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Search results for: REPUTATION
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Dibutyl phthalate disrupts conserved circadian rhythm in Drosophila and human cells
PublicationPeople are constantly exposed to phthalates, due to their common use in the production of plastics, pharmaceuticals, cosmetics and skin care products. The ability of phthalates to disrupt endocrine signaling, leading to developmental, reproductive and metabolic defects, has been studied, yet how phthalates interfere with these biological functions is still unclear. To uncover DBP interacting molecular pathways, we raised Drosophila...
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Activation of endogenous regenerative potential in mammals using epigenetic inhibitor zebularine
PublicationIn this work, a nucleoside inhibitor of DNA methyltransferases, zebularine, was investigated as a wound healing and regeneration promoting agent. It was found that a high dose of intraperitoneally delivered zebularine improved punch wound closure in the ear pinna in mice. Both cytidine, a zebularine analogue, and uridine, a zebularine metabolite, did not promote ear pinna hole closure. The effect of zebularine on ear pinna healing...
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Towards a modification of a regulatory framework aiming at bunker oil spill prevention from ships - A design aspect of bunker tanks vents location guided by CFD simulations
PublicationAlthough accidental bunker oil spills at seaway are relatively rare events, they can be pose real threat to the natural marine environment. One of the reasons for the bunker spill to occur is a design failure; one of the ways it can demonstrate is an improper location or height of vent heads, leading to a bunker oil discharge during heavy rolling, due to sloshing phenomenon. Design of a ship and her systems is guided by various...
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CROWDFUNDING OF RESEARCH PROJECTS IN POLAND
PublicationCrowdfunding recently became a very popular way of funding, which allows funding almost everything, from minor personal projects to expensive commercial ones, as long as we can find investors. It may also be a new opportunity for entrepreneurial researchers, who may attract capital investment in companies that are promised to own developed technologies. Social financing of science is well suited to reduce some of the biggest problems...
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The relationship between standard reduction potentials of catechins and biological activities involved in redox control
PublicationRedox homeostasis involves factors that ensure proper function of cells. The excess reactive oxygen species (ROS) leads to oxidative stress and increased risk of oxidative damage to cellular components. In contrast, upon reductive stress, insufficient ROS abundance may result in faulty cell signalling. It may be expected that dietary antioxidants, depending on their standard reduction potentials (E°), will affect both scenarios....
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Shaping the new planning curricula in the post-socialistic context lessons from Poland and Russia
PublicationPlanning education is the issue widely discussed during various conferences and seminars, especially ones grouping the representatives of universities offering professional education in this field. But to large extend this discourse is dominated by the realities and specifics of the highly- developed countries, which is also reflected in the structure of the organizations of universities offering these. At the same time planning...
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Structure and evolution of the 4-helix bundle domain of Zuotin, a J-domain protein co-chaperone of Hsp70
PublicationThe J-domain protein Zuotin is a multi-domain eukaryotic Hsp70 co-chaperone. Though it is primarily ribosome-associated, positioned at the exit of the 60S subunit tunnel where it promotes folding of nascent polypeptide chains, Zuotin also has off-ribosome functions. Domains of Zuotin needed for 60S association and interaction with Hsp70 are conserved in eukaryotes. However, whether the 4-helix bundle (4HB) domain is conserved remains...
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Review on robust laser light interaction with titania – Patterning, crystallisation and ablation processes
PublicationTitanium dioxide is regarded as a very promising semiconducting material that is widely applied in many everyday-use products, devices, and processes. In general, those applications can be divided into energy or environmental categories, where a high conversion rate, and energy and power density are of particular interest. Therefore, many efforts are being put towards the elaboration of novel production routes, and improving the...
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Journey towards light – evolutionary adaptations of humans, flora and fauna. Guidelines for safe and healthy illumination
PublicationThe paper examines using relatively recent discoveries on how evolution has embedded within all living organisms a natural sensitivity towards their native environment, in particular luminance levels and specific wavelengths of light. The studies conducted so far indicate that lighting installations that are visible after dark impact on humans, flora and fauna and influence our evolutionary dispositions, possibly with negative...
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Spatial Heterogeneity Impacts of Bilateral Foreign Direct Investment on Green Energy Efficiency in China
PublicationAt present, green energy transformation and climate policy are increasingly connected. The need to improve national competitiveness and implement climate and energy strategies means that an energy-consuming country like China must rapidly enhance its green energy efficiency (GEE) and energy consumption structure. The following paper contributes to the existing literature by analyzing the effects of bilateral FDI on GEE from...
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ASSESSMENT OF CLIFF STABILITY AFTER THE DEMOLITION OF THE ENGINEERING FACILITIES
PublicationAs a part of an experiment, cliff in Gdynia Redlowo (southern coast of Baltic Sea, Gdansk Bay) was measured using terrestrial laser scanner. The main reason for taking up the subject of the Orlowo Cliff’s stability was a decision about controlled removal one of the war fortification elements. The main purpose of that analysis was to specify suitability of laser scanning in determination of slope’s stability after a violent event....
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Anticancer imidazoacridinone C-1311 inhibits hypoxia-inducible factor-1α (HIF-1α), vascular endothelial growth factor (VEGF) and angiogenesis
PublicationAntitumor imidazoacridinone C-1311 is a DNA-reactive topoisomerase II and FLT3 receptor tyrosine kinase inhibitor. Here, we demonstrate the mechanism of C-1311 inhibitory action on novel targets: hypoxia-inducible factor-1α (HIF-1α), vascular-endothelial growth factor (VEGF), and angiogenesis. In a cell-free system, C-1311 prevented HIF-1α binding to an oligonucleotide encompassing a canonical hypoxia-responsive element (HRE),...
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Converting beach wrack into a resource as a challenge for the Baltic Sea (an overview)
PublicationThe paper distinguishes beach wrack, the marine generated organic part of beach cast, as a separate management object and discusses research questions related to its management and economically viable use. Based on experiences from the Baltic Sea and existing practices from countries with different management systems clear distinction between the management of natural and anthropogenic components of cast material is seen as an...
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Structural features responsible for control of the eukaryotic GlcN-6-P synthase activity
PublicationGlucosamine-6-phosphate (GlcN-6-P) synthase is responsible for catalysis of the first and practically irreversible step in hexosamine metabolism. As UDP-GlcNAc, the final product of the hexosamine path, constitutes one of the essential substrates for assembly of bacterial and fungal cell walls, the enzyme is an interesting target for antimicrobial therapy.The structure of E. coli enzyme, known since 2001, forms a dimer of two identical...
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DETERMINATION OF SURFACTANTS IN ENVIRONMENTAL SAMPLES. PART II. ANIONIC COMPOUNDS
PublicationSurfactants (SAA) with negative charge of polar group are named as anionic compounds. They are main constituent of most products containing synthetic surfactants. The linear alkylbenzene sulfonates (LAS), alkyl ethoxysulfates (AES) and alkyl sulfates (AS) are typically applied from this class of compounds. Those surfactants are ingredients of household detergents and cleaners, laundry detergents, cosmetic. Moreover they can be...
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Surface treatment of C80U steel by long CO2 laser pulses
PublicationThe paper presents the results of laser-melted C80U steel. The processed steel was placed between two permanent magnets and laser beam whose scanning velocity was 10 mm/s. CO2 laser beam was working in pulse mode. Pulses were generated at 100% of the average preset power of 700W, with 45 ms irradiation, zero interval between pulses and beginning of pulse repetition upon the achievement of the average laser power. During the operation,...
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Możliwości sterowania mocą bierną elektrowni wiatrowej : Reactive power control methods in wind parks
PublicationReferat poświęcony jest zagadnieniu sterowania mocą bierną w elektrowniach wiatrowych. W pierwszej części referatu opisano tło problemu sterowania mocą bierną w parkach wiatrowych, podano powody, dla których moc bierna powinna podlegać regulacji oraz zarysowano metody, które mogą być do niej użyte. W celu sprawdzenia proponowanych metod kompensacji, zbudowano model matematyczny elektrowni wiatrowej, którego poszczególne elementy...
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Direct injection liquid chromatography-mass spectrometry (DI-LC-MS) analysis for rapid lipidomic profiling of extracellular vesicles
PublicationExtracellular vesicles (EVs) are small, spherical particles produced by eukaryotic and prokaryotic cells, surrounded by a bilayer membrane and carrying various bioactive molecules, such as proteins, surface receptors, membrane and soluble proteins, lipids, and nucleic acids. EVs are of substantial interest because of their important roles in cell communication, epigenetic regulation and possible application in disease diagnosis...
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Genome-Wide DNA Methylation and Gene Expression in Patients with Indolent Systemic Mastocytosis
PublicationMastocytosis is a clinically heterogenous, usually acquired disease of the mast cells with a survival time that depends on the time of onset. It ranges from skin-limited to systemic disease, including indolent and more aggressive variants. The presence of the oncogenic KIT p. D816V gene somatic mutation is a crucial element in the pathogenesis. However, further epigenetic regulation may also affect the expression of genes that...
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Towards spectral sensitivity curve for two-photon vision mechanism
PublicationAbstract Purpose: The perceived brightness of different visible light sources can be compared with photometric units based on the standardized luminosity curves (300-780nm range). As reported previously (PNAS 111(50), pp. E5445-E5454 (2014)), near-infrared (NIR) radiation can cause isomerization of visual pigments by one- or two-photon absorption. The perceived color of the stimulus is red in the case of one-photon vision (1PV)...
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Quality prediction of foil capacitors by acoustic emission signals
PublicationJakość i trwałość kondensatorów foliowych jest zależna od ich warunków pracy (np. nadmiarowego napięcia pracy, temperatury, wilgotności) oraz od potencjalnych defektów wprowadzonych na różnych etapach wytwarzania kondensatorów. Nieustanny nacisk na wzrost jakości wytwarzanych elementów przy jednoczesnej redukcji kosztów wytwarzania oznacza, że nowe, tanie i szybkie metody predykcji jakości tych elementów są mocno poszukiwane. W...
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Architektura a dekonstrukcja. Przypadek Petera Eisenmana i Bernarda Tschumiego
PublicationArchitecture and Deconstruction Case of Peter Eisenman and Bernard Tschumi Introduction Towards deconstruction in architecture Intensive relations between philosophical deconstruction and architecture, which were present in the late 1980s and early 1990s, belong to the past and therefore may be described from a greater than...