
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Thyroid peroxidase (TPO) expressed in thyroid and breast tissues shows similar antigenic properties
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Modelling of Thyroid Peroxidase Reveals Insights into Its Enzyme Function and Autoantigenicity
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The New 3D Printed Left Atrial Appendage Closure with a Novel Holdfast Device: A Pre-Clinical Feasibility Animal Study
PublicationMany patients undergoing cardiac surgery have risk factors for both atrial fibrillation and stroke. The left atrial appendage (LAA) is the primary site for thrombi formation. Therefore LAA occlusion devices should be tested for their ability to reduce future cerebral ischemic events in patients with high-risk of haemorrhage. The aim of this study was to evaluate the safety and feasibility of a novel left atrial appendage exclusion...
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Acute hypoxia diminishes the relationship between blood pressure and subarachnoid space width oscillations at the human cardiac frequency
PublicationAcute hypoxia exerts strong effects on the cardiovascular system. Heart-generated pulsatile cerebrospinal fluid motion is recognised as a key factor ensuring brain homeostasis. We aimed to assess changes in heart-generated coupling between blood pressure and subarachnoid space width oscillations during hypoxic exposure.
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Intra-operative biopsy in chronic sinusitis detects pathogenic Escherichia coli that carry fimG/H, fyuA and agn43 genes coding biofilm formation
PublicationThe aim of this study was to investigate whether or not surgical biopsy of sinus tissue in chronic sinusitis, not responsive to treatment, would detect E. coli. We intended to evaluate E. coli virulence genes, therefore dispute the causal role of such an unusual microorganism in chronic sinusitis, as well as consider effective pathogen-targeted therapy. Patients with E. coli isolated by intra-operative puncture biopsy were included...
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The influence of a change in the meniscus cross-sectional shape on the medio-lateral translation of the knee joint and meniscal extrusion
PublicationObjective The purpose of this study was to evaluate the influence of a change in the meniscus cross sectional shape on its position and on the biomechanics of a knee joint. Methods One main finite element model of a left knee joint was created on the basis of MRI images. The model consisted of bones, articular cartilages, menisci and ligaments. Eight variants of this model with an increased or decreased meniscus height were then...
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Molecular Strategy for Survival at a Critical High Temperature in Eschierichia coli
PublicationThe molecular mechanism supporting survival at a critical high temperature (CHT) in Escherichia coli was investigated. Genome-wide screening with a single-gene knockout library provided a list of genes indispensable for growth at 47°C, called thermotolerant genes. Genes for which expression was affected by exposure to CHT were identified by DNA chip analysis. Unexpectedly, the former contents did not overlap with the latter except...
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Transport of Particles in Intestinal Mucus under Simulated Infant and Adult Physiological Conditions: Impact of Mucus Structure and Extracellular DNA
PublicationThe final boundary between digested food and the cells that take up nutrients in the small intestine is a protective layer of mucus. In this work, the microstructural organization and permeability of the intestinal mucus have been determined under conditions simulating those of infant and adult human small intestines. As a model, we used the mucus from the proximal (jejunal) small intestines of piglets and adult pigs. Confocal...
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Cancer-selective, single agent chemoradiosensitising gold nanoparticles
PublicationTwo nanometre gold nanoparticles (AuNPs), bearing sugar moieties and/or thiol-polyethylene glycol-amine (PEG-amine), were synthesised and evaluated for their in vitro toxicity and ability to radiosensitise cells with 220 kV and 6 MV X-rays, using four cell lines representing normal and cancerous skin and breast tissues. Acute 3 h exposure of cells to AuNPs, bearing PEG-amine only or a 50:50 ratio of alpha-galactose derivative and...
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Fusion of Taq DNA polymerase with single-stranded DNA binding-like protein of Nanoarchaeum equitans—Expression and characterization
PublicationDNA polymerases are present in all organisms and are important enzymes that synthesise DNA molecules. They are used in various fields of science, predominantly as essential components for in vitro DNA syntheses, known as PCR. Modern diagnostics, molecular biology and genetic engineering need DNA polymerases which demonstrate improved performance. This study was aimed at obtaining a new NeqSSB-TaqS fusion DNA polymerase from the...
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Increased inspiratory resistance affects the dynamic relationship between blood pressure changes and subarachnoid space width oscillations
PublicationBackground and objective Respiration is known to affect cerebrospinal fluid (CSF) movement. We hypothesised that increased inspiratory resistance would affect the dynamic relationship between blood pressure (BP) changes and subarachnoid space width (SAS) oscillations. Methods Experiments were performed in a group of 20 healthy volunteers undergoing controlled intermittent Mueller Manoeuvres (the key characteristic of the procedure...
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Structure and evolution of the 4-helix bundle domain of Zuotin, a J-domain protein co-chaperone of Hsp70
PublicationThe J-domain protein Zuotin is a multi-domain eukaryotic Hsp70 co-chaperone. Though it is primarily ribosome-associated, positioned at the exit of the 60S subunit tunnel where it promotes folding of nascent polypeptide chains, Zuotin also has off-ribosome functions. Domains of Zuotin needed for 60S association and interaction with Hsp70 are conserved in eukaryotes. However, whether the 4-helix bundle (4HB) domain is conserved remains...
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The first study on the usefulness of recombinant tetravalent chimeric proteins containing fragments of SAG2, GRA1, ROP1 and AMA1 antigens in the detection of specific anti-Toxoplasma gondii antibodies in mouse and human sera
PublicationThis study presents an evaluation of four tetravalent recombinant chimeric proteins containing fragments of the Toxoplasma gondii antigens, SAG2, GRA1, ROP1 and AMA1, as potential replacements of a the soluble, whole-cell tachyzoite lysate (TLA) used in serological assays. Recombinant chimeric proteins (SAG2-GRA1-ROP1-AMA1N, AMA1N-SAG2-GRA1-ROP1, AMA1C-SAG2-GRA1-ROP1, and AMA1-SAG2-GRA1-ROP1) obtained by genetic engineering were...
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Inverse heat transfer problem solution of sounding rocket using moving window optimization
PublicationAn Inverse Heat Transfer Problem is solved for a sounding rocket module given its geometry and measured temperature profile. The solution is obtained via moving window optimization, a technique for solving inverse dynamics. An analysis is performed to modify the method to avoid oscillatory behavior of the resulting heat flux profile. The method parameters are tuned in relation to characteristic phases of the flight. Results are...
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Folate/homocysteine metabolism and lung cancer risk among smokers
PublicationBackground: Folate and homocysteine are involved in DNA synthesis and methylation processes, which are deregulated during carcinogenesis. Objectives: The aim of this study was to assess the relationship between folate/homocysteine concentrations, the functional polymorphisms of folate/homocysteine genes and lung cancer risk among cigarette smokers. Study design: The study included 132 lung cancer patients and 396 controls from...
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The correlation between the MRI-evaluated ectopic fat accumulation and the incidence of diabetes mellitus and hypertension depends on body mass index and waist circumference ratio.
PublicationThe widespread presence of overweight and obesity increases with every decade, and the number of people with body mass index (BMI) >30 kg/m2 has doubled in the last 30 years. The aim of the study is to assess the correlation between MRI-evaluated ectopic fat accumulation in pancreas, skeletal muscles and liver and the incidence of type 2 diabetes and hypertension, depending on BMI and waist circumference ratio. This prospective...
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Comparative analysis of mechanical conditions in bone union following first metatarsophalangeal joint arthrodesis with varied locking plate positions: A finite element analysis
PublicationFirst metatarsophalangeal joint arthrodesis is a typical medical treatment performed in cases of arthritis or joint deformity. The gold standard for this procedure is arthrodesis stabilisation with the dorsally positioned plate. However, according to the authors’ previous studies, medially positioned plate provides greater bending stiffness. It is worth to compare the mechanical conditions for bone formation in the fracture callus...
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Comparative analysis of positioning accuracy of Samsung Galaxy smartphones in stationary measurements
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Diagnostyka budowli i identyfikacja ich modeli jednowymiarowych przy wykorzystaniu oddziaływań środowiskowych
PublicationRozprawa doktorska dotyczy problemów diagnostyki budowli zabytkowych. Zagadnienie potraktowano szeroko. Uwzględniono zarówno rozważania teoretyczne jak i badania eksperymentalne obiektów rzeczywistych. Celem pracy jest zaproponowanie efektywnego algorytmu oceny stanu technicznego budowli, łączącego trzy dziedziny nauki, w których wspólnym mianownikiem jest pomiar drgań konstrukcji przy wymuszeniach środowiskowych (wiatr, ruch uliczny,...
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The Opening of Central and Eastern European Countries to Free Trade: A Critical Assessment
PublicationThree decades after the fall of the Berlin wall and one and a half decades after the Big Bang enlargement of the European Union (2004-2007), we revisit contrasting narratives about the benefit of both free trade and the EU enlargement for Central and Eastern European (CEE) countries. We distinguish old, pre-2004 EU countries from CEE countries that joined the EU in 2004-2007, as well as from the CEE countries that have not become...
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Agnieszka Rudzka (Nee Dudkiewicz) Dr
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Zmiany strukturalne a konkurencyjność polskiego przemysłu
Publicationprzemysł stanowi jeden z najważniejszych strukturalnych komponentów polskiej gospodarki. dotychczasowe analizy, odnoszące się roli przemysłu w polsce koncentrują się wokół analizy udziału całego sektora lub jego działów w tworzeniu pkb czy też w generowaniu wartości dodanej i zatrudnienia. podejście takie nie daje pełnego obrazu, co do roli tego sektora w podnoszeniu konkurencyjności polskiej gospodarki. dlatego też autorka, przy...
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The bioactivity of processed garlic (Allium sativum L.) as shown in vitro and in vivo studies on rats
PublicationCzosnek w trakcie procesu obróbki traci znaczną część swojej bioaktywności. Właściwości przeciwutleniające zmierzone metodą FRAP i DPPH stwierdzono na najwyższym poziomie w przypadku czosnku surowego oraz po krótkim okresie gotowania. Badania na szczurach poddanych diecie z dodatkiem krótkogotowanego czosnku potwierdziły, że proces ten nie zaburza właściwości przeciwutleniających surowego czosnku. U zwierząt stwierdzono poprawę...
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Pomiary szumów i zakłóceń
PublicationPraca zawiera uzasadnienie potrzeby doskonalenia techniki pomiarów szumów i zakłóceń, zwłaszcza sygnałów losowych - zarówno ergodycznych jak i niestacjonarnych, z wykorzystaniem sprzętu komputerowego. Przedstawione zostały uwarunkowania aparaturowe mające zasadniczy wpływ na algorytmiczne wyznaczanie wielkości charakteryzujących szumy i zakłócenia po procesie ich digitalizacji. Podane zostały także przykładowe zastosowania wspomaganych...
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Badanie poziomu zawartości wybranych składników wody wodociągowej na terenie dużej aglomeracji miejskiej (Gdańsk).
PublicationDokonano oceny zasobów wodnych Gdańska oraz ewentualnych źródeł zanieczyszczeń będących zagrożeniem dla ich jakości. W części doświadczalnej przeprowadzono analizę jakości wód z wybranych ujęć głębinowych oraz skontrolowano stan wody w sieci wodociągowej. Woda pochodząca z sieci była dobrej jakości,żaden z badanych wskaźników nie został przekroczony, jedynie zawartość fluorków była poniżej zalecanej. Jakość wody w ujęciach również...