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Wyniki wyszukiwania dla: ALZHEIMER’S DISEASE
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Novel design of sodium alginate based absorbable stent for the use in urethral stricture disease
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Formulation and evaluation of hydrogel containing dry extract of Tormentillae rhizoma designed for periodontal disease
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Supporting Gastroesophageal Reflux Disease Diagnostics by Using Wavelet Analysis in Esophageal pH-Metry
PublikacjaThis paper presents a new approach to computer supported esophageal pH-metry measurement analysis performed in order to diagnose gastroesophageal reflux disease. In this approach wavelet analysis was used to analyse the esophageal pH-metry course. The research was performed on three groups of pH-metry courses: whole 24-hour pH-metry course, sleep only pH-metry course and 20 minutes after the end of a meal pH-metry course. After...
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Monitoring Parkinson's disease patients employing biometric sensors and rule-based data processing
PublikacjaArtykuł prezentuje automatyczny system wykrywania pogorszenia zdrowia pacjentów z chorobą Parkinsona opracowany w ramach projektu PERFORM.The paper presents how rule-based processing can be applied to automatically evaluate the motor state of Parkinson's Disease patients. Automatic monitoring of patients by using biometric sensors can provide assessment of the Parkinson's Disease symptoms. All data on PD patients' state are compared...
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Structural Studies of Thyroid Peroxidase Show the Monomer Interacting With Autoantibodies in Thyroid Autoimmune Disease
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Analysis of exhaled breath for dengue disease detection by low-cost electronic nose system
PublikacjaThis paper presents a procedure and a set-up of an electronic nose system analyzing exhaled breath to detect the patients suffering from dengue – a mosquito-borne tropical disease. Low-power resistive gas sensors (MiCS-6814, TGS8100) were used to detect volatile organic compounds (VOCs) in the exhaled breath. The end-tidal phase of patients exhaled breath was collected with a BioVOCTM breath sampler. Two strategies were assessed...
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Trimethylamine N-oxide and the reverse cholesterol transport in cardiovascular disease: a cross-sectional study
PublikacjaThe early atherosclerotic lesions develop by the accumulation of arterial foam cells derived mainly from cholesterol-loaded macrophages. Therefore, cholesterol and cholesteryl ester transfer protein (CETP) have been considered as causative in atherosclerosis. Moreover, recent studies indicate the role of trimethylamine N-oxide (TMAO) in development of cardiovascular disease (CVD). The current study aimed to investigate the association...
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Conformational solution studies of the SDS micelle-bound 11-28 fragment of two Alzheimer's β-amyloid variants (E22K and A21G) using CD, NMR, and MD techniques
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Metabolic profiling of pteridines for determination of potential biomarkers in cancer diseases
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Knowledge and Attitudes of Future Healthcare Professionals Toward Rare Diseases
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Dendrimer Structure Diversity and Tailorability as a Way to Fight Infectious Diseases
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Lipophagy and Lipolysis Status in Lipid Storage and Lipid Metabolism Diseases
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Factors and processes modulating phenotypes in neuronopathic lysosomal storage diseases
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Sample preparation and recent trends in volatolomics for diagnosing gastrointestinal diseases
PublikacjaThe analysis of the human volatilome can be successfully used for rapid and non-invasive diagnostics of gastrointestinal diseases. However, the introduction of techniques based on detection of volatiles is limited, among other factors, by difficulties which arise during the sampling stage and instrumental analysis. The aim of this article was to review and discuss medical and analytical literature on the analysis of volatiles in...
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Metals in the environment as risk factors for infectious diseases: gaps and opportunities
PublikacjaThis chapter aims to provide insights into current knowledge and gaps in our understanding of the influence that trace metals in the environment have on the pathogenesis of infectious diseases. By reducing immune function, trace metal deficiencies may substantially contribute to the global burden of diarhea, pneumonia, and malaria. Improved methods and biomarkers for assessing the risk of trace metals deficiencies and toxicities...
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Therapeutic Potential of Carnosine and Its Derivatives in the Treatment of Human Diseases
PublikacjaDespite significant progress in the pathogenesis, diagnosis, treatment, and prevention of cancer and neurodegenerative diseases, their occurrence and mortality are still high around theworld. The resistance of cancer cells to the drugs remains a significant problem in oncology today,while in the case of neuro-degenerative diseases, therapies reversing the process are still yet to be found. Furthermore, it is important to seek new...
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OrphaGPT: An Adapted Large Language Model for Orphan Diseases Classification
PublikacjaOrphan diseases (OD) represent a category of rare conditions that affect only a relatively small number of individuals. These conditions are often neglected in research due to the challenges posed by their scarcity, making medical advancements difficult. Then, the ever-evolving medical research and diagnosis landscape calls for more attention and innovative approaches to address the complex challenges of rare diseases and OD. Pre-trained...
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Missing Puzzle Pieces in Dementia Research: HCN Channels and Theta Oscillations
PublikacjaIncreasing evidence indicates a role of hyperpolarization activated cation (HCN) channels in controlling the resting membrane potential, pacemaker activity, memory formation, sleep, and arousal. Their disfunction may be associated with the development of epilepsy and age-related memory decline. Neuronal hyperexcitability involved in epileptogenesis and EEG desynchronization occur in the course of dementia in human Alzheimer’s Disease...
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Integrative multiomics study for validation of mechanisms in radiation-induced ischemic heart disease in Mayak workers
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Interaction of HLA-DRB1 Alleles with CTLA-4 in the Predisposition to Graves' Disease: The Impact of DRB1*07
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Professional activity, gender and disease-related emotions: The impact on parents' experiences in caring for children with phenylketonuria
PublikacjaIntroduction: Clinical management of rare diseases often fails to acknowledge the challenges faced by caregivers.Whilst management of phenylketonuria (PKU) may not be considered as dire as other conditions, most studiesprimarily concentrate on clinical issues, dietary adherence, or the quality of life of the PKU patients, leavingcaregivers in the background. The aim of the study was to evaluate the psychosocial...
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Reaction to Disease and Coping Strategies in Stressful Situations among Psoriasis Patients: Cross-Sectional Study
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The Gluten-Free Diet and Glycaemic Index in the Management of Coeliac Disease Associated with Type 1 Diabetes
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Associations between plasma lysophospholipids concentrations, chronic kidney disease and the type of renal replacement therapy
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A targeted metabolomic protocol for quantitative analysis of volatile organic compounds in urine of children with celiac disease
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An Overview of Pest and Disease Occurrence in Organic Pome Fruit Orchards in Europe and on the Implementation of Practices for Their Control
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Augmentation index, pulse pressure amplification and superoxide anion production in patients with coronary artery disease
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Influence of increased arterial stiffness on myocardial work efficiency in patients with stable coronary artery disease
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Professional activity, gender and disease-related emotions: The impact on parents' experiences in caring for children with phenylketonuria
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Mitochondrial DNA copy number and trimethylamine levels in the blood: New insights on cardiovascular disease biomarkers
PublikacjaAmong cardiovascular disease (CVD) biomarkers, the mitochondrial DNA copy number (mtDNAcn) is a promising candidate. A growing attention has been also dedicated to trimethylamine-N-oxide (TMAO), an oxidative derivative of the gut metabolite trimethylamine (TMA). With the aim to identify biomarkers predictive of CVD, we investigated TMA, TMAO, and mtDNAcn in a population of 389 coronary artery disease...
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Artificial intelligence support for disease detection in wireless capsule endoscopy images of human large bowel
PublikacjaIn the work the chosen algorithms of disease recognition in endoscopy images were described and compared for theirs efficiency. The algorithms were estimated with regard to utility for application in computer system's support for digestive system's diagnostics. Estimations were achieved in an advanced testing environment, which was built with use of the large collection of endoscopy movies received from Medical University in Gdańsk....
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Sex contribution to average age at onset of Huntington's disease depends on the number of (CAG)n repeats
PublikacjaHuntington’s disease (HD) is a hereditary neurodegenerative disorder caused by the extension of the CAG repeats in exon 1 of the HTT gene and is transmitted in a dominant manner. The present study aimed to assess whether patients’ sex, in the context of mutated and normal allele length, contributes to age on onset (AO) of HD. The study population comprised a large cohort of 3723 HD patients from the European Huntington’s Disease...
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High prevalence of Escherichia coli belonging to the B2+D phylogenetic group in inflammatory bowel disease
PublikacjaBACKGROUND: It is not clear which species of bacteria may be involved in inflammatory bowel disease (IBD). One way of determining which bacteria might be likely candidates is to use culture-independent methods to identify microorganisms that are present in diseased tissues but not in controls. AIMS: (1) To assess the diversity of microbial communities of biopsy tissue using culture-independent methods; (2) to culture the bacteria...
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The role of regulatory T cells and genes involved in their differentiation in pathogenesis of selected inflammatory and neoplastic skin diseases. Part II: The Treg role in skin diseases pathogenesis
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Synthesis and Cholinesterase Inhibitory Activity of N-Phosphorylated /N-Tiophosphorylated Tacrine
PublikacjaNovel phosphorus and thiophosphorus tacrine derivatives were designed, synthesized and their biological activity and molecular modeling was investigated as a new potential anti-Alzheimer's disease (AD) agents. All new synthesized compound exhibited lower toxicity against neuroblastoma cell line (SH-SY5Y) in comparison with tacrine. Two analogues in the series, 7 and 9, demonstrated lack of cytotoxicity against hepatocellular cells...
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C-reactive protein as a diagnostic and prognostic factor in inflammatory bowel diseases
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The Role of Selected Trace Elements in Oxidoreductive Homeostasis in Patients with Thyroid Diseases
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Nutritional Status and the Outcomes of Endoscopic Stenting in Benign and Malignant Diseases of Esophagus
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The Combination of Beta-Blockers and ACE Inhibitors Across the Spectrum of Cardiovascular Diseases
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The molecular mechanism of genistein action in lysosomal storage diseases: A transcriptomic approach
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An application supporting the educational process of the respiratory system obstructive diseases detection
PublikacjaThe paper presents a description of functioning of a platform supporting the detection of obstructive diseases in the respiratory system education process. A 16-parameter model of the respiratory system simulated in the MATLAB/Simulink environment was set in the role of the tested patient. It has been linked to the control layer, developed in the LabVIEW environment, using the SIT library (Simulation Interface Toolkit). This layer...
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Investigation of photothermolysis therapy of human skin diseases using optical phantoms
PublikacjaDermatological diseases, such as neurofibroma (Recklinghausen disease) or hemangiomas can be efficiently treated using photothermolysis from laser irradiation. We have utilized a developed 975 nm fiber diode laser as a low-cost alternative over common Nd:YAG lasers. This paper describes the investigations of interaction of 975 nm diode laser radiation-pulses with optical skin phantoms which were designed and manufactured in our...
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A Formal Approach to Model the Expansion of Natural Events: The Case of Infectious Diseases
PublikacjaA formal approach to modeling the expansion of natural events is presented in this paper. Since the mathematical, statistical or computational methods used are not relevant for development, a modular framework is carried out that guides from the external observation down to the innermost level of the variables that have to appear in the future mathematical-computational formalization. As an example we analyze the expansion of Covid-19....
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The pattern of verbal, visuospatial and procedural learning in Richardson variant of progressive supranuclear palsy in comparison to Parkinson’s disease
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Assessment of Interleukin 16 Serum Levels and Skin Expression in Psoriasis Patients in Correlation with Clinical Severity of the Disease
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Circulating Tumor Cells as a Marker of Disseminated Disease in Patients with Newly Diagnosed High-Risk Prostate Cancer
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29 Metabolic Syndrome and Selected Coronary Heart Disease Risk Factors in the Group of Krakow Adult Residents
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L16 Nutritional Status of Patients with Huntington Disease: Correlations Between Macro- And Micronutrient intake and Severity of HD
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Introductory investigations of dermatologic diode laser with wavelengths 975 nm: clinical therapy of Recklinghausen disease and of hemangiomas
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Inhibitors and Antibody Fragments as Potential Anti-Inflammatory Therapeutics Targeting Neutrophil Proteinase 3 in Human Disease
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