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The antitumor derivative, C-1748, affects CYP3A4: crosstalk between drug metabolism, CYP3A4 expression and enzymatic activity
PublikacjaJedną z głównych przeszkód w przewidywaniu wyników terapii u pacjentów z nowotworem jest indywidualny przebieg metabolizmu stosowanych leków wynikający z polimorfizmu genów enzymów metabolizujących, jak również duża zmienność farmakokinetyki leków obserwowana u różnych pacjentów podczas trwania chemioterapii. Z powodu tzw. ''wąskiego okna terapeutycznego'' występującego w przypadku terapii lekami przeciwnowotworowymi, małe zmiany...
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The antitumor derivatives, C1305 and C1748, were different in effects on CYP3A4 expression and catalytic activity in HepG2 cells
PublikacjaCytochromy P450 (CYP) należą do grupy enzymów biorących udział w 70-80% metabolizmu fazy I większości stosowanych klinicznie leków. Z tego powodu oddziaływanie leków z enzymami cytochromu P450 stało się istotnym elementem w projektowaniu chemoterapeutyków, szczególnie tych, które są stosowane w terapii wielolekowej. Znajomość substratów, induktorów i inhibitorów poszczególnych izoenzymów P450, nie tylko może obniżać częstość występowania...
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Hybrid fuzzy-ontological project framework of a team work simulation system
PublikacjaThe aim of this article is to present the project framework for constructing a Software Process Simulation Modeling (SPSM) system. SPSM systems can be used as a virtual environment for the selection of methods and tools of project management in IT support organizations. The constructed system simulates the Scrum methodology, including the management processes and the project roles. For the implementation of Scrum processes, the...
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Hybrid Fuzzy-Ontological Project Framework of a Team Work Simulation System
PublikacjaThe aim of this article is to present the project framework for constructing a Software Process Simulation Modeling (SPSM) system. SPSM systems can be used as a virtual environment for the selection of methods and tools of project management in IT support organizations. The constructed system simulates the Scrum methodology, including the management processes and the project roles. For the implementation of Scrum processes, the...
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Real-time PCR approach in dermatophyte detection and Trichophyton rubrum identification
PublikacjaDermatophytes are keratinophilic molds that infect human hair, nails and skin. Diagnosis of dermatophytosis is based on morphological, serological and biochemical features. However, identification is difficult and laborious due to similarities between microorganisms. Thus, there is considerable interest to develop mycological diagnostic procedures based on molecular biology methods. In this study, fast, two-step DNA extraction...
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A Planar-Structured Circularly Polarized Single-Layer MIMO Antenna for Wideband Millimetre-Wave Applications
PublikacjaIn this paper, a simple geometry, planar-structured printed multiple-input-multiple-output (MIMO) antenna utilizing dual circular polarization (CP) is presented. The proposed numerically and experimentally validated design features a fully grounded coplanar waveguide (CPW) and a systematically perturbed feedline radiator. The fringing electric (E) field along the feedline is altered by extruding periodic stubs on each side of the...
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High-Performance Machine-Learning-Based Calibration of Low-Cost Nitrogen Dioxide Sensor Using Environmental Parameter Differentials and Global Data Scaling
PublikacjaAccurate tracking of harmful gas concentrations is essential to swiftly and effectively execute measures that mitigate the risks linked to air pollution, specifically in reducing its impact on living conditions, the environment, and the economy. One such prevalent pollutant in urban settings is nitrogen dioxide (NO2), generated from the combustion of fossil fuels in car engines, commercial manufacturing, and food processing. Its...
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Efficient uncertainty quantification using sequential sampling-based neural networks
PublikacjaUncertainty quantification (UQ) of an engineered system involves the identification of uncertainties, modeling of the uncertainties, and the forward propagation of the uncertainties through a system analysis model. In this work, a novel surrogate-based forward propagation algorithm for UQ is proposed. The proposed algorithm is a new and unique extension of the recent efficient global optimization using neural network (NN)-based...
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Constrained aerodynamic shape optimization using neural networks and sequential sampling
PublikacjaAerodynamic shape optimization (ASO) involves computational fluid dynamics (CFD)-based search for an optimal aerodynamic shape such as airfoils and wings. Gradient-based optimization (GBO) with adjoints can be used efficiently to solve ASO problems with many design variables, but problems with many constraints can still be challenging. The recently created efficient global optimization algorithm with neural network (NN)-based prediction...
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Field Calibration of Low-Cost Particulate Matter Sensors Using Artificial Neural Networks and Affine Response Correction
PublikacjaDue to detrimental effects of atmospheric particulate matter (PM), its accurate monitoring is of paramount importance, especially in densely populated urban areas. However, precise measurement of PM levels requires expensive and sophisticated equipment. Although low-cost alternatives are gaining popularity, their reliability is questionable, attributed to sensitivity to environmental conditions, inherent instability, and manufacturing...
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Statistical Data Pre-Processing and Time Series Incorporation for High-Efficacy Calibration of Low-Cost NO2 Sensor Using Machine Learning
PublikacjaAir pollution stands as a significant modern-day challenge impacting life quality, the environment, and the economy. It comprises various pollutants like gases, particulate matter, biological molecules, and more, stemming from sources such as vehicle emissions, industrial operations, agriculture, and natural events. Nitrogen dioxide (NO2), among these harmful gases, is notably prevalent in densely populated urban regions. Given...
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Machine-learning-based precise cost-efficient NO2 sensor calibration by means of time series matching and global data pre-processing
PublikacjaAir pollution remains a considerable contemporary challenge affecting life quality, the environment, and economic well-being. It encompasses an array of pollutants—gases, particulate matter, biological molecules—emanating from sources such as vehicle emissions, industrial activities, agriculture, and natural occurrences. Nitrogen dioxide (NO2), a harmful gas, is particularly abundant in densely populated urban areas. Given its...
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Unequally-Spaced Slot Strategy for Radiation Null Reduction in Single SIW-Embedded Antenna Element
PublikacjaThe incorporation of higher-order modes (HOMs) can substantially augment the antenna gain and bandwidth, but this improvement is typically accompanied by compromised radiation performance including radiation nulls and higher side lobe levels. In this study, an inventive strategy is introduced to reduce the radiation nulls and the side lobe levels of a single antenna element by positioning multiple slots of the radiating element...
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Removal of VOCs from air and assessment of dominant species in a peat-perlite biotrickling filter
PublikacjaAir pollution has become a major concern because it is inevitably connected with the rapid development of both industrial and residential areas. Volatile organic compounds (VOCs) are emitted from various anthropogenic sources e.g. transportation, factories or landfills as well as recycling factories. It is problematic not only because of the direct impact on humans and environment but also from economy viewpoint as it increases...
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Rola mikroorganizmów w dezodoryzacji powietrza metodą biofiltracji
PublikacjaZanieczyszczenie powietrza związkami zapachowymi staje się rosnącym problemem. W celu ograniczenia emisji substancji uciążliwych zapachowo do atmosfery, wykorzystuje się różne techniki dezodoryzacji. Względnie niskie koszty eksploatacyjne, niewielka odpadowość oraz możliwość oczyszczania dużych objętości gazów, zawierających niewysokie stężenia związków zapachowych powodują, że zastosowanie metod biologicznych jest szczególnie...
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The use of various species of fungi in biofiltration of air contaminated with odorous volatile organic compounds
PublikacjaAir pollution with odorous compounds is a significant social and environmental problem. This paper presents biological deodorization methods. The attention is focused on the application of biotrickling filters for air deodorization. Principles of their operation are discussed, indicating the key role of the selection of microorganisms responsible for the degradation of odorous compounds. A literature overview of the used fungal...
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Enhanced uniform data sampling for constrained data‐driven modeling of antenna input characteristics
PublikacjaData-driven surrogates are the most popular replacement models utilized in many fields of engineering and science, including design of microwave and antenna structures. The primary practical issue is a curse of dimensionality which limits the number of independent parameters that can be accounted for in the modelling process. Recently, a performance-driven modelling technique has been proposed where the constrained domain of the...
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A state of the art review on the use of fungi in biofiltration to remove volatile hydrophobic pollutants
PublikacjaThe physical/chemical abatement of gas pollutants creates many technical problems, is costly and entails significant environmental impacts. Biological purification of off-gases is a cheap and ecologically safe way of neutralization of gas pollutants. Despite the recent advances, the main technological challenge nowadays is the purification of volatile organic compounds (VOCs) of hydrophobic character due to their low solubility...
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Design of a Coplanar Waveguide-Fed Wideband Compact-Size Circularly Polarized Antenna and polarization-sense alteration
PublikacjaThis paper presents the design and validation of a geometrically simple circularly polarized(CP) structure featuring flat gain in the sub-6 GHz 5th generation spectrum. The proposed structure is based on coplanar-waveguide-fed, modified wide slot etched in the ground plane. For generating CP waves, the coplanar ground planes are designed with slight asymmetry in both the horizontal and vertical directions. Furthermore, the ground...
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Selected Aspects of Testing the Positioning Accuracy of GNSS Receivers Used in Sports and Recreation by Dynamic Measurements
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Three-Dimensional Thematic Map Imaging of the Yacht Port on the Example of the Polish National Sailing Centre Marina in Gdańsk
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Comparative analysis of positioning accuracy of Garmin Forerunner wearable GNSS receivers in dynamic testing
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Wyznaczanie linii podstawowej i zewnętrznej granicy morza terytorialnego – aspekt metodyczny
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Modeling 3D Objects for Navigation Purposes Using Laser Scanning
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Air-sparged hydrocyclone (ASH) technology for cyanide recovery
PublikacjaPrzewoźną instalację wyposażoną w napowietrzane reaktory cyklonowe zbadano pod kątem przydatności w procesie ciągłego odpędzania i absorpcji HCN z kopalnianych wód procesowych. Zastosowanie reaktora cyklonowego pozwoliło na ponad 99% absorpcję HCN podczas jednego przejścia fazy gazowej przez reaktor. Natomiast uzyskana efektywność odpędzania HCN, zależna przede wszystkim od stałej Henry'ego, przekroczyła 40% dla jednego przejścia...
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Laboratory and pilot scale photodegradation of cyanide-containing wastewaters
PublikacjaW pracy badano efektywność procesu degradacji cyjanków stosując odpowiednie metody utleniania. Roztwory modelowe cyjanków zawierające TiO2 i H2O2 były poddane fotodegradacji przy różnych warunkach pH, temperatury, różnym składzie fazy gazowej i w obecności różnych katalizatorów. Prawie 20% wzrost w efektywności utlenienia cyjanków był zaobserwowany dla fotodegradacji cyjankowych kompleksów miedzi. Dodatkowo badano fotodegradację...
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Air sparged hydrocyclone (ASH) technology for cyanide recovery
PublikacjaMobilna instalacja reaktora cyklonowego została przetestowana do procesu odzysku cyjanków ze ścieków pochodzących z obróbki złota. HCN był usuwany z fazy gazowej podczas pojedynczego 1-sekundowego cyklu z efektywnością ponad 99%.
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Sounding rocket vibration mechanical filter and amplifier
PublikacjaMeasuring accelerations and vibrations of a sounding rocket provides both information for engineers on the launcher vehicle performance as well as environment description for future payload designers. Typically, information on the level of vibration and eigenfrequencies are required to properly design a payload. This paper presents a design of a novel mechanical filter and amplifier for mechanical vibrations. Its key feature is...
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High Cu content LaNi1-xCuxO3-δ perovskites as candidate air electrode materials for Reversible Solid Oxide Cells
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How should we teach cardiopulmonary resuscitation? Randomized multi-center study
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Toxoplasma gondii: Enzyme-Linked Immunosorbent Assay using different fragments of recombinant microneme protein 1 (MIC1) for detection of immunoglobulin G antibodies
PublikacjaTrzy rekombinantowe fragmenty białka antygenowego MIC1 Toxoplasma gondii (r-MIC1ex2, r-MIC1ex34 i r-MIC1) zostały wyprodukowane jako białka fuzyjne (zawierające dwie domeny oligohistydynowe na N- i C-końcu) w komórkach bakteryjnych Escherichia coli. Homogenne preparaty antygenów rekombinantowych otrzymane z zastosowaniem jednoetapowego oczyszczania metodą chromatografii metalopowinowactwa, wykorzystano następnie do immunoidentyfikacji...
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The pattern of verbal, visuospatial and procedural learning in Richardson variant of progressive supranuclear palsy in comparison to Parkinson’s disease
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Integration of Active Clothing with a Personal Cooling System within the NGIoT Architecture for the Improved Comfort of Construction Workers
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Badania wpływu zaawansowanej technologicznie odzieży ochronnej na stan psychofizyczny człowieka
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Assessment of Grassland Biomass Prediction Using AquaCrop Model: Integrating Sentinel-2 Data and Ground Measurements in Wielkopolska and Podlasie Regions, Poland
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Comparative Analysis of Evapotranspiration Estimates: Applying Data from Meteorological Ground Station, ERA5-Land, and MODIS with ECOSTRESS Observations across Grasslands in Central-Western Poland
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Bandwidth-Controllable Third-Order Band Pass Filter Using Substrate Integrated Full- and Semi-Circular Cavities
PublikacjaThe article presents a novel circular substrate integrated waveguide (SIW) bandpass filter (BPF) with controllable bandwidth. The proposed BPF is configured using two microstrip feedlines, semi- circular SIW cavities, capacitive slots, and inductive vias. The circular cavity is bisected into two halves, with the two copies thereof being cascaded. Two bisected and cascaded structures obtained this way are subsequently connected...
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Production of Toxoplasma gondii MAG1 recombinant antigen in Leishmania tarentolae expression system
PublikacjaThe results of the work associated with the production of the Toxoplasma gondii matrix antigen 1 (MAG1) in the eukaryotic expression system of Leishmania tarentolae are shown.
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PCR and real-time PCR assays to detect fungi of Alternaria alternata species
PublikacjaFungi of the Alternaria genus are mostly associated with allergic diseases. However, with a growing number of immunocompromised patients, these fungi, with A. alternata being the most prevalent one, are increasingly recognized as etiological agents of infections (phaeohyphomycoses) in humans. Nowadays, identification of Alternaria spp. requires their pure culture and is solely based on morphological criteria. Clinically, Alternaria...
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Prediction of Bioactive Peptides From Chicken Feather and Pig Hair Keratins Using In Silico Analysis Based on Fragmentomic Approach
PublikacjaBackground: Keratin is among the most abundant structural proteins of animal origin, however it remains broadly underutilized. Objective: Bioinformatic investigation was performed to evaluate selected keratins originating from mass-produced waste products, i.e., chicken feathers and pig hair, as potential sources of bioactive peptides. Methods: Pepsin, trypsin, chymotrypsin, papain, and subtilisin were used for in silico keratinolysis...
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Analysis of Agricultural and Engineering Systems using Simulation Decomposition
PublikacjaThis paper focuses on the analysis of agricultural and engineering processes using simulation decomposition (SD). SD is a technique that utilizes Monte Carlo simulations and distribution decomposition to visually evaluate the source and the outcome of different portions of data. Here, SD is applied to three distinct processes: a model problem, a nondestructive evaluation testing system, and an agricultural food-water energy system....
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Neural Network-Based Sequential Global Sensitivity Analysis Algorithm
PublikacjaPerforming global sensitivity analysis (GSA) can be challenging due to the combined effect of the high computational cost, but it is also essential for engineering decision making. To reduce this cost, surrogate modeling such as neural networks (NNs) are used to replace the expensive simulation model in the GSA process, which introduces the additional challenge of finding the minimum number of training data samples required to...
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An optimal designed experiment for the alkaline hydrolysis of feather keratin
PublikacjaFeathers, burdensome waste from the poultry industry, can be a cheap source of keratin, a protein with excellent physico- chemical, biological, and mechanical properties. Acid and alkaline hydrolyses are usually adopted for isolation of keratin from its natural resources. This study aimed at assessing the statistically significant effect of input variables in the alkaline hydrolysis of keratin from chicken feathers on the process...
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Algorytmy analizy, przetwarzania i wizualizacji danych z sonaru wielowiązkowego w rozproszonych systemach gis
PublikacjaKatedra Systemów Geoinformatycznych prowadzi badania naukowe związane z zastosowaniem nowych technologii implementacji Systemów Informacji Przestrzennej (GIS) w różnych zastosowaniach, a szczególnie w aplikacjach związanych z obszarami morskimi. Prowadzone są też prace badawcze związane z analizą i przetwarzaniem danych dla systemów GIS, ze szczególnym uwzględnieniem danych otrzymywanych z sonarów wielowiązkowych. Niniejszy artykuł...
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Klocki samopompujące w łożyskach hydrodynamicznych = Self-pumping pads in the hydrodynamic bearings
PublikacjaWe współpracy z firmą ALSTOM HYDRO (Szwajcaria), zespół Katedry Konstrukcji i Eksploatacji Maszyn Politechniki Gdańskiej przeprowadził symulacje przepływowe kilku rozwiązań konstrukcyjnych mających na celu zwiększenie niezawodności turbin wodnych. W artykule opisano jedno z takich rozwiązań - tak zwane łożysko z klockami samopompującymi. Głównym celem jest uzyskanie przepływu oleju w układzie smarowania łożyska hydrodynamicznego...
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Dihydroxyanthraquinones as stable and cost-effective TiO2 photosensitizers for environmental and biomedical applications
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Photodynamic Inactivation of Bacteria with Porphyrin Derivatives: Effect of Charge, Lipophilicity, ROS Generation, and Cellular Uptake on Their Biological Activity In Vitro
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Assessing historical church tower asymmetry using point cloud spatial expansion
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Recent Issues and Challenges in the Study of Inland Waters
PublikacjaThis paper addresses several important problems and methods related to studies of inland waters based on the existing scientific literature. The use of UAVs in freshwater monitoring is described, including recent contact and non-contact solutions. Due to a decline in biological diversity in many parts of the globe, the main threats are described together with a modern method for algae and cyanobacteria monitoring utilizing chlorophyll...
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Robust unsupervised georeferencing algorithm for aerial and satellite imagery
PublikacjaIn order to eliminate a human factor and fully automate the process of embedding the spatial localization information in a remote sensed image the integrated georeferencing method was proposed. The paper presents this unsupervised and robust approach which is comprised of pattern recognition, using SIFT-based detector, and RANSAC based outlier removal with matching algorithm.