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Wyniki wyszukiwania dla: RENAL TRANSPLANT, KLEBSIELLA PNEUMONIAE, VIRULENCE FACTORS, HOST FACTORS, URINARY TRACT INFECTION
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Host and pathogen factors in Klebsiella pneumoniae upper urinary tract infections in renal transplant patients
PublikacjaPurpose . To analyse the role of virulence factors (VFs) and host in Klebsiella pneumoniae upper urinary tract infections (UTIs) in renal transplant (RTx) recipients. Methodology. Clinical and demographic data were registered prospectively. Phylogenetic background of K. pneumoniae isolates was analysed by PCR melting profiles (MP) and the following VFs genes: fimH-1, uge, kpn, ycfM, mrkD, rmpA, magA, hlyA, cnf-1, irp-1, irp-2,...
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Urinary Tract Infections Caused by K. pneumoniae in Kidney Transplant Recipients – Epidemiology, Virulence and Antibiotic Resistance
PublikacjaUrinary tract infections are the most common complication in kidney transplant recipients, possibly resulting in the deterioration of a long-term kidney allograft function and an increased risk of recipient’s death. K. pneumoniae has emerged as one of the most prevalent etiologic agents in the context of recurrent urinary tract infections, especially with multidrug resistant strains. This paper discusses the epidemiology and risk...
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The New Klebsiella pneumoniae ST152 Variants with Hypermucoviscous Phenotype Isolated from Renal Transplant Recipients with Asymptomatic Bacteriuria-Genetic Characteristics by WGS.
PublikacjaKlebsiella pneumoniae (Kp) is one of the most important etiological factors of urinary tract infections in renal transplant (RTx) recipients. We described the antimicrobial susceptibility phenotypes and genomic features of two hypermucoviscous (HM) Kp isolates recovered from RTx recipients with asymptomatic bacteriuria (ABU). Using whole genome sequencing (WGS) data, we showed that the strains belong to the ST152 lineage with the...
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Beata Krawczyk dr hab.
Osobydr hab. Beata Krawczyk, prof. uczelni Stopnie naukowe, wykształcenie, kwalifikacje Beata Krawczyk uzyskała tytuł magistra biologii na Wydziale Biologii (wówczas: Wydział Biologii i Nauk o Ziemi), Uniwersytetu Gdańskiego w 1986 roku, a doktorat z biologii molekularnej na Wydziale Biologii (wówczas: Wydział Biologii, Geografii i Oceanologii) Uniwersytetu Gdańskiego w 1996 roku. Stopień doktora habilitowanego w zakresie nauk biologicznych...
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Genetic Background and Antibiotic Resistance Profiles of K. pneumoniae NDM-1 Strains Isolated from UTI, ABU, and the GI Tract, from One Hospital in Poland, in Relation to Strains Nationally and Worldwide
PublikacjaIn recent years, there has been an observed increase in infections caused by carbapenem-resistant Klebsiella pneumonia (Kp) strains. The aim of this study was the phenotypic and genotypic analysis of eight K. pneumoniae NDM (Kp NDM) isolates, recovered in Poland during the years 2016 and 2018 from seven patients with urinary tract infections (UTIs), asymptomatic bacteriuria (ABU), or colonization of the gut. PCR melting profile...
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A shear stress micromodel of urinary tract infection by the Escherichia coli producing Dr adhesin
PublikacjaIn this study, we established a dynamic micromodel of urinary tract infection to analyze the impact of UT-segment-specific urinary outflow on the persistence of E. coli colonization. We found that the adherence of Dr+ E. coli to bladder T24 transitional cells and type IV collagen is maximal at lowest shear stress and is reduced by any increase in flow velocity. The analyzed adherence was effective in the whole spectrum of physiological...
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Identification of antigen Ag43 in uropathogenic Escherichia coli Dr+ strains and defining its role in the pathogenesis of urinary tract infections
PublikacjaUrinary tract infections (UTIs) caused by uropathogenic Escherichia coli (UPEC) are among the most common bacterial infectious diseases in the developed world. The urovirulence of UPEC is mainly associated with the surface-exposed fimbrial adhesins and adhesins of the autotransporter (AT) family. The best studied of theses proteins is antigen 43 (Ag43) mediating cell aggregation, adhesion and biofilm development as the causes of...
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Antibiotic Resistance of Uropathogens Isolated from Patients Hospitalized in District Hospital in Central Poland in 2020
PublikacjaThe aim of this study was to determine antibiotic resistance patterns and the prevalence of uropathogenes causing urinary tract infections (UTIs) in patients hospitalized in January–June 2020 in central Poland. Antimicrobial susceptibility testing was performed using the disk-diffusion method. Escherichia coli (52.2%), Klebsiella pneumoniae (13.7%), Enterococcus faecalis (9.3%), E. faecium (6.2%), and Proteus mirabilis (4,3%) were...
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Charakterystyka oporności Klebsiella pneumoniae New Delhi na karbapenemy
PublikacjaBakterie Klebsiella pneumoniae New Delhi, posiadające gen oporności na karbapenemy (blaNDM) zostały po raz pierwszy wyizolowane w 2008 roku w Szwecji od pacjenta wcześniej hospitalizowanego w Indiach. Bakterie te szybko rozprzestrzeniają się po całym świecie, a od 2011 roku występują również w Polsce. Stanowią one wysokie ryzyko epidemiologiczne, ponieważ gen oporności na karbapenemy przekazywany jest pomiędzy bakteriami poprzez...
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Virulence analysis and antibiotic resistance of Klebsiella pneumoniae isolates from hospitalised patients in Poland
PublikacjaKlebsiella pneumoniae (KP) is a nosocomial pathogen causing difficult-to-treat infections. The presence of virulence genes and antibiotic resistance of 109 KP isolates from hospitalized patients were investigated. Among them, 68.8% were multi-drug resistant (MDR) and 59.6% produced extended-spectrum beta-lactamases (ESBLs). Metallo-β-lactamases (MBLs) were produced by 22% of isolates (mainly from anus), including 16.5% of isolates...
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Optical method supported by machine learning for urinary tract infection detection and urosepsis risk assessment
PublikacjaThe study presents an optical method supported by machine learning for discriminating urinary tract infections from an infection capable of causing urosepsis. The method comprises spectra of spectroscopy measurement of artificial urine samples with bacteria from solid cultures of clinical E. coli strains. To provide a reliable classification of results assistance of 27 algorithms was tested. We proved that is possible to obtain...
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Alternative treatment approaches of urinary tract infections caused by uropathogenic Escherichia coli strains
PublikacjaUrinary tract infections (UTIs) are the most widespread and annoying infections affecting millions of people every year annually. The biggest problem of urinary diseases are recurrences, the increasing resistance of uropathogens to commonly used antibiotics, as well as the high health care costs of afflicted persons. Uropathogenic Escherichia coli strains (UPECs) are the most dominant etiologic agent of community-acquired infections...
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Characterisation of Escherichia coli isolates from the blood of haematological adult patients with bacteraemia: translocation from gut to blood requires the cooperation of multiple virulence factors
PublikacjaThe aim of the study was to investigate whether there are unique pathotypes of Escherichia coli capable of transmission from the gastrointestinal tract to the vascular bed. The study included E. coli strains isolated from clinical materials collected from 115 patients suffering from haematologic malignancies diagnosed with bacteraemia. The genotyping techniques established that 89 E. coli isolates from the blood had the same genotype...
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Urinary tract infection in children: Diagnosis, treatment, imaging – Comparison of current guidelines
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Importance of biofilm formation by uropathogenic E. coli Dr+ strains in urinary tract infections
PublikacjaImportance of biofilm formation by uropathogenic E. coli Dr+ strains in urinary tract infections
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Human Factors
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GROWTH FACTORS
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Escherichia coli Strains with Virulent Factors Typical for Uropathogens were Isolated from Sinuses from Patients with Chronic Rhinosinusitis—Case Report
PublikacjaEscherichia coli were isolated from three patients with chronic rhinosinusitis (CRS) by intraoperative sinus tissue biopsy. Taking into account the unusual replicative niche and previous treatment failures, it was decided to focus on the virulence and drug resistance of these bacteria. The strains turned out to be multi-sensitive, but the rich virulence factors profile of bacteria typical for phylogenetic group B2 deserved attention....
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Extended-spectrum beta-lactamase-producing Klebsiella pneumoniae in a neonatal unit: control of an outbreak using a new ADSRRS technique
PublikacjaSzczepy Klebsiella pneumoniae (EPKP)produkujące beta-laktamazy o rozszerzonym spektrum substratowym (ESBL)stanowią często problem zakażeń na oddziałach noworodkowych. Izolaty od 149 pacjentów poddano typowaniu nową metodą opartą na zjawisku supresji PCR, ADSRRS-fingerprinting, wykazując pochodzenie klonalne badanych szczepów. Użyteczność techniki ADSRRS-finerprinting została potwierdzona innymi metodami - RAPD i PFGE.
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Phage therapy as a novel strategy in the treatment of urinary tract infections caused by E. coli
PublikacjaUrinary tract infections (UTIs) are regarded as one of the most common bacterial infections affecting millions of people, in all age groups, annually in the world. The major causative agent of complicated and uncomplicated UTIs are uropathogenic E. coli strains (UPECs). Huge problems with infections of this type are their chronicity and periodic recurrences. Other disadvantages that are associated with UTIs are accompanying complications...
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Asymptomatic Bacteriuria in Kidney Transplant Recipients—A Narrative Review
PublikacjaUrinary tract infections (UTIs) are the most prevalent complications in kidney transplant (KTx) recipients. The most frequent finding in this group of patients is asymptomatic bacteriuria (ASB). Here, we provide an overview of the available evidence regarding ASB in KTx recipients, including its etiopathology, clinical impact and management. There is a growing body of evidence from clinical trials that screening for and treating...
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Virulence of Clinical Candida Isolates
PublikacjaThe factors enablingCandidaspp. infections are secretion of hydrolytic enzymes, adher-ence to surfaces, biofilm formation or morphological transition, and fitness attributes. The aim of thisstudy was to investigate the correlation between known extracellular virulence factors and survivalofGalleria mellonellalarvae infected with clinicalCandida. The 25 isolates were tested and the activityof proteinases among 24/24, phospholipases...
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JMIR Human Factors
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Response to Letter to the Editor re ‘Urinary tract infection in children: Diagnosis, treatment, imaging – Comparison of current guidelines’
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Genotyping and characterization of virulence factors in Escherichia coli strains isolated from patients from Polish hospital
PublikacjaZakażenia układu moczowego (UTIs - ang. urinary track infections) są jedną z najczęstszy infekcji, za które w 85% przypadków odpowiedzialne są bakterie Escherichia coli. Infekcje układu moczowego mogą prowadzić do groźnych powikłań m. in. odmiedniczkowego zapalenia nerek. Śmiertelność wśród tej grupy pacjentów wynosi 1-3%. Zakażenia układu moczowego występują również u ok. 7% kobiet ciężarnych. W pracy przebadano 82 szczepy E....
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Detailed results of shaping personnel risk factors in enterprise B
Dane BadawczeThe data presents the shape of all the researched personnel risk factors in the B enterprise (which was tested by the author). Further considerations should be started with the presentation of the synthesis of the obtained results, which is presented in this research data.
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Simultaneous determination of creatinine and acetate by capillary electrophoresis with contactless conductivity detector as a feasible approach for urinary tract infection diagnosis
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Detailed results of shaping personnel risk factors in enterprise A
Dane BadawczeThe data presents the shape of all the researched personnel risk factors in the A enterprise (which was tested by the author). Further considerations should be started with the presentation of the synthesis of the obtained results, which is presented in this research data.
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Evaluation of Chemical Changes in Laboratory-Induced Colistin-Resistant Klebsiella pneumoniae
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Functional safety and human factors
PublikacjaRozdział przedstawia istotny problem uwzględnienia czynników ludzkich (H&OF) w analizie bezpieczeństwa funkcjonalnego, które wpływają istotnie na bezpieczeństwo przemysłowych obiektów podwyższonego ryzyka, nie ujęty jednak w normach bezpieczeństwa funkcjonalnego. Przedstawia się metody analizy niezawodności człowieka (HRA) w kontekście tych czynników, które wpływają na błędy człowieka. Czynniki ludzkie i organizacyjne powinny być...
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Analysis of Factors Influencing the Prices of Tourist Offers
PublikacjaTourism is a significant branch of many world economies. Many factors influence the volume of tourist traffic and the prices of trips. There are factors that clearly affect tourism, such as COVID-19. The paper describes the methods of machine learning and process mining that allow for assessing the impact of various factors (micro, mezzo and macro) on the prices of tourist offers. The methods were used on large sets of real data...
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Factors causing degradation of sulfadimetoxine
PublikacjaSulfadimetoxine is a representative of sulfonamide drugs which presence inhibits growth of activated sludge bacteria, rhat is necessary for the effective mineralization of organic and inorganic contaminants. Therefore factors which con prevent this situation are searched. Aim of this study is selection of conditions causing efficien degradation of the drug- sulfadimetoxine. The impact of such aspects as : the type of oxidizing...
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LUTS-Lower Urinary Tract Symptoms
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A synthetic result of the development of personnel risk factors in the A, B, C, D enterprise
Dane BadawczeThe data below presents the shape of all the researched personnel risk factors in the A, B, C, D enterprise (which were tested by the author). Further considerations should be started with the presentation of the synthesis of the obtained results, which is presented in this research data.
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Charakterystyka genetyczna szczepów Klebsiella pneumoniae izolowanych od pacjentów po przeszczepieniu nerki oraz badanie wpływu leków immunosupresyjnych na ekspresję genów bakteryjnych
PublikacjaBakterie z gatunku Klebsiella pneumoniae należą do oportunistycznych patogenów odpowiedzialnych za zakażenia szpitalne. Drobnoustroje te wykazują skłonność do oporności wielolekowej i wysokiej wirulencji, co stanowi poważne zagrożenie dla pacjentów nieimmunokompetentnych. Wśród pacjentów po transplantacji nerki zakażenia układu moczowego (ZUM) stanowią najczęstszą przyczynę powikłań infekcyjnych. Mechanizmy molekularne leżące u...
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The Factors Affecting Group Identity of Cluster Structures
PublikacjaThe paper provides a new approach to cluster analysis, basing on a sociologically rooted concept of identity. The authors state that identity in cluster structures is formed by two main groups of factors – uncontrollable or slightly controllable factors (identity mix) and factors that can be fully controlled by a cluster initiative (corporate identity mix). It means that the cluster coordinator is able to consciously build the...
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Crucial factors for improving the ISO 14001 environmental management system
PublikacjaThe practice of using environmental management systems (EMS) ISO 14001 at the organisational level indicates that the efficacy of such solutions depends on many factors, both endogenous and exogenous in nature. This article aims to identify the fac- tors that determine the opportunities for the improvement of EMS in organisations, the analysis of the relationship between the factors and the classification of the factors due to...
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Human factors in nuclear power engineering in Polish conditions
PublikacjaThe paper “Human factors in nuclear power engineering in polish conditions” focuses on analysis of dynamics of preparing polish society to build first nuclear power plant in XXI century in Poland. Authors compare experience from constructing nuclear power plant Sizewell B (Great Britain) and Sizewell C, which is in preparation phase with polish nuclear power program. Paper includes aspects e.g. of creating nuclear safety culture...
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Human Factors in Nuclear Power Engineering in Polish Conditions
PublikacjaThe paper “Human factors in nuclear power engineering in polish conditions” focuses on analysis of dynamics of preparing polish society to build fi rst nuclear power plant in XXI century in Poland. Authors compare experience from constructing nuclear power plant Sizewell B (Great Britain) and Sizewell C, which is in preparation phase with polish nuclear power program. Paper includes aspects e.g. of creating nuclear safety culture and...
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Factors that strengthen and weaken the identity of the cluster structures
PublikacjaThe main aim of this paper is the application of "identity" to the issues related to "clustering process" and particularly - to the cooperation in the clusters and the cluster initiatives. The authors distinguish these factors that have the greatest influence on the formation and maintenance of identity in mentioned networks of cooperation.
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Functional Safety Analysis including Human Factors
PublikacjaIn this paper selected aspects of human factors are discussed that should be taken into account during the design of safety-related functions for a complex hazardous installation and its protections. The layer of protection analysis (LOPA) methodology is used for simplified risk analysis based on defined accident scenarios. To control the risk the safety instrumented functions (SIFs) are identified and their safety integrity levels...
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The effects of selected factors on pedestrian crossings in urban areas
PublikacjaPedestrian crossings are designed to help pedestrians cross a road. There are at-grade pedestrian crossings with or without traffic lights and grade separated crossings such as subways and footbridges. Pedestrian crossings may be located next to a junction or on road sections between junctions. Where at-grade crossings are involved, pedestrians and motorists interact, which may lead to dangerous situations and road traffic conflicts....
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Enviromental factors az the elements determingthe development of floating homes
PublikacjaThe popularity of Floating Homes in Western Europe and North America is noticeable. The interest in thesefacilities in Poland is also constantly growing. The popularity of Floating Homes is due to climate change, risingland prices and population density in city centers. However, environmental factors play a significant role in theirdevelopment. The publication presents the results of research on the impact of environmental factors...
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Factors disturbing Internet usage in opinion of elderly users
PublikacjaInternet became truly widespread in modern societies. This created its huge economic potential, which is widely used, especially in traditionally communication-oriented societies like USA and Scandinavian countries. This trend enables to create economic growth even despite of worldwide economic slowdown.Together with demographic changes this raise the necessity of research on how older users perceive modern, Internet-based tools...
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Factors affecting the quality of bottled water
PublikacjaThe ever-increasing popularity of bottled water means that it is important to analyze not only its mineral content but also, above all,its content of possible contaminants, especially the organic ones. In this respect, bottled waters are a special case, because apartfrom organic chemical contaminants derived from the well from which they were acquired, their secondary contamination is alwayspossible, during treatment or storage...
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Development of factors and measurement of personnel risk in the marketing services of four Polish pharmaceutical companies
Dane BadawczeThis text contains the presentation and analysis of research results in relation to four companies (A, B, C, D), according to the adopted case study method.Further considerations should be preceded by the assumption that personal risk factors often affect the level of this risk in various directions, so their final impact is the result of the shaping...
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Human Factors and Cognitive Engineering in Functional Safety Analysis
PublikacjaHuman factors and cognitive engineering are considered nowadays as important multidisciplinary domains that focus on improving the relations between humans, technology and systems to be supervised and operated. The industrial automation and control systems (IACS) in hazardous plants are increasingly computerized and perform various safety functions. These are usually designed and implemented according to the functional safety requirements....
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Factors Affecting the Effectiveness of Military Training in Virtual Reality Environment
PublikacjaIn this paper, we explored the factors influencing the effectiveness of military trainings performed in a virtual reality environment. The rationale for taking up the topic is the fact that such trainings are often conducted under specific operational procedures. These procedures may create rigorous frameworks for all elements of the learning environment, including the teacher’s performance. Therefore, to ensure the most conducive...
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Factors influencing decisions to retire – case study of Poland
PublikacjaThe main objective of the article is to present the factors influencing the decisions of the Poles from the older age groups to withdraw from the labour market by retirement, or on the contrary – to remain economically active, also upon reaching the formal retirement age.
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Factors determining selection of production planning and control system
PublikacjaThe article contains a comparative characteristics of selected systems of production planning and control, such as: MRP, kanban/JiT, DBR/TOC. The results of the performed analyses served as a basis for determining key market factors related to production planning and control functions, which determine the choice of an appropriate system.