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Search results for: REGULATORY
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Cooperation between the European Commission and National Regulatory on the example of National Regulatory Authorities in Telecommunications
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Validation and Regulatory Issues for Sample Preparation
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Cell-Based Therapies with T Regulatory Cells
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Small regulatory bacterial RNAs regulating the envelope stress response
PublicationMost bacteria encode a large repertoire of RNA-based regulatory mechanisms. Recent discoveries have revealed that the expression of many genes is controlled by a plethora of base-pairing noncoding small regulatory RNAs (sRNAs), regulatory RNA-binding proteins and RNA-degrading enzymes. Some of these RNA-based regulated processes respond to stress conditions and are involved in the maintenance of cellular homeostasis. They achieve...
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Validation and Regulatory Issues for Sample Preparation in: Comprehensive Sampling and Sample Preparation
PublicationW rozdziale opisano podstawowe terminy związane z walidacja procedury analitycznej. Szczególnie zwrócono uwagę na etapy pobierania i przygotowania próbek do analizy. Podano także rolę i znaczenie poszczególnych składowych procesu kontroli i zapewnienia jakości wyników pomiarów analitycznych.
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Therapy with CD4+CD25+ T regulatory cells – should we be afraid of cancer?
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Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization
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Enhanced Suppressive Activity of Regulatory T Cells in the Microenvironment of Malignant Pleural Effusions
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Regulatory approach to competition law in the practice of the Polish Competition Authority – critical assessment
PublicationThe text provides a critical analysis of the Polish practice of using competition law provisions as regulation provisions
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Evolving gene regulatory networks controlling foraging strategies of prey and predators in an artificial ecosystem
PublicationCo-evolution of predators and prey is an example of an evolutionary arms race, leading in nature to selective pressures in positive feedback. We introduce here an artificial life ecosystem in which such positive feedback can emerge. This ecosystem consists of a 2-dimensional liquid environment and animats controlled by evolving artificial gene regulatory networks encoded in linear genomes. The genes in the genome encode chemical...
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The LA Loop as an Important Regulatory Element of the HtrA (DegP) Protease from Escherichia coli
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Regulatory B Cells Involvement in Autoimmune Phenomena Occurring in Pediatric Graves’ Disease Patients
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Transcriptomics in Toxicogenomics, Part I: Experimental Design, Technologies, Publicly Available Data, and Regulatory Aspects
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Applying a Mesoscopic Transport Model to Analyse the Effects of Urban Freight Regulatory Measures on Transport Emissions—An Assessment
PublicationSustainable urban freight management is a growing challenge for local authorities due to social pressures and increasingly more stringent environmental protection requirements. Freight and its adverse impacts, which include emissions and noise, considerably influence the urban environment. This calls for a reliable assessment of what can be done to improve urban freight and meet stakeholders’ requirements. While changes in a transport...
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Factors affecting long-term efficacy of T regulatory cell-based therapy in type 1 diabetes
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Methylation level of the regulatory regions of the estrogen receptor type 1 gene in paravertebral muscles of girls with idiopathic scoliosis
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State of the art paper Comprehensive insight into immune regulatory mechanisms and vascular wall determinants of atherogenesis – emerging perspectives of immunomodulation
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Stromal-Epithelial Cross-Talk in the Intestinal Stem Cell Niche is Mediated by a Regulatory Network that Involves TGF-Beta and CTGF
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The role of regulatory T cells and genes involved in their differentiation in pathogenesis of selected inflammatory and neoplastic skin diseases. Part I: Treg properties and functions
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A Specific CD44lo CD25lo Subpopulation of Regulatory T Cells Inhibits Anti-Leukemic Immune Response and Promotes the Progression in a Mouse Model of Chronic Lymphocytic Leukemia
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Towards a modification of a regulatory framework aiming at bunker oil spill prevention from ships - A design aspect of bunker tanks vents location guided by CFD simulations
PublicationAlthough accidental bunker oil spills at seaway are relatively rare events, they can be pose real threat to the natural marine environment. One of the reasons for the bunker spill to occur is a design failure; one of the ways it can demonstrate is an improper location or height of vent heads, leading to a bunker oil discharge during heavy rolling, due to sloshing phenomenon. Design of a ship and her systems is guided by various...
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The role of regulatory T cells and genes involved in their differentiation in pathogenesis of selected inflammatory and neoplastic skin diseases. Part II: The Treg role in skin diseases pathogenesis
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The role of regulatory T cells and genes involved in their differentiation in pathogenesis of selected inflammatory and neoplastic skin diseases. Part III: Polymorphisms of genes involved in Tregs’ activation and function
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Cytotoxicity, acute and subchronic toxicity of ionic liquid, didecyldimethylammonium saccharinate, in rats
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The publication of the European Commission's guidelines in an official language of a new Member State as a condition for their application.Case comment to the order of the Polish Supreme Court of 3 September 2009 (Ref. No. III SK 16/09) to refer a preliminary question to the Court of Justice of the European Union (C-410/99 Polska Telefonia Cyfrowa sp. z o.o. v Prezes Urzędu Komunikacji Elektronicznej)
PublicationThe case comment concentrates on two issues. In the first place, it contains an analysis of the legal character of the European Commission Guidelines on market analysis and the assessment of significant market power under the Community regulatory framework for electronic communications networks and services. Secondly, it analyses the consequences of the lack of publication of those Guidelines in Polishlanguage in the Official Journal...
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Ways of Harmonising Polish Competition Law with the Competition Law of the EU
PublicationThis article discusses the harmonisation of laws within the EU focusing on the specific ways of achieving an approximation of the Polish legal system with European competition law. It identifies and gives an overview of three specific ways of harmonising national laws with EU antitrust provisions: (1) spontaneous (or bottom-up) harmonisation; (2) judicial harmonisation and; (3) legislative harmonisation by means of EU Directives....
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Regulation of Telecommunications Markets. Conference Report
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Sleep apnea: epidemiology, pathophysiology, and relation to cardiovascular risk
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Wpływ układów regulacji grupowej na stabilność napięciową systemu elektroenergetycznego.
PublicationW węzłach wytwórczych współpracujących z siecią przesyłową stosuje się układy regulacji grupowej napięcia i mocy biernej. Układ regulacji grupowej węzła wytwórczego- (RGWW) - swoim sterowaniem (nadrzędnym) obejmuje wszystkie układy regulacji biorące udział w procesie U i Q w wężle tzn. regulatory generatora, regulatory transformatorów blokowych (ewentualnie), regulatory transformatorów sprzęgłowych. W węzłach przesyłowych stosuje...
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Corporate Restructuring. The directions of Legislative Changes
PublicationThe aim of the paper is the presentation of new legal regulations regarding corporate restructurization and challenges of their implementation to avoid the regulatory risk.
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Dissolved oxygen control for activated sludge processes
PublicationRegulatory do nadążania za trajektorią referencyjną stężenia tlenu w komorze reaktora biologicznego są proponowane i badane. W artykule badany jest nieliniowy regulator predykcyjny oraz regulator adaptacyjny z modelem referencyjnym. Uwzględniono zarówno usuwanie ze ścieków pożywki oraz fosforu za pomocą technologii osadu czynnego. Podejście do projektowania regulatora wykorzystuje strukturę dynamiki rozpuszczonego tlenu i jej dwie...
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Responsible Court in the Global World - Managerism or Managerialism
PublicationOne can look at the improvement of the effectiveness and efficiency of the justice system from three perspectives: macro, mezo, and micro. After all, the general goal is to enhance the effectiveness and efficiency of the justice system as a whole (the macro perspective), the courts (the mezo scale), and court proceedings (the micro scale). The need to improve the effectiveness and efficiency of the justice system was noticed in...
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Charakterystyka energetyczna budynków mieszkalnych wielorodzinnych w perspektywie wymagań 2017-2021
PublicationOpracowanie zawiera analizę charakterystyki energetycznej przykładowego budynku mieszkalnego wielorodzinnego przeprowadzoną w perspektywie wymagań 2017-2021 r. Wskazano w niej elementy mające wpływ na zapotrzebowanie budynku na energię użytkową, końcową i nieodnawialną energię pierwotną (wskaźnik EP). Zidentyfikowano jednocześnie możliwe problemy ze spełnieniem wymagań określonych w przepisach techniczno-budowlanych oraz wskazano...
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I, Robot: between angel and evil
PublicationThe boosting of most digital innovations within recent technology progress by artificial intelligence (AI) constitutes a growing topic of interest. Besides its technical aspects, increasing research activity may be observed in the domain of security challenges, and therefore of responsibility related to the controlled or hypothetically uncontrolled or autonomous emergence of AI solutions. Consequently, responsibility and ethics...
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Biofilm formation and its regulation in Staphylococcus aureus
PublicationInfections caused by the major human and animal pathogen, Staphylococcus aureus are becoming an important problem due to its emerging resistance mechanisms and variety of virulence factors. Biofilm formation is considered to be one of the most important factor attributed to high pathogenicity of S. aureus. Described in the literature methods used in identification of biofilm forming abilities of bacteria consist of phenotypic and...
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Integration and Dependency in Software Lifecycle Based on Jazz Platform
PublicationSoftware delivery organizations are being asked to meet goals that seem mutually exclusive. Teams are asked to increase product quality, accelerate time to market, and meet increasing mandates from regulatory bodies. As software solutions and software development environments become rapidly more complex. Many business drivers compound these challlenges.
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Optymalizacja nastaw regulatorów PID do sterowania suwnicą 3D
PublicationSuwnica stanowi ciekawy, a zarazem skomplikowany obiekt sterowania, który znajduje zastosowanie w różnych gałęziach przemysłu. W artykule przedstawiono obiekt sterowania wraz jego układami sterowania wykorzystującymi regulatory PID. Następnie dobrano parametry regulatorów wybranymi metodami inżynierskimi i optymalizacyjnymi. Przeprowadzono szczegółową analizę porównawczą zaproponowanych rozwiązań.
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Uniwersytet organizacją służącą otoczeniu
PublicationW opracowaniu przedstawiono warunki, jakie muszą być spełnione, aby uniwersytet przekształcił się w organizację służącą otoczeniu. Wykorzystując koncepcję Wawrzyniaka, zidentyfikowano oczekiwania interesariuszy uczelni, czynniki (regulatory) wpływające na ewolucję uczelni oraz niezbedne zmiany w organizacji uczelni, polegające na ewolucji uczelni w kierunku organizacji opartej na wiedzy.
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Improving the regulation of the derivatives market as an objective prerequisite for sustainable development of the global financial system
PublicationThe development of financial markets is characterized by the emergence of new financial instruments, in particular derivatives, the risk level analysis of which is complicated. Counterparties are not always fully aware of and do not adequately assess the potential risks of derivatives, which may lead to large financial losses and sometimes bankruptcies. The purpose of the study is to generalize approaches to regulating derivative...
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Evolution of chemotaxis in single-cell artificial organisms
PublicationThe model of a liquid two-dimensional environment, which is based on physics of diffusion, allows us to simulate the diffusion of morphogenes. Artificial organisms move using a chemotaxis reacting to concentration difference. Organisms are controlled by a gene regulatory network coded in a linear genome and reproduce by division. We made a lot of experiments presenting organisms’ behaviour in various environment conditions. We...
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Method of selecting programming practices for the safety-critical software development projects
PublicationIn recent years a plan-driven approach traditionally used in safety-critical software development has been put to a test by rapidly changing technologies, more diverse group of clients and volatile market requirements. The need to deliver good quality systems, faster and at lower cost in comparison to competitors encouraged companies to look for more efficient solutions. Agile methodologies are known to successfully address these...
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Introduction to smart solutions for wastewater: Road-mapping the transition to circular economy
PublicationToday there is an urgent need to move from a linear to a circular economy approach with special focus to water and environment. Despite the paramount importance, this transition is hampered by barriers which concern not only technological but embrace also organizational, regulatory, social, and economic aspects. In order to overcome such barriers, innovative water-smart solutions are needed and a robust roadmap for the transition...
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Sterowanie silnikiem indukcyjnym w zakresie osłabiania pola
PublicationPrezentowany w referacie układ regulacji silnika indukcyjnego oparty na modelu multiskalarnym zapewnia zachowanie odsprzężonego sterowania w szerokim zakresie zmian strumienia w szczelinie powietrznej. Układ regulacji zawiera regulatory trzech zmiennych multiskalarnych, co oznacza, że strumień jest sterowany w sposób bezpośredni. Proponowany układ zrealizowano jako bezczujnikowy, przy czym prędkość kątowa wału jest odtwarzana w...
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Introducing agile practices into development processes of safety critical software
PublicationIn this paper we present AgileSafe - a method which supports introduction of agile practices into safety-critical software development processes. To represent safety assurance constraints resulting from the regulatory context, AgileSafe uses assurance case patterns. The knowledge base of AgileSafe helps the user to select the agile practices relevant for the considered software development project. The corresponding assurance case...
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Calculations of notch stress factor of a thin-walled spreader bracket fillet weld with the use of a local stress approach
PublicationPresence of geometric notches in welded joints causes concentration of strains and stresses, therefore reducing fatigue strength of such joints. This article presents an analysis of stress concentrations in a fillet weld of a spreader mounting bracket on a small sailing yacht. The aim of this article is to direct the attention of designers, manufacturers and regulatory bodies to issues of fatigue cracks that form in brackets fastening...
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Evolution of Animats Following a Moving Target in an Artificial Ecosystem
PublicationMany biological animals, even microscopically small, are able to track moving sources of food. In this paper, we investigate the emergence of such behavior in artificial animals (animats) in a 2-dimensional simulated liquid environment. These "predators" are controlled by evolving artificial gene regulatory networks encoded in linear genomes. The fate of the predators is determined only by their ability to gather food and reproduce—no...
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Regulacja transformatorów zasilajacych sieci 110kV w Polsce.
PublicationDo regulacji transformatorów zasilających sieci 110kV w polskim systemie elektroenergetycznym coraz powszechniejsze są tzw. regulatory grupowe ARST. Nie ma różnic w ocenie struktury, wykonania, ani sposobu powiązania ze sterowanym obiektem. Jest spór o algorytm. Przedstawiona w referacie koncepcja algorytmu regulacji ma, zdaniem autora, przewagę nad algorytmami stosowanymi obecnie. Wymiana algorytmów sterowania w istniejących,...
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Quality Assurance and Quality Control in the Analytical Chemical Laboratory. A practical approach : Second edition
PublicationThe second edition defines the tools used in QA/QC, especially the application of statistical tools during analytical data treatment. Clearly written and logically organized, it takes a generic approach applicable to any field of analysis. The authors begin with the theory behind quality control systems, then detail validation parameter measurements, the use of statistical tests, counting the margin of error, uncertainty estimation,...
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The networking of the justice system as part of public court networks
PublicationThe goal of this paper is to look at the organizational structure of the justice system and provide the answer to the basic question of the possible network relations, their force, and imapct. As part od the paper, I have defined public inetrorganisational court network, dividing them into regulatory inter-organisational networks nad voluntary inetrorganisational networks. Emphasis has also been placed on the benefits and threats...
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Modelling, Simulation and Optimization of the Wavemaker in a Towing Tank
PublicationThe paper analyses the problem of experimental identification (frequency response), modelling and optimization of the towing tank wavemaker in the Scilab/Xcos environment. The experimental identification of the objects (the towing tank wavemaker placed in the hydrodynamic laboratory of the CTO S.A. Ship Design and Research Centre (CTO)) and the implementation of the models in the simulation environment, enable to perform: 1. tuning...