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Synthetic genistein derivatives as modulators of glycosaminoglycan storage
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Adjuvant, neoadjuvant, and experimental regimens in overcoming pancreatic ductal adenocarcinoma
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The effect of cigarette smoking on the clinical course of inflammatory bowel disease
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The aberrant overexpression of vimentin is linked to a more aggressive status in tumours of the gastrointestinal tract
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The clinical and prognostic evaluation of GRP94 immunoexpression in Caucasian patients with colorectal adenocarcinoma
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Catalase immunoexpression in colorectal lesions
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The prognostic activity of transforming acidic coiled-coil 3 (TACC3) immunohistochemical expression in colon adenocarcinoma patients
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Vimentin immunoexpression and its prognostic activity in colon cancer among Caucasian patients
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Local anaesthetics upregulate nitric oxide generation in cord blood and adult human neutrophils
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Metody oceny zagrożeń pieszych
PublicationZarządzanie bezpieczeństwem pieszych uczestników ruchu drogowego. Identyfikacja najbardziej niebezpiecznych miejsc dla pieszych na podstawie analizy wypadków. Identyfikacja źródeł zagrożeń w miejscach najbardziej niebezpiecznych na podstawie wyników badań pośrednich miar brd.
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N-Substituted piperazine derivatives as potential multitarget agents acting on histamine H3 receptor and cancer resistance proteins
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Xanthone synthetic derivatives with high anticandidal activity and positive mycostatic selectivity index values
PublicationWith the current massive increases in drug-resistant microbial infection as well as the significant role of fungal infections in the death toll of COVID-19, discovering new antifungals is extremely important. Natural and synthetic xanthones are promising derivatives, although only few reports have demonstrated their antifungal mechanism of action in detail. Newly synthetized by us xanthone derivative 44 exhibited strong antifungal...
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The Effect of Conjugation with Octaarginine, a Cell-Penetrating Peptide on Antifungal Activity of Imidazoacridinone Derivative
PublicationAcridine cell-penetrating peptide conjugates are an extremely important family of compounds in antitumor chemotherapy. These conjugates are not so widely analysed in antimicrobial therapy, although bioactive peptides could be used as nanocarriers to smuggle antimicrobial compounds. An octaarginine conjugate of an imidazoacridinone derivative (Compound 1-R8) synthetized by us exhibited high antifungal activity against reference...
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Electrochemical study of lithium insertion into carbon-rich polymer-derived silicon carbonitride ceramics
PublicationW pracy przedstawiono materiał ceramiczny, bogaty w węgiel krzemo azotek węgla (SiCN), otrzymany na drodze pirolizy w zakresie temperatur od 1100 do 1700°C. Badania elektrochemiczne insercji litu wykazały, że materiał elektrodowy na bazie SiCN może być obiecujący jako anoda w bateriach litowych. Próbka otrzymana w 1300°C cechuje się pojemnością 392 mAh/g i jest stabilna aktywna elektrochemicznie w trakcie interkalacji i deinterkalacji...
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Organomercury Compounds in Environmental Samples: Emission Sources, Toxicity, Environmental Fate, and Determination
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Rip currents in the non-tidal surf zone with sandbars: numerical analysis versus field measurements
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Wyspa Spichrzów - nowy, dobry adres w Gdańsku w kontekście rewitalizacji historycznych struktur miejskich
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Organomercury compounds in environmental samples: emission sources, toxicity, environmental fate and determination.
PublicationIn view of the specific properties of mercury and its capability of forming compounds that can be bioaccumulated and biomagnified at successive levels of the trophic pyramid, it has become necessary to gather detailed information on the sources of emission of this element into the environment and its fate there. Moreover, the increasing awareness of the relationship between the toxicity of mercury and its chemical form has sharpened...
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Organotin Compounds: Environmental Fate and Analytics
PublicationFor more than 50 years, organotin compounds have been used in almost all sectors of industry. As a consequence, specific environmental compartments are affected by the emission of these xenobiotics. The emissions of organotin compounds into the environment from paints used in the shipbuilding industry for ship hull coating, and from the plant protection products are particularly significant.In 2001, the IMO introduced a global...
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Towards a Smart Sustainable City Roadmap
PublicationThis workshop of the CAP4CITY (Erasmus+ Strengthening Governance Capacity for Smart Sustainable Cities) project is to promote and stimulate the discussion and networking in the area of Digital Government. Smart Sustainable Cities and related concepts of Digital, Intelligent and Smart Cities represent a progression of how cities around the world apply digital technology to serve their populations, pursue sustainable socio-economic...
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Genetic variation in C-reactive protein (CRP) gene is associated with retinopathy and hypertension in adolescents with type 1 diabetes
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The relationship between 8-oxo-7,8-dihydro-2′-deoxyguanosine level and extent of cytosine methylation in leukocytes DNA of healthy subjects and in patients with colon adenomas and carcinomas
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Severe oxidatively damaged DNA after cisplatin treatment of cancer patients
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Effects of basal level of antioxidants on oxidative DNA damage in humans
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Oxidative stress and oxidative DNA damage is characteristic for mixed Alzheimer disease/vascular dementia
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DNA repair is responsible for the presence of oxidatively damaged DNA lesions in urine
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Deep Infiltrating Endometriosis in Adolescence: Early Diagnosis and Possible Prevention of Disease Progression
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Znajomość własnego ciśnienia tętniczego i rozpowszechnienie nadciśnienia tętniczego w populacji wiejskiej - Program Kiełpino = The cognizance of patient's own blood pressure values and the hypertension prevalence among rural population - Kiełpino program
PublicationNadciśnienie tętnicze jest jedną z najczęstszych chorób przewlekłych występujących w Polsce. Nieleczone nadciśnienie tętnicze prowadzi do licznych powikłań, jest przyczyna przedwczesnej umieralności, wpływa na pogorszenie komfortu życia pacjenta i zwiększa koszty leczenia. Ocena znajomości własnego ciśnienia tętniczego krwi oraz rozpowszechnienia nadciśnienia tętniczego u pacjentów w wiejskiej praktyce lekarza rodzinnego - jest...
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The Modifications of Haemoglobin, Erythropoietin Values and Running Performance While Training at Mountain vs. Hilltop vs. Seaside
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Monitoring of myocardium state during off-pump coronary artery by-pass grafting
PublicationW pracy przedstawiono technikę pomiarową do oceny procesów zachodzących podczas operacji przesłowania aortalno-wieńcowego wymagających zatrzymania przepływu krwi. Zaproponiwany system i metoda pomiarowa przewidziane są do wykorzystania podczas opercacji na tzw. bijącym sercu. Pokazano przykłady rejestrowanych sygnałów przydatnych do oceny stanu mieśnia serca oraz dokonano oceny właściwości pomiarowych zastosowanych technik.
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Phenotypic consequences of LYS4 gene disruption in Candida albicans
PublicationA BLAST search of the Candida Genome Database with the Saccharomyces cerevisiae LYS4 sequence known to encode homoaconitase (HA) revealed ORFs 19.3846 and 19.11327. Both alleles of the LYS4 gene were sequentially disrupted in Candida albicans BWP17 cells using PCR-based methodology. The null lys4Δ mutant exhibited lysine auxotrophy in minimal medium but was able to grow in the presence of L-Lys and α-aminoadipate, an intermediate...
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Homoisocitrate dehydrogenase from Candida albicans: properties, inhibition, and targeting by an antifungal pro-drug
PublicationThe LYS12 gene from Candida albicans, coding for homoisocitrate dehydrogenase was cloned and expressed as a His-tagged protein in Escherichia coli. The purified gene product catalyzes the Mg2+- and K+-dependent oxidative decarboxylation of homoisocitrate to alpha-ketoadipate. The recombinant enzyme demonstrates strict specificity for homoisocitrate. SDS-PAGE of CaHIcDH revealed its molecular mass of 42.6±1 kDa, while in size-exclusion...
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Soft-mode enhanced type-I superconductivity in LiPd2Ge
PublicationThe synthesis, crystal structure, and physical properties (magnetization, resistivity, heat capacity) in combination with theoretical calculations of the electronic structure and phonon properties are reported for intermetallic compounds LiPd2X (X = Si, Ge, and Sn). LeBail refinement of powder x-ray diffraction data confirms that all compounds belong to the Heusler family (space group Fm-3m, No. 225). The lattice parameter increases...
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Using Long-Short term Memory networks with Genetic Algorithm to predict engine condition
PublicationPredictive maintenance (PdM) is a type of approach for maintenance processes, allowing maintenance actions to be managed depending on the machine's current condition. Maintenance is therefore carried out before failures occur. The approach doesn’t only help avoid abrupt failures but also helps lower maintenance cost and provides possibilities to manufacturers to manage maintenance budgets in a more efficient way. A new deep neural...
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Cellular and Gene Expression Response to the Combination of Genistein and Kaempferol in the Treatment of Mucopolysaccharidosis Type I
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Impact of isoflavone genistein on psoriasis in in vivo and in vitro investigations
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Negative thermal expansion and antiferromagnetism in the actinide oxypnictide NpFeAsO
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Efficiency rating of SG Diagnostics COVID-19 antigen rapid test kit
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The State and Critical Assessment of the Sharing Economy in Europe
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The Sharing Economy in Europe: From Idea to Reality
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Regioselective synthesis of novel 4,5-diaryl functionalized 3,4-dihydropyrimidine-2(1H)-thiones via a non-Biginelli-type approach and evaluation of their in vitro anticancer activity
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Addition of novel benzylmagnesium “ate” complexes of BnR2MgLi type to 2-(thio)pyridones and related compounds
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The role of MR imaging in detection of hepatic iron overload in patients with cirrhosis of different origins
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Optimisation of pressurised liquid extraction for elimination of sulphur interferences during determination of organotin compounds in sulphur-rich sediments by gas chromatography with flame photometric detection
PublicationOpracowano metodę analizy osadów dennych na zawartość związków cynoorganicznych (MBT, DBT, TBT, MPhT, DPhT, TPhT) przy użyciu przyspieszonej ekstrakcji rozpuszczalnikiem i chromatografii gazowej z detektorem płomieniowo-fotometrycznym. Detektor ten pozwala selektywnie wykrywać niewielkie ilości pochodnych cynoorganicznych. Niestety, bardzo często spotykana w osadach siarka oraz jej pochodne zakłócają sygnał detektora. Z tego względu...
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Świadomość posiadania nadwagi pierwszym krokiem w zapobieganiu otyłości i jej powikłaniom = Awaraness of being overweight is the first step to avoid obesity and its complications
Publicationw ostatnim dwudziestoleciu obserwuje się niepokojący wzrost występowania nadwagi i otyłości na całym świecie. Istotnym elementem profilaktyki zapobiegajacej dalszemu nadmiernemu rozpowszechnieniu nadwagi i otyłości jest uświadomienie osobom najbardziej zagrożonym posiadania tych zaburzeń. Niniejsza praca ma na celu ocenę świadomości mieszkańców wsi na temat nadwagi
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Rozpowszechnienie nadwagi i otyłości w populacji wiejskiej - Program ''Kiełpino'' = Prevalence of overweight and obesity in village population - ''Kiełpino Trial''
PublicationNadwaga i otyłość stanowią poważny problem zdrowotny na całym świecie. Są czynnikiem ryzyka wielu chorób przewlekłych, zwłaszcza chorób sercowo-naczyniowych, metabolicznych, a także niektórych nowotworów. Praca ma na celu ocenę rozpowszechnienia nadwagi i otyłości w populacji wiejskiej.
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Synthesis and antimicrobial activity of 6-sulfo-6-deoxy-D-glucosamine and its derivatives
Publication6-Sulfo-6-deoxy-D-glucosamine (GlcN6S), 6-sulfo-6-deoxy-D-glucosaminitol (ADGS) and their N-acetyl and methyl ester derivatives have been synthesized and tested as inhibitors of enzymes catalyzing reactions of the UDP-GlcNAc pathway in bacteria and yeasts. GlcN6S and ADGS at micromolar concentrations inhibited glucosamine-6-phosphate (GlcN6P) synthase of microbial origin. The former was also inhibitory towards fungal GlcN6P N-acetyl...
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MgPd2Sb : A Mg-based Heusler-type superconductor
PublicationWe report the synthesis and physical properties of a full Heusler compound, MgPd2Sb, which we found toshow superconductivity belowTc=2.2K. MgPd2Sb was obtained by a two-step solid-state reaction methodand its purity and cubic crystal structure [Fm-3m,a=6.4523(1) Å] were confirmed by powder x-ray diffrac-tion. Normal and superconducting states were studied by electrical resistivity, magnetic susceptibility, andheat...
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A comprehensive review of sectorial contribution towards greenhouse gas emissions and progress in carbon capture and storage in Pakistan
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Dylematy rozwoju energetyki gazowej w Polsce
PublicationPrzedstawiono prognozę rozwoju energetyki gazowej na tle perspektyw rozwoju setora energii w Polsce .