Filtry
wszystkich: 675
-
Katalog
Wyniki wyszukiwania dla: SAR
-
Mechanism of reaction of RNA-dependent RNA polymerase from SARS-CoV-2
PublikacjaWe combine molecular dynamics, statistical mechanics, and hybrid quantum mechanics/molecular mechanics simulations to describe mechanistically the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA-dependent RNA polymerase (RdRp). Our study analyzes the binding mode of both natural triphosphate substrates as well as remdesivir triphosphate (the active form of drug), which is bound preferentially over ATP by RdRp while...
-
Clinical and Epidemiological Characteristics of 1283 Pediatric Patients with Coronavirus Disease 2019 during the First and Second Waves of the Pandemic—Results of the Pediatric Part of a Multicenter Polish Register SARSTer
Publikacja -
Characterization of Structural and Energetic Differences between Conformations of the SARS-CoV-2 Spike Protein
Publikacja -
Inhibition Ability of Natural Compounds on Receptor-Binding Domain of SARS-CoV2: An In Silico Approach
Publikacja -
Theoretical Investigation of the Coronavirus SARS-CoV-2 (COVID-19) Infection Mechanism and Selectivity
Publikacja -
Nitroreductase reactions of Arabidopsis thaliana thioredoxin reductase
Publikacja -
Redox reactions of the FAD-containing apoptosis-inducing factor (AIF) with quinoidal xenobiotics: A mechanistic study
Publikacja -
In silico assessment and sonochemical synthesis of 2-alkynyl 3-chloropyrazines as prospective ligands for SARS-CoV-2
PublikacjaThe recent global pandemic caused by COVID-19 has triggered an intense effort worldwide towards the development of an effective cure for this disease. In our effort we have explored the 2-alkynyl substituted 3-chloropyrazine framework as a potential template for the design of molecules for this purpose. Our strategy was supported by the in silico studies of representative compounds to assess their binding affinities via docking...
-
Hard tissue samples as markers of occupational exposure in phosphatic fertilizer plant
PublikacjaW pracy opisano zastosowanie próbek włosów i paznokci do oceny narażenia pracowników zakładów nawozów fosforowych na zanieczyszczenie metalami ciężkimi. Jako metodę oznaczania 25 pierwiastków we włosach i paznokciach zastosowano aktywacje neutronową. Do opracowania wyników i ich oceny zastosowano szereg metod chemometrycznych.
-
Virtual screening for small molecular non-covalent binders of the SARS-CoV-2 main protease
Publikacja -
Nutritional behaviors of women and men in Poland during confinement related to the SARS-CoV-2 epidemic
Publikacja -
Nutritional Behaviors of Women and Men in Poland During Confinement Related to the SARS-CoV-2 Epidemic
Publikacja -
Psychopathological Symptoms Among Chronically Ill Patients During SARS-CoV-2 Pandemic in Poland
Publikacja -
SARS-CoV-2 pandemic and the population with dementia. Recommendations under the auspices of the Polish Psychiatric Association
Publikacja -
THE PROTECTIVE MEASURES AGAINST SARS-COV-2 INFECTION IN THE SEAFOOD COMPANY FROM THE PERSPECTIVE OF THE EMPLOYEES
PublikacjaPurpose: To identify and discuss the protective measures implemented to prevent SARS-CoV-2 infection among employees. Design/methodology/approach: The four-stage course of research. Case study and structured interviews with all employees, directly and indirectly, involved in food processing. Research questions: (R1) What measures have been taken to prevent the risk of infection among employees? (R2) What activities and responsibilities...
-
Structure-Activity Relationships in Two-Electron Reduction of Quinones
Publikacja -
Thermochemistry of rare earth perovskites Na3xRE0.67−xTiO3 (RE = La, Ce)
PublikacjaHigh-temperature oxide melt solution calorimetry using sodium molybdate (3Na2O·4MoO3) solvent at 973 K was performed for the Na3xRE0.67−xTiO3 (RE = La, Ce) perovskite series. The enthalpies of formation of lanthanum perovskites from oxides (La2O3, Na2O, TiO2), are −107.25 ± 2.56, −93.83 ± 6.06, −80.68 ± 5.93, and −33.49 ± 4.26 kJ/mol and enthalpies of formation from elements are −1614.05 ± 5.37, −1596.44 ± 7.68, −1594.03 ± 7.58,...
-
Saratov Journal of Medical Scientific Research [ Саратовский научно-медицинский журнал ]
Czasopisma -
Reduction of aliphatic nitroesters and N-nitramines by Enterobacter cloacae PB2 pentaerythritol tetranitrate reductase
Publikacja -
Antiplasmodial activity of quinones: Roles of aziridinyl substituents and the inhibition of Plasmodium falciparum glutathione reductase
Publikacja -
Chinifur, a Selective Inhibitor and "Subversive Substrate" for Trypanosoma congolense Trypanothione Reductase
Publikacja -
DT-diaphorase catalyzes N-denitration and redox cycling of tetryl
Publikacja -
Study of Bioreductive Anticancer Agent RH-1-Induced Signals Leading the Wild-Type p53-Bearing Lung Cancer A549 Cells to Apoptosis
Publikacja -
Changes in Eating Behaviour during SARS-CoV-2 Pandemic among the Inhabitants of Five European Countries
Publikacja -
In silico assessment and sonochemical synthesis of 2-alkynyl 3-chloropyrazines as prospective ligands for SARS-CoV-2
Publikacja -
Highly Conserved Homotrimer Cavity Formed by the SARS-CoV-2 Spike Glycoprotein: A Novel Binding Site
Publikacja -
Mental Health Impact of SARS-COV-2 Pandemic on Long-Term Care Facility Personnel in Poland
Publikacja -
t-SNE Highlights Phylogenetic and Temporal Patterns of SARS-CoV-2 Spike and Nucleocapsid Protein Evolution
Publikacja -
Highly Conserved Homotrimer Cavity Formed by the SARS-CoV-2 Spike Glycoprotein: A Novel Binding Site
PublikacjaAn important stage in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) life cycle is the binding of the spike (S) protein to the angiotensin converting enzyme-2 (ACE2) host cell receptor. Therefore, to explore conserved features in spike protein dynamics and to identify potentially novel regions for drugging, we measured spike protein variability derived from 791 viral genomes and studied its properties by molecular...
-
t-SNE Highlights Phylogenetic and Temporal Patterns of SARS-CoV-2 Spike and Nucleocapsid Protein Evolution
PublikacjaWe propose applying t-distributed stochastic neighbor embedding to protein sequences of SARS-CoV-2 to construct, visualize and study the evolutionary space of the coronavirus. The basic idea is to explore the COVID-19 evolution space by using modern manifold learning techniques applied to evolutionary distances between variants. Evolutionary distances have been calculated based on the structures of the nucleocapsid and spike proteins.
-
Low-volume label-free SARS-CoV-2 detection with the microcavity-based optical fiber sensor
PublikacjaAccurate and fast detection of viruses is crucial for controlling outbreaks of many diseases; therefore, to date, numerous sensing systems for their detection have been studied. On top of the performance of these sensing systems, the availability of biorecognition elements specific to especially the new etiological agents is an additional fundamental challenge. Therefore, besides high sensitivity and selectivity, such advantages...
-
Cytotoxicity of RH1 and related aziridinylbenzoquinones: involvement of activation by NAD(P)H:quinone oxidoreductase (NQO1) and oxidative stress
Publikacja -
Quinone- and nitroreductase reactions of Thermotoga maritima peroxiredoxin–nitroreductase hybrid enzyme
Publikacja -
Preliminary Investigation of the Antibacterial Activity of Antitumor Drug 3-Amino-1,2,4-Benzotriazine-1,4-Dioxide (Tirapazamine) and its Derivatives
Publikacja -
Recent advances on magnetic carbon-related materials in advanced oxidation processes of emerging pollutants degradation
PublikacjaRecently, carbon-related materials have been proposed to improve the charge separation of the photogenerated carriers in the semiconductor matrices’ and surface properties. Carbon-related materials may act as co-catalysts, enhancing the pollutants adsorption on the surface, improving the charge carriers separation and photocatalyst stability and providing more active centres for photocatalytic reactions. This review summarizes...
-
Sarcoidosis - Female, 50 - Tissue image [6200730021587011]
Dane BadawczeThis is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
-
Sarcoidosis - Female, 50 - Tissue image [6200730021584131]
Dane BadawczeThis is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
-
Structural and Evolutionary Analysis Indicate That the SARS-CoV-2 Mpro Is a Challenging Target for Small-Molecule Inhibitor Design
Publikacja -
Multivalent Display of SARS-CoV-2 Spike (RBD Domain) of COVID-19 to Nanomaterial, Protein Ferritin Nanocages
Publikacja -
Structural and Evolutionary Analysis Indicate that the SARS-CoV-2 Mpro is an Inconvenient Target for Small-Molecule Inhibitors Design
Publikacja -
Quantitative Structure–Activity Relationships in Two-Electron Reduction of Nitroaromatic Compounds by Enterobacter cloacae NAD(P)H:Nitroreductase
Publikacja -
Two-electron reduction of quinones by Enterobacter cloacae NAD(P)H:nitroreductase: quantitative structure-activity relationships
Publikacja -
Mercury fractionation in marine macrofauna using thermodesorption technique: Method and its application
Publikacja -
Sara Crucho
Osoby -
Fuzzy Divisive Hierarchical Clustering of Solvents According to Their Experimentally and Theoretically Predicted Descriptors
PublikacjaThe present study describes a simple procedure to separate into patterns of similarity a large group of solvents, 259 in total, presented by 15 specific descriptors (experimentally found and theoretically predicted physicochemical parameters). Solvent data is usually characterized by its high variability, dierent molecular symmetry, and spatial orientation. Methods of chemometrics can usefully be used to extract and explore accurately...
-
A comparative study of the performance of passive samplers
PublikacjaPodstawowym celem podjętych badań było porównanie pracy dozymetrów pasywnych wykorzystywanych na etapie izolacji i wzbogacania lotnych związków organicznych z powietrza atmosferycznego na terenie aglomeracji Trójmiejskiej. Jako próbniki do pobierania próbek analitów zastosowano komercyjne dozymetry pasywne typu dyfuzyjnego (Radiello i Orsa 5) oraz dozymetry typu permeacyjnego własnej konstrukcji wyposażone w półprzepuszczalną membranę...
-
Fuzzy soft modeling of environmental data. A study of the impact of a Phosphatic Fertilizer Plant on the adjacent environment in Gdańsk
PublikacjaAnaliza podobieństwa obejmuje nie tylko zastosowanie logiki rozmytej, ale również wiele innych podejść matematycznych. Opracowano wiele algorytmów, których celem jest wyodrębnienie wyraźnych skupień (hard clusters) z danego zbioru danych. Prawdopodobnie najczęściej stosowanymi algorytmami są tzw. algorytmy c-średnie (c-means algorithms). Twarde c-średnie (hard c-means) służy do ostrej klasyfikacji, podczas której obiekt jest przypisany...
-
Security-oriented agile approach with AgileSafe and OWASP ASVS
PublikacjaIn this paper we demonstrate a security enhancing approach based on a method called AgileSafe that can be adapted to support the introduction of OWASP ASVS compliant practices focused on improving security level to the agile software development process. We also present results of the survey evaluating selected agile inspired security practices that can be incorporated into an agile process. Based on the survey’s results, these...
-
Adapting Agile Practices to Security Context – Practitioners’ Perspective
PublikacjaIn this paper we explore the problem of introducing agile practices to projects dealing with systems with high security requirements. We also propose an approach based on AgileSafe method and OWASP ASVS guidelines, that could support such introduction. What is more, we present the results of two surveys aimed at analyzing IT practitioners’ views on applying agile methods to security reliant systems as well as evaluating the set...
-
Projekt wężownicowego wymiennika ciepła
PublikacjaPrzedmiotem niniejszego artykułu jest zaprezentowanie konstrukcji wężownicowego wymiennika ciepła powstałej w ramach pracy inżynierskiej w Katedrze Energetyki i Aparatury Przemysłowej. Podstawowym założeniem pracy było zoptymalizowanie aparatu cieplnego w taki sposób, aby możliwe było jak najefektywniejsze przekazywanie ciepła do przepływającego płynu. Oparto się tu przede wszystkim na rozważaniach dotyczących wpływu modyfikacji...