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Addition of novel benzylmagnesium “ate” complexes of BnR2MgLi type to 2-(thio)pyridones and related compounds
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Sex contribution to average age at onset of Huntington's disease depends on the number of (CAG)n repeats
PublikacjaHuntington’s disease (HD) is a hereditary neurodegenerative disorder caused by the extension of the CAG repeats in exon 1 of the HTT gene and is transmitted in a dominant manner. The present study aimed to assess whether patients’ sex, in the context of mutated and normal allele length, contributes to age on onset (AO) of HD. The study population comprised a large cohort of 3723 HD patients from the European Huntington’s Disease...
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Solid phase microextraction combined with chromatography - a powerful tool for determination of warfare agents and related compounds
PublikacjaOpisano zastosowanie mikroekstrakcji do fazy stacjonarnej do izolacji wzbogacania środków bojowych i produktów ich degradacji w powietrzu, wodzie i glebie oraz próbkach bilogicznych. Na etapie oznaczeń końcowych stosuje się najczęściej chromatografię gazową. Anality można pobierać przez bezpośrednie zanurzenie włókna w próbce ciekłej i gazowej oraz w fazie nadpowierzchniowej. Stosując SPME-GC można osiągnąć niskie granice oznaczalności...
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Recent advances on magnetic carbon-related materials in advanced oxidation processes of emerging pollutants degradation
PublikacjaRecently, carbon-related materials have been proposed to improve the charge separation of the photogenerated carriers in the semiconductor matrices’ and surface properties. Carbon-related materials may act as co-catalysts, enhancing the pollutants adsorption on the surface, improving the charge carriers separation and photocatalyst stability and providing more active centres for photocatalytic reactions. This review summarizes...
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Challenges and opportunities related to the use of sewage sludge ash in cement-based building materials – A review
PublikacjaDue to the increasingly demanding legal regulations, regarding both sewage sludge (SS) and solid residues obtained during its thermal utilization processes, new solutions to limit their negative impact on the environment are sought. One approach that eliminates the risk of sewage sludge ash (SSA) is its use in cement building materials. The article contains a detailed literature review regarding the use of SSA in mortars and concretes,...
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Reactivation of seizure‐related changes to interictal spike shape and synchrony during postseizure sleep in patients
PublikacjaOBJECTIVE: Local field potentials (LFPs) arise from synchronous activation of millions of neurons, producing seemingly consistent waveform shapes and relative synchrony across electrodes. Interictal spikes (IISs) are LFPs associated with epilepsy that are commonly used to guide surgical resection. Recently, changes in neuronal firing patterns observed in the minutes preceding seizure onset were found to be reactivated during postseizure...
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Evaluation of Three Peptide Immobilization Techniques on a QCM Surface Related to Acetaldehyde Responses in the Gas Phase
PublikacjaThe quartz-crystal microbalance is a sensitive and universal tool for measuring concentrations of various gases in the air. Biochemical functionalization of the QCM electrode allows a label-free detection of specific molecular interactions with high sensitivity and specificity. In addition, it enables a real-time determination of its kinetic rates and affinity constants. This makes QCM a versatile bioanalytical screening tool for...
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Structural and dynamic insights on the EmrE protein with TPP+ and related substrates through molecular dynamics simulations
PublikacjaEmrE is a bacterial transporter protein that forms an anti-parallel homodimer with four transmembrane helices in each monomer. EmrE transports positively charged aromatic compounds, such as TPP+ and its derivatives. We performed molecular dynamics (MD) simulations of EmrE in complex with TPP+, MeTPP+, and MBTPP+ embedded in a membrane. The detailed molecular properties and interactions were analysed for all EmrE-ligand complexes....
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Edge subdivision and edge multisubdivision versus some domination related parameters in generalized corona graphs
PublikacjaGiven a graph G= (V, E), the subdivision of an edge e=uv∈E(G) means the substitution of the edge e by a vertex x and the new edges ux and xv. The domination subdivision number of a graph G is the minimum number of edges of G which must be subdivided (where each edge can be subdivided at most once) in order to increase the domination number. Also, the domination multisubdivision number of G is the minimum number of subdivisions...
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PHYSICAL MODEL OF ENERGY-RELATED PROCESSES IN A ROTATING MECHANICAL SYSTEM FOR THE PURPOSES OF DIAGNOSIS OF TRANSMISSION SHAFTS
PublikacjaIn the present article, selected problems connected with identification of slowly changing energy-related processes accompanying high cyclic fatigue of construction materials of simple mechanical systems, with special consideration of transmission shafts, are mentioned for diagnostic purposes. The article also presents physical models of object and processes that in a simplified way reflect mechanical energy transmission from transmission...
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Phenolic Content and Related Antioxidant Activities in in vitro Cultures of Cephalotaxus Harringtonia L. Grown in Egypt
PublikacjaAbstract: Quantitative estimation of the total phenolics, total flavonoids, antioxidant activity and HPLC analysis of phenolic compounds in the mother plant, in vitro shooting and callus cultures of Cephalotaxus harringtonia L. grown in Egypt were measured. For shooting behaviour, using Woody plant medium (WPM) with 2 mg/l Benzyladinin (BA) in the second subculture gave the highest number of shootlet/explant (2.33 shootlet/explant)...
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Functionalized Peptide Fibrils as a Scaffold for Active Substances in Wound Healing
PublikacjaTechnological developments in the field of biologically active peptide applications in medicine have increased the need for new methods for peptide delivery. The disadvantage of peptides as drugs is their low biological stability. Recently, great attention has been paid to self-assembling peptides that can form fibrils. Such a formulation makes bioactive peptides more resistant to enzymatic degradation and druggable. Peptide fibrils...
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Błażej Kudłak dr hab. inż.
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Cloning, expression, and biochemical characterization of a coldactive GDSL-esterase of a Pseudomonas sp. S9 isolated from Spitsbergen island soil
PublikacjaAn estS9 gene, encoding an esterase of the psychrotolerant bacterium Pseudomonas sp. S9 was cloned and sequenced. The deduced sequence revealed a protein of 636 amino acid residues with a molecular mass of 69 kDa.Further amino acid sequence analysis revealed that the EstS9 enzyme contained a G-D-S-L motif centered at a catalytic serine, an N-terminal catalytic domain and a C-terminal autotransporter domain. Two recombinant E. coli...
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D-loop sequences retrieved from Canis lupus familiaris mitochondrial genome
Dane BadawczeCanine mitochondrial genome is built of 16727 bp. Non-coding control region (mtCR), called also D-loop, begins with 15458 nucleotide and ends with 16727 nucleotide. The length of this fragment is 1270 bp (Kim et al., 1998). D-loop region is responsible for replication and transcription of mitochondrial DNA. Mutations that occur within it may cause irregularity...
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Application of Shape Memory Alloys in Retrofitting of Masonry and Heritage Structures Based on Their Vulnerability Revealed in the Bam 2003 Earthquake
PublikacjaFor decades, one of the most critical considerations of civil engineers has been the construction of structures that can sufficiently resist earthquakes. However, in many parts of the globe, ancient and contemporary buildings were constructed without regard for engineering; thus, there is a rising necessity to adapt existing structures to avoid accidents and preserve historical artefacts. There are various techniques for retrofitting...
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Fully bio-based poly(propylene succinate) synthesis and investigation of thermal degradation kinetics with released gases analysis
PublikacjaOne of the most important information about polyesters is their thermal stability and phase transition tem- peratures. These characteristics give information about the promising behavior of the polyester during proces- sing. In this work, linear bio-based polyester polyols were prepared with the use of succinic acid and 1.3- propanediol (both with natural origin). As a polycondensation catalyst was used tetraisopropyl orthotitanate...
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Influence of service ageing on polyester-reinforced polyvinyl chloride-coated fabrics reported through mathematical material models
PublikacjaIn this paper the coupled service (constructional tension) and environmental (sunlight, rainfalls, temperature variations) ageing influence on the polyester-reinforced polyvinyl chloride (PVC)-coated fabric VALMEX is studied. Two cases of the same fabric have been analyzed: one USED for 20 years on the real construction of the Forest Opera in Sopot (Poland), and one kept as a spare material (NOT USED). The following tests have...
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The effect of job-related stress on psychological well-being = Wpływ stresu zawodowego na dobrostan psychiczny
PublikacjaThe aim of the investigation was to evaluate the effect of job stress factors on psychological well-being of firemen. Goldberg's GHQ-12 for well-being evaluation, the Perceived Job Stress Questionnaire by Dudek et al. for job stress assessment, and indicator of participation in traumatic events were used. 19% of the firemen were qualified to the group with increased risk of mental disorders. Occupational stress had a strong impact...
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Is Easy Access Related to Better Life? Walkability and Overlapping of Personal and Communal Identity as Predictors of Quality of Life
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Technical and Training Related Aspects of Resistance Training Using Blood Flow Restriction in Competitive Sport - A Review
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Therapy-Related Changes in the Serum Proteome Patterns of Early Stage Breast Cancer Patients with Different Outcomes
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Impurity trapped exciton states related to rare earth ions in crystals under high hydrostatic pressure
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Changes in selected parameters related to proteolysis during ageing of dry-cured pork loins inoculated with probiotics
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Real-time proliferation of porcine cumulus cells is related to the protein levels and cellular distribution of Cdk4 and Cx43
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Metamorphosis-related changes in the free fatty acid profiles of Sarcophaga (Liopygia) argyrostoma (Robineau-Desvoidy, 1830)
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Histological evaluation of age-related variations in saphenous vein grafts used for coronary artery bypass grafting
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Mass Spectrometry-Based Proteomic Characterization of Cutaneous Melanoma Ectosomes Reveals the Presence of Cancer-Related Molecules
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The molecular function of kallikrein‐related peptidase 14 demonstrates a key modulatory role in advanced prostate cancer
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Issues Related to Power Supply Reliability in Integrated Electronic Security Systems Operated in Buildings and Vast Areas
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Biofilm Formation and Prevalence of Biofilm-Related Genes Among Clinical Strains of Multidrug-Resistant Staphylococcus aureus
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Age-dependent sympathetic neural responses to ß1 selective beta-blockade in untreated hypertension-related tachycardia
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Functional Interfaces, Biological Pathways, and Regulations of Interferon-Related DNA Damage Resistance Signature (IRDS) Genes
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Effect of resveratrol analogue, DMU-212, on antioxidant status and apoptosis-related genes in rat model of hepatocarcinogenesis
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Cytotoxicity of RH1 and related aziridinylbenzoquinones: involvement of activation by NAD(P)H:quinone oxidoreductase (NQO1) and oxidative stress
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Antibiotic usage at a clinical paediatric hospital before and after the implementation of actions related to the hospital antibiotic policy
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Common methods for the chiral determination of amphetamine and related compounds I. Gas, liquid and thin-layer chromatography
PublikacjaThis article reviews the most common, useful methods for the chiral determination of amphetamine (AM) and AM-deriveddesigner drugs in different of matrix, including blood, hair, urine, medicaments or standard solutions, taking into considerationarticles published in the past 15 years. We consider chromatographic methods (e.g., gas, liquid, high-performance liquid, and thinlayer). We describe several types of chiral derivatization...
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On efficient collaboration between lawyers and software engineers when transforming legal regulations to law-related requirements
PublikacjaAby zapewnić zgodność systemów informatycznych z prawem, konieczna jest współpraca pomiędzy prawnikami a informatykami. W referacie przedstawiono opis problemów dotyczących przekształcania przepisów prawa na wymagania względem systemu z perspektywy prawnika i informatyka. Zaprezentowano również ideę przestrzeni wspólnych informacji umożliwiających efektywną współpracę oraz proces, który integruje analizę wymagań wynikających z...
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Determination of the amount of wash amines and ammonium ion in desulfurization products of process gases and results of related studies
PublikacjaPrzedstawiono metodę oznaczania tzw. amin myjących i ich produktów degradacji, włączając jon amonowy w wodach procesowych i ściekach wytwarzanych podczas odsiarczania gazów. W procesach rafinacji ropy naftowej zastosowano jonowymienną chromatografię cieczową z detektorem refraktometrycznym oraz tanią kationowymienną kolumnę HPLC. Otrzymane wyniki oznaczeń porównano z wynikami uzyskanymi przez miareczkowanie potencjometryczne....
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Serotonergic–Muscarinic Interaction within the Prefrontal Cortex as a Novel Target to Reverse Schizophrenia-Related Cognitive Symptoms
PublikacjaRecent studies revealed that the activation of serotonergic 5-HT1A and muscarinic M1, M4, or M5 receptors prevent MK-801-induced cognitive impairments in animal models. In the present study, the effectiveness of the simultaneous activation of 5-HT1A and muscarinic receptors at preventing MK-801-induced cognitive deficits in novel object recognition (NOR) or Y-maze tests was investigated. Activators of 5-HT1A (F15599), M1 (VU0357017),...
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Scaled agile framework. Dealing with software process‐related challenges of a financial group with the action research approach
PublikacjaThis article reports on a domain-specific software development venture at Nordea. We explore organizational constraints, challenges, and corrective actions undertaken when scaling the agile development approach of their Core Banking Platform program. The fit and required customizations of the rather complex and rigid SAFe framework in a policy-heavy financial institution are audited against the organic growth of the program. In...
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Compatibility of Crude Oil Blends─Processing Issues Related to Asphaltene Precipitation, Methods of Instability Prediction─A Review
PublikacjaProcessing crude oil of variable composition, especially due to the need to process crude oil blends obtained from various sources, presents a tremendous process challenge. This is mainly due to the destabilization of the colloidal system manifested mostly by the precipitation of the asphaltene fraction. The precipitation of asphaltenes from crude oil is a serious problem during extraction, transport, and processing. In the latter...
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Some variants of perfect graphs related to the matching number, the vertex cover and the weakly connected domination number
PublikacjaGiven two types of graph theoretical parameters ρ and σ, we say that a graph G is (σ, ρ)- perfect if σ(H) = ρ(H) for every non-trivial connected induced subgraph H of G. In this work we characterize (γw, τ )-perfect graphs, (γw, α′)-perfect graphs, and (α′, τ )-perfect graphs, where γw(G), τ (G) and α′(G) denote the weakly connected domination number, the vertex cover number and the matching number of G, respectively. Moreover,...
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Common methods for the chiral determination of amphetamine and related compounds II: Capillary electrophoresis and nuclear magnetic resonance
PublikacjaAmphetamine group and related ring-substituted substances are generally synthetic compounds, belonging to one of the most heavily abused drug groups in recent years. Some compounds in this class also originate from plants. Analysis of the enantiomers of AM-type compounds and metabolites is extremely important for a number of scientific disciplines. From studies of biological activity or mechanisms through determination of precursor...
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NRF2-related transcriptomic alterations as a long-term effect of doxorubicin treatment for childhood acute lymphoblastic leukemia
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Impedance plethysmography as a tool for assessing exertion-related blood flow changes in the lower limbs in healthy subjects
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INFINITE DIMENSIONAL ANALYSIS QUANTUM PROBABILITY AND RELATED TOPICS
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Medicinal Plants - International Journal of Phytomedicines and Related Industries
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CaZnO-based nanoghosts for the detection of ssDNA, pCRISPR and recombinant SARS-CoV-2 spike antigen and targeted delivery of doxorubicin
PublikacjaOverexpression of proteins/antigens and other gene-related sequences in the bodies could lead to significant mutations and refractory diseases. Detection and identification of assorted trace concentrations of such proteins/antigens and/or gene-related sequences remain challenging, affecting different pathogens and making viruses stronger. Correspondingly, coronavirus (SARS-CoV-2) mutations/alterations and spread could lead to overexpression...
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Genome Mining Revealed a High Biosynthetic Potential for Antifungal Streptomyces sp. S-2 Isolated from Black Soot
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