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Cellular Nuclei Differentiation Evaluated by Automated Analysis of CLSM Images
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Determination of metronidazole residues in water, sediment and fish tissue samples
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A new approach for the extraction of tetracyclines from soil matrices: application of the microwave-extraction technique
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Effects of five sulphonamides on duckweed (Lemna minor) after prolonged exposure time and their dependency on photoradiation
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Activation maps of convolutional neural networks as a tool for brain degeneration tracking in early diagnosis of dementia in Parkinson's disease based on magnetic resonance imaging
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Synthesis of Fatty Acid Esters of Selected Higher Polyols Over Homogeneous Metallic Catalysts
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Characteristics of titanium nano-oxide (IV) as potent polymethyl metacrylate modifier
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Use of porous glass and silica gel as support media of a surface compound for generation of analytes in gaseous standard mixtures. New method for the determination of the amount of analyte generated
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Comparison of mouse plasma and brain tissue homogenate sample pretreatment methods prior to high-performance liquid chromatography for a new 1,2,4-triazole derivative with anticonvulsant activity
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Are Radiosensitive and Regular Response Cells Homogeneous in Their Correlations Between Copy Number State and Surviving Fraction After Irradiation?
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Markers of Anemia in Children with Type 1 Diabetes
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Greencoin – educational information system for ecoinclusion and empowering urban adaptability.
PublikacjaThe SARS-CoV19 pandemic exposed a broad spectrum of challenges for modern cities, societies and the environment at large. The post-Covid transformation requires new social, ecological and educational solutions, adjusted to modern challenges, but also equipped with technological advances that allow for digital inclusion and sustainable urban development to benefit the local economy and society. Many information systems designed...
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Enzymes of the lysine biosynthetic pathway as targets for antifungals ?
PublikacjaSystemic infections caused by human pathogenic fungi in immunocompromized patients continue to be one of the important clinical problems. Limited availability of safe and efficacious antifungal chemotherapeutics and emerging resistance to existing drugs stimulates search for novel molecular targets for antifungals. The α-aminoadipate pathway (AAP) of L-lysine biosynthesis is unique in fungi and thus has been so far considered...
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DNA-reactive anticancer imidazoacridinone C-1311 is a new inhibitor of hypoxia-inducible factor 1 alpha, vascular endothelial growth factor and tumor angiogenesis
PublikacjaHypoxia-inducible factor 1 (HIF-1) plays a critical role for tumor adaptation to hypoxia and promotes angiogenesis. Antitumor imidazoacridinone C-1311 is a DNA reactive topoisomerase II and FLT3 receptor tyrosine kinase inhibitor selected for phase II clinical trials for breast cancer. Here, we demonstrate the new mechanism of C-1311 action involving HIF-1a, vascular endothelial growth factor (VEGF) and angiogenesis as additional...
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Anticancer imidazoacridinone C-1311 inhibits hypoxia-inducible factor-1α (HIF-1α), vascular endothelial growth factor (VEGF) and angiogenesis
PublikacjaAntitumor imidazoacridinone C-1311 is a DNA-reactive topoisomerase II and FLT3 receptor tyrosine kinase inhibitor. Here, we demonstrate the mechanism of C-1311 inhibitory action on novel targets: hypoxia-inducible factor-1α (HIF-1α), vascular-endothelial growth factor (VEGF), and angiogenesis. In a cell-free system, C-1311 prevented HIF-1α binding to an oligonucleotide encompassing a canonical hypoxia-responsive element (HRE),...
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Ultimate biodegradability and ecotoxicity of orally administered antidiabetic drugs
PublikacjaHypoglycaemic pharmaceuticals are recently more and more frequently detected in the environment. In our previous study, we have shown that even though many of them undergo significant primary degradation some are transformed to stable products or undergo such transformation that a large part of the structure is still preserved. One of the main routes of elimination from wastewaters or surface waters is biodegradation and a lack...
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Thermodynamic, Anticoagulant, and Antiproliferative Properties of Thrombin Binding Aptamer Containing Novel UNA Derivative
PublikacjaThrombin is a serine protease that plays a crucial role in hemostasis, fibrinolysis, cell proliferation, and migration. Thrombin binding aptamer (TBA) is able to inhibit the activity of thrombin molecule via binding to its exosite I. This 15-nt DNA oligonucleotide forms an intramolecular, antiparallel G-quadruplex structure with a chair-like conformation. In this paper, we report on our investigations on the influence of certain...
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Pre-feasibility study for treatment wetland application for wastewater treatment in dispersed development
PublikacjaThe aim of the paper is to present the conducted analyses of pre-feasibility study of different approaches for wastewater management in a settlement of 180 persons. In the assessment both technical and economic aspects were analyzed. The costs were calculated for three different and, at the same time, most popular as well as possible technical solutions like: (i) construction of local wastewater treatment plant with gravitational...
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Primary degradation of antidiabetic drugs
PublikacjaType 2 diabetes is a chronic disease affecting a large portion of the world population and is treated by orally administered drugs. Since these drugs are often taken in high doses and are excreted unchanged or partially metabolised many of them are nowadays detected in surface waters or wastewater treatment plants effluents. Unmetabolised antidiabetics or some of their transformation products retain their pharmacological activity,...
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Interplay between Aryl···Perfluoroaryl and Hydrogen Bonding Interactions in Cocrystals of Pentafluorophenol with Molecules of Trigonal Symmetry
PublikacjaCocrystals of seven star-shaped triaryl compounds with pentafluorophenol (pfp) were prepared and structurally characterized by the single-crystal X-ray diffraction method. Cocrystallization of pfp with planar (or almost planar) compounds gave six 3:1 molecular complexes with well-defined layered structures. The layers are composed of alternating pfp3 trimers, linked by hydrogen bonding, and triaryl molecules held together in planes...
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Die reaktion von tBu2P-P=P(Me)tBu2 mit [Fe2(CO)9] und [(n2-C8H14)2Fe(CO)3]
PublikacjaFosfanofosfinidenofosforan reaguje z nonakarbonylkiem diżelaza oraz z trikarbonylo(diokten)żelazem(0) dając mieszaniny produktów z których udało się wyizolować pochodne będące kompleksami dimeru di(tert)butylo-fosfinofosfini-denu i centrów koordynacji Fe(0).
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Physical, Chemical and Biological Changes in the Gulf of Gdańsk Ecosystem (Southern Baltic Sea).
PublikacjaPrzedstawiono fizyczne, chemiczne i biologiczne zmiany zachodzące w ekosystemie Zatoki Gdańskiej (Południowy Bałtyk. Opisano klimat (temp. wody, opady poziom morza, zasolenie), fluktuację stężeń związków biogennych (azotany,fosforany, krzemiany), poziom organicznych zanieczyszczeń (POP´s, PcB´, pestycydy, WWA) oraz zmiany w biologicznym życiu morza.
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An influence of molecular weight, deacetylation degree of chitosan xerogels on their antimicrobial activity and cytotoxicity. Comparison of chitosan materials obtained using lactic acid and CO2 saturation.
PublikacjaThis paper presents a comparison of the antimicrobial activity and cytotoxicity against L929 cells of chitosan xerogels prepared by dissolving the polymer in a solution of lactic acid (LA) or carbonic acid (CO2) and then freeze-drying. There was no simple relationship between the antimicrobial activity and cytotoxicity of the samples obtained using both techniques (LA and CO2). Chitosan materials obtained by the LA method in a...
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Prognostic value of 5-microRNA based signature in T2-T3N0 colon cancer
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Rapid increase in the incidence of type 1 diabetes in Polish children from 1989 to 2004, and predictions for 2010 to 2025
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Jolanta Wielgus, WETI, ACR+IB, I st., sem. 4 , 2021/2022 L
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Joanna Maria Kowalewska mgr inż. arch.
OsobyJoanna Kowalewska jest absolwentką Wydziału Architektury Politechniki Gdańskiej oraz Ekonomii i Zarządzania na Politechnice Gdańskiej. W 2018 r. otworzyła przewód doktorski na Wydziale Architektury, a jej badania związane są z zagadnieniami dotyczącymi miejskich ogrodów użytkowych. Joanna aktywnie działa w kilku organizacjach pozarządowych: pełniła stanowisko wiceprezesa zarządu fundacji Odyssey of the Mind Polska (2015-2017)....
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Paradigm of deep pectoral myopathy in broiler chickens
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Multicentre, Prospective Observational Study of Pegfilgrastim Primary Prophylaxis in Patients at High Risk of Febrile Neutropenia in Poland: PROFIL Study
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Phase Transitions and Structural Changes in DPPC Liposomes Induced by a 1-Carba-Alpha-Tocopherol Analogue
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Behaviour of water in different types of goats' cheese
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Impact of Housing System on Health and Rearing of Calves Based on Examination of Nasal Cavity Swabs
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Promising Photocytotoxicity of Water-Soluble Phtalocyanine against Planktonic and Biofilm Pseudomonas aeruginosa Isolates from Lower Respiratory Tract and Chronic Wounds
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Photodynamic inactivation of Enterococcus faecalis by conjugates of zinc(II) phthalocyanines with thymol and carvacrol loaded into lipid vesicles
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A ceramic microchip with LDA-APGD as the excitation source for OES – a sensitive Hg detecting sensor for microsample analysis
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Modular Ceramic-Polymeric Device for Analysis of Selected Elements in Liquid Using Microplasma
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Electroporation with Cisplatin against Metastatic Pancreatic Cancer:In VitroStudy on Human Primary Cell Culture
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Anticancer properties of low molecular weight oat beta-glucan – An in vitro study
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A new silylating reagent – dimethyl(3,3,3-trifluoropropyl)silyldiethylamine – for the derivatisation of non-steroidal anti-inflammatory drugs prior to gas chromatography–mass spectrometry analysis
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Epigenetic modifications and NF-κB pathway activity in Cu,Zn-SOD-deficient mice
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Higher Leukocyte 8-Oxo-7,8-Dihydro-2'-Deoxyguanosine and Lower Plasma Ascorbate in Aging Humans?
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A new silylation reagent dimethyl(3,3,3-trifluoropropyl)silyldiethylamine for the analysis of estrogenic compounds by gas chromatography–mass spectrometry
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Valuable polar moieties on cereal-derived biochars
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Oxidative Stress Level in the Testes of Mice and Rats during Nickel Intoxication
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Thermal decomposition of surface compounds for the generation of small quantities of acetaldehyde
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Colorimetric study of zinc oxide poly(methyl methacrylate) nanocomposite – new biomaterial for denture bases
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Preparation and Characterisation of Poly(methyl metacrylate)-Titanium Dioxide Nanocomposites for Denture Bases
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Is the Identification of SNP-miRNA Interactions Supporting the Prediction of Human Lymphocyte Transcriptional Radiation Responses?
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Molecular typing of clinical isolates of Escherichia coli by a new PCR MP method
PublikacjaTypowanie epidemiologiczne bakterii jest rutynową procedurą stosowaną w badaniach zakażeń szpitalnych i wymaga stosowania odpowiednich metod o wysokim potencjale różnicującym. Przedstawiliśmy możliwości nowej techniki PCR MP w różnicowaniu szczepów E. coli. Rezultaty zostały porównane z wynikami uzyskanymi metodą PFGE.
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Molecular typing of clinical isolates of Escherichia coli by a new PCR MP method
PublikacjaTypowanie epidemiologiczne bakterii jest rutynową procedurą stosowaną w badaniach zakażeń szpitalnych i wymaga stosowania odpowiednich metod o wysokim potencjale różnicującym. Przedstawiliśmy możliwości nowej techniki PCR MP w różnicowaniu szczepów E. coli. Rezultaty zostały porównane z wynikami uzyskanymi metodą PFGE.