Filters
total: 4330
-
Catalog
- Publications 3726 available results
- Journals 39 available results
- Conferences 10 available results
- Publishing Houses 1 available results
- People 63 available results
- Projects 3 available results
- Laboratories 2 available results
- e-Learning Courses 41 available results
- Events 5 available results
- Open Research Data 440 available results
displaying 1000 best results Help
Search results for: PROTEIN FOLDING
-
Dissimilar underwater wet welding of HSLA steels
PublicationThe high-strength low-alloy S460ML and S460N steels were chosen for underwater wet welding of dissimilar T-joints using covered electrodes. For improving the quality of joints, the temper bead welding (TBW) method was used. The application of TBW in pad welding conditions has been investigated earlier but the possibility of usage of this technique in welded joints was not analyzed. The main aim of the study was to check the influence...
-
Chalcogen bonding interactions in a series of aromatic selenocyanates
PublicationSelenium atoms in aromatic selenocyanates are characterized by the occurrence of two σ-holes, a stronger one in the prolongation of the NC–Se bond and a weaker one in the prolongation of the Ar–Se bond. The crystal structures of several bis(selenocyanato) derivatives, prepared by a method originally developed for ortho bis-substituted derivatives, illustrate very well this difference, with a short NC–Se⋯NC ChB interaction organizing...
-
International Journal of Material Forming
Journals -
China Welding (English Edition)
Journals -
SCIENCE AND TECHNOLOGY OF WELDING AND JOINING
Journals -
The measurement of conformational stability of proteins adsorbed on siloxanes
Publication -
1.21 Computation of Structure, Dynamics, and Thermodynamics of Proteins
Publication -
Coarse-Grained Models of Proteins: Theory and Applications
Publication -
Computational techniques for efficient conformational sampling of proteins
Publication -
Molecular basis of TRF proteins and their interactions with peptides
Publication -
Integration of speech enhancement and coding techniques
Publication -
Novel approaches to wideband speech coding
PublicationDwie metoda kodowania szerokopasmowego mowy zostały zaprezentowane. W pierwszej metodzie wykorzystano algorytm kompresji i ekspansji czasowej sygnału mowy, pozwalający na kodowanie szerokopasmowe sygnału mowy z wykorzystaniem ustandaryzowanych kodeków. Metoda ta jest przewidziana do zastosowania w adaptacyjnych algorytmach kodowania mowy. Drugie z proponowanych rozwiazan dotyczy nowej metody estymacji obwiedni widma sygnalu mowy...
-
Transient detection for speech coding applications
PublicationSignal quality in speech codecs may be improved by selecting transients from speech signal and encoding them using a suitable method. This paper presents an algorithm for transient detection in speech signal. This algorithm operates in several frequency bands. Transient detection functions are calculated from energy measured in short frames of the signal. The final selection of transient frames is based on results of detection...
-
Patterned protein microarrays for bacterial detection. Langmuir**2003 vol.19 s. 436-439, 5 rys. bibliogr. 25 poz. Specyficzne mikroukłady protein do wykrywania bakterii.
PublicationSkonstruowano i przetestowano specyficzne mikroukłady przeciwciał selektyw-nie wiążących bakterie. Otrzymane układy umożliwiają wykrywanie bakterii E.coli0157:H7 oraz Renibacterium salmoninarum (RS). Matryce wytworzono techni-ką nadruku mikrokontaktów (ćCP). Charakterystykę układów uzyskano stosującmikroskopię skaningową (SPM). Ustalono, że selektywność otrzymanych układówobniża się podczas ekspozycji na bakterie niespecyficzne.
-
Proprotein Convertase Subtilisin/Kexin Type 9, Angiopoietin-Like Protein 8, Sortilin, and Cholesteryl Ester Transfer Protein—Friends of Foes for Psoriatic Patients at the Risk of Developing Cardiometabolic Syndrome?
Publication -
Investigation of Mechanical and Microstructural Properties of Welded Specimens of AA6061-T6 Alloy with Friction Stir Welding and Parallel Friction Stir Welding Methods
PublicationThe present study investigates the effect of two parameters of process type and tool offset on tensile, microhardness, and microstructure properties of AA6061-T6 aluminum alloy joints. Three methods of Friction Stir Welding (FSW), Advancing Parallel-Friction Stir Welding (AP-FSW), and Retreating Parallel-Friction Stir Welding (RP-FSW) were used. In addition, four modes of 0.5, 1, 1.5, and 2 mm of tool offset were used in two welding...
-
Chitosan-protein scaffolds loaded with lysostaphin as potential antistaphylococcal wound dressing materials.
PublicationAIMS: The development of technology for preparing chitosan-protein scaffolds loaded with lysostaphin, which potentially could be used as dressing for wound treatment and soft tissue infections caused by Staphylococcus aureus. METHODS AND RESULTS: The unique technology of chitosan solubilization using gaseous CO(2) instead of organic or inorganic acids was used for the incorporation of lysostaphin, the enzyme that exhibits bactericidal...
-
Unusual structural properties of water within the hydration shell of hyperactive antifreeze protein
PublicationMany hypotheses can be encountered explaining the mechanism of action of antifreeze proteins. One widespread theory postulates that the similarity of structural properties of solvation water of antifreeze proteins to ice is crucial to the antifreeze activity of these agents. In order to investigate this problem, the structural properties of solvation water of the hyperactive antifreeze protein from Choristoneura fumiferana were...
-
Depression as is Seen by Molecular Spectroscopy. Phospholipid- Protein Balance in Affective Disorders and Dementia
Publication -
MUTL PROTEIN AS A COMMON CONSTITUENT OF VSP, BER, NER AND MMR REPAIR SYSTEMS
PublicationMutS and MutL proteins are renowned mostly for their functions in well-characterized, post-DNA replication mismatch repair system (MMR). However, there is growing evidence that MMR system is not the only field of action of these proteins. Moreover, involvement in MMR does not even have to be their primary function. There are some reports indicating involvement of MutL in BER, NER and VSP (very short patch repair). MutL protein...
-
Prediction of Protein Structure by Template-Based Modeling Combined with the UNRES Force Field
Publication -
Performance of protein-structure predictions with the physics-based UNRES force field in CASP11
Publication -
Recent improvements in prediction of protein structure by global optimization of a potential energy function
Publication -
Assembly of Lipopolysaccharide in Escherichia coli Requires the Essential LapB Heat Shock Protein
PublicationHere, we describe two new heat shock proteins involved in the assembly of LPS in Escherichia coli, LapA and LapB (lipopolysaccharide assembly protein A and B). lapB mutants were identified based on an increased envelope stress response. Envelope stress responsive pathways control key steps in LPS biogenesis and respond to defects in the LPS assembly. Accordingly, the LPS content in ΔlapB or Δ(lapA lapB) mutants was elevated, with...
-
Are stabilizing osmolytes preferentially excluded from the protein surface? FTIR and MD studies
PublicationInteractions between osmolytes and hen egg white lysozyme in aqueous solutions were studied by means of FTIR spectroscopy and molecular dynamics. A combination of difference spectra method and chemometric analysis of spectroscopic data was used to determine the number of osmolyte molecules interacting with the protein, and the preferential interaction coefficient in presented systems. Both osmolytes – L-proline and trimethylamine-N-oxide...
-
How water mediates the long-range interactions between remote protein molecules
PublicationThe high crowding of macromolecules in the cytoplasm affects the processes that occur inside a living cell. It can, for example, promote the forming of various loosely connected structures of proteins. It also means that bulk water is, essentially, not present there. The relatively thin layer of solvent that separates macromolecules may be able to participate in the long-range interactions between them and make them respond to...
-
A Colorimetric Microplate Assay for DNA-Binding Activity of His-Tagged MutS Protein
PublicationA simple microplate method was designed for rapid testing DNA-binding activity of proteins. The principle of the assay involves binding of tested DNA by his-tagged protein immobilized on a nickel-coated ELISA plate, following colorimetric detection of biotinylated DNA with avidin conjugated to horseradish peroxidase. The method was used to compare DNA mismatch binding activities of MutS proteins from three bacterial species. The...
-
General Mechanism of Osmolytes’ Influence on Protein Stability Irrespective of the Type of Osmolyte Cosolvent
PublicationThe stability of proteins in an aqueous solution can be modified by the presence of osmolytes. The hydration sphere of stabilizing osmolytes is strikingly similar to the enhanced hydration sphere of a protein. This similarity leads to an increase in the protein stability. Moreover, the hydration sphere of destabilizing osmolytes is significantly different. These solutes generate in their surroundings so-called “structurally different...
-
Hot spot identification by ligand-protein surface interactions mapping – in silico study
Publication -
A comparative study of water distribution and dehydrin protein localization in maturing pea seeds
Publication -
Mapping Mechanostable Pulling Geometries of a Therapeutic Anticalin/CTLA-4 Protein Complex
Publication -
Molecular dynamics insights into protein‐glycosaminoglycan systems from microsecond‐scale simulations
Publication -
Local and long range potentials for heparin‐protein systems for coarse‐grained simulations
Publication -
Chromatin-associated microprocessor assembly is regulated by the U1 snRNP auxiliary protein PRP40
Publication -
Justification of quasi-stationary approximation in models of gene expression of a self-regulating protein
PublicationWe analyse a model of Hes1 gene transcription and protein synthesis with a negative feedback loop. The effect of multiple binding sites in the Hes1 promoter as well as the dimer formation process are taken into account. We consider three, possibly different, time scales connected with: (i) the process of binding to/dissolving from a binding site, (ii) formation and dissociation of dimers, (iii) production and degradation of Hes1...
-
Modeling protein structures with the coarse-grained UNRES force field in the CASP14 experiment
PublicationThe UNited RESidue (UNRES) force field was tested in the 14th Community Wide Experiment on the Critical Assessment of Techniques for Protein Structure Prediction (CASP14), in which larger oligomeric and multimeric targets were present compared to previous editions. Three prediction modes were tested (i) ab initio (the UNRES group), (ii) contact-assisted (the UNRES- contact group), and (iii) template-assisted (the UNRES-template...
-
Determination of viscosity changes of protein hydrolyzate solutions depending on shear rate
Open Research DataRheological characteristics of connective tissue protein solutions were made on the basis of viscosity measurement using a Brookfield viscometer using LV SC4 - 27 spindles and shear rate of 85 s-1 (Fig. 1). Solutions of protein hydrolysates with a concentration of 2% in 0.5M acetic acid were prepared.
-
Karaś P., Kochanowicz K., Pitek M., Domański P., Obuchowski I., Tomiczek B., Liberek K.: Evolution towards simplicity in bacterial small heat shock protein system// eLife -, (2023), s.1-21
PublicationEvolution can tinker with multi-protein machines and replace them with simpler single-protein systems performing equivalent functions in an equally efficient manner. It is unclear how, on a molecular level, such simplification can arise. With ancestral reconstruction and biochemical analysis, we have traced the evolution of bacterial small heat shock proteins (sHsp), which help to refold proteins from aggregates using either...
-
Application of Numerical Simulations on 10GN2MFA Steel Multilayer Welding
Publication -
Numerical Simulations of X22CrMoV12-1 Steel Multilayer Welding
Publication -
Heat Source Models in Numerical Simulations of Laser Welding
Publication -
Parallelisation of genetic algorithms for solving university timetabling problems
PublicationAlgorytmy genetyczne stanowią ważną metodę rozwiązywania problemów optymalizacyjnych. W artykule skupiono się na projekcie równoległego algorytmu genetycznego pozwalającego uzyskiwać uniwersyteckie rozkłady zajęć, spełniające zarówno twarde jak i miękkie ograniczenia. Czytelnika wprowadzono w niektóre znane sposoby zrównoleglenia, przedstawiono również podejście autorów, ykorzystujące MPI. Przyjęto strukturę zarządzania opartą...
-
A polynomial algorithm for finding T-span of generalized cacti.
PublicationW pracy opisano wielomianowy algorytm wyznaczający optymalne T-pokolorowania dla uogólnionych kaktusów.
-
Measurement of filling and discharging loads in a full scale hopper.
PublicationArtykuł przedstawia wyniki doświadczalne naporu piasku na ścinanie uzyskane podczas napełniania i opróżniania leja silosu o pojemności 2.5 m3. Pokazane zostały wartości naporu w funkcji czasu oraz kształt powierzchni górnej materiału dla poszczególnych etapów napełniania i opróżniania.
-
The surface contact characteristics after sliding and rolling burnishing.
PublicationW pracy przedstawiono zastosowanie nowej metody SCGC i odpowiedniego programu komputerowego JKC do oceny pomierzonej mikrostereometrii powierzchni części maszyn, głównie na potrzeby kontroli jakości. Na przykładzie powierzchni nagniatanych wykazano cechy nowej metody: wizualizację ułatwiającą wyobrażenie pomierzonej sfery chropowatości, położenie w niej najważniejszych parametrów oceny (rozkład geometrycznej powierzchni kontaktu,...
-
An approach to fatigue assessment of metals under biharmonic loading.
PublicationRozpatrywane są kryteria nieograniczonej i ograniczonej trwałości zmęczeniowej metalicznych elementów poddanych biharmonicznemu naprężeniu, którego jedna składowa ma niską częstość. Założono, że składowa ta może być traktowana jako wolno zmieniające się w czasie naprężenie średnie. Kryteria zmęczeniowe sformułowano za pomocą równań Goodmana i Soderberga. Dyskutowane są wyniki przykładowych obliczeń.
-
Crowdsourcing and Volunteer Computing as Distributed Approach for Problem Solving
PublicationIn this paper, a combination between volunteer computing and crowdsourcing is presented. Two paradigms of the web computing are described, analyzed and compared in detail: grid computing and volunteer computing. Characteristics of BOINC and its contribution to global Internet processing are shown with the stress put onto applications the system can facilitate and problems it can solve. An alternative instance of a grid computing...
-
Numerical simulation of extreme flooding in a built-up area
PublicationPrzedstawiono dwie numeryczne symulacje propagacji gwałtownej fali powodziowej przez schematyczny model obszaru zabudowanego. Do obliczeń wykorzystano równania przepływu wody płytkiej. Wyniki obliczeń porównano z dostępnymi pomiarami wykonanymi w laboratorium hydraulicznym ENEL-CESI w Mediolanie. Uzyskano zadowalającą zgodność symulacji z eksperymentami.
-
A polynomial algorithm for finding T-span of generalized cacti
Publication -
Design of thermal cutting table - welding technology and construction
PublicationW referacie przedstawiono pionierską pracę dyplomową stopnia inżynierskiego, wykonaną przez dwoje studentów Wydziału Mechanicznego Politechniki Gdańskiej zgodnie z systemem CDIO (Conceive, Design, Implement, Operate). W ramach pracy studenci zaprojektowali stół do cięcia termicznego metali (rysunki i obliczenia wytrzymałościowe metodą elementów skończonych), opracowali technologię spawania stołu oraz samodzielnie go wykonali. Stół...