Wyniki wyszukiwania dla: BIAŁKO WIĄŻĄCE DNA

• Experience-Oriented Intelligence for Internet of Things

  Publikacja

  • H. Zhang
  • F. Li
  • J. Wang
  • C. Sanín
  • E. Szczerbicki

  - CYBERNETICS AND SYSTEMS - Rok 2017

  The Internet of Things (IoT) has gained significant attention from industry as well as academia during the past decade. The main reason behind this interest is the capabilities of the IoT for seamlessly integrating classical networks and networked objects, and hence allows people to create an intelligent environment based on this powerful integration. However, how to extract useful information from data produced by IoT and facilitate...

  Pełny tekst do pobrania w portalu

• Hazard Control in Industrial Environments: A Knowledge-Vision-Based Approach

  Publikacja

  • C. De
  • C. Sanin
  • E. Szczerbicki

  - Advances in Intelligent Systems and Computing - Rok 2018

  This paper proposes the integration of image processing techniques (such as image segmentation, feature extraction and selection) and a knowledge representation approach in a framework for the development of an automatic system able to identify, in real time, unsafe activities in industrial environments. In this framework, the visual information (feature extraction) acquired from video-camera images and other context based gathered...

  Pełny tekst do pobrania w serwisie zewnętrznym

• Synthesis of eosin modified TiO2 film with co-exposed {001} and {101} facets for photocatalytic degradation of para-aminobenzoic acid and solar H2 production

  Publikacja

  • J. Khan
  • M. Sayed
  • N. S. Shah
  • S. Khan
  • Y. Zhang
  • G. Boczkaj
  • H. Khan
  • D. D. Dionysiou

  - APPLIED CATALYSIS B-ENVIRONMENTAL - Rok 2020

  Owing to the increasing photosensitivity and DNA damage properties of para-aminobenzoic acid (PABA), concerns have been raised over the exposure of humans to PABA. Solar light-driven photocatalysis (SPC) provides a promising solution for the effective removal of organic pollutants especially when directed towards sulfate radical (SO4−) production. Herein, we have developed a sulfite-enhanced SPC using Eosin-Y sensitized TiO2/Ti...

  Pełny tekst do pobrania w serwisie zewnętrznym

• Motility activity, slime production, biofilm formation and genetic typing by ERIC-PCR for Pseudomonas aeruginosa strains isolated from bovine and other sources (human and environment)

  Publikacja

  • K. Wolska
  • P. Szweda
  • K. Lada
  • E. Rytel
  • K. M. Gucwa
  • B. Kot
  • M. Piechota

  - POLISH JOURNAL OF VETERINARY SCIENCES - Rok 2014

  The molecular-typing strategy, ERIC-PCR was used in an attempt to determine the genomic relationship of 28 P. aeruginosa strains isolated from faeces of healthy bovine, bovine mastitis and from faeces of hospital patients as well as from environment. ERIC-PCR fingerprinting revealed large molecular differentiation within this group of isolates. Twenty two out of 28 strains tested generated unique patterns of DNA bands and only...

  Pełny tekst do pobrania w portalu

• Neptunium Enhancing Baltic Region Research Cooperation Badanie oddziaływań aktywnych przeciwnowotworowo pochodnych (bis)akrydyny z DNA: podejście elektrochemiczne vs. enzymatyczne jako wstęp do badań in vivo.

  Projekty

  Kierownik projektu: dr hab. inż. Agnieszka Potęga

  Projekt realizowany w Wydział Chemiczny zgodnie z porozumieniem DEC-5/1/2024/IDUB/II.2b/Np z dnia 2024-10-02

• The noncanonical disulfide bond as the important stabilizing element of the immunoglobulin fold of the Dr fimbrial DraE subunit

  Publikacja

  • R. Piątek
  • P. Bruździak
  • M. Wojciechowski
  • B. Zalewska-Piątek
  • J. Kur

  - BIOCHEMISTRY-US - Rok 2010

  Adhezyny fimbrialne bakterii patogennych stanowią liniowe asocjaty białkowe odpowiedzialne za wiązanie do specyficznych receptorów na powierzchni komórek gospodarza. Biogeneza tych struktur odbywa się przez system sekrecji typu chaperone/usher zakonserwowany pośród bakterii Gram-ujemnych. Powyższe struktury adhezyjne charakteryzują się wysoką odpornością na denaturację i deasocjację, powodowane przez temperaturę lub chemiczne czynniki...

  Pełny tekst do pobrania w serwisie zewnętrznym

• Algorytmy analizy i przetwarzania danych z sonarów wielowiązkowych w rozproszonych systemach GIS

  Publikacja

  • A. Chybicki

  - Rok 2011

  Telemonitoring morski oraz szeroko rozumiane badania morza są ważnym elementem aktywności człowieka w sferze badań, nauki oraz gospodarki. Prowadzenie działań związanych z tworzeniem map dna, inspekcją nadbrzeży, umocnień, badaniem fauny morskiej pozwala zrozumieć procesy zachodzące w środowisku morskim oraz przyczynia się do rozwoju wielu gałęzi gospodarki takich jak transport morski, bezpieczeństwo, ochrona portów i inne. W ramach...

• Genetycznie modyfikowane mikroorganizmy narzędziem służącym do usuwania metali ciężkich ze środowiska

  Publikacja

  • M. Banasik

  - Rok 2012

  Metale ciężkie są pierwiastkami metalicznymi i półmetalicznymi o gęstości powyżej 4,5 g•cm-3. Powodują zaburzenia w strukturze DNA, mogą być przyczyną chorób nowotworowych, układu nerwowego, pokarmowego, naczyniowego i kostnego. Wykorzystywane są w przemyśle chemicznym, elektromaszynowym, szklarskim, metalurgicznym, farbiarskim, wydobywczym, energetyce jądrowej. Wiele metali, takich jak kobalt, miedź, nikiel, stanowi mikroelementy...

• StryrKom StyrKom „Ocena wpływu polistyrenu pochodzącego z opakowań i materiałów termoizolacyjnych na DNA organizmów żywych z wykorzystaniem testu kometowego”- Radium

  Projekty

  Kierownik projektu: dr inż. Paweł Filipkowski

  Projekt realizowany w Katedra Chemii,Technologii i Biotechnologii Żywności zgodnie z porozumieniem DEC-2/RADIUM/2021 z dnia 2021-07-13

• Triazoloacridone C-1305 abrogates the restriction checkpoint in cells lacking functional p53 and promotes their accumulation in the G2/M phase of the cell cycle

  Publikacja

  • M. Mauer
  • O. Komina
  • A. Składanowski
  • J. Wesierska-Gadek

  - Journal of Experimental Therapeutis and Oncology - Rok 2011

  Triazoloakrydon C-1305, nowy inhibitor topoizomerazy II, wykazuje wysoką aktywość cytotoksyczną wobec komórek wielu typów nowotworów. Komórki mysie pozbawione genu PARP-1 wykazywały nadwrażliwość na działanie tego związku. W pracy testowaliśmy działanie związku wobec dwóch różnych komóek nowotworowych różniących się statusem p53: komórkami białaczki myelocytarnej HL-60 i raka sutka MCF-7. Wykazaliśmy, że inkubacja ze związkiem...

  Pełny tekst do pobrania w serwisie zewnętrznym

• Microscopic Imaging to Visualize the Distribution of Dietary Nucleic Acids in Food Products of Various Origins

  Publikacja

  • A. Kościelak
  • Z. Koziara
  • A. Pons Maria
  • R. Płatek
  • A. Bartoszek-Pączkowska

  - Foods - Rok 2023

  Dietary nucleic acids (dietNAs) are being increasingly recognized as important food components with nutritional value. However, the precise dietary recommendations for dietNAs are limited, because established methods for determining the quantity and nutritional role of dietNAs are still lacking. One of the tools to narrow this gap could be microscopic imaging, as a convenient approach to visualize the abundance and distribution...

  Pełny tekst do pobrania w portalu

• Genetyka człowieka, seminarium

  Kursy Online

  • A. Stanisławska-Sachadyn

  Tematy referatów: 1. Budowa chromosomu i metody badania (metody cytogenetyczne, FISH, CGH) 2. Badanie DNA w medycynie sądowej 3. Genetyczne podstawy odporności immunologicznej 4. Klonowanie zwierząt i ludzi 5. Genetyka nowotworów 6. Katastrofy elektrowni atomowych w Czarnobylu i w Fukushimie a zachorowalność na nowotwory 7. Dziedziczenie epigenetyczne 8. Mikromacierze hybrydyzacyjne  w badaniu ekspresji genów, metylacji...

• Squamous cell carcinoma, keratinizing, NOS - Unknown, 62 - Tissue image [3300730069389471]

  Dane Badawcze

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• LYMPH NODES, Lymph node face, head ,neck - Unknown, 62 - Tissue image [3300730069384391]

  Dane Badawcze

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• LYMPH NODES, Lymph node face, head ,neck - Unknown, 62 - Tissue image [3300730069383701]

  Dane Badawcze

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• LYMPH NODES, Lymph node face, head ,neck - Unknown, 62 - Tissue image [3300730069382491]

  Dane Badawcze

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Squamous cell carcinoma, keratinizing, NOS - Unknown, 62 - Tissue image [3300730069384751]

  Dane Badawcze

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• LYMPH NODES, Lymph node face, head ,neck - Unknown, 62 - Tissue image [3300730069387581]

  Dane Badawcze

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• LYMPH NODES, Lymph node face, head ,neck - Unknown, 62 - Tissue image [3300730069386901]

  Dane Badawcze

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• LYMPH NODES, Lymph node face, head ,neck - Unknown, 62 - Tissue image [3300730069388751]

  Dane Badawcze

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• LYMPH NODES, Lymph node face, head ,neck - Unknown, 62 - Tissue image [3301001549117101]

  Dane Badawcze

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• LYMPH NODES, Lymph node face, head ,neck - Unknown, 62 - Tissue image [3300730069386181]

  Dane Badawcze

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Squamous cell carcinoma, keratinizing, NOS - Unknown, 62 - Tissue image [3300730069381971]

  Dane Badawcze

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• LYMPH NODES, Lymph node face, head ,neck - Unknown, 62 - Tissue image [3300730069388591]

  Dane Badawcze

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Squamous cell carcinoma, keratinizing, NOS - Unknown, 62 - Tissue image [3300730069383151]

  Dane Badawcze

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• LYMPH NODES, Lymph node face, head ,neck - Unknown, 62 - Tissue image [3300730069383321]

  Dane Badawcze

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• LYMPH NODES, Lymph node face, head ,neck - Unknown, 62 - Tissue image [330073006938321]

  Dane Badawcze

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• LYMPH NODES, Lymph node face, head ,neck - Unknown, 62 - Tissue image [3300730069384201]

  Dane Badawcze

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• LYMPH NODES, Lymph node face, head ,neck - Unknown, 62 - Tissue image [3300730069382121]

  Dane Badawcze

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• LYMPH NODES, Lymph node face, head ,neck - Unknown, 62 - Tissue image [3300730069384081]

  Dane Badawcze

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• LYMPH NODES, Lymph node face, head ,neck - Unknown, 62 - Tissue image [3300730069384551]

  Dane Badawcze

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• LYMPH NODES, Lymph node face, head ,neck - Unknown, 62 - Tissue image [3300730069382081]

  Dane Badawcze

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Chemical Aspects of Biological Activity of Isothiocyanates and Indoles, the Products of Glucosinolate Decomposition

  Publikacja

  • D. Kołodziejski
  • I. Koss-Mikołajczyk
  • A. Y. Abdin
  • J. Claus
  • A. Bartoszek-Pączkowska

  - CURRENT PHARMACEUTICAL DESIGN - Rok 2019

  There is growing evidence that cancer chemoprevention employing natural, bioactive compounds may halt or at least slow down the different stages of carcinogenesis. A particularly advantageous effect is attributed to derivatives of sulfur-organic phytochemicals, such as glucosinolates (GLs) synthesized mainly in Brassicaceae plant family. GLs are hydrolysed enzymatically to bioactive isothiocyanates (ITC) and indoles, which exhibit strong...

  Pełny tekst do pobrania w portalu

• Chemical and biological evaluation of antioxidant activity of endogenous redox-active compounds compared to plant-derived exogenous antioxidants

  Publikacja

  • P. Jakubek

  - Rok 2022

  The research conducted so far has shown that endogenous antioxidants, despite being regarded as the first line of antioxidant defense, may not be sufficient to maintain redox homeostasis in cells exposed to oxidative stress. The results obtained in the doctoral dissertation show that endogenous redox-active compounds were moderate or weak scavengers of ABTS and DPPH radicals, while in cellular setting, their impact on the reducing...

  Pełny tekst do pobrania w portalu

• Morphological and cellular alternations of HepG2 cells overexpressing CYP3A4 after treatment with antitumor imidazoacridinone derivative C-1311

  Publikacja

  • E. Augustin
  • J. Polewska
  • M. Demusiak
  • J. Konopa

  - Folia Histochemica et Cytobiologica - Rok 2008

  W pracy badano odpowiedź biologiczną komórek nowotworu wątroby HepG2 z nadekspresją izoenzymu CYP3A4 pod wpływem pochodnej imidazoakrydonu C-1311. Wyniki porównywano z odpowiedzią komórek HepG2 z tzw. wektorem zerowym.Izoeznym CYP3A4 jest jednym z izoenzymów cytochromu P450 odpowiedzialnych za przemiany metaboliczne pochodnej C-1311. Wykazano, że pochodna C-1311 indukuje w obu liniach komórkowych blok w fazie G2/M cyklu komórkowego,...

  Pełny tekst do pobrania w serwisie zewnętrznym

• An MTA-phosphorylase gene discovered in the metagenomic library derived from Antarctic top soil during screening for lipolytic active clones confers strong pink fluorescence in the presence of rhodamine B.

  Publikacja

  • H. Cieśliński
  • A. Długołecka
  • J. Kur
  • M. Turkiewicz

  - FEMS MICROBIOLOGY LETTERS - Rok 2009

  In this work, we present the construction of a metagenomic library in Escherichiacoli using the pUC19 vector and environmental DNA directly isolated fromAntarctic topsoil and screened for lipolytic enzymes. Unexpectedly, the screeningon agar supplemented with olive oil and rhodamine B revealed one unusual pinkfluorescent clone (PINKuv) out of 85 000 clones. This clone harbored a plasmid,pPINKuv, which has an insert of 8317 bp that...

• A cryptic ribosome binding site, false signals in reporter systems and avoidance of protein translation chaos

  Publikacja

  • P. Sachadyn
  • A. Stanisławska-Sachadyn
  • E. M. Kabat
  • A. Zieli Ńska
  • J. Kur

  - JOURNAL OF BIOTECHNOLOGY - Rok 2009

  The expression of reporter gene may be induced by activation of cryptic signalling sequences, as we found while constructing the mutS-lacZ fusion gene. We cloned the Escherichia coli lacZ gene encoding beta-galactosidase into a plasmid vector carrying the Thermus thermophilus mutS gene. The clones expected to produce beta-galactosidase as the C-terminal fusion were selected for the complementation of beta-galactosidase activity...

  Pełny tekst do pobrania w serwisie zewnętrznym

• Identification and molecular modeling of a novel lipase from an Antarctic soil metagenomic library.

  Publikacja

  • H. Cieśliński
  • A. Białkowska
  • K. Tkaczuk
  • A. Długołęcka
  • J. Kur
  • M. Turkiewicz

  - Polish Journal of Microbiology - Rok 2009

  In this work, we present the construction of a metagenomic library in Escherichia coli using pUC19 vector and environmental DNA directly isolated from Antarctic topsoil and screened for lipolytic enzymes. The screening on agar supplemented with olive oil and rhodamine B revealed one clone with lipolytic activity (Lip1) out of 11,000 E. coli clones. This clone harbored a plasmid, pLip1, which has an insert of 4722 bp that has been...

  Pełny tekst do pobrania w portalu

• Dimeric structure of the N-terminal domain of PriB protein from Thermoanaerobacter tengcongensis solved ab initio

  Publikacja

  • D. Liebschner
  • K. Brzezinski
  • M. Dauter
  • Z. Dauter
  • M. Nowak
  • J. Kur
  • M. Olszewski

  - Acta Crystallographica Section D-Structural Biology - Rok 2012

  PriB is one of the components of the bacterial primosome, which catalyzes the reactivation of stalled replication forks at sites of DNA damage. The N-terminal domain of the PriB protein from the thermophilic bacterium Thermoanaerobacter tengcongensis (TtePriB) was expressed and its crystal structure was solved at the atomic resolution of 1.09 Å by direct methods. The protein chain, which encompasses the first 104 residues of the...

  Pełny tekst do pobrania w portalu

• Ribosomal intergenic spacer analysis as a tool for monitoring methanogenic archaea changes in an anaerobic digester

  Publikacja

  • P. Kowal
  • S. Ciesielski

  - CURRENT MICROBIOLOGY - Rok 2013

  The applicability of a newly-designed PCR primer pair in examination of methanogenic Archaea in a digester treating plant biomass was evaluated by Ribosmal Intergenic Spacer Analysis (RISA). To find a suitable approach, three variants of RISA were tested: (1) standard, polyacrylamide gel-based, (2) automated, utilized capillary electrophoresis (GA-ARISA), and (3) automated microfluidics-based (MF-ARISA). All three techniques yielded...

  Pełny tekst do pobrania w portalu

• Stable nanoconjugates of transferrin with alloyed quaternary nanocrystals Ag–In–Zn–S as a biological entity for tumor recognition

  Publikacja

  • E. Matysiak-Brynda
  • P. Bujak
  • E. Augustin
  • A. Kowalczyk
  • Z. Mazerska
  • A. Pron
  • A. M. Nowicka

  - NANOSCALE - Rok 2018

  One way to limit the negative effects of anti-tumor drugs on healthy cells is targeted therapy employing functionalized drug carriers. Here we present a biocompatible and stable nanoconjugate of transferrin anchored to Ag-In-Zn-S quantum dots modified with 11-mercaptoundecanoic acid (Tf-QD) as a drug carrier versus typical anticancer drug, doxorubicin. Detailed investigations of Tf-QD nanoconjugates without and with doxorubicin...

  Pełny tekst do pobrania w portalu

• Manufacturing Data Analysis in Internet of Things/Internet of Data (IoT/IoD) Scenario

  Publikacja

  • E. Szczerbicki
  • S. I. Shafiq
  • C. Sanin

  - CYBERNETICS AND SYSTEMS - Rok 2018

  Computer integrated manufacturing (CIM) has enormous benefits as it increases the rate of production, reduces errors and production waste, and streamlines manufacturing sub-systems. However, there are some new challenges related to CIM operating in the Internet of Things/Internet of Data (IoT/IoD) scenarios associated with Industry 4.0 and cyber-physical systems. The main challenge is to deal with the massive volume of data flowing...

  Pełny tekst do pobrania w portalu

• Boron-Enhanced Growth of Micron-Scale Carbon-Based Nanowalls: A Route toward High Rates of Electrochemical Biosensing

  Publikacja

  • K. Siuzdak
  • M. Ficek
  • M. Sobaszek
  • J. Ryl
  • M. Gnyba
  • P. Niedziałkowski
  • N. Malinowska
  • J. Karczewski
  • R. Bogdanowicz

  - ACS Applied Materials & Interfaces - Rok 2017

  In this study, we have demonstrated the fabrication of novel materials called boron-doped carbon nanowalls (B:CNWs), which are characterized by remarkable electrochemical properties such as high standard rate constant (k°), low peak-to-peak separation value (ΔE) for the oxidation and reduction processes of the [Fe(CN)6]3–/4– redox system, and low surface resistivity. The B:CNW samples were deposited by the microwave plasma-assisted...

  Pełny tekst do pobrania w portalu

• A Semiautomatic Experience-Based Tool for Solving Product Innovation Problem

  Publikacja

  • M. Waris
  • C. Sanín
  • E. Szczerbicki

  - CYBERNETICS AND SYSTEMS - Rok 2017

  In this paper we present the idea of Smart Innovation Engineering (SIE) System and its implementation methodology. The SIE system is semi-automatic system that helps in carrying the process of product innovation. It collects the experiential knowledge from the formal decisional events. This experiential knowledge is collected from the group of similar products having some common functions and features. The SIE system behaves like...

  Pełny tekst do pobrania w portalu

• Anticancer and antimicrobial properties of novel η6-p-cymene ruthenium(ii) complexes containing a N,S-type ligand, their structural and theoretical characterization

  Publikacja

  • E. Namiecińska
  • B. Sadowska
  • M. Więckowska-Szakiel
  • A. Dołęga
  • B. Pasternak
  • M. Grazul
  • E. Budzisz

  - RSC Advances - Rok 2019

  Ruthenium(II) complexes are lately of great scientific interest due to their chemotherapeutic potential asanticancer and antimicrobial agents. Here we present the synthesis of new pyrazole carbothioamidederivatives and their four arene–ruthenium complexes. The title compounds were characterized with theapplication of IR, NMR, mass spectrometry, elemental analysis and X-ray diffraction. Additionally, for newcomplexes DFT calculations...

  Pełny tekst do pobrania w portalu

• Effect of Ethanol Extracts of Propolis (EEPs) against Staphylococcal Biofilm—Microscopic Studies

  Publikacja

  • K. Grecka
  • Z. R. Xiong
  • H. Chen
  • K. Matejczuk
  • R. Worobo
  • P. Szweda

  - Pathogens - Rok 2020

  Staphylococci growing in the form of biofilm exhibit high resistance to a plethora of antibiotics. The aim of the study was to assess the influence of ethanolic extract of propolis (EEPs) on S. epidermidis ATCC 35984 biofilm using fluorescent microscopy. Propidium iodide (PI) and SYTO 9 were used for differentiation of live and dead cells, and calcofluor white was used to stain the extracellular matrix, the self-produced extracellular...

  Pełny tekst do pobrania w portalu

• Detection of Toxoplasma gondii Infection in Small Ruminants: Old Problems, and Current Solutions

  Publikacja

  • L. Holec-Gąsior
  • K. Sołowińska

  - Animals - Rok 2023

  Toxoplasmosis is a parasitic zoonosis of veterinary importance, with implications for public health. Toxoplasma gondii infection causes abortion or congenital disease in small ruminants. Moreover, the consumption of infected meat, cured meat products, or unpasteurized milk and dairy products can facilitate zoonotic transmission. Serological studies conducted in various European countries have shown the high seroprevalence of specific...

  Pełny tekst do pobrania w portalu

• Quinoline-based thiazolyl-hydrazones target cancer cells through autophagy inhibition

  Publikacja

  • V. Ćurčić
  • M. Olszewski
  • N. Maciejewska
  • A. Višnjevac
  • T. Srdić-rajić
  • V. Dobričić
  • A. T. García-sosa
  • S. B. Kokanov
  • J. B. Araškov
  • R. Silvestri... i 4 innych

  - ARCHIV DER PHARMAZIE - Rok 2024

  Heterocyclic pharmacophores such as thiazole and quinoline rings have a significant role in medicinal chemistry. They are considered privileged structures since they constitute several Food and Drug Administration (FDA)-approved drugs for cancer treatment. Herein, we report the synthesis, in silico evaluation of the ADMET profiles, and in vitro investigation of the anticancer activity of a series of novel thiazolyl-hydrazones based...

  Pełny tekst do pobrania w serwisie zewnętrznym

• Antitumour imidazoacridone C-1311 induces cell death by mitotic catastrophe in human colon carcinoma cells

  Publikacja

  • M. Hyży
  • P. Bożko
  • J. Konopa
  • A. Składanowski

  - Rok 2005

  W przedstawionych badaniach określano mechanizm śmierci komórkowej indukowanej przez imidazoakrydon C-1311 (Symadex) w komórkach HT-29 ludzkiego raka jelita grubego, które wykazywały szczególną wrażliwość na ten związek w eksperymentalnych modelach in vitro i in vivo. Przy stężeniu odpowiadającemu dawce IC99, związek powodował zahamowanie progresji cyklu komórkowej w fazie S po czym następował blok w fazie G2. Po czasach 48-96...

• Modyfikacja β-cyklodekstryny w celu uzyskania pH czułego nośnika leków antracyklinowych

  Publikacja

  • D. Martynow

  - Rok 2016

  W 2012 roku 68% zgonów było spowodowanych przez choroby niezakaźne takie, jak nowotwory, choroby układu krążenia, przewlekłe choroby układu oddechowego [1]. Zgodnie z danymi Światowej Organizacji Zdrowia (ang. World Health Organization, WHO) w 2012 roku 32,6 miliona osób cierpiało z powodu chorób nowotworowych, a 8,2 miliona zmarło z ich powodu [2]. Szacowane jest, że z roku na rok odsetek osób chorujących na choroby nowotworowe...