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Search results for: REGENERATION, P21
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Sequence variants of p21 gene of the MRL/MpJ mouse: a possible association with the deficit of p21 protein and regenerative phenotype.
PublicationThe MRL/MpJ mouse is known for its enhanced regeneration abilities that manifested themselves by scarless ear-hole wound closure. The deficit of p21 found in the MRL is associated with the regenerative capacity as the p21 gene knockout in a mouse strain unrelated to the MRL mouse results in an ear-hole closure effect, similar to that observed in the MRL mouse. Cdkn1a gene encodes p21 protein, a cyclin-dependent kinase inhibitor,...
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Regeneration
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Cell Regeneration
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Inflammation and Regeneration
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Engineered Regeneration
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Study on Microstructural Characterization, Mechanical Properties and Residual Stress of GTAW Dissimilar Joints of P91 and P22 Steels
PublicationThis article deals with the dissimilar joining of two different grade Cr-Mo steel (2.25Cr-1Mo: P22 and modified 9Cr-1Mo: P91) for power plant application. The dissimilar butt-welded joint was produced for conventional V groove design by using the gas tungsten arc welding (GTAW) process with the application of an ERNiCrMo-3 Ni-based super alloy filler. A microstructure characterization was performed to measure the inhomogeneity...
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Neural Regeneration Research
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Ograniczone (p1, p2,...,pk) kolorowanie wierzchołków grafów.
PublicationProblem ograniczonego (p1,...,pk) kolorowania grafów polega na poszukiwaniu odpowiedzi na pytanie, czy istnieje takie pokolorowanie wierzchołków grafu , że krotności użycia poszczególnych barw są równe ustalonym progom p1,...,pk. W ogólnym przypadku problem ten, jako uogólnienie klasycznego kolorowania grafów pozostaje NP-zupełnym. W pracy przedstawiamy wyniki dotyczące ograniczonego kolorowania split grafów, kografów oraz...
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Regenerative Therapy
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Regenerative Biomaterials
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Regenerative Medicine
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Journal of Urban Regeneration and Renewal
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Insight into heart regeneration
PublicationThe mammalian heart is thought to be incapable of regeneration because of the limited ability of cardiomyocytes. to proliferate. However, it has been recently shown that the neonatal murine heart is able to restore its normal function after coronary artery ligation or even partial resection. Unfortunately, this feature is lost in a few days after birth, although lower vertebrates as zebrafish or newt, retain this ability until adulthood. Therefore,...
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The role of epigenetics in regeneration
PublicationComplex changes in chromatin structure and at the transcriptional level occur from the creation of a single parental gamete throughout fertilization, embryo development and the life of an adult organism. Epigenetic changes, such as methylation and hydroxymethylation of DNA or histone methylation and acetylation, are an important part of these processes. Epigenetic regulation has an essential influence on gene expression level. DNA...
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Discovery of small-molecule regenerative drugs using a model of complex tissue injury in mice. Transcriptomic responses of neurodevelopmental genes during pharmacologically induced regeneration
PublicationDespite significant development in regenerative medicine, there is a deficit of effective therapies for wound healing and tissue regeneration. Research performed using animal wound models allows for a better understanding of this complex process, searching for compounds with pro-regenerative properties, and assessing their efficacy and safety. Unfortunately, the lack of adequate preclinical models proves to be an issue as no animal...
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Polydopamine Biomaterials for Skin Regeneration
PublicationDesigning biomaterials capable of biomimicking wound healing and skin regeneration has been receiving increasing attention recently. Some biopolymers behave similarly to the extracellular matrix (ECM), supporting biointerfacial adhesion and intrinsic cellular interactions. Polydopamine (PDA) is a natural bioadhesive and bioactive polymer that endows high chemical versatility, making it an exciting candidate for a wide range of...
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Identity and authenticity in urban regeneration
PublicationArtykuł dotyczy zagadnienia relacji pomiędzy kwestiami ochrony autentyzmu a budowy jego tożsamości w programach rewitalizacji urbanistycznej.
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npj Regenerative Medicine
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Regenerative Medicine Research
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Current Regenerative Medicine
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Power Generation Technology
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Urban Waterfront Regeneration: Origins of the Issue
PublicationThis paper deals with the origins of the issue of urban waterfront regeneration. The process of city-water interface was described with references to the three generations of port structures.
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Challenges of Cogeneration
PublicationPrzedstawiono problemy skojarzonego wytwarzania ciepła i energii elektrycznej w Polsce. Omówiono układy technologiczne i problemy sprawności wytwarzania skojarzonego. podano przykłady problemów, które powinny być rozwiązane w nowych warunkach ekonomicznych zarówno w dziedzinie optymalizacji ekonomicznej jak i technologicznej.
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From Regenerative Buildings to Regenerative Urban Projects: Design frameworks to scale up within the area of regenerative practice
PublicationIn this chapter, a discussion will be presented of design frameworks and assessment tools that are useful for boosting the scale jumping of regenerative design practices and the paradigm shift. Our main objectives will be to identify existing design and assessment frameworks, to describe the way they work and how they can contribute to scale-jumping regenerative design, as well as to identify shortcomings and opportunities. We...
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Places of worship, spiritual healing and urban regeneration
PublicationMany researchers demonstrated that it is possible to help people achieve mental and physical regeneration with proper architecture, urban and landscape planning. The term therapeutic landscapes could also be applied to places of worship, where people gather for spiritual healing and renewal. Public space that they offer is inclusively open to all. Addition- ally, they serve to reinvigorate the places where they are located. Shrines...
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Sources of investment risk in urban regeneration projects
PublicationThe scope of the article includes multidimensional risk analysis of urban regeneration projects, whose base is to identify areas of its occurrence. Authors thoroughly analyze the sources of potential threats and attempts to answer the question, what is their contribution into overall urban regeneration’ investment risk. The target concept will be used to assess the level of investment risk at the stage of initiation, preparation...
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Urban development and regeneration in Poland - contemporary issues
PublicationArtykuł obejmuje skrótowe omówienie współczesnych procesów rozwoju i rewitalizacji miast w Polsce. Zaprezentowano w nim zarówno procesy planowe jak i zachodzące spontanicznie, a także typologie obszarów poddawanym współczesnym procesom przekształceń
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Market Regeneration in Line with Sustainable Urban Development
PublicationThis article presents the study of the optimal design solutions for regeneration of marketplaces. It examines the design variants for the revitalisation of the marketplace, in particular, investment in their modernisation in order to find the most optimal model for transforming these public spaces to have a significant impact on the city’s development. The research is a comparative analysis of the implementation of regeneration...
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Definition of urban regeneration projects in Russian cities
PublicationUrban regeneration is extremely important process for Russian cities, which faced to the challenges of post-industrial economy. In an attempt, to explain needs of urban regeneration in Russian megacities author analyzed the social and economic trends and some historic features of Russian cities development. The article identified the key areas for regeneration such as the regeneration of historic core, the regeneration of the urban...
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c-Myc inhibition and p21 modulation contribute to unsymmetrical bisacridines-induced apoptosis and senescence in pancreatic cancer cells
PublicationBackground Pancreatic cancer (PC) is one of the most aggressive cancers and is the seventh leading cause of cancer-related death worldwide. PC is characterized by rapid progression and resistance to conventional treatments. Mutations in KRAS, CDKN2A, TP53, SMAD4/DPC4, and MYC are major genetic alterations associated with poor treatment outcomes in patients with PC. Therefore, optimizing PC therapy is a tremendous challenge. Unsymmetrical...
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Tissue Engineering and Regenerative Medicine
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Regenerative Engineering and Translational Medicine
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Piotr Lorens prof. dr hab. inż. arch.
PeopleProf. Piotr Lorens - PhD, DSc., urban planner. Lecturer in urban design and development and - since 2007 - Head of the Department of Urban Design and Regional Planning at the Faculty of Architecture, Gdansk University of Technology. His university activities also include coordination of the research and EU Social Fund projects. Based on these projects he was responsible for organization and coordination of the post-graduate studies...
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Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
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Dye decomposition on P25 with enhanced adsorptivity
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Evaluation of Antifungal Properties of Titania P25
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NEW GENERATION COMPUTING
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Public Lighting in a Context of Regeneration Processes in Polish Cities
PublicationThe purpose of this paper is to reflect on the role of electric lighting design in urban regeneration processes. The landscape of the modern city is the result of an accumulation of the various physical, economic, social and cultural layers over the centuries. Urban lighting may be described as one of the physical layers which due recent developments in the technology of efficient light sources overcomes a major evolution. With...
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Regeneration of marine engine valves using laser surfacing
PublicationThis article presents an analysis of the applicability of laser surfacing of the exhaust valve face of a marine diesel engine using cobalt-based powder. After preparation by machining, the selected valves were subjected to laser surfacing using a high-power ROFIN DL020 laser. The EuTroLoy 16012 powder was used in the surfacing process. One of the valves was cut and subjected to metallographic examination and hardness measurements,...
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Comparative Analysis of Contemporary Regeneration of Waterfronts in Port Cities
PublicationThe paper includes comparative analysis of the selected waterfront case studies in cities around Europe and North America.
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Intelligent artificial joint and regeneration problems in articular joints
PublicationPraca przedstawia zasady działania inteligentnych sztucznych stawów biodrowych człowieka oraz problemy regeneracji chrząstek stawowych w stawach naturalnych człowieka. Postuluje się wagę podjętych badań w powyższym problemie.Zwrócono uwagę na problemy związane ze sterowaniem własności sztucznych stawów biodrowych oraz z identyfikacją impulsów przekazywanych naturalnym połączeniom stawowym człowieka.
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ANALYSIS OF THE INCREASE OF CONSTRUCTION COSTS IN URBAN REGENERATION PROJECTS
PublicationThe subject of this paper is the analysis and evaluation of the reasons for construction costs increases in urban regeneration projects. The analysis considers major refurbishments of real estates’, as well as heavy repair and modernization of the road system. For the period mentioned, the costs from works and expenditure schedules were compared with the costs of additional works, which shows the percentage cost increase in relation...
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Polylysine for Skin Regeneration: A Review of Recent Advances and Perspectives
PublicationThere have been several attempts to find promising biomaterials for skin regeneration, among which polylysine (a homopolypeptide) has shown benefits in the regeneration and treatment of skin disorders. This class of biomaterials has shown exceptional abilities due to their macromolecular structure. Polylysine-based biomaterials can not only be used as tissue engineering scaffolds for skin regeneration, but also as drug carriers...
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A Review on Deactivation and Regeneration of Catalysts for Dimethyl Ether Synthesis
Publicationhe deactivation of catalysts and their regeneration are two very important challenges that need to be addressed for many industrial processes. The most quoted reasons for the deterioration of dimethyl ether synthesis (DME) concern the sintering and the hydrothermal leaching of copper particles, their migration to acid sites, the partial formation of copper and zinc hydroxycarbonates, the formation of carbon deposits, and surface...
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Journal for New Generation Sciences
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IET Generation Transmission & Distribution
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Next Generation Digital
PublicationThe paper outlines the major objectives of the MENAID research project, eimed at novel architectures of digital documents. Such documents will enable reduction of information overflow and strain, a major threat to the growth of a digital society. They will be forward compatible, technology neutral and lightweight, allowing workers of network organizations to use personal devices of any type.
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Optimization of the geometry of the crankshaft for an internal combustion engine with heat regeneration
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NEIGHBOURHOOD SPORT AS A TOOL OF URBAN REGENERATION - A WARSAW CASE STUDY
PublicationThere are many connections between sport and urban regeneration. They can be observed while organizing top-down projects, such as sporting mega-events. But sport and urban renewal can also be linked within bottom-up sport initiatives, ones that relate mostly to physical recreation or sport for all. The main goals of physical activity is caring for health, improving fitness, practicing hobbies, and achieving social integration....
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Participatory Budgeting in Poland – Missing Link in Urban Regeneration Process
PublicationIn last thirty years Poland has gone a long way toward democracy and decentralization. Role of public participation in planning is increasing rapidly and recently many new instruments of empowering the community is being introduced, participatory budgeting is one of the most important. On the other hand, urban regeneration is one of the most important challenges of polish cities are facing. Technical and transport infrastructure...