Wyniki wyszukiwania dla: CORROSION%20INHIBITION
-
IN VIVO DEGRADATION OF BIOMATERIALS
PublikacjaThe material designed to be introduced into the human tissue should be biocompatible and biofunctional. Unless it is so, the body may respond to the implant in different ways. An inflammation reaction may appear such as: parting of items of the implant surface resulting from fraction or pressure. The condition of the surface has an important influence on the usefulness of the implant. The required values depend on the implant function...
-
Morphology and properties of nanotubular oxide layer on the Ti13Zr13Nb alloy
PublikacjaThe Ti13Zr13Nb alloy in solid and porous form was oxidised. The constant voltage 20 V, oxidation time 0.5 and 1 h, and 1 M H3PO4 (orthophosphoric acid) with addition of HF (hydrofluoric acid) as a test solution were applied. SEM (Scanning Electron Microscope) examinations of surface, EDS (Energy Dispersive X-ray Spectroscopy) chemical analysis, nanohardness and nano-scratch tests, and corrosion potentiokinetic tests at various...
-
Chitosan/poly(4-vinylpyridine) coatings formed on AgNPs-decorated titanium
PublikacjaElectrophoretic deposition (EPD) of chitosan/poly(4-vinylpyridine) (chit/P4VP) coatings on titanium substrates previously decorated with silver nanoparticles (AgNPs) was performed at different content of P4VP in the suspension and different voltage values. The results revealed that the composite coatings were formed, well-adjacent to the titanium substrate, of suitable roughness, hydrophilicity, and corrosion resistance. The voltage...
-
Impact of binary mixtures of ketoprofen and chloramphenicol on the germination of Sorghum bicolor (sorgo) seeds
Dane BadawczeResearch was carried out for various ratios of the previously determined EC50 values for mixture of ketoprofen and chloramphenicol, the first substance at 100% of its EC50 concentration was mixed with the second substance at 100% of its EC50 concentration, or the first substance at 50% of its EC50 concentration was mixed with the second substance at...
-
Impact of binary mixtures of ketoprofen and diclofenac on the germination of Sorghum bicolor (sorgo) seeds
Dane BadawczeResearch was carried out for various ratios of the previously determined EC50 values for mixture of ketoprofen and diclofenac, the first substance at 100% of its EC50 concentration was mixed with the second substance at 100% of its EC50 concentration, or the first substance at 50% of its EC50 concentration was mixed with the second substance at 150%...
-
Impact of binary mixtures of ketoprofen and oxytetracycline on the germination of Sorghum bicolor (sorgo) seeds
Dane BadawczeResearch was carried out for various ratios of the previously determined EC50 values for mixture of ketoprofen and oxytetracycline the first substance at 100% of its EC50 concentration was mixed with the second substance at 100% of its EC50 concentration, or the first substance at 50% of its EC50 concentration was mixed with the second substance at...
-
Formation of Porous Structure of the Metallic Materials Used on Bone Implants
PublikacjaResearch on improvement of structure and fabrication methods of the bone implants are carried out for many years. Research are aimed to shape the structures, that will have a Young's modulus value similar to the value of the human bones Young's modulus. Depending on theporosity, Young's moduli can even be tailored to match the modulus of bone closer than solid metals can, thus reducing the problems associated with stress shielding...
-
Mathematical modeling and prediction of pit to crack transition under cyclic thermal load using artificial neural network
PublikacjaThe formation of pitting is a major problem in most metals, which is caused by extremely localized corrosion that creates small holes in metal and subsequently, it changes into cracks under mechanical load, thermo-mechanical stress, and corrosion process factors. This research aims to study pit to crack transition phenomenon of steel boiler heat tubes under cyclic thermal load, and mathematical modeling...
-
Balanand Santhosh Ph.D.
OsobyDr. Balanand Santhosh, obtained his Ph.D. (cum laude) in Materials, Mechatronics and Systems engineering from the Department of Industrial Engineering, University of Trento, Italy. He is currently working as Research Assistant Professor at Gdansk Univerity of Technology, Poland. Formerly he was working as a post-doctoral researcher at University of Trento, Italy. His research expertise is mainly in the area of ceramic processing...
-
The synthesis and biological activity of lipophilic derivatives of bicine conjugated with n3-(4-methoxyfumaroyl)-l-2,3-diaminopropanoic acid(fmdp) - an inhibitor of glucosamine-6-phosphate synthase
PublikacjaOtrzymano serię pochodnych bicyny połączonych z inhibitorem syntazy glukozamino-6-fosforanu (fmdp)oraz zbadano ich właściwości lipofilowe i aktywność przeciwgrzybową. otrzymane związki charakteryzowały się wyższą llipofilowością niż fmdp. wszystkie otrzymane związki wykazywały także wyższą aktywność przeciwgrzybową niż fmdp.
-
Chemical reactivity and antimicrobial activity of N-substituted maleimides
PublikacjaZsyntezowano kilkanaście N-podstawionych maleimidów, zawierających w swojej strukturze podstawniki o różnej wielkości i polarności.Maleimidy o charakterze obojętnym wykazywały silny efekt przeciwgrzybowy; ich aktywność przeciwbakteryjna była zróżnicowana. Niską aktywność przeciwbakteryjną, ale wysoką aktywność cytostatyczną stwierdzono dla maleimidów o charakterze zasadowym. Reaktywność chemiczna i lipofilowość miały wpływ na aktywność...
-
Synthesis of the inosine 5′-monophosphate dehydrogenase (IMPDH) inhibitors
Publikacja -
Synthesis of the inosine 5'-monophosphate dehydrogenase (IMPDH) inhibitors
PublikacjaIn this review are summrized newly described IMPDH inhibitors. The article concerns both synthetic pathways and biological activities of the most promising compounds.
-
Novel synthesis scheme and in vitro antimicrobial evaluation of a panel of (E)-2-aryl-1-cyano-1-nitroethenes
Publikacja -
Synthesis and biological activity of ester derivatives of mycophenolic acid and acridines/acridones as potential immunosuppressive agents
PublikacjaImproved derivatives of mycophenolic acid (MPA) are necessary to reduce the frequency of adverse effects, this drug exerts in treated patients. In this study, MPA was coupled with N-(x-hydroxyalkyl)-9-acridone-4-carboxamides or N-(x-hydroxyalkyl)acridine-4-carboxamides to give respective ester conjugates upon Yamaguchi protocol. This esterification required protection of phenol group in MPA. Designed conjugates revealed higher...
-
Flavonoids as inhibitors of human neutrophil elastase
Publikacja -
Flavonoids as tyrosinase inhibitors in in silico and in vitro models: basic framework of SAR using a statistical modelling approach
Publikacja -
Antiglycoxidative properties of amantadine – a systematic review and comprehensive in vitro study
Publikacja -
9,10-Dioxoanthracenyldithiocarbamates effectively inhibit the proliferation of non-small cell lung cancer by targeting multiple protein tyrosine kinases
PublikacjaAnthraquinones have attracted considerable interest in the realm of cancer treatment owing to their potent anticancer properties. This study evaluates the potential of a series of new anthraquinone derivatives as anticancer agents for non-small-cell lung cancer (NSCLC). The compounds were subjected to a range of tests to assess their cytotoxic and apoptotic properties, ability to inhibit colony formation, pro-DNA damage functions,...
-
Development of potent and effective SARS-CoV-2 main protease inhibitors based on maleimide analogs for the potential treatment of COVID-19
PublikacjaIn the present work, we report a new series of potent SARS-CoV-2 Main Protease (Mpro) inhibitors based on maleimide derivatives. The inhibitory activities were tested in an enzymatic assay using recombinant Mpro (3CL Protease from coronavirus SARS-CoV-2). Within the set of new Mpro inhibitors, 6e demonstrated the highest activity in the enzymatic assay with an IC50 value of 8.52 ± 0.44 mM. The IC50 value for Nirmatrelvir (PF-07321332,...
-
New potent steroid sulphatase inhibitors based on 6-(1-phenyl-1H-1,2,3-triazol-4-yl)naphthalen-2-yl sulphamate derivatives
PublikacjaIn the present work, we report a new class of potent steroid sulphatase (STS) inhibitors based on 6-(1-phenyl-1H-1,2,3-triazol-4-yl)naphthalen-2-yl sulphamate derivatives. Within the set of new STS inhibitors, 6-(1-(1,2,3-trifluorophenyl)-1H-1,2,3-triazol-4-yl)naphthalen-2-yl sulphamate 3L demonstrated the highest activity in the enzymatic assay inhibiting the STS activity to 7.98% at 0.5 µM concentration. Furthermore, to verify...
-
Novel amides of mycophenolic acid and some heterocyclic derivatives as immunosuppressive agents
PublikacjaThe group of new amide derivatives of mycophenolic acid (MPA) and selected heterocyclic amines was synthesised as potential immunosuppressive agents functioning as inosine-5'-monophosphate dehydrogenase (IMPDH) uncompetitive inhibitors. The synthesis employed uronium-type activating system (TBTU/HOBt/DIPEA) while or phosphonic acid anhydride method (T3P/Py) facilitating amides to be obtained in moderate to excellent yields without...
-
Design, synthesis and biological evaluation of novel N-phosphorylated and O-phosphorylated tacrine derivatives as potential drugs against Alzheimer’s disease
PublikacjaIn this work, we designed, synthesised and biologically investigated a novel series of 14N- and O-phosphorylated tacrine derivatives as potential anti-Alzheimer’s disease agents. In the reaction of 9-chlorotacrine and corresponding diamines/aminoalkylalcohol we obtained diamino and aminoalkylhydroxy tacrine derivatives. Next, the compounds were acid to give final products 6–13 and 16–21 that were characterised by 1H, 13 C, 31P...
-
Inhibitors of glucosamine-6-phosphate synthase as potential antimicrobials or antidiabetics – synthesis and properties
PublikacjaGlucosamine-6-phosphate synthase (GlcN-6-P synthase) is known as a promising target for antimicrobial agents and antidiabetics. Several compounds of natural or synthetic origin have been identified as inhibitors of this enzyme. This set comprises highly selective L-glutamine, amino sugar phosphate or transition state intermediate cis-enolamine analogues. Relatively low antimicrobial activity of these inhibitors, poorly penetrating...
-
Recent progress in the development of steroid sulfatase inhibitors – examples of the novel and most promising compounds from the last decade
PublikacjaThe purpose of this review article is to provide an overview of recent achievements in the synthesis of novel steroid sulfatase (STS) inhibitors. STS is a crucial enzyme in the biosynthesis of active hormones (including estrogens and androgens) and, therefore, represents an extremely attractive molecular target for the development of hormone-dependent cancer therapies. The inhibition of STS may effectively reduce the availability...
-
COMPARISON OF TWO MODELS OF CONDENSATION
PublikacjaIn the low-pressure part of steam turbine, the state path usually crosses the saturation line in penultimate stages. At least last two stages of this part of turbines operate in two –phase region. The liquid phase in this region in mainly created in the process of homogeneous and heterogeneous condensation. Several observations confirm however, that condensation often occurs earlier than it is predicted by theory i.e. before the...
-
Performance of zinc-rich coatings evaluated using AFM-based electrical properties imaging
PublikacjaThe paper presents the results of investigation of polyvinyl zinc-rich coating exposed to 97% relativehumidity atmosphere for 40 days. Condition of the coating and evolution of its protective properties weredetermined with the novel AFM-based approach capable of providing surface profiles, local dc currentmaps as well as local impedance spectra. The proposed technique allowed insight into the local changesof coating topography...
-
Structural Reliability Assessment Of Corroded Tanker Ship Based On Experimentally Estimated Ultimate Strength
PublikacjaThis work deals with the reliability assessment of a tanker ship hull structure subjected to a vertical bending moment and corrosion degradation. The progressive collapse and ultimate load carrying capacity are estimated based on experimentally tested scaled box-shaped-specimens. The translation of the strength estimate of the scaled specimen to the real tanker ship hull structure is performed based on the dimensional theory developing...
-
Effect of Storage Conditions of Rutile Flux Cored Welding Wires on Properties of Welds
PublikacjaThe influence of storage locations of two grades of rutile flux cored welding wires on their surface condition and the strength of the welds made with them were studied. Wires were stored in real urban conditions (Gdańsk and Katowice) for 1 month, simultaneously recording changes in conditions: temperature and relative humidity of the environment. Visual tests of wires in the delivered and stored condition as well as visual and...
-
The determinants of morphology and properties of the nanohydroxyapatite coating deposited on the Ti13Zr13Nb alloy by electrophoretic techniqe
PublikacjaThe titanium and its alloys belong at present to the most preferred and commonly applied biomaterials for load- bearing implants. The surfaces of biomaterials are subjected to modification, including the hydroxyapatite coatings deposited in order to ensure corrosion resistance and better joining between an implant and a bone through the possibility of ingrowth bone into the coating. In this paper, the morphology and properties...
-
The impact of material degradation on the resistance and reliability of truss structures
PublikacjaThe paper analyses limit load-carrying capacity and buckling load of truss towers used to support high voltage power lines. The analysed typical structure was subjected to characteristic loads and their combinations. The results were applied to assess structural resistance with regard to steel corrosion in the long-term operation. The extent of structural deterioration was assessed due to Young's modulus decrement in the course...
-
A Simple Replica Method as the Way to Obtain a Morphologically and Mechanically Bone-like Iron-Based Biodegradable Material
PublikacjaPorous iron-based scaffolds were prepared by the simple replica method using polyurethane foam as a template and applying the sintering process in a tube furnace. Their surface morphology was characterized using scanning electron microscopy (SEM) and phase homogeneity was confirmed using X-ray diffraction (XRD). Corrosion behavior was determined using immersion and potentiodynamic polarization methods in phosphate buffered saline...
-
Random field modelling of mechanical behaviour of corroded thin steel plate specimens
PublikacjaThe objective of this work is to explore the possibility of corrosion degradation modelling of thin steel plate specimens with the use of random field approach. The mechanical properties are obtained via the nonlinear Finite Element Analysis with the use of an explicit dynamic solver. The fully nonlinear material model is adopted to obtain the proper stress-strain response. Sensitivity analysis considering the main statistical...
-
Influence of silver nanoparticles addition on antibacterial properties of PEO coatings formed on magnesium
PublikacjaMagnesium is a biodegradable material and thus could be a choice for bone fixation devices and implants with a specific purpose. This study aims to enhance the anti-corrosive, biocompatible, and antibacterial properties on magnesium-based materials through ceramic coatings formation. To achieve this the silicate-based electrolyte was used to create of Plasma Electrolytic Oxidation (PEO) coatings. During investigation the bioactive...
-
Sulfonamides with hydroxyphenyl moiety: Synthesis, structure, physicochemical properties, and ability to form complexes with Rh(III) ion
PublikacjaSulfonamides are the first successfully synthesized antimicrobial drugs. The mechanism of sulfonamides’ antimicrobial action involves competitive inhibition of folic acid synthesis and prevention of the growth and reproduction of bacteria. Even though they have been applied in therapy for more than 75 years, sulfonamides are still the drugs of choice for the treatment of various diseases. The aim of this work was to synthesize...
-
The impact of training and neurotrophins on functional recovery after spinal cord transection: cellular and molecular mechanisms contributing to motor improvement
PublikacjaBeneficial effects of locomotor training on the functional recovery after complete transection of the spinal cord indicate that in chronic spinal animals spontaneous recovery processes are enhanced and shaped by the training. The mechanisms of that use-dependent improvement are still not fully understood. This review tackles three aspects of this issue: (1) neurochemical attributes of functional improvement...
-
ADAPTATION OF THE ACTIVATED SLUDGE TO THE DIGESTATE LIQUORS DURING THE NITRIFICATION AND DENITRIFICATION PROCESSES
PublikacjaThe activated sludge process of the digestate liquors after chemical separation was conducted using a 10 L lab-scale sequencing batch reactor (SBR) and a 0.50 m3 pilotscale SBR independently (with pH control). Due to the relatively high concentration of free ammonia (FA), clear inhibitory effects of the digestate liquors on the nitrifying bacteria were observed. The adaptation of the activated sludge to the toxicity was evaluated...
-
Modelling AOB-NOB competition in shortcut nitrification compared with conventional nitrification-denitrification process
PublikacjaIn particular, mainstream deammonification and/or shortened nitrificationdenitrification via nitrite (so-called “nitrite shunt”) is a promising new treatment concept that has the potential to revolutionise how nitrogen removal is achieved at WWTPs. Understanding the role of the AOB/NOB competition in the nitrogen cycle in wastewater treatment systems will change operational strategies of the novel nitrogen removal processes. The...
-
API 5L X65 steel - tensile properties in room temperature -10°C, along rolling direction
Dane BadawczeSteel designated as API 5L X65 is often used for oil and gas transportation pipelines. It is caused due to its high ductility, weldability and good corrosion resistance. API 5L X65 is a low alloy steel with carbon content less than 0.3% (depends on delivery condition). Once installed, a pipeline remains in place for many years. Throughout its life,...
-
API 5L X65 steel - CMOD-force record in -10°C, along rolling direction
Dane BadawczeSteel designated as API 5L X65 is often used for oil and gas transportation pipelines. It is caused due to its high ductility, weldability and good corrosion resistance. API 5L X65 is a low alloy steel with carbon content less than 0.3% (depends on delivery condition). Once installed, a pipeline remains in place for many years. Throughout its life,...
-
API 5L X65 steel - tensile properties in room temperature +20°C, across rolling direction
Dane BadawczeSteel designated as API 5L X65 is often used for oil and gas transportation pipelines. It is caused due to its high ductility, weldability and good corrosion resistance. API 5L X65 is a low alloy steel with carbon content less than 0.3% (depends on delivery condition). Once installed, a pipeline remains in place for many years. Throughout its life,...
-
API 5L X65 steel - tensile properties in room temperature -10°C, across rolling direction
Dane BadawczeSteel designated as API 5L X65 is often used for oil and gas transportation pipelines. It is caused due to its high ductility, weldability and good corrosion resistance. API 5L X65 is a low alloy steel with carbon content less than 0.3% (depends on delivery condition). Once installed, a pipeline remains in place for many years. Throughout its life,...
-
API 5L X65 steel - CMOD-force record in -10°C, across rolling direction
Dane BadawczeSteel designated as API 5L X65 is often used for oil and gas transportation pipelines. It is caused due to its high ductility, weldability and good corrosion resistance. API 5L X65 is a low alloy steel with carbon content less than 0.3% (depends on delivery condition). Once installed, a pipeline remains in place for many years. Throughout its life,...
-
API 5L X65 steel - tensile properties in room temperature +20°C, along rolling direction
Dane BadawczeSteel designated as API 5L X65 is often used for oil and gas transportation pipelines. It is caused due to its high ductility, weldability and good corrosion resistance. API 5L X65 is a low alloy steel with carbon content less than 0.3% (depends on delivery condition). Once installed, a pipeline remains in place for many years. Throughout its life,...
-
API 5L X65 steel - fracture documentation of CMOD-force test in -10°C, along rolling direction
Dane BadawczeSteel designated as API 5L X65 is often used for oil and gas transportation pipelines. It is caused due to its high ductility, weldability and good corrosion resistance. API 5L X65 is a low alloy steel with carbon content less than 0.3% (depends on delivery condition). Once installed, a pipeline remains in place for many years. Throughout its life,...
-
API 5L X65 steel - fracture documentation of CMOD-force test in -10°C, across rolling direction
Dane BadawczeSteel designated as API 5L X65 is often used for oil and gas transportation pipelines. It is caused due to its high ductility, weldability and good corrosion resistance. API 5L X65 is a low alloy steel with carbon content less than 0.3% (depends on delivery condition). Once installed, a pipeline remains in place for many years. Throughout its life,...
-
Badania stanu technicznego ścianek szczelnych strony południowej i północnej komory południowej śluzy Dzierżno
PublikacjaPrace dotyczyły badań nieniszczących łączników (zamków) Paine`a oraz ścianek szczelnych. Ściany boczne komory południowej śluzy Dzierżno zbudowane są ze stalowych pasów blachy o grubości około 16mm i długości 22m połączonych ze sobą wzdłuż dłuższej krawędzi za pomocą zamków Peine`a. System ten umożliwia uzyskanie szczelnego połączenia na całej długości ścianki. Zaawansowany proces korozji spowodował rozszczelnienie połączenia...
-
Human carnosinases: A brief history, medicinal relevance, and in silico analyses
PublikacjaCarnosine, an endogenous dipeptide, has been found to have a plethora of medicinal properties, such as antioxidant, antiageing, and chelating effects, but with one downside: a short half-life. Carnosinases and two hydrolytic enzymes, which remain enigmatic, are responsible for these features. Hence, here we emphasize why research is valuable for better understanding crucial concepts like ageing, neurodegradation, and cancerogenesis,...
-
Types of wear and tear of biomaterials used in orthopaedic surgery
PublikacjaPurpose of this paper is presentation of observations on different kinds of wear and tear of biomaterials used in contemporary orthopaedic surgery. Types of prosthesis damage, encountered in medical practice, and their causes have been described. Results of many clinical studies were analysed to review prosthesis damage from the stage of implanting (such as intrusion of a foreign object between its components) to their natural...
-
Measurements of flicker noise in supercapacitor cells
PublikacjaFlicker noise (1/f-like noise) is often used to assess the quality of various materials and devices. This phenomenon has been observed in different electrochemical devices or reactions (e.g., smart windows, pitting corrosion events). In our exploratory studies we consider how to measure and utilize 1/f noise for the quality assessment of supercapacitors. This task requires special attention because of enormous capacitance of the...