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Increased risk of thyroid pathology in patients with thyroid hemiagenesis: results of a large cohort case–control study
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Genetic inactivation and chemical inhibition of PARP-1 lead to increased cytotoxicity to antitumor triazoloacridone C-1305
PublikacjaOkreśliliśmy aktywność cytotoksyczną związku C-1305 wobec komórek z obniżoną aktywnością PARP-1 w wyniku działania inhibitora tego enzymu związku NU1025. Dane wskazują, że w zależności od rodzaju inhibitora topoizomerazy II obniżenie aktywności PARP-1 przez związek NU1025 prowadzi do zwiększenia bądź obniżenia cytotoksyczności tych leków. Działanie NU1025 prowadzi również do re-aktywacji szlaku p53 w komórkach HeLa, czego jak dotąd...
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Increased concentration of Taq DNA polymerase as a solution for GC-rich templates from clinical and environmental samples
PublikacjaDNA polymerase is an enzyme which plays crucial role in replication and DNA repair. It found application in PCR (polymerase chain reaction) where catalyses process of in vitro DNA synthesis. To meet the demands posed by mod- ern diagnostic, molecular biology or genetic engineering it is necessary to improve DNA polymerases to obtain new or better features useful in these fields. So far implemented modifications in majority are...
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Taq DNA polymerase fused with DNA binding protein with increased resistance to inhibitors from clinical samples
PublikacjaNowadays PCR method is commonly used in molecular diagnostic. However, in many cases PCR is limited, by the presence of inhibitory substances in biological, soil or food samples Efficiency and fidelity of amplification is strongly connected with DNA polymerase and reaction conditions. To meet the requirements of modern diagnostic methods it is essential to seeking for new DNA polymerases with better properties useful in these field....
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Continuous blood pressure monitoring by photoplethysmography - signal preprocessing requirements based on blood flow modelling
PublikacjaObjective. The aim of the study is to investigate the effect of the signal sampling frequency and low-pass filtering on the accuracy of the localisation of the fiducial points of the photoplethysmographic signal (PPG), and thus on the estimation of the blood pressure (i.e. the accuracy of the estimation). Approach. Statistical analysis was performed on 3,799 data samples taken from a publicly available database. Four PPGfiducial...
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Non-invasive hemodynamic monitoring as a guide to drug treatment of uncontrolled hypertensive patients: effects on home blood pressure in the BEAUTY study
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High Pressure Luminescence of Cr-Related Centers in (3CaO-Ga 2 O 3 -3GeO 2 ) Glasses
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A novel in vivo approach to assess strains of the human abdominal wall under known intraabdominal pressure
PublikacjaThe study concerns mechanical behaviour of a living human abdominal wall. A better mechanical understanding of a human abdominal wall and recognition of its material properties is required to find mechanically compatible surgical meshes to significantly improve the treatment of ventral hernias. A non-invasive methodology, based on in vivo optical measurements is proposed to determine strains of abdominal wall corresponding to...
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Pressure evolution of LiBaF3:Eu2+luminescence
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Pressure dependence of the Sr2Si5N8:Eu2+ luminescence
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Pressure dependence of the emission in CaF2 : Yb2+
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Aging of silicone pressure-sensitive adhesives
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Blood pressure in acute ischemic stroke
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Transversal Pressure Effect in Circulative Separators
PublikacjaPrzeanalizowano podobieństwa i różnice między podstawowymi kategoriami separatorów odśrodkowych (wirówki, cyklony, separatory wirowe). Zaproponowano model pola prędkości w separatorze. Wyznaczono rozkład ciśnienia i obliczono siłę dryfu poprzecznego (efekt poprzecznej zmiany ciśnienia). Przeprowadzono pomiary ciśnienia w separatorze laboratoryjnym, uzyskując pozytywną weryfikację przedstawionego modelu.
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Taylor type predictor for pressure changes
PublikacjaCelem pracy jest ocena predykcji ciśnienia za pomocą rozwinięcia funkcji w szereg Taylora. Przewidywana wartość ciśnienia jest obliczana jako iloczyn wcześniejszych wartości mnożonych przez współczynniki wagowe wyznaczone w oparciu o szereg Taylora. Zaletą takiego podejścia jest możliwość analizy danych próbkowanych nierównomiernie. Podstawową wadą jest założenie, że ciśnienie jest dobrze aproksymowane przez wielomian niskiego...
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Solubility of Carbon Dioxide in Deep Eutectic Solvents Based on 3-Amino-1-Propanol and Tetraalkylammonium Salts at Low Pressure
PublikacjaDeep eutectic solvents (DESs) became an object of a great interest as an alternative to ionic liquids (ILs) and commonly used in CO2 capture amine solutions. In the present study, five different DESs based on 3-amino-1-propanol as physical-chemical CO2 absorbents were used. The composition was chosen in order to estimate the effects of hydrogen bond acceptor:hydrogen bond donor (HBA:HBD) molar ratio, anion type and length of alkyl...
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TIME- AND FREQUENCY-DOMAIN QUASI-2D SMALL-SIGNAL MOSFET MODELS
PublikacjaA novel approach to small-signal MOSFET modeling is presented in this book. As a result, time- and frequency-domain physics-based quasi-2D NQS four-terminal small-signal MOSFET models are proposed. The time-domain model provides the background to a novel DIBL-included quasi‑2D NQS four-terminal frequency-domain small-signal MOSFET model. Parameters and electrical quantities of the frequency-domain model are described by explicit...
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Systolic blood pressure control prevents cognitive decline and slows development of white matter lesions in the brain: the SPRINT MIND study outcomes
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LDFEM analysis of pore water pressure development in cohesive soil due to FDP auger drilling
PublikacjaThis paper presents the preliminary modelling of FDP auger drilling in soft soil with emphasis on excess pore water pressure (EPWP) development using CEL formulation and Abaqus software suit. The EPWP generation in single points is investigated and the results of a numerical analysis are compared with the field measurements. It is found that numerical model qualitatively reflects the field measurements. However,...
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Increased Levels of Platelets and Endothelial-Derived Microparticles in Patients With Non-Valvular Atrial Fibrillation During Rivaroxaban Therapy
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Acute hypoxia diminishes the relationship between blood pressure and subarachnoid space width oscillations at the human cardiac frequency
PublikacjaAcute hypoxia exerts strong effects on the cardiovascular system. Heart-generated pulsatile cerebrospinal fluid motion is recognised as a key factor ensuring brain homeostasis. We aimed to assess changes in heart-generated coupling between blood pressure and subarachnoid space width oscillations during hypoxic exposure.
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Renal denervation achieved by endovascular delivery of ultrasound in RADIANCE-HTN SOLO or by radiofrequency energy in SPYRAL HTN-OFF and SPYRAL-ON lowers blood pressure
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The chemical and mechanical pressure influence on chromium luminescence
Dane BadawczeIn this study, we aim to compare the changes in the luminescence properties of Ga2O3:Cr3+ modified by Al or Sc ion substitution (chemical pressure) and hydrostatic pressure. We find the same behavior for Ga2–xAlxO3:Cr3+ and different behavior for Ga2–xScxO3:Cr3+ in terms of the optical properties under chemical and mechanical pressure. We consider Al...
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Pulsed Laser Deposition of Bismuth Vanadate Thin Films—The Effect of Oxygen Pressure on the Morphology, Composition, and Photoelectrochemical Performance
PublikacjaThin layers of bismuth vanadate were deposited using the pulsed laser deposition technique on commercially available FTO (fluorine-doped tin oxide) substrates. Films were sputtered from a sintered, monoclinic BiVO4 pellet, acting as the target, under various oxygen pressures (from 0.1 to 2 mbar), while the laser beam was perpendicular to the target surface and parallel to the FTO substrate. The oxygen pressure strongly affects...
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Experimental study of pressure rise at the evaporator of capillary pumped loop with acetone and water as working fluids
PublikacjaIn this work studied is the possibility of fluid pumping using capillary forces in the capillary pumped loop. Experimental and theoretical studies have been performed to understand the phenomena associated with heat transfer in porous structure of the evaporator. The capillary effect was studied during operation of two different capillary porous structures with two different working fluids, namely water and acetone. The results...
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Pressure-induced flow processing behind the superior mechanical properties and heat-resistance performance of poly(butylene succinate)
PublikacjaWe propose a pressure-induced flow (PIF) processing method for the simultaneous enhancement of strength, toughness, and heat resistance of biodegradable poly(butylene succinate) (PBS). The pressure and temperature were systematically adjusted to optimize the tensile strength of PBS. Under the optimized processing conditions, the structured PBS was characterized by relatively high strength of 89.5 MPa, toughness of 21.4 kJ·m−2 ,...
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Pore Water Pressure Development in Soft Soil due to Installation and Loading of Controlled Modulus Columns
PublikacjaExcess pore water pressure (EPWP) development and decay due to the installation and static loading tests of controlled modulus columns (CMC) in soft soil was measured with piezometers equipped with low air entry (LAE) filters and a piezocone (CPTU) equipped with a high air entry (HAE) filter. The HAE filter allows for detailed detection of EPWP in short time intervals during construction of CMC. The influence zone due to the installation...
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Relationship between heart rate variability, blood pressure and arterial wall properties during air and oxygen breathing in healthy subjects
PublikacjaPrevious studies reported that normobaric hyperoxia influences heart rate, arterial pressure, cardiac output and systemic vascular resistance, but the mechanisms underlying these changes are still not fully understood. Several factors are considered including degeneration of endothelium-derived nitric oxide by reactive oxygen species, the impact of oxygen-free radicals on tissues and alterations of autonomic nervous system function....
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Urinary Kidney Injury Molecule-1 but Not Urinary Neutrophil Gelatinase Associated Lipocalin Is Increased after Short Maximal Exercise
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Euthyroid sick syndrome as a prognostic indicator of COVID-19 pulmonary involvement, associated with poorer disease prognosis and increased mortality
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Inline Microstrip Bandpass Filter With Two Transmission Zeros and Increased Order Using Spurious Resonance of Frequency-Dependent Inverter
PublikacjaA design method for a class of fourth-order inline microstrip bandpass filter with two transmission zeros and 20% fractional bandwidth is presented. The filter consists of two quarter-wavelength transmission-line resonators coupled by a frequency-dependent inverter. The inverter is composed of two open-ended stubs that are connected by an interdigital capacitor and introduces two poles and two transmission zeros in the filter response....
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Pressure-Enhanced Environment Effects in Ferrocene Phases
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Influence of high pressure on Sr2SiO4:Eu2+ luminescence
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Energy levels in CaWO4:Tb3+ at high pressure
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High pressure evolution of YVO4:Pr3+luminescence
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High pressure luminescence spectra of CaMoO4:Pr3+
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Pressure effects on the luminescence properties of CaWO4:Pr3+
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Pulse pressure amplification in relation to body fatness
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Low-temperature high-pressure cryogelation of nanooxides
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Hydrodynamic pressure in micro-and nano bearing gap
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Thermal decomposition of acrylic pressure-sensitive adhesives
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Pressure and capacity in hip joint afte injury.
PublikacjaPraca przedstawia zarys analitycznego wyprowadzenia równania Reynoldsa do wyznaczania rozkładów wartości ciśnienia w szczelinie sferycznego stawu biodrowego człowieka po udarze w nieustalonym ruchu impulsywnym. W wyprowadzonym modelu uwzględniono lepkosprężyste właściwości cieczy synowialnej oraz stochastyczny opis chropowatości chrząstki stawowej. Numeryczne wartości ciśnienia wyznaczono w programie Mathcad 2001 przy wykorzystaniu...
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Model of pressure distribution in vortex flow controls
PublikacjaThe paper is devoted to the vortex valve. Existing devices are described by CFD-methods, or by means of simple empirical relations. A rational method of the considered object design is proposed, on the base of the input and dissipation energy balance., what gives a simple algebraic equation. Conformity between calcul;ated and measured parameters of the vortex valve allows for acceptation of the proposed concept.
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Reduction of pressure forces in turbine labyrinth seals
PublikacjaPrzedstawiono nową metodę zmniejszani sił samowzbudnych typu aerodynamicznego. zastosowano ją do różnych typów nadbandażowych uszczelnień labiryntowych. Efektywność rdukcji sił samowzbudnych wynosiła nawet ponad 60%. Potwierdzone rezultay obliczeniami i eksperymentalnie.
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Optical Emission Spectroscopy of Microwave (915 MHz) Plasma in Atmospheric Pressure Nitrogen with Addition of Ethanol Vapour
PublikacjaIn this paper results of optical emission spectroscopic study of microwave 915 MHz plasma in atmospheric pressure nitrogen with an addition of ethanol vapour are presented. The plasma was generated in waveguide- -supplied cylinder-type nozzleless microwave plasma source. The aim of research was to determine the rotational Trot and vibrational Tvib temperatures of CN and C2. A method called bubbling was employed to introduce alcohol (ethanol)...
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Coupling between Blood Pressure and Subarachnoid Space Width Oscillations during Slow Breathing
PublikacjaThe precise mechanisms connecting the cardiovascular system and the cerebrospinal fluid (CSF) are not well understood in detail. This paper investigates the couplings between the cardiac and respiratory components, as extracted from blood pressure (BP) signals and oscillations of the subarachnoid space width (SAS), collected during slow ventilation and ventilation against inspiration resistance. The experiment was performed on...
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Experimental and comparative study on the two-phase pressure drop of air-water mixture in U-bend and straight pipe annuli
PublikacjaIn this paper, the experimental and theoretical analysis of pressure drop in singlephase and two phase-flow were presented for straight and U-bend smooth tube annulus and tube annulus with wire coil insert. Experiments for various boundary conditions were performed. In case of U-tube and straight tube with and without turbulator, tests were made for the water-water and air-water systems. The study covered a wide measuring range,...
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The effect of pressure on luminescence properties of Cr3+ ions in LiSc(WO4)2 crystals—Part I: Pressure dependent emission lineshape
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A Case for Less Intensive Blood Pressure Control: It Matters to Achieve Target Blood Pressure Early and Sustained Below 140/90mmHg
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Comparitive study of heat transfer and pressure drop during flow boiling and flow condensation in minichannels
PublikacjaIn the paper a method developed earlier by authors is applied to calculations of pressure drop and heat transfer coefficient for flow boiling and also flow condensation for some recent data collected from literature for such fluids as R404a, R600a, R290, R32,R134a, R1234yf and other. The modification of interface shear stresses between flow boiling and flow condensation in annular flow structure are considered through incorporation...