Wyniki wyszukiwania dla: THERAPEUTIC GARDENS
-
Journal of Experimental Therapeutis and Oncology
Czasopisma -
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
Czasopisma -
Aravind Ayyolath
OsobyI am interested in the biology of bacterial stress response and its growth under stress conditions. Our lab focuses on two aspects; protein folding and lipopolysaccharide biosynthesis and we address them with Escherichia coli models. Our recent studies have provided more evidence regarding several genes involved in the survival of bacteria under stress. I am also interested in disease biology and also in identifying proper therapeutic...
-
Anita Jaśkiewicz-Sojak dr inż. arch.
OsobyAnita Jaśkiewicz-Sojak (dr inż. arch.) architekt, historyk architektury, konserwator zabytków. Adiunkt w Katedrze Historii, Teorii Architektury i Konserwacji Zabytków na Wydziale Architektury Politechniki Gdańskiej. Wykształcenie: studia architektoniczne i doktorskie na Politechnice Gdańskiej, historyczne na Uniwersytecie Gdańskim oraz podyplomowe konserwatorskie na Wydziale Architektury Politechniki Krakowskiej. Rozprawa doktorska...
-
INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS
Czasopisma -
Smart Garden Suburb_Urban design II 2022/23
Kursy OnlineIn the twenty-first century the idea of living in a perfect place combines the need for beauty&identity of the place with the ecology. Metropolises around the world are waiting for concepts that will expose the landscape values and give life in the suburbs high quality including energy efficiency and climate neutrality. A new concepts of are being discussed. Join this trend and look for solutions which merge expression of beauty...
-
Urban Design II _ New Urban Living 2023/24
Kursy OnlineIn the twenty-first century the idea of living in a perfect place combines the need for beauty&identity of the place with the ecology. Metropolises around the world are waiting for concepts that will expose the landscape values and give life in the suburbs high quality including energy efficiency and climate neutrality. A new concepts of are being discussed. Join this trend and look for solutions which merge expression of beauty...
-
Photodynamic therapy of cancer with liposomal photosensitizers
Publikacja -
Photographic documentation of the Palace in Osiek (Oświęcim County, Lesser Poland) at the turn of the 19th and 20th centuries
Dane BadawczeThis dataset presents photographic documentation of the Palace settled in Osiek (Oświęcim County, Małopolskie Voivodeship – Lesser Poland) from the first half of the 19th century. In 1972, the Palace was listed as a Palace and park complex. The complex consists of a palace, the outbuilding "Kasztel" (Castellum), the "Judge's House" outbuilding, the...
-
Results of modeling of pharmaceuticals mixtures toxicity with deviation ratio and best-fit functions models using Saccharomyces cerevisiae yeast as model organism
Dane BadawczeThe research was concerned with verifying the impact of binary mixtures of nine pharmaceuticals against a selected organism, i.e., the yeast Saccharomyces cerevisiae. S cerevisiae is used as a model organism in the monitoring of endocrine disruptors in environmental and reference samples in Xenometrix® systems - XenoScreen®. Tested pharmaceuticals,...
-
Results of pharmaceuticals mixtures toxicity on inhibition of bioluminescence of Vibrio fischeri (Microtox)
Dane BadawczeThe research was concerned with verifying the impact of mixtures of nine pharmaceuticals against a selected organism, i.e., the bacterium Aliivibrio fischeri. A. fisheri is used as a model organism in the monitoring of acute toxicity in environmental and reference samples in Microtox® systems. Tested pharmaceuticals, namely: diclofenac (sodium salt),...
-
Dynamic analysis of the impact of the wind spectrum according to the theory of Davenport for lightweight structures of the roof in sports hall Czyzyna in Cracow.
PublikacjaThe main aim of this analysis is to characterize numerical simulations connected with modeling dynamic influence of wind on the lightweight structures of the roof in sports hall – “Czyżyna”. This hall is built in Cracow. The article also involves the proposals of the solutions connected with dynamic influence of the wind – Davenport’s method has been used. These proposals have not been taken into consideration at the detailed engineering...
-
Beata Krawczyk dr hab.
Osobydr hab. Beata Krawczyk, prof. uczelni Stopnie naukowe, wykształcenie, kwalifikacje Beata Krawczyk uzyskała tytuł magistra biologii na Wydziale Biologii (wówczas: Wydział Biologii i Nauk o Ziemi), Uniwersytetu Gdańskiego w 1986 roku, a doktorat z biologii molekularnej na Wydziale Biologii (wówczas: Wydział Biologii, Geografii i Oceanologii) Uniwersytetu Gdańskiego w 1996 roku. Stopień doktora habilitowanego w zakresie nauk biologicznych...
-
The role of glucuronidation in drug resistance
PublikacjaThe final therapeutic effect of a drug candidate, which is directed to a specific molecular target strongly depends on its absorption, distribution, metabolism and excretion (ADME). The disruption of at least one element of ADME may result in serious drug resistance. In this work we described the role of one element of this resistance: phase II metabolism with UDP-glucuronosyltransferases (UGTs). UGT function is the transformation...
-
Zwischenruf
PublikacjaNa przykładzie łącznika pomiędzy budynkami Królewskiej Szkoły Baletu i Opery Królewskiej w Covent Garden (Londyn), podkreślono aktualne trendy w budownictwie skierowane na integrowanie formy (estetyka) z przeznaczeniem budowli (konstrukcja).
-
Modifications of total synthesis of mycophenolic acid
PublikacjaThe total synthesis of mycophenolic acid (MPA), a potent immunosuppressant, was modified. The obtained mycophenolic acid was suitable for further preparation of new prospective immunosuppressants with improved therapeutic properties.
-
ZASPA NOVA - połączeni dziedzictwem blokowisk/ connected by the heritage of housing estates
PublikacjaWizje nowe Zaspy – Zaspa Nova – prezentują koncepcje architektoniczne dla wybranych, kluczowych stref osiedla. Węzeł komunikacyjny, wnętrze urbanistyczne między blokami i obszar rekreacyjny powiązany funkcjonalnie z ogródkami działkowymi zyskały w propozycjach europejskich studentów architektury nowy kształt i wyraz przestrzenny.
-
O modelowaniu numerycznym dźwigarów zespolonych
PublikacjaThe paper is a general review of theoretical problems and corresponding numerical procedures actually available in commercial engineering software. Several possibilities of numerical simulation for composite girders are presented. Effectivity of meshing is showed on the simple example. Finally several examples of structural numeric models for real bridges are included. In the author's opinion, presented available procedures for...
-
Influence of the Widespread Use of Corten Plate on the Acoustics of the European Solidarity Centre Building in Gdansk
PublikacjaThis paper describes the relationship between a strong architectural vision that is difficult to balance, and user expectations in terms of acoustics. The focus is on the use of corten steel as the dominant finishing material on façades and interiors to achieve an expressive, symbolic message through program-based design. The architectural premises justifying the adopted solutions are presented, especially the universality and...
-
Application of a three‑dimensional (3D) breast cancer model to study macrophage polarization
Publikacja -
Nanomaterials for photothermal and photodynamic cancer therapy
PublikacjaIn recent years, the role of optically sensitive nanomaterials has become powerful moieties in therapeutic techniques and has become particularly emphasized. Currently, by the extraordinary development of nanomaterials in different fields of medicine, they have found new applications. Phototherapy modalities, such as photothermal therapy (PTT) by toxic heat generation and photodynamic therapy (PDT) by reactive oxygen species, are...
-
The health impact of urban parks along waterways
PublikacjaWell designed parks along waterways could promote health and well-being of local inhabitants. The way the human settlements meet water bodies can influence the habits of local population. How people spend their time have significant impact on their health. For example, a team of Japanese scientists has proven that a well designed walk-able green spaces are crucial for the longevity of elderly citizens (Takano T. et al, 2002). Nature...
-
Utilization of New Activated Carbon Derived from an Oak Leaves for Removal of Crystal Violet from Aqueous Solution
PublikacjaSignificant negative environmental impact has been noticed at the campus garden of Gdansk University of Technology , Poland, when the withered leaves of Quercus robur Oak Tree (OL) cover large areas at such places. In this regards,an attempt has been made to recycle the most abundant agricultural leaf waste into a high quality local activated carbon (LAC) for use in the decolorizating processes of dye industrial waste- water.
-
EPILEPTIC BEHAVIOR WITH A DISTINGUISHED PREICTAL PERIOD IN A LARGE-SCALE NEURAL NETWORK MODEL
PublikacjaWe present a neural network model capable of reproducing focal epileptic behavior. An important property of our model is the distinguished preictal state. This novel feature may shed light on the pathologi-cal mechanisms of seizure generation and, in perspective, help develop new therapeutic strategies to manage refractory partial epilepsy.
-
Polish Lymphoma Research Group Experience With Bexarotene in the Treatment of Cutaneous T-Cell Lymphoma
Publikacja -
Safety and efficacy of P2X3 receptor antagonist for the treatment of refractory or unexplained chronic cough: A systematic review and meta-analysis of 11 randomized controlled trials
Publikacja -
DNA methylation analysis with methylation‐sensitive high‐resolution melting (MS‐HRM) reveals gene panel for glioma characteristics
Publikacja -
SZTUKA WIZUALNA W OBIEKTACH MEDYCZNYCH = VISUAL ARTS IN MEDICAL FACILITIES
PublikacjaWspółczesna architektura obiektów służby zdrowia podlega dynamicznym przeobrażeniom formalnym wynikającym zarówno z rozwoju technologii medycznych, zmian zachodzących w podejściu wobec pacjenta. Narastający w naukach medycznych kierunek holistyczny ustawia pacjenta jako użytkownika w trzech wymiarach: biologicznym, społecznym i psychologicznym. Stąd pojawiające się w procesie projektowym dotyczącym szpitali czy przychodni nowe...
-
Pharmaceutical applications of surfactants
PublikacjaIn this study we focused on biological activity of various surfactants. According to our research, they con act both as carriers as well as therapeutic agents. Depending on their concentration, they can create different structures in a solution, which influence their properties. Liposomes have a significant role in drug delivery system. Surfactants in from of bilayer are analogous to natural biological cell membrane.
-
Creating a radiological database for automatic liver segmentation using artificial intelligence.
PublikacjaImaging in medicine is an irreplaceable stage in the diagnosis and treatment of cancer. The subsequent therapeutic effect depends on the quality of the imaging tests performed. In recent years we have been observing the evolution of 2D to 3D imaging for many medical fields, including oncological surgery. The aim of the study is to present a method of selection of radiological imaging tests for learning neural networks.
-
Antimicrobial peptides (AMPs) as drug candidates: a patent review (2003–2015)
Publikacja -
Inhibitors of cathepsin G: a patent review (2005 to present)
Publikacja -
Pregnane X receptor dependent up-regulation of CYP2C9 and CYP3A4 in tumor cells by antitumor acridine agents, C-1748 and C-1305, selectively diminished under hypoxia
PublikacjaInduction of proteins involved in drug metabolism and in drug delivery has a significant impact on drug-drug interactions and on the final therapeutic effects. Two antitumor acridine derivatives selected for present studies, C-1748 (9-(2’-hydroxyethylamino)-4-methyl-1-nitroacridine) and C-1305 (5-dimethylaminopropylamino-8-hydroxy-triazoloacridinone), expressed high and low susceptibility to metabolic transformations with liver...
-
Analysis of multi-class pharmaceuticals in fish tissues by ultra-high-performance liquid chromatography tandem mass spectrometry
PublikacjaA new sensitive method based on pressurized liquid extraction (PLE) and purification by gel permeation chromatography (GPC) prior to ultra-high-performance liquid chromatography coupled to tandem mass spectrometry (UHPLC–MS/MS) was developed for the determination in fish homogenate, liver and muscle of twenty pharmaceuticals compounds and metabolites from seven commonly used therapeutic families. An extensive matrix effect evaluation...
-
Phage Therapy—Challenges, Opportunities and Future Prospects
PublikacjaThe increasing drug resistance of bacteria to commonly used antibiotics creates the need to search for and develop alternative forms of treatment. Phage therapy fits this trend perfectly. Phages that selectively infect and kill bacteria are often the only life-saving therapeutic option. Full legalization of this treatment method could help solve the problem of multidrug-resistant infectious diseases on a global scale. The aim of...
-
Results of modeling of pharmaceuticals mixtures toxicity with deviation ratio and best-fit functions models using Aliivibrio fischeri bacterium as model organism
Dane BadawczeThe research was concerned with verifying the impact of mixtures of nine pharmaceuticals against a selected organism, i.e., the bacterium Aliivibrio fischeri. A. fisheri is used as a model organism in the monitoring of acute toxicity in environmental and reference samples in Microtox® systems. Tested pharmaceuticals, namely: diclofenac (sodium salt),...
-
Value of tax preferences in 2009-2015 as a percentage of Polish GDP
Dane BadawczeThis research data shows the percentage of the amount of tax preferences as a percentage of Polish GDP between 2009-2015. The data contained in this dataset has been collected by the Polish Ministry of Finance.
-
An Overview of Several Inhibitors for Alzheimer’s Disease: Characterization and Failure
Publikacja -
Alternative treatment approaches of urinary tract infections caused by uropathogenic Escherichia coli strains
PublikacjaUrinary tract infections (UTIs) are the most widespread and annoying infections affecting millions of people every year annually. The biggest problem of urinary diseases are recurrences, the increasing resistance of uropathogens to commonly used antibiotics, as well as the high health care costs of afflicted persons. Uropathogenic Escherichia coli strains (UPECs) are the most dominant etiologic agent of community-acquired infections...
-
Computer-Supported Polysensory Integration Technology for Educationally Handicapped Pupils
PublikacjaIn this paper, a multimedia system providing technology for hearing and visual attention stimulation is shortly presented. The system aims to support the development of educationally handicapped pupils. The system has been presented in the context of its configuration, architecture, and therapeutic exercise implementation issues. Results of pupils’ improvements after 8 weeks of training with the system are also provided. Training...
-
Future of medicine: personalized oncology
PublikacjaUnderstanding genetic and epigenetic mechanisms of tumorigenesis allows identifying many vital mutations affected the formation of various malignancies. This led to the discovery of a new therapeutic approach, based on molecular mechanisms in the world of medicine, which is called personalized medicine (PM). This review aims to outline the state of the art of the personalized medicine in treatment, taking into account anti-cancer...
-
Seeding enhancement for microcrystaline diamond layers growth on non-diamond substrates
PublikacjaThe present paper gives an overview on the possible methods of seeding substrates for diamond layers growth. Diamond in reason of his properties is very desirable material in microelectronic, biomedical and waste treatment sensors. Microcrystalline diamond for these applications must be grown on silicon substrate in microwave plasma assisted chemical vapor deposition (MPACVD). To grow diamond on non-diamond surface pre-growth...
-
Involvement of human glutathione S-transferase M1-1 in the glutathione conjugation of the antitumor unsymmetrical bisacridine derivative C-2028.
Dane BadawczeUnsymmetrical bisacridines (UAs) are a novel potent class of antitumor-active therapeutics. The aim of this study was to investigate the possible role of human glutathione S-transferase M1-1 (hGSTM1-1) in the glutathione (GSH) conjugation of a representative UA, C‑2028.
-
Thematic Areas in the Polish Countryside and Their Role in Local Development
PublikacjaThe article defines the phenomenon of space thematisation with regards to rural areas in Poland. The typology of thematic spaces and criteria of their comparative description have been proposed. Thematic villages, home gardens, amusement parks and housing estates have been distinguished. They have been compared in terms of spatial availability, the degree of user participation and the commercial vs. non-commercial creation purpose....
-
Dilemmas associated with the implementation of quality management systems in Polish smaller health care units
PublikacjaThe article presents the considerations and recommendations for the implementation of the process-oriented quality management systems (QMS) in small health care units. As an example, the unit providing services for children with disabilities (therapy and rehabilitation) localized in northern part of Poland have been selected. The essential elements of the implementation of the quality system, taking into account the objectives...
-
Tuftsin-Properties and Analogs
PublikacjaImmunomodulation is one of the significant therapeutic strategies. It includes both stimulation or suppression of the immune system by a variety of substances called immunomodulators, designed to regulate the immune response of the organism to infections of varying etiology. An example of such a substance is tuftsin (TKPA) 3 (Fig. (1)). Tuftsin is an endogenous immunomodulator of a wide spectrum of biological activity. Tetrapeptide...
-
Conformational Studies of [11è12(CN4)]ScyII and [15è16(CN4)]ScyII? Two Scyliorhinin II Analogues by means of 2D NMR Spectroscopy and Theoretical Methods
Publikacja -
DNA-damaging imidazoacridinone C-1311 induces autophagy followed by irreversible growth arrest and senescence in human lung cancer cells
PublikacjaImidazoacridinone 5-diethylaminoethylamino-8-hydroxyimidazoacridinone (C-1311) is an antitumor inhibitor of topoisomerase II and FMS-like tyrosine kinase 3 receptor. In this study, we describe the unique sequence of cellular responses to C-1311 in human non-small cell lung cancer (NSCLC) cell lines, A549 and H460. In A549 cells, C-1311 (IC80 = 0.08 µM) induced G1 and G2/M arrests, whereas H460 cells (IC80 = 0.051 µM) accumulated...
-
Triazoloacridone C-1305 abrogates the restriction checkpoint in cells lacking functional p53 and promotes their accumulation in the G2/M phase of the cell cycle
PublikacjaTriazoloakrydon C-1305, nowy inhibitor topoizomerazy II, wykazuje wysoką aktywość cytotoksyczną wobec komórek wielu typów nowotworów. Komórki mysie pozbawione genu PARP-1 wykazywały nadwrażliwość na działanie tego związku. W pracy testowaliśmy działanie związku wobec dwóch różnych komóek nowotworowych różniących się statusem p53: komórkami białaczki myelocytarnej HL-60 i raka sutka MCF-7. Wykazaliśmy, że inkubacja ze związkiem...
-
Overcoming Phobias: Harnessing the Power of Immersive Virtual Reality Therapy
PublikacjaThe goal of the chapter was to review the different therapeutic techniques used in the treatment of various forms of phobias, with particular emphasis on virtual reality treatment. We define different types of phobias, including social ones. We also describe treatment techniques – adopted from behavioral therapy – which have been developed to aid the treatment of phobias. Particular emphasis has been placed on the flooding, implosive...