Search
Filters
total: 1243
filtered: 978
Search results for: compression therapy
-
pH-Responsive Drug Delivery Nanoplatforms as Smart Carriers of Unsymmetrical Bisacridines for Targeted Cancer Therapy
PublicationSelective therapy and controlled drug release at an intracellular level remain key challenges for effective cancer treatment. Here, we employed folic acid (FA) as a self-navigating molecule in nanoconjugates containing quantum dots (QDs) and β-cyclodextrin (β-CD) for the delivery of antitumor unsymmetrical bisacridine compound (C-2028) to lung and prostate cancers as well as normal cells. The bisacridine derivative can form the...
-
Dynamic analysis of the first stage compressor bladed disc of an aircraft engine
Publication -
HEALTH MONITORING OF A COMPRESSION IGNITION ENGINE FED WITH DIFFERENT LOW-SULPHUR MARINE FUELS BY ENDOSCOPIC IMAGE PROCESSING AND ANALYSIS
PublicationThis article characterises the methodology for the endoscopic testing of a laboratory diesel engine used for testing marine fuels. The ‘Shadow’ measurement method used in the XLG3 type EVEREST digital endoscope, for quantitative and qualitative identification of detected surface defects, was approximated. Representative endoscopic images of the elements limiting the working space of the research engine are demonstrated, having...
-
Effect of free water on the quasi‑static compression behavior of partially‑saturated concrete with a fully coupled DEM/CFD approach.
PublicationThe work aims to numerically investigate the quasi-static response of partially fluid-saturated concrete under two-dimensional uniaxial compression at the mesoscale. We investigated how the impact of free pore fluid content (water and gas) affected the quasi-static strength of concrete. The totally and partially fluid-saturated concrete behavior was simulated using an improved pore-scale hydro-mechanical model based on DEM/CFD....
-
Ultimate compressive strength assessment of uncleaned and cleaned corroded plates with locked crack
PublicationThe work presented here investigates the structural response of cleaned corroded plates, subjected to compressive load in the presence of a locked crack, where the change of mechanical properties as a result of corrosion development and the cleaning process is also accounted for. A Finite Element model for assessing the compressive strength, considering geometric and material nonlinearities, is developed, and the analysed plates...
-
Concrete Compressive Strength Under Changing Environmental Conditions During Placement Processes
PublicationThe technological process of concrete production consists of several parts, including concrete mix design, concrete mix production, transportation of fresh concrete mix to a construction site, placement in concrete framework, and curing. Proper execution of these steps provides good quality concrete. Some factors can disturb the technological process, mainly temperature and excessive precipitation. Changing daily temperature and...
-
Advanced numerical modelling for predicting residual compressive strength of corroded stiffened plates
PublicationAn advanced methodology for predicting the residual compressive strength of corroded stiffened plates is developed here using the non-linear finite element method. The non-uniform loss of a plate thickness is accounted for on a macro-scale. In contrast, mechanical properties are changed using the constitutive model to reflect the corrosion degradation impact on a micro-scale. Three different stiffened plate thicknesses are considered,...
-
Add-On Therapy with a Nighttime Dose of Doxazosin in Patients with Uncontrolled Hypertension: Effects on Autonomic Modulation of the Cardiovascular System
Publication -
Microbeam radiation therapy: Tissue dose penetration and BANG-gel dosimetry of thick-beams’ array interlacing
Publication -
Factors affecting long-term efficacy of T regulatory cell-based therapy in type 1 diabetes
Publication -
Introductory investigations of dermatologic diode laser with wavelengths 975 nm: clinical therapy of Recklinghausen disease and of hemangiomas
Publication -
Therapy-Related Changes in the Serum Proteome Patterns of Early Stage Breast Cancer Patients with Different Outcomes
Publication -
Influence of one‐night CPAP therapy on the changes of HIF‐1α protein in OSA patients: A pilot study
Publication -
Oral antibiotic therapy improves fat absorption in cystic fibrosis patients with small intestine bacterial overgrowth
Publication -
Polyamidoamine Dendrimers Decorated Multifunctional Polydopamine Nanoparticles for Targeted Chemo- and Photothermal Therapy of Liver Cancer Model
Publication -
Remdesivir-based therapy improved recovery of patients with COVID-19 in the SARSTer multicentre, real-world study
Publication -
Remdesivir-based therapy improved recovery of patients with COVID-19 in the SARSTer multicentre, real-world study
Publication -
The Value of Serum MicroRNA Expression Signature in Predicting Refractoriness to Bortezomib-Based Therapy in Multiple Myeloma Patients
Publication -
Evaluation of the Combination of Muscle Energy Technique and Trigger Point Therapy in Asymptomatic Individuals with a Latent Trigger Point
Publication -
Phthalocyanine Derivatives Possessing 2-(Morpholin-4-yl)ethoxy Groups As Potential Agents for Photodynamic Therapy
Publication -
Dendrimeric Sulfanyl Porphyrazines: Synthesis, Physico-Chemical Characterization, and Biological Activity for Potential Applications in Photodynamic Therapy
Publication -
Evaluation of brain volume alterations in HCV-infected patients after interferon-free therapy: A pilot study
Publication -
PSMA-D4 Radioligand for Targeted Therapy of Prostate Cancer: Synthesis, Characteristics and Preliminary Assessment of Biological Properties
Publication -
The Influence of Bacteriophages on the Metabolic Condition of Human Fibroblasts in Light of the Safety of Phage Therapy in Staphylococcal Skin Infections
Publication -
Biological aspects of phage therapy versus antibiotics against Salmonella enterica serovar Typhimurium infection of chickens
Publication -
The activity of antioxidant enzymes in blood platelets in different types of renal replacement therapy: a cross-sectional study
Publication -
Limitation of Futile Therapy in the Opinion of Nursing Staff Employed in Polish Hospitals—Results of a Cross-Sectional Study
Publication -
Primary mediastinal B-cell lymphoma – metabolic and anatomical features in 18FDG-PET/CT and response to therapy
Publication -
Optical properties of the chemotherapy drugs used in the central nervous system lymphoma therapy: monitoring drug delivery
PublicationOur aim is to optically monitor the delivery of the chemotherapy drugs for brain tumours, particularly used in the central nervous system (CNS) lymphoma therapy. In vivo monitoring would help to optimize the treatment and avoiding unnecessary medications. Moreover, it would be beneficial to be able to measure which of the multi-regimen drugs actually do penetrate and how well into the brain tissue. There exist several potential...
-
Numerical model of human head phantom to ensure dosimetry of dose components for boron neutron capture therapy
PublicationExtremely important aspects of the boron neutron capture therapy are, first of all, administering to the patient a boron compound that selectively reaches the neoplastic cells, and in the second step, the verification of the irradiation process. This paper focuses on the latter aspect, which is the detailed dosimetry of the processes occurring after the reaction of thermal neutrons with the boron-10 isotope. The results of computer...
-
Influence of Acute Jugular Vein Compression on the Cerebral Blood Flow Velocity, Pial Artery Pulsation and Width of Subarachnoid Space in Humans
PublicationCelem pracy jest zaprezentowanie wyników badań dotyczących oceny wpływu silnego obustronnego zwężenia żył szyjnych na amplitudę pulsacji i zmiany szerokości przestrzeni podpajęczynówkowej, prędkość przepływu mózgowego krwi, obwodowe ciśnienie krwi oraz możliwe relacje między wymienionymi parametrami.
-
Deformation of thin metal and composite sheets by using anti-buckling fixture for large deformation under tension–compression cyclic loading
Publication -
Comparison of the powers of energy losses in a variable capacity displacement pump determined without or with taking into account the power of hydraulic oil compression
PublicationPowers of energy losses in a variable capacity displacement pump are compared with or without taking into account the power of hydraulic oil compression. Evaluation of power of liquid compression in the pump was made possible by the use of method, proposed by the Author, of determining the degree of liquid aeration in the pump. In the method of determining the liquid aeration in the pump and of powers of volumetric losses of liquid...
-
Coexpression of human chorionic gonadotropin beta subunit and its receptor in nontrophoblastic gynecological cancer
Publication -
Isothermal Calorimetry and Compressive Strength Tests of Mortar Specimens for Determination of Apparent Activation Energy
PublicationThe hydration process of cementitious materials involves a thermally activated reaction that depends on the composition of the mixture and the curing temperature. The main parameter affecting the temperature variation of cast-in-place concrete is the apparent activation energy, which can be used for the efficient prediction of the temperature evolution and maturity index of hardening concrete. This paper discusses two methods to...
-
Ultimate strength of stiffened plates subjected to compressive load and spatially distributed mechanical properties
PublicationThe present study deals with the ultimate strength of stiffened plates subjected to spatially distributed mechanical properties and compressive load. Normally, mean values of mechanical properties based on tensile tests are used to validate the numerical assessment with experimental results. However, mechanical properties may vary within a single specimen. To investigate the impact of that, random fields of yield stress and Young...
-
Edgewise Compressive Behavior of Composite Structural Insulated Panels with Magnesium Oxide Board Facings
PublicationEdgewise compression response of a composite structural insulated panel (CSIP) with magnesium oxide board facings was investigated. The discussed CSIP is a novel multifunctional sandwich panel introduced to the housing industry as a part of the wall, floor, and roof assemblies. The study aims to propose a computational tool for reliable prediction of failure modes of CSIPs subjected to concentric and eccentric axial loads. An advanced...
-
Correlation between Compressive Strength and Heat of Hydration of Cement Mortars with Siliceous Fly Ash
PublicationThis paper presents the results of calorimetric and strength tests of mortars with ordinary Portland cement and two substitution rates (10 and 20%) of cement by siliceous fly ash. The prepared samples were cured under isothermal conditions at four different temperatures: 23, 33, 43 and 53 °C. Heat of hydration was measured using an isothermal calorimeter dedicated to monitor the hydration process of cementitious composites such...
-
Machine-learning methods for estimating compressive strength of high-performance alkali-activated concrete
PublicationHigh-performance alkali-activated concrete (HP-AAC) is acknowledged as a cementless and environmentally friendly material. It has recently received a substantial amount of interest not only due to the potential it has for being used instead of ordinary concrete but also owing to the concerns associated with climate change, sustainability, reduction of CO2 emissions, and energy consumption. The characteristics and amounts of the...
-
Theophylline Therapy for Cheyne-Stokes Respiration During Sleep in a 41-Year-Old Man With Refractory Arterial Hypertension
Publication -
DNA methylation in cancer development, diagnosis and therapy-multiple opportunities for genotoxic agents to act as methylome disruptors or remediators
PublicationThe role of DNA methylation and recently discovered hydroxymethylation in the function of the human epigenome is currently one of the hottest topics in the life sciences. Progress in this field of research has been further accelerated by the discovery that alterations in the methylome are not only associated with key functions of cells and organisms, such as development, differentiation and gene expression, but may underlie a number...
-
Association of Hepcidin mRNA Expression With Hepatocyte Iron Accumulation and Effects of Antiviral Therapy in Chronic Hepatitis C Infection
Publication -
Interferon‐free therapy as the cause of white matter tracts and cerebral perfusion recovery in patients with chronic hepatitis C
Publication -
St. Jude Total Therapy studies from I to XVII for childhood acute lymphoblastic leukemia: a brief review
Publication -
Physical and Mechanical Evaluation of Silicone-Based Double-Layer Adhesive Patch Intended for Keloids and Scar Treatment Therapy
PublicationGrowing interest in silicone elastomers for pharmaceutical purposes is due to both theirbeneficial material effect for scar treatment and their potential as drug carriers. Regarding their morphological structure, silicone polymers possess unique properties, which enable a wide range of applicability possibilities. The present study focused on developing a double-layer adhesive silicone film (DLASil) by evaluating its physical...
-
Increased Levels of Platelets and Endothelial-Derived Microparticles in Patients With Non-Valvular Atrial Fibrillation During Rivaroxaban Therapy
Publication -
Physical and Mechanical Evaluation of Silicone-Based Double-Layer Adhesive Patch Intended for Keloids and Scar Treatment Therapy
Publication -
Comparison of siRNA-mediated silencing of glycosaminoglycan synthesis genes and enzyme replacement therapy for mucopolysaccharidosis in cell culture studies.
Publication -
Cytocompatibility of stabilized black phosphorus nanosheets tailored by directly conjugated polymeric micelles for human breast cancer therapy
PublicationThe novel procedure of few-layer black phosphorus (FLBP) stabilization and functionalisation was here proposed. The cationic polymer PLL and non-ionic PEG have been involved into encapsulation of FLBP to allow sufficient time for further nanofabrication process and overcome environmental degradation. Two different spacer chemistry was designed to bind polymers to tumor-homing peptides. The efficiency of functionalisation was examined...
-
Dual-Activity Fluoroquinolone-Transportan 10 Conjugates offer alternative Leukemia therapy during Hematopoietic Cell Transplantation
PublicationHematopoietic cell transplantation (HCT) is often considered a last resort leukemia treatment, fraught with limited success due to microbial infections, a leading cause of mortality in leukemia patients. To address this critical issue, we explored a novel approach by synthesizing antileukemic agents containing antibacterial substances. This innovative strategy involves conjugating fluoroquinolone antibiotics, such as ciprofloxacin...