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Wyniki wyszukiwania dla: RATIONAL DRUG DESIGN
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Cancer Drug Resistance
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THERAPEUTIC DRUG MONITORING
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Piotr Jaskuła dr hab. inż.
OsobyI am a Faculty member (Associate Professor, Highway and Transportation Research Department) at the Faculty of Civil and Environmental Engineering, Gdansk University of Technology, Poland).My main research interests include: pavement structures, interlayer bonding, pavement materials, recycling of road pavements, asphalt mixtures, bitumens, construction and maintenance of pavement structures.My lectures at the University include:...
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Updating a hospital building. A task for innovation design
PublikacjaRefurbishment of a hospital, especially located in a historical building, is a task that goes far beyond a standard framework of architectural practice. A concept of modularity in the architecture of the late nineteenth and early twentieth century was only just to happen, building system installations and technical equipment appeared as the simplest solutions. Inscribing complex functional solutions into such a space is an interesting...
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Automated microwave planar filter design with generalized Chebyshev characteristics.
PublikacjaIn this paper a technique of automatization of design of microwave filters with generalized Chebyshev characteristics is presented. A full wave electromagnetic simulator linked with the Matlab computing environment is used to ensure a rigorous numerical analysis while at the same time allowing automatization. To decrease time of optimization and overall design process, the Cauchy interpolation technique was used. An automated design...
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RANS-based design optimization of dual-rotor wind turbines
PublikacjaPurpose An improvement in the energy efficiency of wind turbines can be achieved using dual rotors. Because of complex flow physics, the design of dual-rotor wind turbines (DRWTs) requires repetitive evaluations of computationally expensive partial differential equation (PDE) simulation models. Approaches for solving design optimization of DRWTs constrained by PDE simulations are investigated. The purpose of this study is to determine...
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Design and testing of a radial-axial microturbine for domestic applications
PublikacjaIn the paper presented is a new design of the radial-axial microturbine of 3-4kW capacity for operation with ethanol as working fluid
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MULTI-CRITERIA MODEL IN MULTIFUNCTIONAL BUILDING SYSTEM DESIGN PROCESS
PublikacjaThe paper presents a multi-criteria approach in multifunctional building system design process. The aim is to develop a theory relative to the engineering system of multifunctional with a mathematical representation defined by a holistic network for the lifecycle of the designed object. The idea of work was to define the structure of a complex system. Background for the presented field is to develop a design strategy for multifunctional...
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Mechatronics design, modelling and controlling of the Stewart-Gough platform
PublikacjaThis paper presents a mechatronics design of a low cost Stewart-Gough platform (SGP) with rotary actuators. The designed SGP is supposed to be applied in a ball & plate control system. The synthesis of the ball & plate control system is also within the subject of the paper. A mechatronics design process of the SGP was conducted with computer-aided design (CAD) software. Unique analytical solutions of an inverse kinematics problem...
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On the low-cost design of abbreviated multisection planar matching transformer
PublikacjaA numerically demanding wideband matching transformer composed of three nonuniform transmission lines (NUTLs) has been designed and optimized at a low computational cost. The computational feasibility of the design has been acquired through the exploitation of low-fidelity NUTL models in most steps of the design procedure and an implicit space mapping optimization engine, providing high accuracy results with only a handful of EM...
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Design-Oriented Constrained Modeling of Antenna Structures
PublikacjaFast surrogate models are crucially important to reduce the cost of design process of antenna structures. Due to curse of dimensionality, standard (data-driven) modeling methods exhibit serious limitations concerning the number of independent geometry parameters that can be handled but also (and even more importantly) their parameter ranges. In this work, a design-oriented modeling framework is proposed in which the surrogate is...
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Design of Resilient Vehicle-to-Infrastructure Systems
PublikacjaVehicular ad hoc networks (VANETs) have recently gained noticeable attention due to advantages in improving road traffic safety, shaping the road traffic and providing infotainment opportunities to travellers. However, transmission characteristics following from the IEEE 802.11p standard and the high mobility of VANET nodes remarkably reduce the lifetime, reach and capacity of wireless links, and often lead to simultaneous disruptions...
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Single-wall carbon nanotubes based anticancer drug delivery system
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Magnetic Silica Nanotubes: Synthesis, Drug Release, and Feasibility for Magnetic Hyperthermia
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Multi‐wall carbon nanotubes – a vehicle for targeted Irinotecan drug delivery
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Antimicrobial peptides (AMPs) as drug candidates: a patent review (2003–2015)
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Natural carbon-based quantum dots and their applications in drug delivery: A review
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The significance of lumican expression in ovarian cancer drug-resistant cell lines
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Quantitative proteomic analysis of anticancer drug RH1 resistance in liver carcinoma
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Chemometric Evaluation of THz Spectral Similarity for the Selection of Early Drug Candidates
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The impact of lipophilicity on environmental processes, drug delivery and bioavailability of food components
PublikacjaLipophilic properties of the compound allow to predict its fate in living organisms and to propose the models of chemicals transport and accumulation in the ecosystem. Lipophilicity is also useful as the characteristic of chemicals in respect to their optimal attributes for specific biological and non-biological tasks. The lipophilicity descriptors define the potency of endo- and xenobiotics to metabolic transformations and their...
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pH-dependent composite coatings for controlled drug delivery system - Review
PublikacjaNowadays in case of long-term implants, the most common postoperative complications are bacterial infections, which in consequence may provoke loos- ening of the implants in the primary phase of stabilization. Bacterial infections are currently the most frequent cause of revision surgery of the implants such as hip joint endoprosthesis, knee joint endoprosthesis and dental implants. In order to provide the local and long-term antibacterial...
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Influence of Escherichia coli on Expression of Selected Human Drug Addiction Genes
PublikacjaThe impact of enteric microflora on the expression of genes associated with cocaine and amphetamine addiction was described. Human genome-wide experiments on RNA transcripts expressed in response to three selected Escherichia coli strains allowed for significant alteration (p > 0.05) of the linear regression model between HT-29 RNA transcripts associated with the KEGG pathway:hsa05030:Cocaine addiction after 3 h stimulation with...
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Computationally Efficient Design Optimization of Compact Microwave and Antenna Structures
PublikacjaMiniaturization is one of the important concerns of contemporary wireless communication systems, especially regarding their passive microwave components, such as filters, couplers, power dividers, etc., as well as antennas. It is also very challenging, because adequate performance evaluation of such components requires full-wave electromagnetic (EM) simulation, which is computationally expensive. Although high-fidelity EM analysis...
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Electromagnetic Simulation with 3D FEM for Design Automation in 5G Era
PublikacjaElectromagnetic simulation and electronic design automation (EDA) play an important role in the design of 5G antennas and radio chips. The simulation challenges include electromagnetic effects and long simulation time and this paper focuses on simulation software based on finite-element method (FEM). The state-of-the-art EDA software using novel computational techniques based on FEM can not only accelerate numerical analysis, but...
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Computer-Aided Automated Greenery Design—Towards a Green BIM
PublikacjaContemporary climate challenges are changing the architect’s awareness, which results in a broader spectrum of interest. The available software enables the design of vegetation, but it is often very limited and requires specialist knowledge. The available software allows the creation of individual solutions based on visual algorithms or writing scripts; however, they are still not common methods used in architecture and urban planning....
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Micromouse robot - technical design and construction
PublikacjaW ostatnich latach obserwuje się intensywny rozwój robotyki. Roboty znajdują zastosowanie w różnych gałęziach przemysłu i życiu codziennym. Ich projektowanie wymaga interdyscyplinarnej wiedzy obejmującej obszary mechaniki, elektroniki, metrologii, automatyki i informatyki. W artykule przedstawiono poszczególne etapy wykonania robota typu Micromouse. Jest to specyficzne urządzenie, którego zadaniem jest zbadanie labiryntu, dotarcie...
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Methodology for hospital design in architectural education
PublikacjaThe architecture of a hospital should be a response to strong user requirements. Recommendations on how to shape the environment of such facilities are highly complex, integrating guidelines from many fields of science. If contradictions between them exist, the designer is required to set priorities for spatial activities. This issue is particularly important during architectural education. The learning process should include projects...
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Multi-objective antenna design by means of sequential domain patching
PublikacjaA simple yet robust methodology for rapid multiobjective design optimization of antenna structures has been presented. The key component of our approach is sequential domain patching of the design space which is a stencil-based search that aims at creating a path that connects the extreme Pareto-optimal designs, obtained by means of single-objective optimization runs. The patching process yields the initial approximation of the...
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A conceptual design and numerical analysis of the mixerless urea-SCR system
PublikacjaIn the present study, an innovative design of the urea-selective catalytic reduction (SCR) system without conventional mixing elements was developed. The aim was to obtain a high degree of urea decomposition, and uniform ammonia distribution at the inlet to the catalyst, while minimising the liquid film deposition and keeping the compact design. The concept of the design was based on creating high turbulences and elongating...
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Structural design and sensitivity analysis of semi-rigid pavement of a motorway
PublikacjaThis paper presents application of mechanistic-empirical methods in design of semi-rigid pavement for a section of a motorway in Poland. The stage construction was assumed. Three fatigue criteria were applied in the design. For asphalt fatigue cracking and subgrade soil the criteria from the Asphalt Institute (USA) were applied. For fatigue cracking of cement stabilized bases the Dempsey (USA) and De Beer (South Africa) criteria...
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Experience based decisional DNA to support smart product design
PublikacjaThis paper presents the idea of Smart Virtual Product Development (SVPD) system to support product design. The foundations of the system are based upon smart knowledge management techniques called Set of Experience Knowledge Structure (SOEKS) and Decisional DNA (DDNA). It enhances the industrial product development process by using the previous experiential knowledge gathered from the formal decisional activities. This experiential...
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Adam Dąbrowski dr inż.
OsobyAdam Dąbrowski uzyskał stopień doktora nauk inżynieryjno-technicznych w dyscyplinie inżynieria mechaniczna na Politechnice Gdańskiej oraz ukończył studia II stopnia na kierunku mechatronika na Technische Universität Hamburg a także double degree Engineering and Management of Space Systems na Hochschule Bremen. Posiada doświadczenie przemysłowe (Instytut Lotnictwa w Warszawie, SICK AG w Hamburgu, Blue Dot Solutions w Gdańsku, Niemieckie...
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Integracja narzędzi do zarządzania wymaganiami oraz zarządzania projektem na przykładzie IBM Rational Requirements Composer i Team Concert
PublikacjaInżynieria wymagań jest jednym z najistotniejszych elementów przedsięwzięcia informatycznego, w szczególności programistycznego.
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Experience Based Decisional DNA (DDNA) to Support Sustainable Product Design
PublikacjaThis paper presents the idea of providing engineering design knowledge to designers working on sustainable product design and development process. The new product development process often requires significant amount of design knowledge which can be saved and recalled by designers during the design process. This knowledge is very important for successful sustainable product development as it can include material selection, product...
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Importance of model tests in design and operation of watercraft for example CTO
PublikacjaShip Hydromechanics Division is a specialized research and development department of Ship Design and Research Centre conducting tests and research in the field of hydromechanics, connected with design and operation of ships and other floating structures, in scope of: predictions, numerical analyses, designs of - hull shape optimized with respect to the ship’s functions with the application of modern design tools, screw propellers...
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Lighting design for urban revitalization. The case of Poland
PublikacjaThis paper reflects on the basic research done in the area of public lighting in regard to revitalization processes. The general purpose of this scientific paper is to research a role of an implementation of public lighting design within revitalization frameworks. Referring to a wide spectrum of academic publications, the paper provides an overview of revitalization and public lighting objectives. The emphasize is put on a need...
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Structural Design and Sensitivity Analysis of Semi-Rigid Pavement of a Motorway
PublikacjaThis paper presents application of mechanistic-empirical methods in design of semi-rigid pavement for a section of a motorway in Poland. The stage construction was assumed. Three fatigue criteria were applied in the design. For asphalt fatigue cracking and subgrade soil the criteria from the Asphalt Institute (1981) were applied. For fatigue cracking of cement stabilized bases the Dempsey (1984) and De Beer (1992) criteria were...
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Electrical Engineering [Design and Production Engineering][2023/24]
Kursy OnlineAdditional teaching materials for Electrical Engineering for Design and Production Engineering of the Faculty of Mechanical Engineering and Ship Technology course, conducted at the Faculty of Electrical and Control Engineering - 4'th semester, undergraduate
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Design of reverse curves adapted to the satellite measurements
PublikacjaThe paper presents a new method for designing railway route in the direction change area adapted to the Mobile Satellite Measurements technique. The method may be particularly useful in the situations when both tangents cannot be connected in an elementary way using a circular arc with transition curves. Thus, the only solution would be the application of two circular arcs of opposite curvature signs, that is, the use of an inverse...
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Wiktoria Wojnicz dr hab. inż.
OsobyDSc in Mechanics (in the field of Biomechanics) - Lodz Univeristy of Technology, 2019 PhD in Mechanics (in the field of Biomechanics) - Lodz Univeristy of Technology, 2009 (with distinction) Publikacje z listy MNiSW (2009 - ) Wojnicz W., Wittbrodt E., Analysis of muscles' behaviour. Part I. The computational model of muscle. Acta of Bioengineering and Biomechanics, Vol. 11, No.4, 2009, p. 15-21 Wojnicz W., Wittbrodt E., Analysis...
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Modernization of tram lines with the use of railway design standards
PublikacjaThe article presents the main differences between the process of upgrading railway and tram routes. Geometrical layout designing is an issue of the interest. Railway designing rules that may be helpful in the design of the modernization are specified.
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Future research directions in design of reliable communication systems
PublikacjaIn this position paper on reliable networks, we discuss new trends in the design of reliable communication systems. We focus on a wide range of research directions including protection against software failures as well as failures of communication systems equipment. In particular, we outline future research trends in software failure mitigation, reliability of wireless communications, robust optimization and network design, multilevel...
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Podejście środowiskowe w dydaktyce projektowania Sustainable approach in teaching of design
PublikacjaThe aim of the paper is to assess the inclusion of academic teaching design to the process of sustainable development and proposals for an integrated approach in training architects. The article presents an original interpretation of environmental design in the field of architecture and urban planning. The significance of the environmental perspective is presented in the context of growing spatial and social fragmentation. The...
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Design Philosophy Papers
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Journal of Design History
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Harvard Design Magazine
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Design Discourse (The) (Japan)
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Journal of Urban design
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COMPUTER-AIDED DESIGN
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