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Sub-lethal photodynamic inactivation renders Staphylococcus aureus susceptible to silver nanoparticles
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O07 Filaggrin insufficiency renders keratinocyte-derived small extracellular vesicles capable of affecting CD1a-mediated T-cell responses and promoting allergic inflammation
PublikacjaThe association between FLG loss-of-function mutations and the development of atopic dermatitis (AD) indicates that filaggrin is critical to skin barrier function; the mutations are also linked to additional allergic manifestations, but it is unknown how the skin may influence inflammation in distant tissues. Here we investigated the impact of filaggrin insufficiency on keratinocyte-derived exosome-enriched small extracellular...
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Photos and rendered images of LEGO bricks
PublikacjaThe paper describes a collection of datasets containing both LEGO brick renders and real photos. The datasets contain around 155,000 photos and nearly 1,500,000 renders. The renders aim to simulate real-life photos of LEGO bricks allowing faster creation of extensive datasets. The datasets are publicly available via the Gdansk University of Technology “Most Wiedzy” institutional repository. The source files of all tools used during...
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The innovative exploitation of Brassica vegetables in the production of quality food for health. From lab bench to field and fork.
PublikacjaThe specific chemical composition of vegetables belonging to Brassicaceace , as regard both nutrients and non-nutrients, renders them particularly suitable for the health food production chain. The ability of these plants to accumulate heavy metals may be utilised for phytoremediation of arable soils, but also as a vehicle to fortify foods in micronutriens such as selenium. The bioactive organosulfur compounds, especially glucosinolates...
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Estimating the uncertainty of the liquid mass flow using the orifice plate
PublikacjaThe article presents estimation of measurement uncertainty of a liquid mass flow using the orifice plate. This subject is essential because of the widespread use of this type of flow meters, which renders not only the quantitative estimation but also qualitative results of this type so those measurements are important. To achieve this goal, the authors of the paper propose to use the theory of uncertainty. The article shows the...
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Targeting shelterin proteins for cancer therapy.
PublikacjaAs a global health challenge, cancer prompts continuous exploration for innovative therapies that are also based on new targets. One promising avenue is targeting the shelterin protein complex, a safeguard for telomeres crucial in preventing DNA damage. The role of shelterin in modulating ataxia- telangiectasia mutated (ATM) and ataxia-telangiectasia and Rad3-related (ATR) kinases, key players in the DNA damage response (DDR),...
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Generic invariant measures for iterated systems of interval homeomorphisms
PublikacjaIt is well known that iterated function systems generated by orientation preserving homeomorphisms of the unit interval with positive Lyapunov exponents at its ends admit a unique invariant measure on (0, 1) provided their action is minimal. With the additional requirement of continuous differentiability of maps on a fixed neighbourhood of {0,1} { 0 , 1 } , we present a metric in the space of such systems which renders it complete....
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The innovative exploitation of Brassica vegetables in the health quality food production chain
PublikacjaIn this overview the multidirectional opportunities of innovative exploitation of chemical and biological properties of vegetables from Brassiceae family are discussed. The specific chemical composition of brassicas, as regard both nutrients and non-nutrients, renders them particularly suitable for the health food production chain, literally from field to fork. the ability of these plants to accumulate heavy metals may be utilised...
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The innovative Exploitation of Brassica Vegetables in the Health Quality Food Production Chain
PublikacjaIn this overview the multidirectional opportunities of innovative exploitation of chemical and biological properties of vegetables from Brassiceae family are discussed. The specific chemical composition of brassicas, as regard both nutrients and non-nutrients, renders them particularly suitable for the health food production chain, literally from field to fork. the ability of these plants to accumulate heavy metals may be utilised...
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Synthesis of Combretastatin A-4 Analogs and their Biological Activities
PublikacjaCombretastatin A-4 (CA-4) is a natural product, which consists of two phenyl rings, linked by an ethylene bridge. CA-4, inhibitor of polymerization of tubulin to microtubules, possesses a strong antitumor and anti-vascular properties both in vitro and in vivo. Previous studies showed that disodium phosphate salt of CA-4, a water-soluble prodrug is well tolerated at therapeutically useful doses. However, it should be noted that...
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Pressure drop and heat transfer during boiling and condensation at subcritical region
PublikacjaMost of the data presented in the literature relate to saturation temperatures in the range - 20°C to 40°C due to the application in refrigeration technology. There is necessity to extend databases to higher values of saturation temperature due to new applications such as Organic Rankine Cycle and high temperature heat pumps. Only few papers contain data for high reduced pressure for low boiling point liquids. This paper focus...
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Towards an Understanding of the Stability Assessment of Floating Buildings
PublikacjaOne of the most important aspects of the design of floating facilities such as ships, floating offshore structures or floating houses is stability. Its impact on both general safety and operational aspects renders it a fundamental consideration already in preliminary design stages. Usually, the concept of sufficient stability of floating buildings is associated with the ability to keep an allowed heel angle and residual freeboard,...
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Self-healing mechanism of metallopolymers investigated by QM/MM simulations and Raman spectroscopy
PublikacjaThe thermally induced self-healing mechanisms in metallopolymers based on bisterpyridine complexes of iron(II) sulfate and cadmium(II) bromide, respectively, were studied by means of combined quantum mechanical/molecular mechanical (QM/MM) simulations and Raman spectroscopy. Two possible healing schemes, one based on a decomplexation of the cross-linking complexes and a second one relying on the dissociation of ionic clusters,...
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The effect of reduced pressure on carbon dioxide flow boiling heat transfer in minichannels
Publikacja. In the paper presented are the results of the study on the effect of reduced pressure on flow boiling heat transfer data in minichannels as well as conventional ones. That effect renders that most of heat transfer correlations fail to return appropriate results of predictions. Mostly they have been developed for the reduced pressures from the range 0.1-0.3. The special correction has been postulated to the in-house model of flow...
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A Novel Ru(II) Polypyridine Black Dye Investigated by Resonance Raman Spectroscopy and TDDFT Calculations
PublikacjaThe optical properties of a new(bipyridine)2Ru(4H-imidazole) complex presenting a remarkablebroad absorption in the visible range are investigated. Thestrong overlap of the absorption with the solar radiationspectrum renders the studied complex promising as a blackabsorber and hence as a starting structure for applications inthe field of dye-sensitized solar cells. The correlations betweenstructural and electronic features for...
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Application of Open-Hardware-Based Solutions for Rapid Transition From Stationary to the Remote Teaching Model During Pandemic
PublikacjaWhile research indicates usefulness of remote laboratories in teaching of digital hardware systems, their main application is to complement stationary classes. This work presents a low-cost, scalable architecture that supports rapid transformation of teaching to a model based solely on remote access mechanisms. Background: Adaptation of online laboratory solutions from the literature to en-masse teaching of digital circuits is...
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Filter-Hilbert Method for Automatic Correction of Non-Anechoic Antenna Measurements with Embedded Self-Calibration Mechanism
PublikacjaOne of the most important steps in the process of antenna development involves measurements of its prototype. Far-field performance of radiators is normally characterized in strictly controlled environments such as anechoic chambers which can ensure certification-grade accuracy. Unfortunately, they are also characterized by high construction costs which might not be justified for low-budget research and/or teaching-related activities....
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Engineering TADF, Mechanochromism, and Second Harmonic Up- conversion Properties in Regioisomeric Substitution Space
PublikacjaThis research article explores the distinct TADF efficiency of three donor-acceptor based regio-isomers: DPAOCN (ortho- isomer), DPAMCN (meta-isomer), and DPAPCN (para-isomer). DPAPCN exhibits maximum TADF efficiency in both solution and solid-state with an impressive reverse inter-system crossing (RISC) rate of ~ 106 s-1; the underlying cause being the minimum singlet-triplet splitting energy or ∆EST and maximum SOC (spin-orbit...
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Quantum structure in competing lizard communities
PublikacjaAlmost two decades of research on applications of the mathematical formalism of quantum theory as a modeling tool in domains different from the micro-world has given rise to many successful applications in situations related to human behavior and thought, more specifically in cognitive processes of decision-making and the ways concepts are combined into sentences. In this article, we extend this approach to animal behavior, showing...
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KRAJOBRAZOWY WYMIAR RURALISTYKI
PublikacjaTytuł Krajobrazowy wymiar ruralistyki w pełni oddaje treść pracy. Najogólniej mówiąc, rozprawa relacjonuje poszukiwania sposobów udziału krajobrazu w planowaniu przestrzennym obszarów wiejskich. Książka, wbrew swojemu układowi, nie powstawała według zwyczajowej ścieżki: od tezy, mieszczącej się w dziedzinie architektury i urbanistyki, do argumentów, które wywiedzione z tej dyscypliny, przemówiłyby za nią. Analiza stanu badań wskazywała...
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The issues of participation in didactics of design. Case studies
PublikacjaThis article seeks to present and assess the usefulness of didactic methods aimed at preparing future architects for their role in the process of social participation. The article focuses on [a] a general overview of selected participation methods and tools, along with the examples of their application in the context of spatial management in Poland; [b] an overview of teaching methods used with a view to enhancing participation...
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Improved Modeling of Microwave Structures Using Performance-Driven Fully-Connected Regression Surrogate
PublikacjaFast replacement models (or surrogates) have been widely applied in the recent years to accelerate simulation-driven design procedures in microwave engineering. The fundamental reason is a considerable—and often prohibitive—CPU cost of massive full-wave electromagnetic (EM) analyses related to solving common tasks such as parametric optimization or uncertainty quantification. The most popular class of surrogates are data-driven...
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Porous carbon derived from rice husks as sustainable bioresources: insights into the role of micro-/mesoporous hierarchy in hosting active species for lithium–sulphur batteries
PublikacjaThe exploration of natural resources as sustainable precursors affords a family of green materials. Exploring highly abundant and available biowaste precursors remaining from food processing throughout a scalable and cost-effective material synthesis path is highly important especially for new materials discovery in emerging energy storage technologies such as lithium–sulphur (Li–S) batteries. Herein, we have produced a series...
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Efficient Calibration of Cost-Efficient Particulate Matter Sensors Using Machine Learning and Time-Series Alignment
PublikacjaAtmospheric particulate matter (PM) poses a significant threat to human health, infiltrating the lungs and brain and leading to severe issues such as heart and lung diseases, cancer, and premature death. The main sources of PM pollution are vehicular and industrial emissions, construction and agricultural activities, and natural phenomena such as wildfires. Research underscores the absence of a safe threshold for particulate exposure,...
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Expedited constrained multi-objective aerodynamic shape optimization by means of physics-based surrogates
PublikacjaIn the paper, computationally efficient constrained multi-objective design optimization of transonic airfoil profiles is considered. Our methodology focuses on fixed-lift design aimed at finding the best possible trade-offs between the two objectives: minimization of the drag coefficient and maximization of the pitching moment. The algorithm presented here exploits the surrogate-based optimization principle, variable-fidelity computational...
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Two small RNAs conserved in Enterobacteriaceae provide intrinsic resistance to antibiotics targeting the cell wall biosynthesis enzyme glucosamine-6-phosphate synthase
PublikacjaFormation of glucosamine-6-phosphate GlcN6P) by enzyme GlcN6P synthase (GlmS) represents the first step in bacterial cell envelope synthesis. In Escherichia coli, expression of glmS is controlled by small RNAs (sRNAs) GlmY and GlmZ. GlmZ activates the glmS mRNA by base-pairing. When not required, GlmZ is bound by adapter protein RapZ and recruited to cleavage by RNase E inactivating the sRNA. The homologous sRNA GlmY activates...
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Pilicides effectively hinder chaperone-usher interactions in all Gram-negative bacteria
PublikacjaThe chaperone-usher pathway of adhesive structures biogenesis is highly conserved in all Gram-negative bacteria. Pili are polymers of thousands protein subunits that possess conserved immunoglobuline-like structure denoted by lack of the seventh G strand. The effect of this structural defect is a hydrophobic acceptor cleft. The folding of protein subunits is strictly dependent on the action of specific periplasmic chaperone protein...