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Wyniki wyszukiwania dla: IN VITRO LIPOLYSIS
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Bioreactor shoot cultures of Rhododendron tomentosum (Ledum palustre) for a large-scale production of bioactive volatile compounds
PublikacjaRhododendron tomentosum Harmaja (Ledum palustre), a peat bog plant from Ericaceae family, has been used in traditional medicine as the anti-arthritis agent. Although modern researches confirm its anti-inflammatory properties, it remains threatened by habitat degradation and possibilities to collect this endangered species from its natural environment for further biological activity studies are limited. Therefore, R. tomentosum...
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Bioactive and bioavailability of minerals in rats loaded with cholesterol and kiwi fruit
PublikacjaThe aim of this study was to compare the content of polyphenols (TP), minerals, ascorbic acid (AA) and total antioxidant capacities (TAC) of conventional and organic kiwifruit ‘Hayward’ treated with ethylene after harvest and to determine their influence on plasma TAC, mineral content in the liver and bioavailability (RBV — relative bioavailability value) in rats fed diet containing cholesterol. Organic and conventionally grown...
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Opracowanie optymalnych warunków rozdzielania i identyfikacji metabolitów ro lin z rodzaju droseraceae, z zastosowaniem wysokosprawnej kolumnowej chromatografii cieczowej= A research on the composition of eluent for separation of plant metabolites by column reversed phase liquid chromatography
PublikacjaOd kilku lat na świecie trwają badania składników roślin owadożernych wykazujących atrakcyjne właściwości biologicznie czynne, tj. działanie przeciwbakteryjne, przeciwgrzybowe, antyoksydacyjne, a być może, także, przeciwnowotworowe. Pozyskiwanie substancji biologicznieaktywnych z materiału naturalnego, na drodze hodowli in vitro a następnie ekstrakcji i rozdzielania jest bardziej korzystne pod względem ekonomicznym, niż ich wytwarzanie...
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Encapsulation of Amikacin into Microparticles Based on Low-Molecular-Weight Poly(lactic acid) and Poly(lactic acid-co-polyethylene glycol)
PublikacjaThe aim of this study was to fabricate novel microparticles (MPs) for efficient and long-term delivery of amikacin (AMI). The emulsification method proposed for encapsulating AMI employed low-molecular-weight poly(lactic acid) (PLA) and poly(lactic acid-co-polyethylene glycol) (PLA−PEG), both supplemented with poly(vinyl alcohol) (PVA). The diameters of the particles obtained were determined as less than 30 μm. Based on an in-vitro...
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PVA-Based Films with Strontium Titanate Nanoparticles Dedicated to Wound Dressing Application
PublikacjaBioactive materials may be applied in tissue regeneration, and an example of such materials are wound dressings, which are used to accelerate skin healing, especially after trauma. Here, we proposed a novel dressing enriched by a bioactive component. The aim of our study was to prepare and characterize poly(vinyl alcohol) films modified with strontium titanate nanoparticles. The physicochemical properties of films were studied,...
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Identification of antigen Ag43 in uropathogenic Escherichia coli Dr+ strains and defining its role in the pathogenesis of urinary tract infections
PublikacjaUrinary tract infections (UTIs) caused by uropathogenic Escherichia coli (UPEC) are among the most common bacterial infectious diseases in the developed world. The urovirulence of UPEC is mainly associated with the surface-exposed fimbrial adhesins and adhesins of the autotransporter (AT) family. The best studied of theses proteins is antigen 43 (Ag43) mediating cell aggregation, adhesion and biofilm development as the causes of...
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O07 Filaggrin insufficiency renders keratinocyte-derived small extracellular vesicles capable of affecting CD1a-mediated T-cell responses and promoting allergic inflammation
PublikacjaThe association between FLG loss-of-function mutations and the development of atopic dermatitis (AD) indicates that filaggrin is critical to skin barrier function; the mutations are also linked to additional allergic manifestations, but it is unknown how the skin may influence inflammation in distant tissues. Here we investigated the impact of filaggrin insufficiency on keratinocyte-derived exosome-enriched small extracellular...
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SOILPROM Modelowanie transportu zanieczyszczeń w kontinuum grunt-woda-atmosfera, oraz wpływ na funkcje ekosystemu
ProjektyProjekt realizowany w Katedra Geotechniki i Inżynierii Wodnej zgodnie z porozumieniem 101156589 - SOILPROM - HORIZON-MISS-2023-SOIL-01 z dnia 2024-05-17
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Pre‐exascale HPC approaches for molecular dynamics simulations. Covid‐19 research: A use case
PublikacjaExascale computing has been a dream for ages and is close to becoming a reality that will impact how molecular simulations are being performed, as well as the quantity and quality of the information derived for them. We review how the biomolecular simulations field is anticipating these new architectures, making emphasis on recent work from groups in the BioExcel Center of Excellence for High Performance Computing. We exemplified...
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White light thermoplasmonic activated gold nanorod arrays enable the photo-thermal disinfection of medical tools from bacterial contamination
PublikacjaThe outspread of bacterial pathogens causing severe infections and spreading rapidly, especially among hospitalized patients, is worrying and represents a global public health issue. Current disinfection techniques are becoming insufficient to counteract the spread of these pathogens because they carry multiple antibiotic-resistance genes. For this reason, a constant need exists for new technological solutions that rely on physical...
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Distant Non-Obvious Mutations Influence the Activity of a Hyperthermophilic Pyrococcus furiosus Phosphoglucose Isomerase
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Hazard assessment of sediments from a wetland system for treatment of landfill leachate using bioassays
PublikacjaFour bioassays were used in this study for the hazard assessment of sediments from sediment traps and several ponds in a treatment wetland for landfill leachate at Atleverket, Sweden. In the 6-day solid phase microbiotest with the sediment-dwelling crustacean Heterocypris incongruens both acute and chronic effects were observed with a gradual decrease and loss of toxicity with treatment in the wetland system. Some samples showed...
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Selected topics in electrical engineering – modelling of, electrical machines [2021/22]
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CAD. Integrated Architectural Design BSc in Arch., sem 3 2022/2023
Kursy OnlineDuring the course students will learn how to use BIM (Building Information Modelling) tools to model the project site and to develop preliminary design concept.Students will work in pairs or groups, using Autodesk Revit software for terrain, site and building modelling.
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Environmental Protection in Energetics, L, E, sem.01, zimowy 22/23
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Environmental Protection in Energetics, W, E, sem.01, zimowy 22/23
Kursy OnlineThe principle of sustainable development. Non-renewable and renewable energy sources. Environmental aspects of the use of different energy sources. Atmospheric pollution. Methods of reducing the emission of pollutants into the atmosphere. Waste and hazardous waste. Water and Wastewater. Legal aspects of environmental protection.
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Supplementary Course in Higher Physics DPE tutorial (PG_00056611) zima 21/22
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Advances in materials engineering instrumentation: new trends and applications 2022/2023
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[Soft Skills] 2 YEAR Didactic methods in the modern teaching process
Kursy Online{mlang pl} Dyscyplina: wszystkie dyscypliny Zajęcia obowiązkowe dla doktorantów 2 roku Prowadząca: dr hab. Joanna Mytnik, prof. uczelni Liczba godzin: 15 Forma zajęć: warsztaty {mlang} {mlang en} Discipline: all disciplines Obligatory course for 2nd-year PhD students Academic teacher: Joanna Mytnik, Ph.D., ass. prof. Total hours of training: 15 teaching hours Course type: workshop {mlang} Soft skills, area I - didactic...
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Environmental Protection in Energetics, L, E, sem.1, zimowy 24/25
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[Soft Skills] Workshop in research ethics gr.2 AEEITK, ITIT, IMe
Kursy Online{mlang pl} Dyscyplina: Wszystkie dyscypliny Zajęcia obowiązkowe dla doktorantów III roku Prowadzący: A. Karalus Liczba godzin: 5 {mlang} {mlang en} Discipline: All disciplines Obligatory course for 3rd year PhD students Academic teacher: A. Karalus Total hours of training: 5 teaching hours {mlang}
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[Soft Skills] Workshop in research ethics gr.3 NCh, IMa, NF
Kursy Online{mlang pl} Dyscyplina: Wszystkie dyscypliny Zajęcia obowiązkowe dla doktorantów III roku Prowadzący: A. Karalus Liczba godzin: 5 {mlang} {mlang en} Discipline: All disciplines Obligatory course for 3rd year PhD students Academic teacher: A. Karalus Total hours of training: 5 teaching hours {mlang}
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Application of Mathematics in Technology, ET, sem 3, 23/24, (PG_00049767)
Kursy OnlineApplication of Mathematics MOODLE ENV localdevtestprod
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Environmental Protection in Energetics, L, E, sem.1, zimowy 23/24
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DAYLIGHT IN ARCHITECTURE (Elective Project I: MSc term 1) - 23-24
Kursy OnlineThe objectives of this course are: To familiarize students with the role and importance of daylight in shaping building spaces and interiors. To learn about the basics of daylight simulations in the context of complex design decisions and for LEED and BREEAM, integrated design purposes. Proposed assignments 1 & 2: 1. Daylight analysis exterior, the interior of the iconic building (sunlight provision, daylight factor, and...
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Processing of Polyester-Urethane Filament and Characterization of FFF 3D Printed Elastic Porous Structures with Potential in Cancellous Bone Tissue Engineering
PublikacjaThis paper addresses the potential of self-made polyester-urethane filament as a candidate for Fused Filament Fabrication (FFF)-based 3D printing (3DP) in medical applications. Since the industry does not provide many ready-made solutions of medical-grade polyurethane filaments, we undertook research aimed at presenting the process of thermoplastic polyurethane (TPU) filament formation, detailed characteristics, and 3DP of specially...
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Honey antibacterial activity: A neglected aspect of honey quality assurance as functional food
PublikacjaBackground Honey is considered as a functional food with health-promoting properties. Its potent antibacterial and antibiofilm effects are the major attributes of so called ‘medical-grade honey’ which is topically used for the treatment of burns, wounds and skin disorders. Nevertheless, the current set of honey quality parameters adopted in the European Union do not include its biological properties. Furthermore, in light of the...
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Determination of estrogenic endocrine disruptors in environmental samples - a review of chromatographic methods
PublikacjaWśród związków endokrynnych to estrogeny zarówno naturalne jak i syntetyczne zostały wskazane i opisane jako związki niosące ze sobą największy potencjał aktywności estrogennej. Wysoki potencjał estrogenny jaki posiadają związki z grupy hormonów płciowych potwierdziły badania przeprowadzone zarówno in vitro jak i in vivo. W dużej części (50-95%) próbek ścieków pochodzących z oczyszczalni ścieków zostały wykryte związki z grupy...
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Emerging anticancer activity of candidal glucoseamine-6-phosphate synthase inhibitors upon nanoparticle-mediated delivery
PublikacjaNumerous glutamine analogues have been reported as irreversible inhibitors of the glucosamine-6-phosphate (GlcN-6-P) synthase in pathogenic Candida albicans in the last 3.5 decades. Among the reported inhibitors, the most effective N3-(4-methoxyfumaroyl)-L-2,3- diaminopropanoic acid (FMDP) has been extensively studied in order to develop its more active analogues. Several peptide−FMDP conjugates were tested to deliver FMDP to its...
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Multiple transcriptional factors regulate transcription of the rpoE gene in Escherichia coli under different growth conditions and when the lipopolysaccharide biosynthesis is defective.
PublikacjaThe RpoE sigma factor is essential for the viability of Escherichia coli. RpoE regulates extracytoplasmic functions including lipopolysaccharide (LPS) translocation and some of its non-stoichiometric modifications. Transcription of the rpoE gene is positively autoregulated by EσE and by unknown mechanisms that control the expression of its distally located promoter(s). Mapping of 5′ ends of rpoE mRNA identified five new transcriptional...
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Development of a Peptide Derived from Platelet-Derived Growth Factor (PDGF-BB) into a Potential Drug Candidate for the Treatment of Wounds
PublikacjaObjective: This study evaluated the use of novel peptides derived from platelet-derived growth factor (PDGF-BB) as potential wound healing stimulants. One of the compounds (named PDGF2) was subjected for further research after cytotoxicity and proliferation assays on human skin cells. Further investigation included evaluation of: migration and chemotaxis of skin cells, immunological and allergic safety, the transcriptional analyses...
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Essential Oils, Silver Nanoparticles and Propolis as Alternative Agents Against Fluconazole Resistant Candida albicans, Candida glabrata and Candida krusei Clinical Isolates
PublikacjaDevelopment of effective and safe therapeutic treatment of fungal infections remains one of the major challenge for modern medicine. The aim of presented investigation was to analyze the in vitro antifungal activity of selected essential oils, ethanolic extracts of propolis and silver nanoparticles dropped on TiO2 against azole-resistant C. albicans (n = 20), C. glabrata (n = 14) and C. krusei (n = 10) clinical isolates. Among...
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Imidazoacridinone antitumor agent C-1311 as a selective mechanism- based inactivator of human cytochrome P450 1A2 and 3A4 isoenzymes.
Publikacja5-Diethylaminoethylamino-8-hydroxyimidazoacridinone (C-1311), a promising antitumor agent that is also active against autoimmune diseases, was determined to be a selective inhibitor of the cytochrome P450 (CYP) 1A2 and 3A4 isoenzymes. Therefore, C-1311 might modulate the effectiveness of other drugs used in multidrug therapy. The present work aimed to identify the mechanism of the observed C-1311-mediated inactivation of CYP1A2...
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Novel 2-(2-alkylthiobenzenesulfonyl)-3-(phenylprop-2-ynylideneamino)guanidine derivatives as potent anticancer agents – Synthesis, molecular structure, QSAR studies and metabolic stability
PublikacjaA series of new 2-(2-alkylthiobenzenesulfonyl)-3-(phenylprop-2-ynylideneamino)guanidine derivatives have been synthesized and evaluated in vitro by MTT assays for their antiproliferative activity against cell lines of colon cancer HCT-116, cervical cancer HeLa and breast cancer MCF-7. The obtained results indicated that these compounds display prominent cytotoxic effect. The best anticancer properties have been observed for derivatives...
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Nutritional and Pharmaceutical Properties of Bioactive Compounds in Organic and Conventional Growing Kiwifruit
PublikacjaThe bioactivity of two kiwifruit’s cultivars growing under organic and conventional conditions were studied and compared. The bioactive compounds were extracted with water and ethanol using similar conditions which are applied in pharmaceutical applications and for daily fruit consumption such as tea drink. Antioxidant radical scavenging assays [ferric-reducing/antioxidant power (FRAP); cupric reducing antioxidant capacity (CUPRAC);...
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LC–MS/MS analysis, antioxidant and anticholinergic properties of galanga (Alpinia officinarum Hance) rhizomes
PublikacjaGalanga (Alpinia officinarum Hance) is a pungent and aromatic rhizome, which is a member of the ginger family (Zingiberaceae). The rhizomes of this plant have been used as a traditional medicine in far east countries for relieving stomach ache, invigorating the circulatory system, treating colds, and reducing swelling. The aim of this study was to investigate antioxidant and anticholinergic properties of galanga. For this purpose,...
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Teloxantron inhibits the processivity of telomerase with preferential DNA damage on telomeres
PublikacjaTelomerase reactivation is one of the hallmarks of cancer, which plays an important role in cellular immortalization and the development and progression of the tumor. Chemical telomerase inhibitors have been shown to trigger replicative senescence and apoptotic cell death both in vitro and in vivo. Due to its upregulation in various cancers, telomerase is considered a potential target in cancer therapy. In this study, we identified...
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A mechanistically approached review upon assorted cell lines stimulated by athermal electromagnetic irradiation
PublikacjaThe probable influence of electromagnetic irradiation on cancer treatment has been deduced from the interaction of artificial electromagnetic emissions with biological organisms. Nonetheless, the suspected health effects induced by electromagnetic-based technology imply that such a treatment may contaminate the adjacent healthy cells. Thus, gaining mechanistic insights into the problem is required to avoid athermal health hazards....
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Ensembling noisy segmentation masks of blurred sperm images
PublikacjaBackground: Sperm tail morphology and motility have been demonstrated to be important factors in determining sperm quality for in vitro fertilization. However, many existing computer-aided sperm analysis systems leave the sperm tail out of the analysis, as detecting a few tail pixels is challenging. Moreover, some publicly available datasets for classifying morphological defects contain images limited only to the sperm head. This...
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Elective design I: Waterfront Areas in a Changing Climate – Solutions for Gdańsk
Kursy OnlineElective design I:Waterfront Areas in a Changing Climate – Solutions for Gdańsk for MSc in Arch. Seminars & assignments: 30 hTeacher: Lucyna Nyka, Jakub Szczepański, Justyna Borucka + assist. teacher from Gdańsk Tech Waterfront Areas in a Changing Climate – Solutions for Gdańsk – This course explores challenges, conflicts and concepts in waterfront areas, their connection to architectural and urban design in the time of...
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XII edition – 2019-21, International MBA in Strategy, Programme and Project Management
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XV edition 2022-24, International MBA in Strategy, Programme and Project Management
Kursy Online1 2 3
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Application of Mathematics in Technology, ET, sem. 3, winter 2022/2023, (PG_00049767)
Kursy OnlineApplication of Mathematics lectures and exercises
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X edition 2018-20, International MBA in Strategy, Programme and Project Management
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IX edition 2017-19, International MBA in Strategy, Programme and Project Management
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XI edition – 2019-21, International MBA in Strategy, Programme and Project Management
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XIV edition 2021-23, International MBA in Strategy, Programme and Project Management
Kursy Online1 2 3
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Environmental Protection in Energetics (PG_00049751), W, ET, sem.1, winter 2024/2025
Kursy OnlineEnvironmental aspects of energy production and processing.
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XIII edition – 2020-22, International MBA in Strategy, Programme and Project Management
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A comprehensive evaluation of flexible FDM/FFF 3D printing filament as a potential material in medical application
PublikacjaThe use of FDM/FFF in 3D printing for medical sciences is becoming common. This is due to the high availability and decent price of both 3D printers and filaments useful for FDM/FFF. Currently, researchers' attention is focused mainly on the study of medical filaments based on PLA, PCL or their modifications. This contributes to insufficient diversity of medical-grade filaments on the market. Moreover, due to the lack of specified...