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Search results for: INTESTINAL PERMEABILITY
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Sodium alginate decreases the permeability of intestinal mucus
PublicationIn the small intestine the nature of the environment leads to a highly heterogeneous mucus layer primarily composed of the MUC2 mucin. We set out to investigate whether the soluble dietary fibre sodium alginate could alter the permeability of the mucus layer. The alginate was shown to freely diffuse into the mucus and to have minimal effect on the bulk rheology when added at concentrations below 0.1%. Despite this lack of interaction...
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Comparing the permeability of human and porcine small intestinal mucus for particle transport studies
PublicationThe gastrointestinal mucus layer represents the last barrier between ingested food or orally administered pharmaceuticals and the mucosal epithelium. This complex gel structure plays an important role in the process of small intestinal absorption. It provides protection against hazardous particles such as bacteria but allows the passage of nutrients and drug molecules towards the intestinal epithelium. In scientific research, mucus...
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Permeability of the small intestinal mucus for physiologically relevant studies: Impact of mucus location and ex vivo treatment
PublicationThe small intestinal mucus is a complex colloidal system that coats the intestinal mucosa. It allows passage on nutrients/pharmaceuticals from the gut lumen towards the epithelium, whilst preventing it from direct contact with luminal microorganisms. Mucus collected from intestinal tissue is often used in studies looking at inter-mucosal transport of food particulates, drug carriers, etc. However, detaching the highly hydrated...
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Intestinal Research
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Modern approach for determination of lactulose, mannitol and sucrose in human urine using HPLC-MS/MS for the studies of intestinal and upper digestive tract permeability
PublicationA new analytical procedure was described for the simultaneous determination of lactulose, mannitol and sucrose in urine, in which HILIC chromatography and tandem mass spectrometry detection are used. Sugars are orally administered for the estimation of intestinal permeability in children digestive tract. Samples were purified by dispersive solid phase extraction (d-SPE) using Amberlite MB150 resin. Raffinose was selected as an...
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Intestinal Permeability in Children with Celiac Disease after the Administration of Oligofructose-Enriched Inulin into a Gluten-Free Diet—Results of a Randomized, Placebo-Controlled, Pilot Trial
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Inflammatory Intestinal Diseases
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Transport of Particles in Intestinal Mucus under Simulated Infant and Adult Physiological Conditions: Impact of Mucus Structure and Extracellular DNA
PublicationThe final boundary between digested food and the cells that take up nutrients in the small intestine is a protective layer of mucus. In this work, the microstructural organization and permeability of the intestinal mucus have been determined under conditions simulating those of infant and adult human small intestines. As a model, we used the mucus from the proximal (jejunal) small intestines of piglets and adult pigs. Confocal...
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Cellular Interactions in the Intestinal Stem Cell Niche
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Effect of oxidation and in vitro intestinal hydrolysis on phospholipid toxicity towards HT29 cell line serving as a model of human intestinal epithelium
PublicationOxidation of food-derived phospholipids (PLs) can influence nutrient digestion and induce oxidative stress in gastrointestinal epithelium. In this study, hen egg yolk PL fraction was used to evaluate the effect of lipoxygenase (LOX)-induced PL oxidation on the rate of PL hydrolysis catalyzed by pancreatic phospholipase A2 (PLA2) in the presence of bile salts (BSs). Then, PL/BS solutions containing native or oxidized PLs were used...
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Role of inertia in falling head permeability test
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Influences of grain shape and size distribution on permeability
PublicationThe present study investigates the effects of shape and size distributions of grains on the coefficient of permeability (k). A series of constant head permeability tests were performed to characterize the coefficient of permeability. Three particle size ranges (4.75- 0.075, 1.18- 0.075 and 0.300-0.075 mm) of two different sands (Narli Sand, Crushed Stone Sand) having different shapes were tested in a constant head permeability...
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Laboratory assessment of permeability of sand and biopolymer mixtures
PublicationLaboratory assessment of permeability of sand and biopolymer mixtures. This research presents a method of creating seepage barriers in a sandy soil using biopolymer additives (biosubstance), which consist of polysaccharides and water. Polysaccharides strongly interact with water to produce a viscous suspension. The paper aims to investigate the infl uence of a biosubstance employed in a highly permeable sandy soil. Amount of the...
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Structure and oxygen permeability of BaCo0.7Fe0.3−In O3− ceramic membranes
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Approximate Solutions for Non-stationary Gas Permeability Tests
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COLLOIDS IN SEPTIC TANK EFFLUENT AND THEIR INFLUENCE ON FILTER PERMEABILITY
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Intentional model of SMES growth
PublicationRozdział opisuje rolę intencji w funkcjonowaniu firmy. Autorzy opracowali intencyjny model wzrostu, który został opisany w oparciu o przeprowadzone badania w ramach Pomorskiego Obserwatorium Gospodarczego.
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Modeling Reservoir Gas Permeability Tests for Cylindrical and Spherical Geometry
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Study of NaCl permeability through a non-porous polypropylene film
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The ORBIT bleeding score is associated with lysis and permeability of fibrin clots
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Permeability of Waterfronts—Contemporary Approach in Designing Urban Blue Spaces
PublicationThe constant struggle with rising sea levels and flood hazards has resulted in the change of the paradigm in shaping urban waterfronts towards increasing their permeability and creation of urban blue spaces. The aim of the paper was to indicate a new approach in designing public spaces at the sea–land interface by presenting a comparative study of the design solutions used in case of the four selected case studies: the Sea Organs...
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Isolation and 3-dimensional Culture of Primary Murine Intestinal Epithelial Cells
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The influence of small intestinal mucus structure on particle transport ex vivo
PublicationMucus provides a barrier to bacteria and toxins while allowing nutrient absorption and waste transport. Unlike colonic mucus, small intestinal mucus structure is poorly understood. This study aimed to provide evidence for a continuous, structured mucus layer and assess the diffusion of different sized particles through it. Mucus structure was assessed by histology and immunohistochemistry. Ultra-structure was assessed by scanning...
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Colloidal transport of lipid digesta in human and porcine small intestinal mucus
PublicationSmall intestinal mucus transport of food-derived particulates has not been extensively studied, despite mucus being a barrier nutrients need to cross before absorption. We used complex dispersions of digesta obtained from simulated, dynamic gastrointestinal digestion of yogurt to examine the penetrability of human and porcine mucus to the particles formed of lipolysis products. Quantitative, time-lapse confocal microscopy revealed...
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Breastfeeding as a regulating factor of the development of the intestinal microbiome in the early stages of life
PublicationSince the first bacterial inhabitants of the human gastrointestinal tract were identified, a lot of research into the study of the human microbiome and its effects on health has been conducted. Currently, it is accepted that humans have a symbiotic relationship with the gut microbiome, though the specifics of this relationship are not well understood. The microbiome of neonates constantly changes and appears to influence many facets...
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U-Tube Method of Identification of Drag Parameters for High Permeability Materials
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Theoretical assessment of fabric and permeability changes in clays affected by organic contaminants
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A Comprehensive Review: Applications of the Kozeny–Carman Model in Engineering with Permeability Dynamics
PublicationIn this review article, we investigate the dynamic nature of the Kozeny–Carman Model concerning permeability and its application in engineering contexts. Providing insights into the changing dynamics of permeability within mining, petroleum, and geotechnical engineering, among other engineering applications. While some are complex and require additional modifcations to be applicable, others are simple and still function in specifc...
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Comment on permeability conditions in finite element simulation of bone fracture healing
PublicationThe most popular model of the bone healing considers the fracture callus as poroelastic medium. As such it requires an assumption of the callus’ external permeability. In this work a systematic study of the influence of the permeability of the callus boundary on the simulated bone healing progress is performed. The results show, that these conditions starts to play significant role with the decrease of the callus size. Typically...
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Development and validation of GC–MS/MS method useful in diagnosing intestinal dysbiosis
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EFFECTIVENESS OF THE SANDPITS SECURITY SYSTEM AGAINST MICROORGANISMS AND INTESTINAL PARASITES SAND CONTAMINATION
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Novel Resveratrol-Based Substrates for Human Hepatic, Renal, and Intestinal UDP-Glucuronosyltransferases
PublicationTrans-Resveratrol (tRes) has been shown to have powerful antioxidant, anti-inflammatory, anti-carcinogenic, and anti-aging properties; however, its use as a therapeutic agent is limited by its rapid metabolism into its conjugated forms by UDP-Glucuronosyltransferases (UGTs). The aim of the current study was to test the hypothesis that the limited bioavailability of tRes can be improved by modifying its structure to create analogs...
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Identification of Drag Parameters of Flow in High Permeability Materials by U-Tube Method
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Numerical analysis of permeability and Darcy effect in heat transfer of pyramid-shaped structure
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Fibrin Clot Permeability as a Predictor of Stroke and Bleeding in Anticoagulated Patients With Atrial Fibrillation
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Permeability of sandy soils estimated from particle size distribution and field measurements
PublicationAccurate estimation of soil permeability is crucial in many geotechnical applications. Empirical and theoretical equations based on soil particle size distribution (PSD) offer a fast and cheap way for preliminary estimation of permeability in granular soils, however the results obtained from various formulas available in the literature often show significant discrepancies. While several comparative studies on this topic have been...
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Estimation of Broadband Complex Permeability Using SIW Cavity-Based Multimodal Approach
PublicationIn this article, an attractive multimodal substrate integrated waveguide (SIW) based methodology is presented for the characterization of magnetic materials in the broadband microwave frequency. The proposed approach employs a modified feed under-coupled SIW cavity instead of conventional feed over-coupled multiple SIW cavities; it uses the modified closedform expression, developed from the first principle to consider the effect...
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The bile salt content of human bile impacts on simulated intestinal proteolysis of β-lactoglobulin
PublicationThe gastrointestinal hydrolysis of food proteins has been portrayed in scientific literature to predominantly depend on the activity and specificity of proteolytic enzymes. Human bile has not been considered to facilitate proteolysis in the small intestine, but rather to assist in intestinal lipolysis. However, human bile can potentially influence proteins that are largely resistant to gastric digestion, and which are mainly hydrolysed...
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Blood–brain barrier permeability mechanisms in view of quantitative structure–activity relationships (QSAR)
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W-tube system with bi-exponential response – A model for permeability tests in heterogeneous aquifers
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Experimental determination of intrinsic permeability of limestone and concrete: Comparison between in situ and laboratory results
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Determination of Complex Permeability of Silicon Steel for Use in High-Frequency Modeling of Power Transformers
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Influence of the Type of Amino Acid on the Permeability and Properties of Ibuprofenates of Isopropyl Amino Acid Esters
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Applications of permeability, oedometer and direct shear tests to the sand mixed with waste tire crumb
PublicationThe amount of the used waste rubbers in the world has been increasing every year, and their utilization, become a major environmental problem worldwide. The present experimental work has been performed to investigate the influence of rubber inclusion on the behavior of a sand. Geotechnical properties of the sand, and sand with tire crumb at various ratios mixtures (0%, 2.5%, 7.5%, and 15%) were investigated through a series of...
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Modelling water flow in unsaturated porous media: Accounting for nonlinear permeability and material heterogeneity
PublicationW pracy przedstawiono problematykę matematycznego modelowania przepływów w nienasyconych ośrodkach porowatych, ze szczególnym uwzględnieniem dwóch aspektów. Pierwszym z nich jest obliczanie średniego współczynnika przewodności hydraulicznej między węzłami siatki w numerycznym rozwiązaniu równania przepływu nienasyconego. Drugim zagadnieniem jest wpływ lokalnej zmienności parametrów ośrodka porowatego (współczynnika przewodności...
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The effect of 7-ketocholesterol and 25-hydroxycholesterol on the integrity of the human aortic endothelial and intestinal epithelial barriers
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Evaluation of the effects of Bidens tripartita extracts and their main constituents on intestinal motility – An ex vivo study
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Assessment of blood–brain barrier permeability using micellar electrokinetic chromatography and P_VSA-like descriptors
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Carotid Artery Stenting and Blood–Brain Barrier Permeability in Subjects with Chronic Carotid Artery Stenosis
PublicationFailure of the blood-brain barrier (BBB) is a critical event in the development and progression of diseases such as acute ischemic stroke, chronic ischemia or small vessels disease that affect the central nervous system. It is not known whether BBB breakdown in subjects with chronic carotid artery stenosis can be restrained with postoperative recovery of cerebral perfusion. The aim of the study was to assess the short-term effect...
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Effects of Xanthan Gum Biopolymer on the Permeability, Odometer, Unconfined Compressive and Triaxial Shear Behavior of a Sand
PublicationBiopolymers, which are microbially induced polymers, can be used as an alternative material to improve engineering performance of soils. In this paper, a laboratory study of 0.075-1.0 mm size sand and biopolymer (i.e., xanthan gum) mixtures with various mix ratios (0%, 0.5%, 1.0%, and 1.5%) was performed. The materials, specimen preparation, and test methods are described, as are the results of a suite of permeability, odometer, unconfined...