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Wyniki wyszukiwania dla: Ultra rare disease
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New recombinant chimeric antigens, P35-MAG1, MIC1-ROP1, and MAG1-ROP1, for the serodiagnosis of human toxoplasmosis
PublikacjaThe aim of the study was to evaluate the usefulness of 3 chimeric Toxoplasma gondii antigens, P35-MAG1,MIC1-ROP1 andMAG1-ROP1, in the serodiagnosis of an acute toxoplasmosis in humans. Proteins were produced as fusion proteins containing His tags ends and then further purified by metal affinity chromatography. Their application for the diagnosis of recently acquired T. gondii infection was tested in IgG and IgM enzyme-linked immunosorbent...
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A novel chemiluminescent immunoassay for detection of Toxoplasma gondii IgG in human sera
PublikacjaThis study describes Toxoplasma gondii IgG chemiluminescent immunoassay (CLIA) based on the use of a novel immunochemical reagents in the form of the conjugates of original acridinium ester (AE) labels attached to antibodies and SAG2-GRA1-ROP1L chimeric antigen and shows that this test is useful for diagnostic purposes.
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Application of IR UWB Spectrum Shaping to IEEE 802.15.4a Standard
PublikacjaCoexistence of existing narrowband systems and new ultra wideband devices in the same frequency range requires using some interference mitigation techniques, for example based on spectrum shaping. This paper presents efficiency of impulse radio spectrum shaping methods, applied to IEEE 802.15.4a UWB alternate physical layer signals. Basic parameters of 802.15.4a signal structure and outline of proposed spectrum shaping methods...
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The luminescence study of Ca14Zn6Ga10−xMnxO35 coumpounds.
Dane BadawczeManganese in the pentavalent state (Mn 5+) is both rare and central in materials exhibiting narrow-band near-infrared (NIR) emission and is highly sought after for phosphor-converted light-emitting diodes as promising candidates for future miniature solid-state NIR light source. We develop the Ca 14 Zn 6 Ga 10−x Mn x O 35 (x = 0.3, 0.5, 1.0, 1.25, 1.5,...
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Does pandemic denial help or harm? Belief in COVID-19 and experience of it affect psychological consequences of using neurotic defence mechanisms
PublikacjaObjective: The COVID-19 pandemic may activate thoughts of death, leading to aversive psychological states. In such situations, defence mechanisms emerge; however, their adaptability depends on many factors. The aim of the study was to investigate the relationship between neurotic defence style and depressive symptoms. We assumed that the sense of coherence underlies this correlation and investigated how both believing (or not)...
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Dependable Integration of Medical Image Recognition Components
PublikacjaComputer driven medical image recognition may support medical doctors in the diagnosis process, but requires high dependability considering potential consequences of incorrect results. The paper presentsa system that improves dependability of medical image recognition by integration of results from redundant components. The components implement alternative recognition algorithms of diseases in thefield of gastrointestinal endoscopy....
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Luminescence properties of TeOx-Eu thin films
Dane BadawczeThe DataSet contains the emission and excitation spectra of TeOx-Eu thin films. The material was obtained by the sol-gel method. The starting solution was prepared by mixing telluric acid (precursor) with thetraetylene glycol, water, and ethanol. Next, the 5% mol of europium ions were added, the nitrates were used as a source of rare-earth ions. The...
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Luminescence properties of TeOx-Tb thin films
Dane BadawczeThe DataSet contains the emission and excitation spectra of TeOx-Tb thin films. The material was obtained by the sol-gel method. The starting solution was prepared by mixing telluric acid (precursor) with thetraetylene glycol, water, and ethanol. Next, the 5% mol of terbium ions were added, the nitrates were used as a source of rare-earth ions. The...
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Luminescence properties of TeOx-Dy thin films
Dane BadawczeThe DataSet contains the emission and excitation spectra of TeOx-Dy thin films. The material was obtained by the sol-gel method. The starting solution was prepared by mixing telluric acid (precursor) with thetraetylene glycol, water, and ethanol. Next, the 5% mol of dysprosium ions were added, the nitrates were used as a source of rare-earth ions....
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DIFFRACTION PHASE MICROSCOPY FOR OBSERVATION ON RED BLOOD CELLS FLUCTUATION
PublikacjaNowadays there is quite huge need for more and more precise and effective fast diagnostics methods in hematology diseases. One of the most important blood components are erythrocytes – RBCs (Red Blood Cells). Due to their size they are easy to observe using microscopy. It is commonly known that the shape and lifetime of RBCs allows for early disease identification. Authors present special measurement system for RBCs fluctuations observation...
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Agnieszka Pastula Dr
OsobyAgnieszka received her masters degree in biology at Jagiellonian University (Poland). Besides standard university classes, she did multiple extracurricular research internships in both basic science and medical life sciences e.g. at Warsaw University, Jagiellonian University College of Medicine, University of Medical Sciences in Poznań and University Medical Center Utrecht, that provided her with excellent interdisciplinary training...
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WYKORZYSTANIE SIECI NEURONOWYCH I METODY WEKTORÓW NOŚNYCH SVM W PROCESIE ROZPOZNAWANIA AKTYWNOŚCI RUCHOWEJ PACJENTÓW DOTKNIĘTYCH CHOROBĄ PARKINSONA
PublikacjaChoroba Parkinsona (ang. PD - Parkinson Disease) zaliczana jest do grupy chorób neurodegeneracyjnych. Jest to powoli postępująca choroba zwyrodnieniowa ośrodkowego układu nerwowego. Jej powstawanie związane jest z zaburzeniem produkcji dopaminy przez komórki nerwowe mózgu. Choroba manifestuje się zaburzeniami ruchowymi. Przyczyna występowania tego typu zaburzeń nie została do końca wyjaśniona. Leczenie osób dotkniętych PD oparte...
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Novel monovalent and multivalent recombinant proteins of Borrelia burgdorferi sensu lato with potential diagnostic value – construction and biotechnological production
PublikacjaThe diverse antigenic structure of Borrelia burgdorferi sensu lato (s.l.) and the low degree of protein sequence conservation between genospecies causes many limitations in serodiagnosis of Lyme disease (LD). Using expression systems based on Escherichia coli, five monovalent B. burgdorferi s.l. recombinant proteins were produced. i.e., BB0108, BB0126, BB0298, BB0323, BB0689 (each in three variants derived from Borrelia afzelii,...
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Bioactivities of Phenolic Compounds from Kiwifruit and Persimmon
PublikacjaFruit used in the common human diet in general, and kiwifruit and persimmon particularly, displays health properties in the prevention of heart disease. This study describes a combination of bioactivity, multivariate data analyses and fluorescence measurements for the differentiating of kiwifruit and persimmon, their quenching and antioxidant properties. The metabolic differences are shown, as well in the results of bioactivities...
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Silicon microcantilever with impedance sensor
Dane BadawczeThe issue of microelectromechanical systems (MEMS) [1] has been enjoying popularity and interest since the 90s of the 20th century. Microcells are one of the simplest devices of this type, but they can be widely used in sensors. There are reports on the possibility of using this type of sensors in the context of such important issues as diagnostics...
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Study of the chemical state of Gd in a Ba-La-Gd-Co based ceramic
Dane BadawczeBarium, Lanthanum, Gadolinium and Cobaltium precursors were used for production of ceramic materials. Samples were produced by standard solid state reaction. Samples were annealed at 300 Celsius degree in wet and dry atmosphere. Annealing takes 72h or 2h. Results of annealing on a Gadolinum were observed by X-Ray photoemission spectroscopy (XPS), OmicronNanotechnology....
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Expedited EM-driven multi-objective antenna design in highly-dimensional parameter spaces
PublikacjaA technique for low-cost multi-objective optimization of antennas in highly-dimensional parameter spaces is presented. The optimization procedure is expedited by exploiting fast surrogate models, including coarse-discretization EM antenna simulations and response surface approximations (RSA). The latter is utilized to yield an initial set of Pareto non-dominated designs which are further refined using response correction methods....
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Fast Simulation-Driven Design of a Planar UWB Dipole Antenna with an Integrated Balun
PublikacjaThe paper presents a design of an ultra-wideband (UWB) antenna with an integrated balun. A fully planar balun interfacing the microstrip input of the structure to the coplanar stripline (CPS) input of the dipole antenna is introduced. The electromagnetic (EM) model of the structure includes the dipole, the balun, and the microstrip input to account for interactions over the UWB band. The EM model is adjusted for low reflection...
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Deep Learning-Based LOS and NLOS Identification in Wireless Body Area Networks
PublikacjaIn this article, the usage of deep learning (DL) in ultra-wideband (UWB) Wireless Body Area Networks (WBANs) is presented. The developed approach, using channel impulse response, allows higher efficiency in identifying the direct visibility conditions between nodes in off-body communication with comparison to the methods described in the literature. The effectiveness of the proposed deep feedforward neural network was checked on...
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Lightweight structures in architecture: scenarios for the future
PublikacjaLightweight structures - structures with a reduced weight, which otherwise retain the qualities necessary for the building performance, ensuring a proper durability and strength, safety, indoor environmental quality and energy efficiency; stuctures which strive for the optimization of structural systems - are in tune with current trends and socio-economic, environmental and technological factors. The growing interest in the lightweight...
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Pr-doped TiO2: The effect of metal content on photocatalytic activity
PublikacjaThe Pr-TiO2 nanoparticles were prepared by using the sol-gel method. As-prepared samples were characterized by BET measurements, X-ray powder diffraction analysis (XRD) and UV-Vis spectra. Visible and ultraviolet light photocatalytic activity of the sample was studied by photodegradation of phenol while considering the influence of the dopant concentration. TiO2 doped with 0.25 mol% of praseodymium showed the highest photocatalytic...
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Growth Orientation and the Profile of Micro-Entrepreneurs From the Pomorskie Province
PublikacjaThe article begins with the presentation of the concept of Entrepreneurial Orientation. Entrepreneurial Orientation assumes that some enterprises, regardless of size, behave in an entrepreneurial way and are proactive, innovative and willing to take risks. The relationships between Entrepreneurial Orientation and the results of enterprises are also subject to research, although its results are not clear – mainly due to the different...
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Luminescence properties of TeOx-Dy thin films annealing under an oxidizing atmosphere
Dane BadawczeThe DataSet contains the emission and excitation spectra of TeOx-Dy thin films. The material was obtained by the sol-gel method. The starting solution was prepared by mixing telluric acid (precursor) with thetraetylene glycol, water, and ethanol. Next, the 5% mol of dysprosium ions were added, the nitrates were used as a source of rare-earth ions....
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Luminescence properties of TeOx-Tb thin films annealing under an oxidizing atmosphere
Dane BadawczeThe DataSet contains the emission and excitation spectra of TeOx-Tb thin films. The material was obtained by the sol-gel method. The starting solution was prepared by mixing telluric acid (precursor) with thetraetylene glycol, water, and ethanol. Next, the 5% mol of terbium ions were added, the nitrates were used as a source of rare-earth ions. The...
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Luminescence properties of TeOx-Eu thin films annealing under an oxidizing atmosphere
Dane BadawczeThe DataSet contains the emission and excitation spectra of TeOx-Eu thin films. The material was obtained by the sol-gel method. The starting solution was prepared by mixing telluric acid (precursor) with thetraetylene glycol, water, and ethanol. Next, the 5% mol of europium ions were added, the nitrates were used as a source of rare-earth ions. The...
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Molecularly imprinted polymers for the detection of volatile biomarkers
PublikacjaIn the field of cancer detection, the development of affordable, quick, and user-friendly sensors capable of detecting various cancer biomarkers, including those for lung cancer (LC), holds utmost significance. Sensors are expected to play a crucial role in the early-stage diagnosis of various diseases. Among the range of options, sensors emerge as particularly appealing for the diagnosis of various diseases, owing to their cost-effectiveness,...
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Nanoparticles: Taking a Unique Position in Medicine
PublikacjaThe human nature of curiosity, wonder, and ingenuity date back to the age of humankind. In parallel with our history of civilization, interest in scientific approaches to unravel mechanisms underlying natural phenomena has been developing. Recent years have witnessed unprecedented growth in research in the area of pharmaceuticals and medicine. The optimism that nanotechnology (NT) applied to medicine and drugs is taking serious...
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Using Convolutional Neural Networks for Corneal Arcus Detection Towards Familial Hypercholesterolemia Screening
PublikacjaFamilial hypercholesterolemia (FH) is a highly undiagnosed disease. Among FH patients, the onset of premature coronary artery disease is 13 times higher than in the general population. Early diagnosis and treatment is essential to prevent cardiovascular diseases and their complications, and to prolong life. One of the clinical criteria of FH is the occurrence of a corneal arcus (CA) among patients, especially those under 45 years...
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Deep CNN based decision support system for detection and assessing the stage of diabetic retinopathy
PublikacjaThe diabetic retinopathy is a disease caused by long-standing diabetes. Lack of effective treatment can lead to vision impairment and even irreversible blindness. The disease can be diagnosed by examining digital color fundus photographs of retina. In this paper we propose deep learning approach to automated diabetic retinopathy screening. Deep convolutional neural networks (CNN) - the most popular kind of deep learning algorithms...
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A Comprehensive Experimental and Theoretical Study on the[{(η5-C5H5)2Zr[P(µ-PNEt2)2P(NEt2)2P]}2O Crystalline System
PublikacjaThe structure of tetraphosphetane zirconium complex C52H100N8OP10Zr21 was determined by single crystal X-ray diffraction analysis. The crystal belongs to the monoclinic system, space group P21/c, with a = 19.6452(14), b = 17.8701(12), c = 20.7963(14)Å, α = γ = 90°, β = 112.953(7)°, V = 6722.7(8)Å3, Z = 4. The electronic structure of the organometallic complex has been characterized within the framework of Quantum Chemical Topology....
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Review on Current Status of Echinocandins Use
PublikacjaFungal infections are rising all over the world every year. There are only five medical compound classes for treatment: triazoles, echinocandins, polyenes, flucytosine and allylamine. Currently, echinocandins are the most important compounds, because of their wide activity spectrum and much lower sides effects that may occur during therapy with other drugs. Echinocandins are secondary metabolites of fungi, which can inhibit the...
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ADSRRS-fingerprinting and PCR MP techniques for studies of intraspecies genetic relatedness in Staphylococcus aureus
PublikacjaW pracy pokazano użyteczność dwóch nowych metod do typowania molekularnego Staphylococcus aureus, ADSRRS-fingerprinting (Amplification of DNA fragments Surrounding Rare Restriction Sites) i PCR MP (PCR melting profile). Przebadano 37 szczepów Staphylococcus aureus izolowanych od pacjentów z czyracznością. Jako metodę referencyjną zastosowano REA-PFGE. Okazało się, że izolaty Staphylococcus aureus z nosa od niektórych pacjentów...
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Optymalizacja i walidacja metody ADSRRS-fingerprinting - konstrukcja zestawu diagnostycznego do różnicowania genetycznego drobnoustrojów
PublikacjaSpośród wszystkich metod typowania mikroorganizmów na szczególną uwagę zasługują metody oparte na analizie całego materiału genetycznego zawartego w komórce. Jedną z nich jest stosunkowo nowa technika ADSRRS-fingerprinting (ang. Amplification of DNA Fragments Surrounding Rare Restriction Sites). Na podstawie naszych badań można stwierdzić, iż charakteryzuje się ona wysokim potencjałem różnicującym, wiarygodnością, powtarzalnością...
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Electrolytic deposition of reactive element thin films on Crofer 22 APU and evaluation of the resulting high-temperature corrosion protection properties at 700 °C–900 °C
PublikacjaThis article presents electrolytic deposition of thin Rare Earth (RE) coatings on Crofer 22 APU stainless steel substrates for high temperature applications, such as interconnects in solid oxide cell stacks. The deposition of coatings based on yttrium-, gadolinium-, lanthanum-, and cerium nitrates is discussed. The high temperature corrosion properties of surface-modified steels were examined using thermogravimetry and electrical...
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New methodology for calculating cost-efficiency of different ways of voting: is internet voting cheaper?
PublikacjaNew ways of voting in elections are being sought by electoral administrations worldwide who want to reverse declining voter turnouts without increasing electoral budgets. This paper presents a novel approach to cost accounting for multi-channel elections based on local elections in Estonia. By doing so, it addresses an important gap in the academic literature in this field. The authors confirm that internet voting was most cost-efficient...
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Bridge Ergonomic Design: A Review
PublikacjaHuman error remains the most common cause of marine incidents and it is worth emphasizing that navigator’s performance is directly affected by ergonomic factors on the bridge. Studies regarding influence of bridge design and work environment on the operator are rare, thus the main purpose of this paper is to fill in this gap. Documents issued by recognized organizations, research publications and additional sources were reviewed...
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Ryszard Katulski prof. dr hab. inż.
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Analog CMOS processor for early vision processing with highly reduced power consumption
PublikacjaA new approach to an analog ultra-low power visionchip design is presented. The prototype chip performs low-levelconvolutional image processing algorithms in real time. Thecircuit is implemented in 0.35 μm CMOS technology, contains64 x 64 SIMD matrix with embedded analogue processors APE(Analogue Processing Element). The photo-sensitive-matrix is of2.2 μm x 2.2 μm size, giving the density of 877 processors permm2. The matrix dissipates...
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UWB-Based Indoor Navigation in a Flexible Manufacturing System Using a Custom Quadrotor UAV
PublikacjaA novel solution for indoor navigation of a transportation drone in flexible manufacturing is presented in this paper. To address the challenges of accurate and robust drone navigation in occluded environments, an ultra-wideband (UWB) navigation system has been integrated with a commercially available open source control platform. The system offers high accuracy (± 20 mm), low power consumption, resistance to electronic interference,...
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Turmeric nanofiber-encapsulated natural product formulation act as a phytogenic feed additive—A study in broilers on growth performance, biochemical indices of blood, and E. coli in cecum
PublikacjaA phytogenic feed additive (PFA) formulation was prepared with bioactive molecules—curcuminoids, gingerol, and carvacrol by encapsulating in nanofiber isolated from turmeric spent (turmeric nanofiber, TNF). This formulation was completely characterized by scanning electron microscope, ultra performance liquid chromatography, and gas chromatography and evaluated for its efficacy. PFA-encapsulated TNF (PFA@TNF) considerably increased...
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Next generation ITS implementation aspects in 5G wireless communication network
PublikacjaIn the paper the study of Intelligent Transportation systems implementation in the 5G wireless communication network is presented. Firstly, small-cell concept in Ultra Dense Heterogeneous network was analyzed. Secondly, the 5G network requirements were presented which are important from the point of view of transportation systems development. Next, the study on the 5G network architectures proposals dedicated to the ITS systems...
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SMALL INTESTINE, Duodenum - Female, 16 - Tissue image [7220729599721211]
Dane BadawczeThis is the histopathological image of SMALL INTESTINE tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Genome-Wide DNA Methylation and Gene Expression in Patients with Indolent Systemic Mastocytosis
PublikacjaMastocytosis is a clinically heterogenous, usually acquired disease of the mast cells with a survival time that depends on the time of onset. It ranges from skin-limited to systemic disease, including indolent and more aggressive variants. The presence of the oncogenic KIT p. D816V gene somatic mutation is a crucial element in the pathogenesis. However, further epigenetic regulation may also affect the expression of genes that...
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Determination of antibiotic residues in honey
PublikacjaHoney produced by honeybees is a valuable food product. The presence of xenobiotics in honey may harm its quality and constitute a danger to human health. Antibiotics are commonly applied by beekeepers to eliminate disease among honeybees. Moreover, ubiquitous administration of antibiotics may cause bacteria to become resistant to many drugs and spread antibioticresistant strains of bacteria. Appropriate sample preparation and...
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Observation on red blood cells fluctuations by diffraction phase microscopy
PublikacjaNowadays there is quite huge need for more and more precise and effective fast diagnostics methods in hematology diseases. One of the most important blood components are erythrocytes – Red Blood Cells (RBCs). Due to their size they are easy to observe using microscopy. It is commonly known that the shape and lifetime of RBCs allows for early disease identification. Authors present special measurement system for RBCs fluctuations...
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Design of a Planar UWB Dipole Antenna with an Integrated Balun Using Surrogate-Based Optimization
PublikacjaA design of an ultra-wideband (UWB) antenna with an integrated balun is presented. A fully planar balun configuration interfacing the microstrip input of the structure to the coplanar stripline (CPS) input of the dipole antenna is introduced. The electromagnetic (EM) model of the structure of interest includes the dipole, the balun, and the microstrip input to account for coupling and radiation effects over the UWB band. The EM...
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A new method of current limitation. Nowa metoda ograniczania prądu.
PublikacjaZaprezentowano nowa ideę hybrydowego, bezstykowego ogranicznika prądów zwarciowych oraz możliwości jego aplikacji. W ograniczniku tym zastąpiono łącznik zestykowy bezpiecznikiem o ultra krótkim topiku, dzięki czemu uniknięto niedogodności związanych z napędem występujących w klasycznych łącznikach hybrydowych. Rolą bezpiecznika w tym nowym zestawie jest wyłącznie zadziałanie w warunkach zwarciowych, a po przejęciu prądu...
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Malignant neoplasm of breast - Female, 48 - Tissue image [2270630026307681]
Dane BadawczeThis is the histopathological image of BREAST tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Malignant neoplasm of breast - Female, 48 - Tissue image [2270630026318631]
Dane BadawczeThis is the histopathological image of BREAST tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Malignant neoplasm of breast - Female, 48 - Tissue image [2270630026308641]
Dane BadawczeThis is the histopathological image of BREAST tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.