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Search results for: ANTIPROLIFERATIVE ACTIVITY
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Antimicrobal and ostheointegration activity of bone cement contains nanometals
PublicationPurpose: One of the major problems in bone surgery are infections – especially thoseoccurring in the course of the operating on the patients with lowered immunity system,because they carry the danger of complications. In the Mechanical Department of TechnicalUniversity of Gdansk, there has been carried the research with the use of bone cement andmetal nanoparticles.Design/methodology/approach: The bone cement was used without supplement...
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Inhibitors of angiogenesis in cancer therapy – synthesis and biological activity
PublicationAngiogenesis is the process of formation of new capillaries from preexisting blood vessels. Angiogenesis is involved in normal physiological processes, and plays an important role in tumor invasion and development of metastases. Vascular endothelial growth factor (VEGF) plays a key role in angiogenesis. VEGF is a mitogen for vascular endothelial cells and stimulates their proliferation. By inhibiting the biological activity of...
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Selected organophosphorus compounds with biological activity. Applications in medicine
PublicationThe purpose of this article is to provide an overview of the latest applications of organophosphorus compounds (OPs) that exhibit biological activity. A large family of OPs have become popular in recent years. The practical application of OPs in modern medicine has been attributed to their unique properties. In this article, the methods used to select these compounds will be emphasized. This paper will first outline the findings...
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Territorial Aspects of Entrepreneurial Activity in Polish Suburban Zones
PublicationGlobalization has led to an increased correlation and integration of various fields in modern civilization, including those connected with allocation of entrepreneurial functions. Connection, on a global scale, has shown an increased significance of worldwide corporations. Territorial allocation of the entrepreneurial function has become the subject of translocation and revaluation. Translocation can be understood as the change...
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Knowledge representation of motor activity of patients with Parkinson’s disease
PublicationAn approach to the knowledge representation extraction from biomedical signals analysis concerning motor activity of Parkinson disease patients is proposed in this paper. This is done utilizing accelerometers attached to their body as well as exploiting video image of their hand movements. Experiments are carried out employing artificial neural networks and support vector machine to the recognition of characteristic motor activity...
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Biological activity of conjugates of muramyl dipeptides with batracylin derivatives
PublicationW artykule opisano aktywność biologiczną koniugatów muramylo-dipeptydów z batracyliną lub pochodnymi batracyliny. Badania przeprowadzone w Akademii Medycznej w Gdańsku miały na celu oznaczenie immunomodulacyjnych właściwości tych koniugatów wobec subpopulacji leukocytów krwi obwodowej hodowanych w obecności komórek nowotworowych (K562, WEHI164, Ab melanoma). Leukocyty izolowane były z krwi obwodowej uzyskanej od zdrowych ochotników....
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A.D.A.M. test (Antibiofilm Dressing's Activity Measurement) — Simple method for evaluating anti-biofilm activity of drug-saturated dressings against wound pathogens
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S09 Insights into the development of the physical activity environment policy index, a tool for benchmarking implementation of public policies to create healthy physical activity policy environments
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S09-4 The development of the Physical Activity Environment Policy Index (PA-EPI): a tool for monitoring and benchmarking government policies and actions to improve physical activity
PublicationBackground Insufficient physical activity (PA) is a global issue for health. A multifaceted response, including government action, is essential to improve population levels of PA. The purpose of this study was to develop the ‘Physical Activity Environment Policy Index’ (PA-EPI) monitoring framework to assess government policies and actions for creating a healthy PA environment. Methods An iterative process was undertaken. This...
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The comparison of cytotoxic and genotoxic activities of glucosinolates, isothiocyanates, and indoles
PublicationChemopreventive properties of Brassica vegetables are attributed mainly to their characteristic compounds—glucosinolates (GLs) and their main hydrolysis products—isothiocyanates (ITCs) and indoles. In this study, we compared antiproliferative activity (MTT test in HT29 cells) and genotoxic effects (comet assay in HT29 cells and restriction analysis in a cell-free system) of three GLs (sinigrin (SIN), glucotropaeolin (GTL), and...
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Prediction of antimicrobial activity of imidazole derivatives by artificial neural networks
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Anticariogenic effects of extracts and fractions of Potentilla recta and their antioxidant activity
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Synthesis of novel, peptidic kinase inhibitors with cytostatic/cytotoxic activity
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Comparative Study on Antistaphylococcal Activity of Lipopeptides in Various Culture Media
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Anti-inflammatory Activity and Phytochemical Profile of Galinsoga Parviflora Cav.
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Accelerometer signal pre-processing influence on human activity recognition
PublicationA study of data pre-processing influence on accelerometer-based human activity recognition algorithms is presented. The frequency band used to filter-out the accelerometer signals and the number of accelerometers involved were considered in terms of their influence on the recognition accuracy.
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Antimicrobial and surface activity of 1-alkyl-3-methylimidazolium derivatives
PublicationWiedza na temat zależności struktura-aktywność umożliwia projektowanie i syntezę nowych kationowych związków amfifilowych ze zoptymalizowaną aktywnością antymikrobową na rzecz przyszłego rozwoju nowych środków dezynfekujących, sanityzujących czy konserwujących. Potrzeba projektowania i identyfikowania nowych związków posiadających właściwości przeciwbakteryjne jest rezultatem pojawienia się bardziej odpornych mikroorganizmów w...
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Photocatalytic activity and surface properties of carbon-doped titanium dioxide
PublicationTiO2 domieszkowany węglem otrzymano poprzez hydrolizę izopropanolanu tytanu(IV) i kalcynację w 350ºC w atmosferze powietrza przez 2h. Przeprowadzone badania wykazały, że fenol (0.21 mM) jest efektywnie degradowany w fazie wodnej, w obecności otrzymanego fotokatalizatora oraz światła z zakresu widzialnego (λ>400 nm). Pole powierzchni właściwej otrzymanego C-TiO2 wynosiło około 127 m2/g, fotokatalizator absorbuje światło z zakresu...
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Photodynamic Activity of Tribenzoporphyrazines with Bulky Periphery against Wound Bacteria
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The neuroprotective activity of new phenylalanine-based AMPA receptor antagonists
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Hybrid nanolayers of star polymers and silver nanoparticles with antibacterial activity
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THE DETERMINANTS OF ENTERPRISE PROFI TABILITY DURING REDUCED ECONOMIC ACTIVITY
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Enzymatic Activity as New Moorsh-Forming Process Indicators of Peatlands
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The activity of superoxide dismutases (SODs) at the early stages of wheat deetiolation
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Synthesis and biological activity of mycophenolic acid-amino acid derivatives
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The Total Efficiency of Teaching Activity of Polish Higher Education Institutions
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A Novel Method for the Combined Photocatalytic Activity Determination and Bandgap Estimation
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Characteristic and specificity of protease activity of thermophilic bacteria Meiothermus ruber
PublicationThe primary purpose of research was to establish the possibility of using thermophilic bacteria Meiothermus ruber as a source of proteolytic enzymes. The main reason of searching new proteases is their commercial value especially in production of detergents, food, pharmaceuticals, leather, diagnostics or waste management. The development of this type processes will be possible by utilization of enzymes which have unique characteristics...
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Evaluation of physiological and physical activity by means of a wireless multi-sensor
Publicationmonitorowanie osób starszych, upośledzonych ruchowo i/lub rekonwalescentów w warunkach domowych jest dynamicznie rozwijającą się dyscypliną nauki i techniki. szczególnego znaczenia nabierają systemy przeznaczone dla osób starszych żyjących samotnie. w pracy przedstawiono zintegrowany system umożliwiający monitorowanie wybranych parametrów fizjologicznych (ekg, ikg, resp) oraz aktywności fizycznej za pomocą akcelerometru. działanie...
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Photocatalytic activity and OH radical formation on TiO2 in the relation to crystallinity
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TiO2 Nanoparticles with High Photocatalytic Activity Under Visible Light
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Manganese dioxide (MnO2) nanoparticles influence on the nitrification and anammox activity
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PhageScore: A simple method for comparative evaluation of bacteriophages lytic activity
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Temperature-induced changes of HtrA2(Omi) protease activity and structure
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Cathepsin G activity lowers plasma LDL and reduces atherosclerosis
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Sympathetic Activity in Obese Subjects With and Without Obstructive Sleep Apnea
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A Biofeedback System that Uses the Game to Study Electrical Muscle Activity
PublicationThe aim of this project was to design a system that will allow performing repetitive muscle exercises using a biofeedback device. It is supposed to enhance the motivation and attractiveness of the performed tasks thanks to an interactive game developed for mobile devices with the Android operating system. The built-in calibration mechanisms enable the users to play a game that is independent of their abilities which evens out the...
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Enhanced photocatalytic activity of transparent carbon nanowall/TiO2 heterostructures
PublicationThe synthesis of novel tunable carbon-based nanostructure represented a pivotal point to enhance the efficiency of existing photocatalysts and to extend their applicability to a wider number of sustainable processes. In this letter, we describe a transparent photocatalytic heterostructure by growing boron-doped carbon nanowalls (B-CNWs) on quartz, followed by a simple TiO2 sol-gel deposition. The effect on the thickness and boron-doping...
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Design, synthesis, and biological evaluation of tetrahydroquinolinones and tetrahydroquinolines with anticancer activity
PublicationColorectal cancer (CRC) is the most commonly diagnosed cancer in Europe and the United States and the second leading cause of cancer related mortality. A therapeutic strategy used for the treatment of CRC involves targeting the intracellular levels of reactive oxygen species (ROS). In this study, we synthesized a series of novel tetrahydroquinolinones and assessed their ability to inhibit CRC growth and proliferation by evoking...
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Jaw biomechanics: Estimation of activity of muscles acting at the temporomandibular joint
PublicationThe aim of this study was to elaborate a method of estimation of activity of surface muscles acting at the temporomandibular joint of the healthy subjects by using a surface electromyography (EMG). The scope of this study involved testing chosen jaw motions (open, close, lateral deviation) and process of mastication occurring during eating food with different toughness (chewing gum, cereal and carrot) by using mixed sides, right...
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Photocatalytic activity of layered MoS2 in the reductive degradation of bromophenol blue
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Habitual physical activity and estradiol levels in women of reproductive age
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Covalent conjugation of graphene oxide with methotrexate and its antitumor activity
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Effect of graphene thickness on photocatalytic activity of TiO2-graphene nanocomposites
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Synthesis and structure-activity studies of peptide-acridine/acridone conjugates
PublicationW artykule opisano strukturę, syntezę i biologiczną aktywność peptydowych koniugatów akrydyny i akrydonu jako potencjalnych leków o aktywności przeciwnowotworowej i przeciwwirusowej.
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Antibacterial activity of gelatin-based films incorporated with chitosan or silver
PublicationFolie żelatynowe z dodatkiem srebra jonowego powodowały redukcję komórek Escherichia coli i Staphylococcus aureus o 90% pod powierzchnią folii. Nie obserwowano natomiast strefy zahamowania wzrostu dookoła krążków folii. W przypadku filmów chitozanowych lub żelatynowo-chitozanowych ich przeciwdrobnoustrojowa aktywność zależała od stopnia deacetylacji chitozanu.
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Accelerometer-based Human Activity Recognition and the Impact of the Sample Size
PublicationThe presented study focused on the recognition of eight user activities (e.g. walking, lying, climbing stairs) basing on the measurements from an accelerometer embedded in a mobile device. It is assumed that the device is carried in a specific location of the user’s clothing. Three types of classifiers were tested on different sizes of the samples. The influence of the time window (the duration of a single trial) on selected activities...
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Elderly persons professional activity - substantive issues and methodical challenges
PublicationPopulation ageing and mass withdrawal of persons around retirement age from the labour market constitutes a serious threat for European Union economy, especially in the so-called new member states. The coming years are expected to bring a considerable increase in public spending on pensions and health care, as well as changes in the structure and size of consumer demand and an increase in the number of socially excluded individuals....
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The influence of food phytochemicals on cyclic phosphodiesterase 4 (PDE4) activity
PublicationCyclic phosphodiesterase 4 (PDE4) belongs to family of cyclic phosphodiesterases, which are expressed predominantly in inflammatory cells, airway smooth muscles, cardiovascular tissues and brain. Inhibitors of this family of enzymes found medicinal applications as antidepressants, antiinflamatory drugs (mainly in airway diseases) or antiasthmatics (Ibudilast). PDE4 inhibitors are also being tested for preventing the development...
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Synthesis and biological activity of mycophenolic acid-amino acid derivatives
PublicationIn search of new immunosuppressants, mycophenolic acid (MPA) was coupled with amino acid methyl esters followed by hydrolysis to analogs bearing free carboxylic groups. The obtained compunds were tested in vitro as growth inhibitors of lymphoid cell line (Jurkat) and human peripheral blood mononuclear cells (PBMC) from healthy donors. According to obtained results recovering of free carboxylic group increased their activity. Additionally,...